ATE212341T1 - N-benzyldioxothiazolidylbenzamid-derivate und verfahren zu ihrer herstellung - Google Patents
N-benzyldioxothiazolidylbenzamid-derivate und verfahren zu ihrer herstellungInfo
- Publication number
- ATE212341T1 ATE212341T1 AT96920002T AT96920002T ATE212341T1 AT E212341 T1 ATE212341 T1 AT E212341T1 AT 96920002 T AT96920002 T AT 96920002T AT 96920002 T AT96920002 T AT 96920002T AT E212341 T1 ATE212341 T1 AT E212341T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- groups
- group
- atoms
- preparing
- Prior art date
Links
- HNWXYYXDKGPQTJ-UHFFFAOYSA-N N-benzyl-3,4-dioxo-2-(2H-1,3-thiazol-2-id-4-yl)cyclohexa-1,5-diene-1-carboxamide Chemical class C(C1=CC=CC=C1)NC(C1=C(C(C(C=C1)=O)=O)C=1N=[C-]SC=1)=O HNWXYYXDKGPQTJ-UHFFFAOYSA-N 0.000 title abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- -1 methylenedioxy group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15978195 | 1995-06-02 | ||
| JP15313996A JP3144624B2 (ja) | 1995-06-02 | 1996-05-24 | N−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| PCT/JP1996/001459 WO1996038428A1 (en) | 1995-06-02 | 1996-05-30 | N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE212341T1 true ATE212341T1 (de) | 2002-02-15 |
Family
ID=26481850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96920002T ATE212341T1 (de) | 1995-06-02 | 1996-05-30 | N-benzyldioxothiazolidylbenzamid-derivate und verfahren zu ihrer herstellung |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6030990A (de) |
| EP (1) | EP0846693B1 (de) |
| JP (1) | JP3144624B2 (de) |
| KR (1) | KR100456177B1 (de) |
| CN (2) | CN1069901C (de) |
| AT (1) | ATE212341T1 (de) |
| AU (1) | AU698896B2 (de) |
| CA (1) | CA2220698C (de) |
| DE (1) | DE69618792T2 (de) |
| DK (1) | DK0846693T3 (de) |
| ES (1) | ES2170858T3 (de) |
| HU (1) | HU225039B1 (de) |
| PT (1) | PT846693E (de) |
| TW (1) | TW400328B (de) |
| WO (1) | WO1996038428A1 (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2159938A1 (en) * | 1994-10-07 | 1996-04-08 | Hiroaki Yanagisawa | Oxime derivatives, their preparation and their therapeutic use |
| CZ293016B6 (cs) * | 1995-06-01 | 2004-01-14 | Sankyo Company Limited | Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem |
| WO1997032863A1 (en) * | 1996-03-08 | 1997-09-12 | Torii Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivatives |
| CZ2001965A3 (cs) | 1998-09-17 | 2002-02-13 | Bristol-Myers Squibb Company | Lék pro oąetřování atherosklerózy nebo diabetes typu II, farmaceutická kombinace a její pouľití |
| US6756360B1 (en) | 1998-12-24 | 2004-06-29 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes |
| KR100700304B1 (ko) * | 1999-08-23 | 2007-03-29 | 교린 세이야꾸 가부시키 가이샤 | 치환된 벤질티아졸리딘-2,4-디온 유도체 |
| KR100738245B1 (ko) * | 1999-08-23 | 2007-07-12 | 교린 세이야꾸 가부시키 가이샤 | 치환된 벤질티아졸리딘-2,4-디온 유도체 |
| EP1207156B1 (de) | 1999-08-23 | 2005-05-18 | Kyorin Pharmaceutical Co., Ltd. | Substituierte benzylthiazolidin-2,4-dion derivate |
| WO2001014352A1 (en) * | 1999-08-23 | 2001-03-01 | Kyorin Pharmaceutical Co., Ltd. | Substituted benzylthiazolidine-2,4-dione derivatives |
| HUP0202731A3 (en) * | 1999-09-17 | 2003-10-28 | Kyorin Seiyaku Kk | O-anisamide derivatives, process for their preparation and pharmaceutical compositions containing them |
| TWI262185B (en) * | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
| EP1243266A4 (de) * | 1999-11-11 | 2007-03-07 | Kyorin Seiyaku Kk | Feststoffzubereitung zur oralen anwendung |
| MXPA02006156A (es) * | 1999-12-22 | 2003-09-22 | Metabasis Therapeutics Inc | Nuevos profarmacos de bisamidato fosfonato. |
| ATE340168T1 (de) * | 2000-02-01 | 2006-10-15 | Kyorin Seiyaku Kk | Alkalimetallsalz von thiazolidin-2,4-dion- derivaten |
| WO2001066549A1 (en) * | 2000-03-07 | 2001-09-13 | Kyorin Pharmaceutical Co., Ltd. | Intermediate compounds |
| CN1426402A (zh) * | 2000-04-25 | 2003-06-25 | 杏林制药株式会社 | 噻唑烷二酮衍生物的新颖的稳定晶体及其制法 |
| AU2001274502A1 (en) * | 2000-06-14 | 2001-12-24 | Kyorin Pharmaceutical Co. Ltd. | Process for the preparation of thiazolidinedione derivatives |
| US7563774B2 (en) * | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| EP1354602B1 (de) * | 2000-12-26 | 2006-10-04 | Sankyo Company, Limited | Medizinische zusammensetzungen mit diuretischem und die insulinresistenz verbesserndem mittel |
| US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
| JP4711600B2 (ja) * | 2001-01-26 | 2011-06-29 | シェーリング コーポレイション | シトステロール血症の処置のための置換アゼチジノン化合物の使用 |
| SI1413331T1 (sl) * | 2001-01-26 | 2008-02-29 | Schering Corp | Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije |
| CA2434488A1 (en) * | 2001-01-26 | 2002-08-01 | Harry R. Davis | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications |
| US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| US20020147184A1 (en) * | 2001-01-26 | 2002-10-10 | Schering Corporation | Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions |
| DK1385548T3 (da) * | 2001-01-26 | 2007-09-10 | Schering Corp | Kombinationer af sterolabsorptionsinhibitor(er) med (et eller flere) kardiovaskulære midler til behandling af vaskulære tilstande |
| EP1785144A3 (de) * | 2001-01-26 | 2007-05-23 | Shering Corporation | Kombinationen von Gallensäurebinder(n) und Sterolabsorptionshemmer(n) und entsprechende Behandlung für vaskuläre Indikationen |
| US7253178B2 (en) | 2001-03-28 | 2007-08-07 | Eisai Co., Ltd. | Carboxylic acids |
| US7244861B2 (en) | 2001-03-30 | 2007-07-17 | Eisai Co., Ltd. | Benzene compound and salt thereof |
| TWI311133B (en) | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
| WO2002096415A2 (en) * | 2001-05-25 | 2002-12-05 | Schering Corporation | Use of azetidinone substituted derivatives in the treatment of alzheimer's disease |
| EP1394147A4 (de) | 2001-06-04 | 2007-10-24 | Eisai R&D Man Co Ltd | Carbonsäurederivat und eine ein salz oder ein ester davon enthaltende medizin |
| US7371777B2 (en) | 2001-08-17 | 2008-05-13 | Eisai Co., Ltd. | Cyclic compound and PPAR agonist |
| US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
| US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| US7132415B2 (en) * | 2001-09-21 | 2006-11-07 | Schering Corporation | Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors |
| PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
| WO2003042190A1 (en) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
| ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
| WO2003088962A1 (en) * | 2002-04-16 | 2003-10-30 | Merck & Co., Inc. | Combination therapy using a ppar alpha/gamma agonist |
| US6821524B2 (en) * | 2002-06-03 | 2004-11-23 | Jan Marini Skin Research, Inc. | Cosmetic skin care compositions |
| CN1662487A (zh) | 2002-06-19 | 2005-08-31 | 伊莱利利公司 | 酰胺连接基过氧化物酶体增殖物激活受体调节剂 |
| CA2504878A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of demyelination |
| US7071223B1 (en) * | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
| PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
| DE10308351A1 (de) | 2003-02-27 | 2004-11-25 | Aventis Pharma Deutschland Gmbh | 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7148246B2 (en) | 2003-02-27 | 2006-12-12 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals |
| DE10308353A1 (de) | 2003-02-27 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10308352A1 (de) | 2003-02-27 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| DE10308355A1 (de) | 2003-02-27 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| CN100439361C (zh) | 2003-03-07 | 2008-12-03 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| JP4589919B2 (ja) * | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
| CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| MXPA05012086A (es) * | 2003-05-12 | 2006-02-22 | Pfizer Prod Inc | Inhibidores de benzamida del receptor p2x7. |
| US7829552B2 (en) | 2003-11-19 | 2010-11-09 | Metabasis Therapeutics, Inc. | Phosphorus-containing thyromimetics |
| DE602004004631D1 (de) | 2004-04-01 | 2007-03-22 | Sanofi Aventis Deutschland | Oxadiazolone, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Pharmazeutika |
| AU2005258924A1 (en) * | 2004-06-29 | 2006-01-12 | Pfizer Products Inc. | Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3H-`1,2,4!-triazin-2-YK!benzamide derivatives with P2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid |
| JP2008504363A (ja) * | 2004-06-29 | 2008-02-14 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | P2x7受容体のベンズアミド阻害剤を利用する併用療法 |
| JP2008504360A (ja) * | 2004-06-29 | 2008-02-14 | ファイザー・プロダクツ・インク | ヒドロキシル保護された前駆体を脱保護することによる5−[4−(2−ヒドロキシ−プロピル)−3,5−ジオキソ−4,5−ジヒドロ−3h−1,2,4−トリアジン−2−イル]−ベンズアミド誘導体の製造方法 |
| JP2008510018A (ja) * | 2004-08-18 | 2008-04-03 | メタバシス・セラピューティクス・インコーポレイテッド | フルクトース−1,6−ビスホスファターゼの新規チアゾール阻害物質 |
| DE102005026762A1 (de) | 2005-06-09 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
| KR100958831B1 (ko) * | 2006-09-19 | 2010-05-24 | 주식회사유한양행 | 헤테로아릴피리미딘 유도체, 이들의 제조방법, 및 이들을포함하는 조성물 |
| US20120046364A1 (en) | 2009-02-10 | 2012-02-23 | Metabasis Therapeutics, Inc. | Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5061717A (en) * | 1988-03-08 | 1991-10-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| NO302519B1 (no) * | 1991-12-26 | 1998-03-16 | Sankyo Co | Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat |
-
1996
- 1996-05-24 JP JP15313996A patent/JP3144624B2/ja not_active Expired - Fee Related
- 1996-05-30 ES ES96920002T patent/ES2170858T3/es not_active Expired - Lifetime
- 1996-05-30 PT PT96920002T patent/PT846693E/pt unknown
- 1996-05-30 CA CA002220698A patent/CA2220698C/en not_active Expired - Fee Related
- 1996-05-30 AT AT96920002T patent/ATE212341T1/de not_active IP Right Cessation
- 1996-05-30 AU AU58446/96A patent/AU698896B2/en not_active Ceased
- 1996-05-30 KR KR1019970708916A patent/KR100456177B1/ko not_active Expired - Fee Related
- 1996-05-30 CN CN96194390A patent/CN1069901C/zh not_active Expired - Fee Related
- 1996-05-30 DK DK96920002T patent/DK0846693T3/da active
- 1996-05-30 DE DE69618792T patent/DE69618792T2/de not_active Expired - Fee Related
- 1996-05-30 US US08/952,672 patent/US6030990A/en not_active Expired - Lifetime
- 1996-05-30 EP EP96920002A patent/EP0846693B1/de not_active Expired - Lifetime
- 1996-05-30 WO PCT/JP1996/001459 patent/WO1996038428A1/ja not_active Ceased
- 1996-05-30 HU HU9802565A patent/HU225039B1/hu not_active IP Right Cessation
- 1996-06-01 TW TW085106555A patent/TW400328B/zh not_active IP Right Cessation
-
2000
- 2000-10-17 CN CNB001301381A patent/CN1133627C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9802565A2 (hu) | 1999-04-28 |
| CN1336366A (zh) | 2002-02-20 |
| CN1133627C (zh) | 2004-01-07 |
| PT846693E (pt) | 2002-05-31 |
| JPH0948771A (ja) | 1997-02-18 |
| CA2220698C (en) | 2003-06-17 |
| EP0846693A4 (de) | 1999-03-03 |
| KR100456177B1 (ko) | 2004-12-30 |
| CN1069901C (zh) | 2001-08-22 |
| CN1186489A (zh) | 1998-07-01 |
| AU5844696A (en) | 1996-12-18 |
| JP3144624B2 (ja) | 2001-03-12 |
| TW400328B (en) | 2000-08-01 |
| HU225039B1 (en) | 2006-05-29 |
| AU698896B2 (en) | 1998-11-12 |
| ES2170858T3 (es) | 2002-08-16 |
| DE69618792T2 (de) | 2002-10-10 |
| DE69618792D1 (de) | 2002-03-14 |
| CA2220698A1 (en) | 1996-12-05 |
| HUP9802565A3 (en) | 2000-01-28 |
| EP0846693B1 (de) | 2002-01-23 |
| WO1996038428A1 (en) | 1996-12-05 |
| US6030990A (en) | 2000-02-29 |
| KR19990022435A (ko) | 1999-03-25 |
| EP0846693A1 (de) | 1998-06-10 |
| DK0846693T3 (da) | 2002-05-06 |
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