PY0101650A - 2-phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethyla-mine derivatives - Google Patents

2-phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethyla-mine derivatives

Info

Publication number
PY0101650A
PY0101650A PY200100101650A PY0101650A PY0101650A PY 0101650 A PY0101650 A PY 0101650A PY 200100101650 A PY200100101650 A PY 200100101650A PY 0101650 A PY0101650 A PY 0101650A PY 0101650 A PY0101650 A PY 0101650A
Authority
PY
Paraguay
Prior art keywords
hydroxycycloalk
ethyla
hydroxycycloalkyl
enyl
phenyl
Prior art date
Application number
PY200100101650A
Other languages
English (en)
Inventor
A Muth Eric
E Morris Husbands G
P Yardley John
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27048740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PY0101650(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Home Prod filed Critical American Home Prod
Publication of PY0101650A publication Critical patent/PY0101650A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/70—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention provides a grop of hydroxycycloalk-anephenethyl amine antidepressant derivatives of the following structural fórmula...
PY200100101650A 1983-04-19 2001-01-26 2-phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethyla-mine derivatives PY0101650A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48659483A 1983-04-19 1983-04-19
US06/545,701 US4535186A (en) 1983-04-19 1983-10-26 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives

Publications (1)

Publication Number Publication Date
PY0101650A true PY0101650A (es) 2001-12-03

Family

ID=27048740

Family Applications (1)

Application Number Title Priority Date Filing Date
PY200100101650A PY0101650A (es) 1983-04-19 2001-01-26 2-phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethyla-mine derivatives

Country Status (2)

Country Link
US (1) US4535186A (es)
PY (1) PY0101650A (es)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826844A (en) * 1987-09-30 1989-05-02 American Home Products Corporation Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols
US6440457B1 (en) * 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
ES2304041T3 (es) 1993-06-28 2008-09-01 Wyeth Nuevos tratamientos que utilizan derivados de fenetilamina.
SG49680A1 (en) * 1994-02-14 1998-06-15 American Home Prod Medicament for the inducement of cognition enhancement
US5506270A (en) * 1995-01-30 1996-04-09 American Home Products Corporation Venlafaxine in the treatment of hypothalamic amenorrhea in non-depressed women
US20060068018A1 (en) * 1996-03-25 2006-03-30 Wyeth Extended release formulation
US20030215507A1 (en) * 1996-03-25 2003-11-20 Wyeth Extended release formulation
US6274171B1 (en) 1996-03-25 2001-08-14 American Home Products Corporation Extended release formulation of venlafaxine hydrochloride
PE57198A1 (es) 1996-03-25 1998-10-10 American Home Prod Formula de liberacion prolongada
EP1331003B1 (en) 1996-03-25 2015-08-26 Wyeth LLC Extended release formulation containing venlafaxine
US6069177A (en) * 1997-07-08 2000-05-30 The Hong Kong University Of Science And Technology 3-Hydroxy-propanamine derived neuronal reuptake inhibitors
US6342533B1 (en) 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
PL350924A1 (en) * 1999-04-06 2003-02-10 Sepracor Inc Derivatives of venlafaxine and methods of preparing and using the same
US20020022662A1 (en) * 1999-06-15 2002-02-21 American Home Products Corporation Enantiomers of O-desmethyl venlafaxine
US20020035158A1 (en) * 1999-06-15 2002-03-21 American Home Products Corporation Enantiomers of N-desmethyl venlafaxine
US6348494B1 (en) 2000-11-21 2002-02-19 American Home Products Corporation Ethers of o-desmethyl venlafaxine
US7291646B2 (en) * 1999-11-24 2007-11-06 Wyeth Ethers of O-desmethyl venlafaxine
US6572890B2 (en) 2000-01-13 2003-06-03 Osmotica Corp. Osmotic device containing venlafaxine and an anti-psychotic agent
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US20020183553A1 (en) * 2000-10-19 2002-12-05 Ben-Zion Dolitzky Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof
KR20030059206A (ko) * 2000-10-19 2003-07-07 테바 파마슈티컬 인더스트리즈 리미티드 결정질 벤라팍신 염기 및 벤라팍신 히드로클로라이드의신규한 다형태, 이의 제조 방법
AU2002238421A1 (en) * 2000-12-20 2002-07-01 Ciba Specialty Chemicals Holding Inc. Process for the preparation of phenethylamine derivatives
US7141697B2 (en) * 2000-12-20 2006-11-28 Sandoz Ag Process for the preparation of phenethylamine derivatives
DE60221642T3 (de) 2001-02-12 2017-10-26 Wyeth LLC (n.d.Ges.d. Staates Delaware) O-desmethyl-venlafaxine succinat salz
US6504044B2 (en) * 2001-02-28 2003-01-07 Council Of Scientific And Industrial Research Process for the preparation of 1-[cyano(aryl)methyl] cyclohexanol
DE60136263D1 (de) * 2001-04-10 2008-12-04 Alembic Ltd Zwischenprodukt zur Herstellung von 1-Ä2-Dimethylamino-1-(4-methoxyphenyl)-ethylÜ-cyclohexanol
KR20030000217A (ko) * 2001-06-22 2003-01-06 와이어쓰 시클로헥사놀 유도체의 제조방법
US20040186310A1 (en) * 2001-06-22 2004-09-23 Kim Keun-Sik Process for preparation of cyclohexanol derivatives
GB0126036D0 (en) * 2001-10-30 2001-12-19 Amedis Pharm Ltd Silicon compounds
US20040034101A1 (en) * 2001-11-05 2004-02-19 Cypress Bioscience, Inc. Treatment and prevention of depression secondary to pain (DSP)
WO2003042162A1 (en) * 2001-11-17 2003-05-22 Neurosearch A/S Prodrugs of antidepressants and their use for treating depressions
UA80543C2 (en) 2001-12-04 2007-10-10 Wyeth Corp Method for the preparation of o-desmethylvenlafaxine
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
CA2482569C (en) * 2002-03-26 2010-11-09 Nicholas Piramal India Limited Manufacture of phenyl ethylamine compounds, in particular venlafaxine
AU2003226748A1 (en) * 2002-03-28 2003-10-13 Synthon B.V. Compositions of venlafaxine base
AR039162A1 (es) * 2002-03-28 2005-02-09 Synthon Bv Formulaciones de venlafaxina de liberacion extendida
WO2003082804A1 (en) 2002-03-28 2003-10-09 Synthon B.V. Venlafaxine besylate
AU2003226751A1 (en) 2002-03-28 2003-10-13 Synthon B.V. Low water-soluble venlafaxine salts
WO2003090743A1 (en) * 2002-04-24 2003-11-06 Cypress Bioscience, Inc. Prevention and treatment of functional somatic disorders, including stress-related disorders
TW200402289A (en) * 2002-05-17 2004-02-16 Wyeth Corp Methods of treating gastrointestinary and genitourinary pain disorders
BR0311693A (pt) * 2002-06-10 2005-03-22 Wyeth Corp Sal de formato de o-desmetil-venlafaxina
US20040180879A1 (en) * 2002-10-15 2004-09-16 Deecher Darlene Coleman Novel method of treating vasomotor symptoms
US7345096B2 (en) * 2002-10-15 2008-03-18 Wyeth Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms
US20040152710A1 (en) * 2002-10-15 2004-08-05 Deecher Darlene Coleman Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms
US6703044B1 (en) 2002-10-25 2004-03-09 Dexcel Pharma Tech, Ltd Venlafaxine formulations
CN1232501C (zh) * 2002-11-29 2005-12-21 重庆凯林制药有限公司 用于制备万拉法新中间体的环己醇衍生物的制备工艺
US20040235925A1 (en) * 2002-12-17 2004-11-25 Pharmacia Corporation Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof
US20070077301A1 (en) * 2002-12-23 2007-04-05 Meyer Glenn A Venlafaxine osmotic device formulation
TWI306092B (en) * 2003-03-11 2009-02-11 Wyeth Corp Process for preparation of phenethylamine derivatives
MXPA05011225A (es) * 2003-04-18 2005-12-14 Pharmacia & Upjohn Co Llc Politerapias.
EP1473030B2 (en) * 2003-05-02 2014-05-14 Dexcel Ltd. Extended release Venlafaxine tablet formulation
US20050048118A1 (en) * 2003-07-25 2005-03-03 Joan Cucala Escoi Modified release venlafaxine hydrochloride tablets
TW200507850A (en) * 2003-07-25 2005-03-01 Kyowa Hakko Kogyo Kk Pharmaceutical composition
MXPA06002789A (es) 2003-09-12 2006-06-14 Pfizer Combinaciones que comprenden ligandos alfa-2-delta.
EP1523981A1 (en) * 2003-10-13 2005-04-20 Wyeth Extended release formulations of venlafaxine
EP1523979A1 (en) * 2003-10-13 2005-04-20 Wyeth Extended release pharmaceutical dosage form
US20050130987A1 (en) * 2003-10-14 2005-06-16 Wyeth Methods of treating vasomotor symptoms
US7402698B2 (en) * 2003-10-14 2008-07-22 Wyeth Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use
US7365076B2 (en) 2003-10-14 2008-04-29 Wyeth Substituted aryl cycloalkanol derivatives and methods of their use
US7419980B2 (en) * 2003-10-14 2008-09-02 Wyeth Fused-aryl and heteroaryl derivatives and methods of their use
US7531543B2 (en) * 2003-10-14 2009-05-12 Wyeth Phenylpiperazine cycloalkanol derivatives and methods of their use
US7550485B2 (en) * 2003-10-14 2009-06-23 Wyeth Substituted N-heterocycle derivatives and methods of their use
US7491723B2 (en) * 2003-10-14 2009-02-17 Wyeth Alkanol and cycloalkanol-amine derivatives and methods of their use
US7524846B2 (en) * 2003-10-14 2009-04-28 Wyeth Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use
US7470435B2 (en) * 2003-11-17 2008-12-30 Andrx Pharmaceuticals, Llc Extended release venlafaxine formulation
EP1689721B1 (en) * 2003-11-26 2010-07-14 Pfizer Products Inc. Aminopyrazole derivatives as gsk-3 inhibitors
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
US20050142203A1 (en) * 2003-12-30 2005-06-30 Grant Heinicke Oral dosage formulations of active pharmaceutical ingredients and methods of preparing the same
WO2005074895A1 (en) * 2004-02-04 2005-08-18 Alembic Limited Extended release coated microtablets of venlafaxine hydrochloride
WO2005077340A1 (en) 2004-02-06 2005-08-25 Wyeth Multiparticulate o-desmethylvenlafaxine salts and uses thereof
US7414052B2 (en) * 2004-03-30 2008-08-19 Wyeth Phenylaminopropanol derivatives and methods of their use
US7517899B2 (en) * 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
US20050226923A1 (en) * 2004-04-07 2005-10-13 Gassert Chad M Venlafaxine compositions in the form of microtablets
US20070292500A1 (en) * 2004-05-21 2007-12-20 Lupin Ltd. Novel Extended Release Composition of Venlafaxine Hydrochloride Containing Polyvinyl Acetate
US7776358B2 (en) * 2004-07-22 2010-08-17 Synthon Ip Inc. Extended release venlafaxine besylate tablets
WO2006035457A1 (en) * 2004-09-17 2006-04-06 Amoli Organics Ltd. A process for the manufacture of venlafaxine and intermediates thereof
KR20060067613A (ko) * 2004-12-15 2006-06-20 에스케이 주식회사 1-[시아노-(파라-메톡시페닐)메틸]시클로헥사놀의 제조방법
US20060193912A1 (en) * 2005-02-28 2006-08-31 Penwest Pharmaceuticals Co. Controlled release O-desmethylvenlafaxine formulations
CN101151026A (zh) * 2005-03-31 2008-03-26 惠氏公司 O-去甲文拉法辛和巴泽昔芬联合产品及其应用
CA2605554A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists
PE20061298A1 (es) 2005-04-22 2006-12-24 Wyeth Corp Compuestos derivados de dihidrobenzofurano como agonistas del receptor de serotonina 5-ht2c
PE20061319A1 (es) * 2005-04-22 2006-12-28 Wyeth Corp Cristales formados de clorhidrato de {[(2r)-7-(2,6-diclorofenil)-5-fluoro-2-3-dihidro-1-benzofurano-2-il]metil}amina
WO2006116170A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
US7378552B2 (en) * 2005-06-07 2008-05-27 Neurocrine Biosciences, Inc. Monoamine re-uptake inhibitors and methods relating thereto
CN1955159B (zh) 2005-06-17 2010-11-24 山东绿叶制药有限公司 用于阻断5-羟色胺以及去甲基肾上腺素再摄取的化合物,其制备方法及其用途
JP2009500420A (ja) * 2005-07-06 2009-01-08 セプラコア インコーポレーテッド エスゾピクロン及びｏ−デスメチルベンラファキシンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法
ZA200800440B (en) 2005-07-15 2009-12-30 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US7595340B2 (en) * 2005-07-15 2009-09-29 Wyeth Serotonin and norepinephrine reuptake inhibitor and uses thereof
AR057662A1 (es) * 2005-07-15 2007-12-12 Wyeth Corp Inhibidor de la recaptacion doble de serotonina y norepinefrina con alta selectividad y uso del mismo
US7687520B2 (en) * 2005-07-15 2010-03-30 Wyeth Llc Serotonin and norepinephrine reuptake inhibitors and uses thereof
GT200600397A (es) * 2005-09-07 2007-08-28 Formulas topicas conteniendo o-desmetil venlafaxina (odv) o sus sales
GT200600396A (es) * 2005-09-07 2007-04-23 Dispositivos para la aplicacion de medicamentos transdermicos conteniendo o-desmetil venlafaxina (odv) o sus sales
KR20080056311A (ko) * 2005-10-19 2008-06-20 테바 파마슈티컬 인더스트리즈 리미티드 고순도1-[2-디메틸아미노-(4-메톡시페닐)에틸)시클로헥산올염산염의 제조 방법
WO2007064697A1 (en) * 2005-12-01 2007-06-07 Auspex Pharmaceuticals, Inc. Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
WO2007067501A1 (en) * 2005-12-05 2007-06-14 Wyeth Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols
EP1973866A1 (en) * 2005-12-20 2008-10-01 Synthon B.V. Process for making desvenlafaxine
TW200806300A (en) * 2006-03-24 2008-02-01 Wyeth Corp New therapeutic combinations for the treatment of depression
MX2007016179A (es) * 2006-04-17 2008-03-11 Teva Pharma Formas cristalinas de o-desmetilvenlafaxina.
TW200806282A (en) * 2006-05-05 2008-02-01 Wyeth Corp Solid dosage formulations
US20090137846A1 (en) * 2006-07-26 2009-05-28 Valerie Niddam-Hildesheim Processes for the synthesis of O-Desmethylvenlafaxine
CA2656167A1 (en) * 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
US20090069601A1 (en) * 2006-07-26 2009-03-12 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
US20080221356A1 (en) * 2006-07-26 2008-09-11 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
EP1934167A2 (en) * 2006-07-26 2008-06-25 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
WO2008015584A2 (en) * 2006-08-04 2008-02-07 Medichem, S.A. Improved process for synthesizing desvenlafaxine free base and salts or solvates thereof
US20100035994A1 (en) * 2006-08-08 2010-02-11 Gore Vinayak G Novel hydrate form of o-desmethyl venlafaxine succinate
WO2008059525A2 (en) * 2006-09-29 2008-05-22 Calyx Chemicals And Pharmaceuticals Ltd. An improved process for the preparation of venlafaxine and its analogs
PE20081138A1 (es) * 2006-10-25 2008-09-18 Wyeth Corp Metabolitos aislados de hidroxi y n-oxido y derivados de desmetil venlafaxina y metodos de tratamiento
AU2008211711A1 (en) * 2007-01-31 2008-08-07 Generics [Uk] Limited Process for the preparation of O-desmethyl venlafaxine
SG175611A1 (en) 2007-02-21 2011-11-28 Sepracor Inc Solid forms comprising (-) o-desmethylvenlafaxine and uses thereof
EP2049465A2 (en) * 2007-03-14 2009-04-22 Teva Pharmaceutical Industries Ltd. Processes for preparing solid states of o-desmethylvenlafaxine succinate
AU2008251773A1 (en) * 2007-03-15 2008-11-20 Auspex Pharmaceuticals, Inc. Deuterated venlafaxines and 0-desmetylvenlafaxines with serotoninergic and / or norepinephrinergic activity
KR20100040881A (ko) * 2007-06-26 2010-04-21 솔베이 파마슈티칼스 비. 브이 전구약물로서 벤라팍신 및 ｏ－데스메틸벤라팍신의 ｎ－옥사이드
CA2692738A1 (en) * 2007-07-12 2009-01-15 Dr. Reddy's Laboratories, Ltd. O-desmethylvenlafaxine
US8329952B2 (en) * 2007-07-16 2012-12-11 Matrix Laboratories Limited Process for the preparation of O-desmethylvenlafaxine succinate polymorphic forms
US20090048233A1 (en) * 2007-08-16 2009-02-19 Cypress Biosciences, Inc. Enhancing the Tolerability of a Seratonin Antagonist and a NSRI, a SNRI or a RIMA by Using Them in Combination
CA2702664A1 (en) * 2007-10-16 2009-04-23 Alphapharm Pty Ltd Controlled-release pharmaceutical formulation
EP2212275A2 (en) * 2007-10-22 2010-08-04 Actavis Group PTC EHF Solid forms of (±)-o-desmethylvenlafaxine salts
CA2703647A1 (en) 2007-10-26 2009-04-30 Generics [Uk] Limited Process for preparing o-desmethylvenlafaxine
KR101343027B1 (ko) * 2007-11-26 2013-12-18 테바 파마슈티컬 인더스트리즈 리미티드 Ｏ-데스메틸벤라팍신 푸마레이트의 결정형
EP2072495A1 (en) 2007-12-21 2009-06-24 Siegfried Ltd. Preparation of phenethyl tertiary amine derivatives
WO2009084039A2 (en) * 2007-12-26 2009-07-09 Matrix Laboratories Limited Process for producing 1-[2-(dimethylamino)-1-(4-phenol)ethyl]cyclohexanol
US20090234020A1 (en) * 2008-03-06 2009-09-17 Valarie Niddam-Hildesheim Processes for the preparation of odesmethylvenlafaxine, free from its dimer impurities
IN2008CH00818A (es) * 2008-04-01 2009-10-09 Actavis Group Ptc Ehf
KR100965527B1 (ko) 2008-05-08 2010-06-23 제일약품주식회사 신규(4-(2-(디메틸아미노)-1-(1-하이드록시사이클로헥실)에틸)페녹시)포스페이트 또는 이의 약학적으로 허용가능한 염,이의 제조방법 및 이를 유효성분으로 함유하는 중추신경계질환 예방 및 치료용 조성물
US20110052690A1 (en) * 2008-06-02 2011-03-03 Avi Avramoff Process for manufacture of a medicament with granulation and pan coating
KR20100132069A (ko) * 2008-06-16 2010-12-16 테바 파마슈티컬 인더스트리즈 리미티드 Ｏ-데스메틸벤라팍신염의 고체 상태
US20100016638A1 (en) * 2008-07-21 2010-01-21 Zdenko Hamersak Method for preparation of o-desmethylvenlafaxine using polythiolates
WO2010046808A2 (en) * 2008-10-21 2010-04-29 Alembic Limited A process for the preparation of venlafaxine hydrochloride
CZ2008756A3 (cs) * 2008-11-27 2010-03-24 Zentiva, A. S. Zpusob prípravy desvenlafaxinu a jeho solí
CZ200969A3 (cs) 2009-02-06 2010-06-30 Zentiva, K.S. Nové soli desvenlafaxinu a zpusob jejich prípravy
KR101830447B1 (ko) 2009-05-12 2018-02-20 알바니 몰레큘라 리써치, 인크. 7-(［1,2,4］트리아졸로［1,5-α］피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
CN102638982B (zh) 2009-05-12 2015-07-08 百时美施贵宝公司 (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
CZ2009454A3 (cs) 2009-07-15 2010-11-10 Zentiva, K. S. Zpusob prípravy desvenlafaxinu a jeho solí
JP2012532923A (ja) 2009-07-16 2012-12-20 シプラ・リミテッド Ｏ−デスメチルベンラファキシンの製造方法及びそれに使用される中間体
US20110098506A1 (en) * 2009-10-26 2011-04-28 Intas Pharmaceuticals Limited Method of preparing o-desmethylvenlafaxine
US8754261B2 (en) 2009-12-16 2014-06-17 Pharmathen S.A. Process for the preparation of O-desmethyl-venlafaxine and salts thereof
US20110184067A1 (en) * 2010-01-25 2011-07-28 Intas Pharmaceuticals Ltd. O-desmethylvenlafaxine succinate polymorph & process for preparing thereof
CN101781221A (zh) * 2010-02-11 2010-07-21 上海凯米侬医药科技有限公司 一种o-去甲基文拉法辛的制备方法
WO2011121452A2 (en) 2010-03-29 2011-10-06 Pliva Hrvatska D.O.O. Crystal forms of o-desmethylvenlafaxine fumarate
EP2552419A2 (en) 2010-03-31 2013-02-06 Wockhardt Limited Modified release dosage form comprising desvenlafaxine or salts thereof
CZ303249B6 (cs) 2010-04-06 2012-06-20 Zentiva, K.S. Zpusob výroby 4-(2-(substituovaných)-1-(1-hydroxycyklohexyl)ethyl)fenolu O-demethylací jejich methyletheru pomocí nepáchnoucích aromatických thiolu
CN102241664B (zh) * 2010-05-13 2014-11-12 上海医药工业研究院 芳烷二胺类衍生物及其作为抗抑郁症药物的应用
CA2788526A1 (en) 2010-05-14 2011-11-17 Alembic Limited Extended release formulations of desvenlafaxine base
US9045468B2 (en) 2010-08-17 2015-06-02 Albany Molecular Research, Inc. 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
CN103588652B (zh) 2010-10-01 2015-04-22 山东绿叶制药有限公司 4-甲基苯甲酸4-[2-二甲基胺基-1-(1-羟基环己基)乙基]苯酯盐酸盐的多晶型物、制备方法及其应用
US8933123B2 (en) 2010-10-08 2015-01-13 Cadila Healthcare Limited Polymorphic forms of O-desmethyl-venlafaxine succinate
BR112013025766A2 (pt) 2011-04-12 2016-12-20 Lupin Ltd composições farmacêuticas de liberação modificada de desvenlafaxina
US8481596B2 (en) 2011-06-08 2013-07-09 Lupin Limited Polymomorph of desvenlafaxine benzoate
MX367362B (es) 2016-06-29 2019-08-16 Alparis Sa De Cv Nuevas formas solidas de desvenlafaxina.
EP3580198B1 (en) 2017-02-09 2023-08-09 R L Finechem Private Limited A process for preparation of1-[2-(dimethylamino)-1-(4-hydroxyphenyl) ethyl]-cyclohexanol and salts thereof
CN109535017B (zh) * 2018-12-29 2023-08-08 合肥立方制药股份有限公司 一种盐酸文拉法辛制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA737473A (en) * 1966-06-28 Flick Kurt Phenol ethers containing basic groups and method of preparing these compounds
US3132179A (en) * 1959-08-27 1964-05-05 Sterling Drug Inc Ethers of alpha-hydroxymethyl-beta-monocarbocyclic aryl ethyl amines and their preparation
DE1124485B (de) * 1960-02-12 1962-03-01 Hoechst Ag Verfahren zur Herstellung von analeptisch wirksamen Phenylcycloalkylmethylaminen
GB1098835A (en) * 1965-07-13 1968-01-10 Jacques Logeais Sa Lab Spiro-oxazolidinones, spiro-oxazines, their process of preparation and therapeutic compositions containing said derivatives
US3758527A (en) * 1969-07-04 1973-09-11 Ciba Geigy Corp Esters of 1-aminoalkyl-cycloalkanols
US3928626A (en) * 1972-04-06 1975-12-23 American Home Prod Benzylamine analgesics
US3847950A (en) * 1972-09-28 1974-11-12 Colgate Palmolive Co Alpha,alpha-dialkylphenethylamine derivatives
US3974157A (en) * 1974-03-04 1976-08-10 Pennwalt Corporation 1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters
US3979444A (en) * 1974-05-28 1976-09-07 The Upjohn Company 4-Arylcyclohexylamines
CA1130318A (en) * 1978-10-11 1982-08-24 Peter M. Muller Cyclohexadiene derivatives

Also Published As

Publication number Publication date
US4535186A (en) 1985-08-13

Similar Documents

Publication Publication Date Title
PY0101650A (es) 2-phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethyla-mine derivatives
BG41820A3 (en) Method for preparing n- (3- hydroxy- 4- piperidinyl) benzamide derivatives
ES8609229A1 (es) Un procedimiento para la preparacion de alquilsulfonamidofe-nilalquilaminas
UA39099C2 (uk) Циклічні азотовмісні похідні, суміш їх ізомерів або окремі ізомери, або їх солі
NL1002835A1 (nl) Synergistisch stabilisatormengsel.
ES527195A0 (es) Un derivado de amina.
BG41130A3 (en) Method for preparing 8- chlor-1, 5- benzo- thiazepine derivatives
ES8600306A1 (es) Un procedimiento para la preparacion de derivados de penem-2-metil sustituidos.
IT8422922A0 (it) Composti di 1,2,4-triazolone adattivita' antidepressiva.
FI851661A0 (fi) N-substituerade neuraminsyraderivat och foerfarande foer framstaellning av dessa.
ES8306765A1 (es) "un procedimiento para preparar un derivado de antraciclina".
IT8521675A0 (it) Procedimento per la preparazione di un elisir.
ES2072288T3 (es) Preparacion de enantiomeros de dropropizina.
GR1001309B (el) Μεθοδος παρασκευης παραγωγου ενωσεως της διχλωροανιλινης.
RO91594A (ro) Compozitie erbicida solida
FI832900A7 (fi) Mikrobipolysakkaridien eristäminen amiiniaddukteistaan.
NO852418L (no) Fremgangsmaate for fremstilling av aminderivater.
ES8801647A1 (es) Un procedimiento para la preparacion de piridazinilimidazolidinonas
ES8504799A1 (es) Procedimiento de obtencion de piridopirimidinonas
BG41127A3 (en) Method for preparing 1, 4- dihydropyridine derivatives
SU1160709A1 (ru) Гидрохлорид 6-метил-1-оксо-1,2,3,4-тетрагидроиндоло/2,3-с/-хинолина, обладающий транквилизирующей активностью
DE3461189D1 (en) New 3-alkylthio-2-o-carbamoyl-propane-1.2-diol-1-o-phosphocholines, and processes for their preparation
SU1185834A1 (ru) Производные 2,2-дифтор-1,3,2-диоксаборинов в качестве сенсибилизаторов поли-n- эпоксипропилкарбазола
IT8026742A0 (it) Procedimento per la produzione di 1,3,5-triclorobenzene.
SU1202241A1 (ru) Натриевая соль 5-n-хлорбензилидентиазолидиндиона-2,4, обладающая противогрибковой активностью