PT846693E - Derivados da n-benzildioxotiazolidilbenzamida e processo para a producao dos mesmos - Google Patents

Derivados da n-benzildioxotiazolidilbenzamida e processo para a producao dos mesmos

Info

Publication number
PT846693E
PT846693E PT96920002T PT96920002T PT846693E PT 846693 E PT846693 E PT 846693E PT 96920002 T PT96920002 T PT 96920002T PT 96920002 T PT96920002 T PT 96920002T PT 846693 E PT846693 E PT 846693E
Authority
PT
Portugal
Prior art keywords
carbon atoms
groups
same
group
atoms
Prior art date
Application number
PT96920002T
Other languages
English (en)
Inventor
Susumu Kinoshita
Toshio Maeda
Masahiro Nomura
Katsuya Awano
Hiroya Satoh
Koji Murakami
Masaki Tsunoda
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of PT846693E publication Critical patent/PT846693E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
PT96920002T 1995-06-02 1996-05-30 Derivados da n-benzildioxotiazolidilbenzamida e processo para a producao dos mesmos PT846693E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15978195 1995-06-02
JP15313996A JP3144624B2 (ja) 1995-06-02 1996-05-24 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法

Publications (1)

Publication Number Publication Date
PT846693E true PT846693E (pt) 2002-05-31

Family

ID=26481850

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96920002T PT846693E (pt) 1995-06-02 1996-05-30 Derivados da n-benzildioxotiazolidilbenzamida e processo para a producao dos mesmos

Country Status (15)

Country Link
US (1) US6030990A (pt)
EP (1) EP0846693B1 (pt)
JP (1) JP3144624B2 (pt)
KR (1) KR100456177B1 (pt)
CN (2) CN1069901C (pt)
AT (1) ATE212341T1 (pt)
AU (1) AU698896B2 (pt)
CA (1) CA2220698C (pt)
DE (1) DE69618792T2 (pt)
DK (1) DK0846693T3 (pt)
ES (1) ES2170858T3 (pt)
HU (1) HU225039B1 (pt)
PT (1) PT846693E (pt)
TW (1) TW400328B (pt)
WO (1) WO1996038428A1 (pt)

Families Citing this family (64)

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WO1997032863A1 (fr) * 1996-03-08 1997-09-12 Torii Pharmaceutical Co., Ltd. Derives de thiazolidine-2,4-dione
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US6756360B1 (en) 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
DE60020573T2 (de) * 1999-08-23 2006-03-16 Kyorin Pharmaceutical Co., Ltd. Substituierte benzylthiazolidin-2,4-dion derivate
DE60020375T2 (de) * 1999-08-23 2006-11-23 Kyorin Pharmaceutical Co., Ltd. Substituierte benzylthiazolidin-2,4-dion derivate
CN1155586C (zh) * 1999-08-23 2004-06-30 杏林制药株式会社 取代的苄基噻唑烷-2,4-二酮衍生物
HUP0202893A3 (en) 1999-08-23 2004-12-28 Kyorin Seiyaku Kk Substituted benzylthiazolidine-2,4-dione derivatives and pharmaceutical compositions containing them
DE60025621T2 (de) * 1999-09-17 2006-11-23 Kyorin Pharmaceutical Co., Ltd. O-anisamid-derivate
TWI262185B (en) * 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
CA2390557A1 (en) * 1999-11-11 2001-05-17 Kyorin Pharmaceutical Co., Ltd. Solid preparations for oral use
CN100595204C (zh) * 1999-12-22 2010-03-24 症变治疗公司 双氨基化膦酸酯前药
CA2401276A1 (en) * 2000-02-01 2001-08-09 Kyorin Pharmaceutical Co., Ltd. Alkali metal salt of thiazolidine-2,4-dione derivatives
WO2001066549A1 (fr) * 2000-03-07 2001-09-13 Kyorin Pharmaceutical Co., Ltd. Composes intermediaires
HUP0300475A3 (en) * 2000-04-25 2004-10-28 Kyorin Seiyaku Kk Novel stable crystal of thiazolidinedione derivative and process for producing the same
WO2001096321A1 (fr) * 2000-06-14 2001-12-20 Kyorin Pharmaceutical Co., Ltd. Elaboration de derives de thiazolidinedione
US7563774B2 (en) * 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
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DE60216890T2 (de) * 2001-01-26 2007-08-30 Schering Corp. Kombinationen von einem hemmer der sterol-absorption und einem ppar-aktivator zur behandlung von kardiovaskulären indikationen
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US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
CZ305202B6 (cs) * 2001-01-26 2015-06-10 Merck Sharp & Dohme Corp. Farmaceutický prostředek
AR035739A1 (es) * 2001-01-26 2004-07-07 Schering Corp Composiciones farmaceuticas y combinaciones terapeuticas que comprenden secuestrante (s) de los acidos biliares y de inhibidor (es) de la absorcion de los esteroles y el uso de dichas composiciones para la manufactura de un medicamento para el tratamiento de indicaciones vasculares
RU2314126C2 (ru) * 2001-01-26 2008-01-10 Шеринг Корпорейшн Комбинации ингибитора (ингибиторов) всасывания стерина с модификатором (модификаторами) крови, предназначенные для лечения патологических состояний сосудов
AU2002240050A1 (en) * 2001-01-26 2002-08-06 Schering Corporation Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
WO2002079162A1 (fr) 2001-03-28 2002-10-10 Eisai Co., Ltd. Acides carboxyliques
JP4549021B2 (ja) 2001-03-30 2010-09-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 ベンゼン化合物およびその塩
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
PT1392287E (pt) * 2001-05-25 2007-02-28 Schering Corp Métodos para tratamento de doença de alzheimer e/ou regulação dos níveis de peptídeos β amilóide num sujeito
WO2002098840A1 (fr) 2001-06-04 2002-12-12 Eisai Co., Ltd. Derive de l'acide carboxylique et medicament comprenant un sel ou un ester dudit derive
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US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
AU2002336609B2 (en) * 2001-09-21 2006-08-24 Merck Sharp & Dohme Corp. Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
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ITRM20020016A1 (it) * 2002-01-15 2003-07-15 Sigma Tau Ind Farmaceuti Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza
WO2003088962A1 (en) * 2002-04-16 2003-10-30 Merck & Co., Inc. Combination therapy using a ppar alpha/gamma agonist
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US7071223B1 (en) * 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
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DE10308353A1 (de) 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
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FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
NO302519B1 (no) * 1991-12-26 1998-03-16 Sankyo Co Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat

Also Published As

Publication number Publication date
CN1186489A (zh) 1998-07-01
EP0846693B1 (en) 2002-01-23
JPH0948771A (ja) 1997-02-18
ATE212341T1 (de) 2002-02-15
HUP9802565A2 (hu) 1999-04-28
HUP9802565A3 (en) 2000-01-28
WO1996038428A1 (fr) 1996-12-05
TW400328B (en) 2000-08-01
CA2220698A1 (en) 1996-12-05
DE69618792T2 (de) 2002-10-10
HU225039B1 (en) 2006-05-29
CN1336366A (zh) 2002-02-20
KR100456177B1 (ko) 2004-12-30
US6030990A (en) 2000-02-29
AU5844696A (en) 1996-12-18
DE69618792D1 (de) 2002-03-14
DK0846693T3 (da) 2002-05-06
EP0846693A1 (en) 1998-06-10
CN1133627C (zh) 2004-01-07
CN1069901C (zh) 2001-08-22
EP0846693A4 (en) 1999-03-03
JP3144624B2 (ja) 2001-03-12
ES2170858T3 (es) 2002-08-16
CA2220698C (en) 2003-06-17
KR19990022435A (ko) 1999-03-25
AU698896B2 (en) 1998-11-12

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