RO86363B - Procedeu pentru prepararea unor derivati de metiltiopirimidina - Google Patents

Procedeu pentru prepararea unor derivati de metiltiopirimidina

Info

Publication number
RO86363B
RO86363B RO109750A RO10975083A RO86363B RO 86363 B RO86363 B RO 86363B RO 109750 A RO109750 A RO 109750A RO 10975083 A RO10975083 A RO 10975083A RO 86363 B RO86363 B RO 86363B
Authority
RO
Romania
Prior art keywords
group
general formula
phenyl
alkoxyalkyl
alkenyl
Prior art date
Application number
RO109750A
Other languages
English (en)
Other versions
RO86363A (ro
Inventor
Ishikawa Katsutoshi
Shimotori Hitoshi
Lida Noboru
Anihiro Kazuo
Shuji Ozawa
Original Assignee
Mitsui Toatsu Chemicals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Incorporated filed Critical Mitsui Toatsu Chemicals Incorporated
Publication of RO86363A publication Critical patent/RO86363A/ro
Publication of RO86363B publication Critical patent/RO86363B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Inven#355;ia se refera la un procedeu de preparare a unor derivati de metiltiopirimidina cu formula generala i:(vezi formula) în care R1 este o grupa alchil avînd de la 1 la 6 atomi de carbon sau o grupa fenil, benzil, alchenil sau alcoxialchil; R2 reprezinta o grupare alchil de la 1 la 6 atomi de carbon, fenil, fenil substituit cu halogen, alchenil, alchenil omegafenil substituit, alchinil, alcoxialchil, alcoxicarbonil amonialchil, alcoxialcoxialchil, alchiltioalchil, tetreahidrofuril sau o grupa în care r3 si R4 reprezinta în mod individual un atom de hidrogen sau o grupa metil, Y este hidrogen sau halogen, metil sau metoxi, n reprezinta un numar întreg, 1 sau 2 si X reprezinta oxigen sau sulf. Procedeul consta în aceea ca (a) 5-metiltio-2,4,6-triclor-pirimidina reactioneaza cu 2 echivalenti din compusul cu formula generala Ii: R1-OH în care R1 are semnificatiile de mai sus, în prezenta unei baze aleasa din grupul constînd din metal alcalin; hidrura de sodiu, hidrura de potasiu, hidroxide metal alcalin si compusii analogi, la o temperatura cuprinsa între -10 degree C si punctul de fierbere al solventului, în calitate de solvent fiind folosit cel putin unul ales din grupul constînd din tetrahidrofuran, dioxan tilfosfortriamida, benzen, toluen, ater si chiar alcoolul R1-OH astfel încît sa formeze un derivat cu formula generala III: (vezi formula) în care R1 are aceeasi semnificatie ca mai sus ; (b) derivatul dialcoxipirimidinic reactioneaza apoi cu un compus cu formula generala IV: R2XH în care R2 are semnificatiile de mai sus în prezenta aceluiasi baze indicate mai sus.
RO109750A 1982-01-20 1983-01-17 Procedeu pentru prepararea unor derivati de metiltiopirimidina RO86363B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57006142A JPS58124773A (ja) 1982-01-20 1982-01-20 ５−メチルチオピリミジン誘導体とその製造法と農園芸用殺菌剤

Publications (2)

Publication Number Publication Date
RO86363A RO86363A (ro) 1985-03-15
RO86363B true RO86363B (ro) 1985-03-31

Family

ID=11630260

Family Applications (4)

Application Number Title Priority Date Filing Date
RO83116655A RO89714A (ro) 1982-01-20 1983-01-17 Procedeu de preparare a unor derivati de 5-metiltiopirimidina
RO109750A RO86363B (ro) 1982-01-20 1983-01-17 Procedeu pentru prepararea unor derivati de metiltiopirimidina
RO83116657A RO89716A (ro) 1982-01-20 1983-01-17 Compozitie fungicida lichida
RO83116656A RO89715A (ro) 1982-01-20 1983-01-17 Compozitie fungicida solida

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO83116655A RO89714A (ro) 1982-01-20 1983-01-17 Procedeu de preparare a unor derivati de 5-metiltiopirimidina

Family Applications After (2)

Application Number Title Priority Date Filing Date
RO83116657A RO89716A (ro) 1982-01-20 1983-01-17 Compozitie fungicida lichida
RO83116656A RO89715A (ro) 1982-01-20 1983-01-17 Compozitie fungicida solida

Country Status (11)

Country Link
US (1) US4540698A (ro)
JP (1) JPS58124773A (ro)
DD (2) DD219654A5 (ro)
DE (1) DE3301106A1 (ro)
FR (1) FR2519983B1 (ro)
GB (1) GB2113216B (ro)
IN (1) IN157931B (ro)
IT (1) IT1163039B (ro)
NL (1) NL8300193A (ro)
PL (1) PL138343B1 (ro)
RO (4) RO89714A (ro)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227867A (ja) * 1983-06-09 1984-12-21 Mitsui Toatsu Chem Inc ５―メチルチオピリミジン誘導体とその製造法と農園芸用殺菌剤
JPH0635450B2 (ja) * 1984-03-16 1994-05-11 三井東圧化学株式会社 チオシアノピリミジン誘導体、その製造法および農園芸用殺菌剤
JPS6345269A (ja) * 1986-04-28 1988-02-26 Mitsui Toatsu Chem Inc ジハロゲン置換チオシアノピリミジン誘導体、その製造法および農園芸用殺菌剤
JPS63112566A (ja) * 1986-10-28 1988-05-17 Nissan Chem Ind Ltd ピリミジノン誘導体、その製法および殺虫・殺ダニ・殺菌剤
JPH0827122A (ja) * 1994-07-15 1996-01-30 Kureha Chem Ind Co Ltd ２−（ベンジルオキシ）（フェノキシ）ピリミジン誘導体、その製造方法及び除草剤
EP0940392A4 (en) * 1996-10-31 2002-08-14 Kumiai Chemical Industry Co PYRIMIDINYLALIC ACID AMID DERIVATIVES AND FUNGICIDES FOR USE IN AGRICULTURE AND GARDENING
US6638926B2 (en) 2000-09-15 2003-10-28 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
CA2432799C (en) * 2000-12-21 2008-08-19 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
MXPA04007697A (es) * 2002-02-06 2004-11-10 Vertex Pharma Compuestos de heteroarilo utiles como inhibidores de gsk-3.
ATE468336T1 (de) * 2002-03-15 2010-06-15 Vertex Pharma Azolylaminoazine als proteinkinasehemmer
MY141867A (en) * 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
PT1532145E (pt) * 2002-08-02 2007-01-31 Vertex Pharma Composiçoes de pirazole úteis como inibidores de gsk-3
US7601718B2 (en) * 2003-02-06 2009-10-13 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
CA2548172A1 (en) * 2003-12-04 2005-06-23 Vertex Pharmaceuticals Incorporated Quinoxalines useful as inhibitors of protein kinases
JP2009504771A (ja) * 2005-08-18 2009-02-05 バーテックス ファーマシューティカルズ インコーポレイテッド ピラジンキナーゼ阻害剤
WO2007056163A2 (en) 2005-11-03 2007-05-18 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
DE602007004750D1 (de) * 2006-11-02 2010-03-25 Vertex Pharma Als inhibitoren von proteinkinasen geeignete aminopyridine und aminopyrimidine
WO2008077086A1 (en) * 2006-12-19 2008-06-26 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
NZ579485A (en) * 2007-03-09 2012-02-24 Vertex Pharma Aminopyrimidines useful as inhibitors of protein kinases
EP2134709A1 (en) 2007-03-09 2009-12-23 Vertex Pharmaceuticals, Inc. Aminopyridines useful as inhibitors of protein kinases
MX2009009590A (es) * 2007-03-09 2009-11-10 Vertex Pharma Aminopirimidinas utiles como inhibidores de proteinas cinasas.
NZ580343A (en) 2007-04-13 2012-03-30 Vertex Pharma Aminopyrimidines useful as kinase inhibitors
JP5389785B2 (ja) * 2007-05-02 2014-01-15 バーテックス ファーマシューティカルズ インコーポレイテッド キナーゼ阻害剤として有用なチアゾールおよびピラゾール
CA2694381A1 (en) * 2007-05-02 2008-11-13 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
CA2688584A1 (en) * 2007-05-02 2008-11-13 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
AU2008257044A1 (en) * 2007-05-24 2008-12-04 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
AU2008282156B2 (en) * 2007-07-31 2014-07-17 Vertex Pharmaceuticals Incorporated Process for preparing 5-fluoro-1H-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof
CN102215816A (zh) * 2008-09-03 2011-10-12 沃泰克斯药物股份有限公司 共晶和包含所述共晶的药物制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199583A (en) * 1970-07-13 1980-04-22 The Upjohn Company Antifungal method, formulations and compounds
US4126459A (en) * 1976-05-14 1978-11-21 Polaroid Corporation Thioether substituted silver halide solvents
US4211559A (en) * 1976-09-30 1980-07-08 Texas Instruments Incorporated Photographic processes and compositions employing thioether containing silver halide solvents

Also Published As

Publication number Publication date
GB2113216B (en) 1985-12-04
IN157931B (ro) 1986-07-26
DD209447A5 (de) 1984-05-09
RO89716A (ro) 1986-07-30
GB8300400D0 (en) 1983-02-09
PL240209A1 (en) 1984-06-18
FR2519983A1 (fr) 1983-07-22
JPS58124773A (ja) 1983-07-25
JPH0378383B2 (ro) 1991-12-13
PL138343B1 (en) 1986-09-30
RO86363A (ro) 1985-03-15
NL8300193A (nl) 1983-08-16
GB2113216A (en) 1983-08-03
IT8319164A0 (it) 1983-01-18
IT1163039B (it) 1987-04-08
RO89715A (ro) 1986-07-30
FR2519983B1 (fr) 1985-12-06
RO89714A (ro) 1986-07-30
US4540698A (en) 1985-09-10
DE3301106A1 (de) 1983-07-28
DD219654A5 (de) 1985-03-13

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