PT888289E - Derivados enantiomericos de aminoacidos anticonvulsivos - Google Patents
Derivados enantiomericos de aminoacidos anticonvulsivos Download PDFInfo
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- PT888289E PT888289E PT97916897T PT97916897T PT888289E PT 888289 E PT888289 E PT 888289E PT 97916897 T PT97916897 T PT 97916897T PT 97916897 T PT97916897 T PT 97916897T PT 888289 E PT888289 E PT 888289E
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910001923 silver oxide Inorganic materials 0.000 description 1
- VFWRGKJLLYDFBY-UHFFFAOYSA-N silver;hydrate Chemical compound O.[Ag].[Ag] VFWRGKJLLYDFBY-UHFFFAOYSA-N 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 210000001768 subcellular fraction Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- IRYJRGCIQBGHIV-UHFFFAOYSA-N trimethadione Chemical compound CN1C(=O)OC(C)(C)C1=O IRYJRGCIQBGHIV-UHFFFAOYSA-N 0.000 description 1
- 229960004453 trimethadione Drugs 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1352296P | 1996-03-15 | 1996-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT888289E true PT888289E (pt) | 2001-09-28 |
Family
ID=21760388
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97916897T PT888289E (pt) | 1996-03-15 | 1997-03-17 | Derivados enantiomericos de aminoacidos anticonvulsivos |
| PT00109377T PT1038522E (pt) | 1996-03-15 | 1997-03-17 | Derivados enantiomericos anticonvulsivos de aminoacidos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00109377T PT1038522E (pt) | 1996-03-15 | 1997-03-17 | Derivados enantiomericos anticonvulsivos de aminoacidos |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP0888289B1 (enExample) |
| JP (1) | JP3145414B2 (enExample) |
| AT (2) | ATE202079T1 (enExample) |
| AU (1) | AU718577B2 (enExample) |
| CA (1) | CA2248317C (enExample) |
| DE (3) | DE69705210T2 (enExample) |
| DK (2) | DK1038522T3 (enExample) |
| ES (2) | ES2218024T3 (enExample) |
| FR (1) | FR09C0006I2 (enExample) |
| NL (1) | NL300376I1 (enExample) |
| PT (2) | PT888289E (enExample) |
| WO (1) | WO1997033861A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048899A (en) * | 1997-03-17 | 2000-04-11 | Research Corporation Tech., Inc. | Anticonvulsant enantiomeric amino acid derivatives |
| EP1642889A1 (en) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| EP1873527A1 (en) | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Method for identifying CRMP modulators |
| US8093426B2 (en) * | 2007-12-04 | 2012-01-10 | Ranbaxy Laboratories Limited | Intermediate compounds and their use in preparation of lacosamide |
| DE102008059155A1 (de) | 2008-11-27 | 2010-06-02 | Ratiopharm Gmbh | Trockenverarbeitung und neue Formen von Lacosamid |
| WO2011015617A1 (en) | 2009-08-06 | 2011-02-10 | Medichem, S.A. | Solid forms of an n-(phenylmethyl)propanamide derivative and processes of preparation |
| EP2480524A1 (en) * | 2009-09-25 | 2012-08-01 | Cadila Healthcare Limited | Processes for the preparation of lacosamide and intermediates thereof |
| IT1398044B1 (it) * | 2010-01-29 | 2013-02-07 | Archimica Srl | Processo per la preparazione della lacosamide |
| US8759582B2 (en) | 2010-02-08 | 2014-06-24 | Natco Pharma Limited | Process for the preparation of lacosamide |
| US8907132B2 (en) * | 2010-02-09 | 2014-12-09 | Msn Laboratories Private Limited | Process for preparing (R)-2-acetamido-N-benzyl-3-methoxy-propionamide |
| EP2399901A1 (en) | 2010-06-23 | 2011-12-28 | Archimica GmbH | Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide |
| EP2621893A1 (en) | 2010-10-01 | 2013-08-07 | UCB Pharma GmbH | Process for the preparation of amino acid derivatives |
| EP2627639B1 (en) | 2010-10-15 | 2021-12-22 | Nektar Therapeutics | N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides |
| PL2444390T3 (pl) | 2010-10-19 | 2017-06-30 | Euticals Gmbh | Sposób wytwarzania Lakozamidu |
| EP2646001A2 (en) | 2010-12-02 | 2013-10-09 | UCB Pharma GmbH | Formulation of lacosamide |
| EP2468261A1 (en) | 2010-12-02 | 2012-06-27 | UCB Pharma GmbH | Formulation of lacosamide |
| CN104771356A (zh) * | 2014-01-09 | 2015-07-15 | 山东方明药业集团股份有限公司 | 一种拉科酰胺注射液及其制备方法 |
| US11278634B1 (en) | 2021-02-12 | 2022-03-22 | Extrovis Ag | Stable parenteral composition of lacosamide |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK173553B1 (da) * | 1985-02-15 | 2001-03-12 | Res Corp Technologies Inc | Aminosyrederivater, antikonvulsant præparat som indeholder aminosyrederivat samt anvendelse af aminosyrederivater til frems |
| US5378729A (en) * | 1985-02-15 | 1995-01-03 | Research Corporation Technologies, Inc. | Amino acid derivative anticonvulsant |
-
1997
- 1997-03-17 AT AT97916897T patent/ATE202079T1/de active
- 1997-03-17 WO PCT/US1997/004579 patent/WO1997033861A1/en not_active Ceased
- 1997-03-17 DK DK00109377T patent/DK1038522T3/da active
- 1997-03-17 EP EP97916897A patent/EP0888289B1/en not_active Expired - Lifetime
- 1997-03-17 DE DE69705210T patent/DE69705210T2/de not_active Expired - Lifetime
- 1997-03-17 AU AU25394/97A patent/AU718577B2/en not_active Expired
- 1997-03-17 ES ES00109377T patent/ES2218024T3/es not_active Expired - Lifetime
- 1997-03-17 JP JP53292897A patent/JP3145414B2/ja not_active Expired - Lifetime
- 1997-03-17 PT PT97916897T patent/PT888289E/pt unknown
- 1997-03-17 DK DK97916897T patent/DK0888289T3/da active
- 1997-03-17 ES ES97916897T patent/ES2157567T3/es not_active Expired - Lifetime
- 1997-03-17 DE DE69729392T patent/DE69729392T2/de not_active Expired - Lifetime
- 1997-03-17 EP EP00109377A patent/EP1038522B1/en not_active Expired - Lifetime
- 1997-03-17 CA CA002248317A patent/CA2248317C/en not_active Expired - Lifetime
- 1997-03-17 DE DE122009000010C patent/DE122009000010I2/de active Active
- 1997-03-17 AT AT00109377T patent/ATE268169T1/de active
- 1997-03-17 PT PT00109377T patent/PT1038522E/pt unknown
-
2009
- 2009-02-16 NL NL300376C patent/NL300376I1/nl unknown
- 2009-02-26 FR FR09C0006C patent/FR09C0006I2/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1038522B1 (en) | 2004-06-02 |
| DK1038522T3 (da) | 2004-10-11 |
| NL300376I1 (nl) | 2009-05-06 |
| DE122009000010I2 (de) | 2010-10-21 |
| DE69729392T2 (de) | 2005-06-02 |
| CA2248317A1 (en) | 1997-09-18 |
| AU2539497A (en) | 1997-10-01 |
| JP3145414B2 (ja) | 2001-03-12 |
| PT1038522E (pt) | 2004-10-29 |
| ATE202079T1 (de) | 2001-06-15 |
| FR09C0006I1 (enExample) | 2009-04-17 |
| DE69729392D1 (de) | 2004-07-08 |
| EP1038522A3 (en) | 2003-01-15 |
| WO1997033861A1 (en) | 1997-09-18 |
| EP0888289A1 (en) | 1999-01-07 |
| DK0888289T3 (da) | 2001-09-03 |
| ATE268169T1 (de) | 2004-06-15 |
| ES2157567T3 (es) | 2001-08-16 |
| ES2218024T3 (es) | 2004-11-16 |
| DE69705210T2 (de) | 2001-09-20 |
| FR09C0006I2 (fr) | 2009-12-18 |
| CA2248317C (en) | 2003-12-02 |
| DE69705210D1 (de) | 2001-07-19 |
| EP0888289B1 (en) | 2001-06-13 |
| AU718577B2 (en) | 2000-04-13 |
| EP1038522A2 (en) | 2000-09-27 |
| DE122009000010I1 (de) | 2009-05-20 |
| JP2000505476A (ja) | 2000-05-09 |
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