ES8504799A1 - Procedimiento de obtencion de piridopirimidinonas - Google Patents

Procedimiento de obtencion de piridopirimidinonas

Info

Publication number
ES8504799A1
ES8504799A1 ES525995A ES525995A ES8504799A1 ES 8504799 A1 ES8504799 A1 ES 8504799A1 ES 525995 A ES525995 A ES 525995A ES 525995 A ES525995 A ES 525995A ES 8504799 A1 ES8504799 A1 ES 8504799A1
Authority
ES
Spain
Prior art keywords
pyridopyrimidinones
compounds
useful
formula
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525995A
Other languages
English (en)
Other versions
ES525995A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES8504799A1 publication Critical patent/ES8504799A1/es
Publication of ES525995A0 publication Critical patent/ES525995A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE PIRIDOPIRIMIDINONAS.COMPRENDE: A) REDUCIR AL ANILLO DE PIRIDINA DE COMPUESTOS DE FORMULA (II), POR HIDROGENACION CATALITICA CON CATALIZADORES DE NI, PD O PT PARA OBTENER UNA MEZCLA DE CUATRO DIASTEREOMEROS DE FORMULA (III); B) CICLAR A (III) CON DIALQUILACETAL O ACETAL DE AMIDAS COMO DIMETILACETAMIDA, DIMETILBENZAMIDA Y OTROS, PARA OBTENER COMPUESTOS DIAZABICICLOS DE FORMULA (IV); Y C) REDUCIR A (IV) POR REACCION CON HIDRURO METALICO ACTIVO, COMO HIDRURO DE LITIO Y ALUMINIO, PARA OBTENER LOS COMPUESTOS DE FORMULA (I). DONDE: R1 ES H, ALQUILO DE C 1 A 6 O FENILO; Y ES H O UN RADICAL DE FORMULA (V); X ES H, HALOGENO Y OTROS; Z ES H O UN RADICAL DE FORMULA (VI); R2 Y R3 SON ALQUILOS DE C 1 A 6 Y R4 ES H O ALQUILO DE C 1 A 6 Y N VA DE 1 A 6.SE UTILIZAN COMO AGENTES ANTIARRITMICOS.
ES525995A 1982-09-27 1983-09-27 Procedimiento de obtencion de piridopirimidinonas Granted ES525995A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42493682A 1982-09-27 1982-09-27
US53212083A 1983-09-14 1983-09-14

Publications (2)

Publication Number Publication Date
ES8504799A1 true ES8504799A1 (es) 1985-04-16
ES525995A0 ES525995A0 (es) 1985-04-16

Family

ID=27026521

Family Applications (1)

Application Number Title Priority Date Filing Date
ES525995A Granted ES525995A0 (es) 1982-09-27 1983-09-27 Procedimiento de obtencion de piridopirimidinonas

Country Status (5)

Country Link
EP (1) EP0104647B1 (es)
AU (1) AU574652B2 (es)
CA (1) CA1213586A (es)
DE (1) DE3376113D1 (es)
ES (1) ES525995A0 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560754A (en) * 1983-09-14 1985-12-24 G. D. Searle & Co. Substituted 5-phenyl-5-(aminoalkyl)-1,3-diazabicyclo[4.4.0]decan-4-ones and 5-phenyl-5-(aminoalkyl)-1,3-diazabicyclo[4.4.0]dec-2-en-4-ones
US4567270A (en) * 1984-09-17 1986-01-28 G. D. Searle & Co. Hexahydroindolizinones useful for treating cardiac arrhythmia, thrombotic disorders in mammals
US4791199A (en) * 1985-09-19 1988-12-13 G. D. Searle & Co. Process for antiarrhythmic 1,3-diazabicyclo[4.4.0]dec-2-en-4-ones

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6704169A (es) * 1966-04-06 1967-10-09

Also Published As

Publication number Publication date
AU574652B2 (en) 1988-07-14
EP0104647A3 (en) 1985-05-15
EP0104647A2 (en) 1984-04-04
AU1960083A (en) 1984-04-05
EP0104647B1 (en) 1988-03-30
CA1213586A (en) 1986-11-04
DE3376113D1 (de) 1988-05-05
ES525995A0 (es) 1985-04-16

Similar Documents

Publication Publication Date Title
ES477695A1 (es) Un procedimiento para preparar derivados de deshidrociclici-minoacidos.
ES8307763A1 (es) Un procedimiento para la preparacion de nuevas n-aril-piperazin alcanamidas.
GB2133973B (en) Improvements relating to the positioning of equipment, such as medical equipment
GR82211B (es)
HK10786A (en) Compositions useful as flocculating agents
ES8600737A1 (es) Procedimiento de preparar compuestos de sulfonio
EP0113778A4 (en) AMINOMETHYLBENZENE ARYL-SUBSTITUTED DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS.
GR79463B (es)
ES8704931A1 (es) Un procedimiento para la preparacion de derivados de piridimilmidazolidiona.
ES476504A1 (es) Un procedimiento para la preparacion de vincadiformina
ZA851552B (en) Benzisoselenazolethiones,processes for their preparation and pharmaceutical products containing these compounds
IE792241L (en) Hydroxypropyltriazoles
DE3381898D1 (de) Prostaglandin enthaltende zusammensetzungen.
GB2151630B (en) The invention provides compounds of the formula i
HU9500559D0 (en) New mercapto-acetamide tricyclic derivatives as enkephalinase-inhibitors
ES8701159A1 (es) Procedimiento para la obtencion de derivados de piperidina con actividad cardiovascular.
GR78106B (es)
ES8701737A1 (es) Un procedimiento para la preparacion de nuevas quinazolindionas.
GB2129841B (en) Backizing compositions for textiles
IE781022L (en) Benzo-thieno-pyridines
ES8203916A1 (es) Procedimiento para preparar n6-adenosina
ES8504799A1 (es) Procedimiento de obtencion de piridopirimidinonas
CA1268468C (en) PROSTAGLANDIN ANALOGS WITH SUBSTITUTE THIABICYCLOHEPTAN GROUP
GR82125B (es)
IE780186L (en) Imidazopyridazines