PT3023788T - Composições de neoantigénios específicos de tumor para utilização no tratamento de tumores - Google Patents
Composições de neoantigénios específicos de tumor para utilização no tratamento de tumoresInfo
- Publication number
- PT3023788T PT3023788T PT151982840T PT15198284T PT3023788T PT 3023788 T PT3023788 T PT 3023788T PT 151982840 T PT151982840 T PT 151982840T PT 15198284 T PT15198284 T PT 15198284T PT 3023788 T PT3023788 T PT 3023788T
- Authority
- PT
- Portugal
- Prior art keywords
- compositions
- tumor specific
- specific neoantigens
- neoantigens
- tumor
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P35/00—Antineoplastic agents
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- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
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- G01—MEASURING; TESTING
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70539—MHC-molecules, e.g. HLA-molecules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Hospice & Palliative Care (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33486610P | 2010-05-14 | 2010-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3023788T true PT3023788T (pt) | 2020-05-18 |
Family
ID=44915022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT151982840T PT3023788T (pt) | 2010-05-14 | 2011-05-16 | Composições de neoantigénios específicos de tumor para utilização no tratamento de tumores |
Country Status (14)
Country | Link |
---|---|
US (8) | US9115402B2 (pt) |
EP (3) | EP2569633B1 (pt) |
JP (5) | JP5948319B2 (pt) |
KR (4) | KR102095670B1 (pt) |
CN (2) | CN103180730B (pt) |
AU (1) | AU2011252795B2 (pt) |
BR (2) | BR122021014039B1 (pt) |
CA (2) | CA2797868C (pt) |
DK (1) | DK3023788T3 (pt) |
ES (2) | ES2564841T3 (pt) |
HU (1) | HUE049886T2 (pt) |
PL (1) | PL3023788T3 (pt) |
PT (1) | PT3023788T (pt) |
WO (1) | WO2011143656A2 (pt) |
Families Citing this family (153)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
US9732131B2 (en) | 2006-02-27 | 2017-08-15 | Calviri, Inc. | Identification and use of novopeptides for the treatment of cancer |
KR102095670B1 (ko) * | 2010-05-14 | 2020-03-31 | 더 제너럴 하스피톨 코포레이션 | 종양 특이적 신생항원을 확인하는 조성물 및 방법 |
ME03498B (me) | 2011-05-24 | 2020-04-20 | Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh | Individualizovane vakcine protiv kancera |
SI3892295T1 (sl) | 2011-05-24 | 2023-09-29 | BioNTech SE | Individualizirana cepiva proti raku |
US20140303020A1 (en) * | 2011-08-02 | 2014-10-09 | The University Of Tokyo | Method for Assessing Myelodysplastic Syndrome or Myeloid Tumor Predisposition, Polypeptide and Antibody Therefor, and Candidate Screening Method for Therapeutic Drug or Prophylactic Drug Therefor |
JP2014530013A (ja) * | 2011-09-29 | 2014-11-17 | トローバジーン インコーポレイテッド | Sf3b1遺伝子における変異および慢性リンパ性白血病 |
WO2013086464A1 (en) * | 2011-12-07 | 2013-06-13 | The Broad Institute, Inc. | Markers associated with chronic lymphocytic leukemia prognosis and progression |
GB201121308D0 (en) | 2011-12-12 | 2012-01-25 | Cell Medica Ltd | Process |
US20150010519A1 (en) | 2012-02-09 | 2015-01-08 | Baylor College Of Medicine | Pepmixes to generate multiviral ctls with broad specificity |
WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
US10640535B2 (en) | 2012-05-25 | 2020-05-05 | Agenus Inc. | Identification of MHC class I phospho-peptide antigens from breast cancer utilizing SHLA technology and complementary enrichment strategies |
CN104662171B (zh) * | 2012-07-12 | 2018-07-13 | 普瑟姆尼股份有限公司 | 个性化癌症疫苗和过继免疫细胞治疗 |
GB201214007D0 (en) * | 2012-08-07 | 2012-09-19 | Scancell Ltd | Anti-tumour immune responses to modified self-epitopes |
EP3718556A3 (en) | 2012-08-31 | 2020-12-30 | University Of Virginia Patent Foundation | Target peptides for immunotherapy and diagnostics |
AU2013312529A1 (en) | 2012-09-05 | 2015-04-16 | The University Of Birmingham | Target peptides for colorectal cancer therapy and diagnostics |
AU2013323368B2 (en) * | 2012-09-28 | 2019-03-21 | The University Of Connecticut | Identification of tumor-protective epitopes for the treatment of cancers |
WO2014082729A1 (en) * | 2012-11-28 | 2014-06-05 | Biontech Ag | Individualized vaccines for cancer |
GB2508414A (en) * | 2012-11-30 | 2014-06-04 | Max Delbrueck Centrum | Tumour specific T cell receptors (TCRs) |
BR112015018989B1 (pt) | 2013-02-22 | 2023-11-14 | Curevac Ag | Combinação de vacina/inibidor da via de pd-1, inibidor da via de pd-1 e vacina de rna |
BR122021025267B1 (pt) | 2013-02-22 | 2023-12-05 | Curevac Ag | Partes de kit e composição farmacêutica compreendendo um inibidor da via de pd-1 |
CN105431523B (zh) | 2013-03-14 | 2020-08-21 | 约翰·霍普金斯大学 | 纳米级人工抗原呈递细胞 |
KR102341899B1 (ko) * | 2013-04-07 | 2021-12-21 | 더 브로드 인스티튜트, 인코퍼레이티드 | 개인맞춤화 신생물 백신을 위한 조성물 및 방법 |
WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
US10801070B2 (en) | 2013-11-25 | 2020-10-13 | The Broad Institute, Inc. | Compositions and methods for diagnosing, evaluating and treating cancer |
US11725237B2 (en) | 2013-12-05 | 2023-08-15 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
EP4052724A1 (en) * | 2013-12-06 | 2022-09-07 | The Broad Institute Inc. | Formulations for neoplasia vaccines |
KR20160101073A (ko) * | 2013-12-20 | 2016-08-24 | 더 브로드 인스티튜트, 인코퍼레이티드 | 신생항원 백신과의 병용 요법 |
SG10201805674YA (en) * | 2014-01-02 | 2018-08-30 | Memorial Sloan Kettering Cancer Center | Determinants of cancer response to immunotherapy |
CA2935878C (en) | 2014-03-12 | 2023-05-02 | Curevac Ag | Combination of vaccination and ox40 agonists |
US10654908B2 (en) | 2014-04-15 | 2020-05-19 | University Of Virginia Patent Foundation | Isolated T cell receptors and methods of use therefor |
US11338026B2 (en) | 2014-09-10 | 2022-05-24 | The University Of Connecticut | Identification of immunologically protective neo-epitopes for the treatment of cancers |
US20170224799A1 (en) * | 2014-09-10 | 2017-08-10 | The University Of Connecticut | Identification of immunologically protective neo-epitopes for the treatment of cancers |
AU2015315005B9 (en) | 2014-09-10 | 2021-08-12 | Genentech, Inc. | Immunogenic mutant peptide screening platform |
AU2015314776A1 (en) * | 2014-09-14 | 2017-04-06 | Washington University | Personalized cancer vaccines and methods therefor |
KR20170078619A (ko) * | 2014-09-17 | 2017-07-07 | 더 존스 홉킨스 유니버시티 | 항원-특이적 t 세포 식별, 농축, 및/또는 증식을 위한 시약 및 방법 |
CA2959197C (en) * | 2014-09-17 | 2023-03-14 | Herlev Hospital | Vaccine compositions comprising tryptophan 2,3-dioxygenase or fragments thereof |
WO2016045732A1 (en) | 2014-09-25 | 2016-03-31 | Biontech Rna Pharmaceuticals Gmbh | Stable formulations of lipids and liposomes |
CN107075479A (zh) | 2014-10-02 | 2017-08-18 | 美国卫生和人力服务部 | 分离对癌症特异性突变具有抗原特异性的t细胞的方法 |
MX2017004708A (es) * | 2014-10-10 | 2017-10-12 | Idera Pharmaceuticals Inc | Tratamiento del cáncer con agonista de tlr9 con inhibidores de punto de control. |
MA40737A (fr) * | 2014-11-21 | 2017-07-04 | Memorial Sloan Kettering Cancer Center | Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 |
WO2016100975A1 (en) | 2014-12-19 | 2016-06-23 | Massachsetts Institute Ot Technology | Molecular biomarkers for cancer immunotherapy |
WO2016100977A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute Inc. | Methods for profiling the t-cel- receptor repertoire |
WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
AU2016238290B9 (en) * | 2015-03-25 | 2019-06-13 | The Regents Of The University Of Michigan | Compositions and methods for delivery of biomacromolecule agents |
EP3280738A4 (en) | 2015-04-08 | 2019-01-02 | Nantomics, LLC | Cancer neoepitopes |
EP3286361A4 (en) | 2015-04-23 | 2019-05-08 | Nantomics, LLC | CANCER NEO-EPITOPES |
GB201507030D0 (en) | 2015-04-24 | 2015-06-10 | Immatics Biotechnologies Gmbh | Immunotherapy against lung cancers, in particular NSCLC |
IL298497A (en) * | 2015-04-27 | 2023-01-01 | Cancer Research Tech Ltd | A method for treating cancer |
AU2016258845B2 (en) | 2015-05-01 | 2022-03-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating T cells and T cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood |
MA42420A (fr) | 2015-05-13 | 2018-05-23 | Agenus Inc | Vaccins pour le traitement et la prévention du cancer |
CN116196401A (zh) * | 2015-05-20 | 2023-06-02 | 博德研究所 | 共有的新抗原 |
TWI750122B (zh) * | 2015-06-09 | 2021-12-21 | 美商博德研究所有限公司 | 用於贅瘤疫苗之調配物及其製備方法 |
EP3323070B1 (en) * | 2015-07-14 | 2024-05-08 | Personal Genome Diagnostics Inc. | Neoantigen analysis |
EP3328394A4 (en) * | 2015-07-30 | 2019-03-13 | ModernaTX, Inc. | PEPTIDE CONCATEMERIC EPITAOPE RNA |
GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
WO2017049291A1 (en) * | 2015-09-18 | 2017-03-23 | Baylor College Of Medicine | Immunogenic antigen identification from a pathogen and correlation to clinical efficacy |
WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
KR20180087244A (ko) * | 2015-10-12 | 2018-08-01 | 난토믹스, 엘엘씨 | 체크포인트 억제제에 대한 감도를 예측하는 msi 및 네오에피토프를 발견하기 위한 위한 시스템, 조성물 및 방법 |
KR20240010089A (ko) * | 2015-10-12 | 2024-01-23 | 난토믹스, 엘엘씨 | 네오에피토프의 반복적 발견 및 이에 대한 적응성 면역치료 및 방법 |
CN108604257B (zh) * | 2015-10-12 | 2022-12-13 | 南托米克斯有限责任公司 | 产生特异性免疫治疗组合物及其相关核酸构建体的方法 |
MX2018004544A (es) * | 2015-10-12 | 2018-11-09 | Nantomics Llc | Composiciones y métodos para los neoepítopos de cáncer viral. |
WO2017070618A1 (en) * | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Cancer vaccines |
JP7094880B2 (ja) | 2015-11-06 | 2022-07-04 | ヴェンタナ メディカル システムズ, インク. | 代表診断法 |
TWI733719B (zh) | 2015-12-07 | 2021-07-21 | 美商河谷控股Ip有限責任公司 | 改善的組合物及用於新表位之病毒遞送的方法及其應用 |
PE20181535A1 (es) * | 2015-12-16 | 2018-09-26 | Gritstone Oncology Inc | Identificacion, fabricacion y uso de neoantigeno |
CA3048204A1 (en) * | 2015-12-23 | 2017-06-29 | Moonshot Pharma Llc | Methods for inducing an immune response |
US20170224796A1 (en) | 2016-02-05 | 2017-08-10 | Xeme Biopharma Inc. | Therapeutic Cancer Vaccine Containing Tumor-Associated Neoantigens and Immunostimulants in a Delivery System |
EP3414692A4 (en) * | 2016-02-12 | 2020-07-29 | Nantomics, LLC | HIGH-RATE IDENTIFICATION OF PATIENT-SPECIFIC NEOEPITOPES AS THERAPEUTIC TARGETS FOR CANCER IMMUNOTHERAPIES |
AU2017219901B2 (en) | 2016-02-19 | 2022-07-14 | Nant Holdings Ip, Llc | Methods of immunogenic modulation |
CN105720176A (zh) * | 2016-02-19 | 2016-06-29 | 京东方科技集团股份有限公司 | 一种胶囊量子点和发光二极管、制备方法及显示装置 |
EP3475434A4 (en) * | 2016-03-24 | 2020-07-29 | Nantcell, Inc. | SEQUENCE ARRANGEMENTS AND SEQUENCES FOR NEOEPITOP REPRESENTATION |
CA3056212A1 (en) * | 2016-04-07 | 2017-10-12 | Bostongene Corporation | Construction and methods of use of a therapeutic cancer vaccine library comprising fusion-specific vaccines |
US20190062272A1 (en) * | 2016-04-13 | 2019-02-28 | Capten Therapeutics Inc. | Small molecules for immunogenic treatment of cancer |
US20190247435A1 (en) * | 2016-06-29 | 2019-08-15 | The Johns Hopkins University | Neoantigens as targets for immunotherapy |
DK3488443T3 (da) * | 2016-07-20 | 2021-09-27 | BioNTech SE | Udvælgelse af neoepitoper som sygdomsspecifikke mål for terapi med øget virkning |
EP3493836A4 (en) * | 2016-08-02 | 2020-03-04 | Nantcell, Inc. | TRANSFECTION OF DENDRITIC CELLS AND RELATED METHODS |
WO2018045249A1 (en) * | 2016-08-31 | 2018-03-08 | Medgenome, Inc. | Methods to analyze genetic alterations in cancer to identify therapeutic peptide vaccines and kits therefore |
US10350280B2 (en) | 2016-08-31 | 2019-07-16 | Medgenome Inc. | Methods to analyze genetic alterations in cancer to identify therapeutic peptide vaccines and kits therefore |
MX2019002925A (es) | 2016-09-15 | 2019-09-05 | Idera Pharmaceuticals Inc | Modulacion inmune con agonistas de tlr9 para el tratamiento del cancer. |
WO2018057447A1 (en) * | 2016-09-23 | 2018-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of preparing an isolated population of dendritic cells and methods of treating cancer using same |
US20190240257A1 (en) * | 2016-10-13 | 2019-08-08 | The Johns Hopkins University | Compositions and methods for identifying functional anti-tumor t cell responses |
WO2018089637A1 (en) | 2016-11-11 | 2018-05-17 | Nantbio, Inc. | Immunomodulatory compositions, processes for making the same, and methods for inhibiting cytokine storms |
WO2018102613A2 (en) | 2016-12-01 | 2018-06-07 | Nantomics, Llc | Tumor antigenicity processing and presentation |
US11549149B2 (en) | 2017-01-24 | 2023-01-10 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
CN110505877A (zh) * | 2017-02-01 | 2019-11-26 | 摩登纳特斯有限公司 | Rna癌症疫苗 |
CA3051252A1 (en) | 2017-02-01 | 2018-08-09 | Modernatx, Inc. | Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides |
CN110651036A (zh) | 2017-03-20 | 2020-01-03 | 健诺西生物科学公司 | 治疗方法 |
WO2018183544A1 (en) * | 2017-03-31 | 2018-10-04 | Dana-Farber Cancer Institute, Inc. | Method for identification of retained intron tumor neoantigens from patient transcriptome |
SG11201909652WA (en) * | 2017-04-19 | 2019-11-28 | Gritstone Oncology Inc | Neoantigen identification, manufacture, and use |
KR102306403B1 (ko) | 2017-04-24 | 2021-09-28 | 난트셀, 인크. | 표적화된 네오에피토프 벡터 및 그에 관한 방법 (targeted neoepitope vectors and methods therefor) |
JP2020518648A (ja) | 2017-05-08 | 2020-06-25 | グリットストーン オンコロジー インコーポレイテッド | アルファウイルス新生抗原ベクター |
WO2018209145A1 (en) | 2017-05-10 | 2018-11-15 | The Broad Institute, Inc. | Methods and compositions for determination of mutations in single replication events |
US20200276285A1 (en) * | 2017-06-02 | 2020-09-03 | Arizona Board Of Regents On Behalf Of Arizona State University | A method to create personalized cancer vaccines |
WO2018234506A2 (en) * | 2017-06-21 | 2018-12-27 | Transgene Sa | PERSONALIZED VACCINE |
SG11202000425QA (en) | 2017-07-21 | 2020-02-27 | Berkeley Lights Inc | Antigen-presenting synthetic surfaces, covalently functionalized surfaces, activated t cells, and uses thereof |
WO2019036043A2 (en) * | 2017-08-16 | 2019-02-21 | Medgenome Inc. | METHOD FOR GENERATING A COCKTAIL OF PERSONALIZED ANTICANCER VACCINES FROM TUMOR DERIVED GENETIC MODIFICATIONS FOR THE TREATMENT OF CANCER |
US12025615B2 (en) | 2017-09-15 | 2024-07-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods of classifying response to immunotherapy for cancer |
US20200362418A1 (en) * | 2017-10-02 | 2020-11-19 | Curematch, Inc. | Method of prediction of tumor-derived neo-peptide antigenicity and/or immunogenicity using mutational signature patterns |
JP2020536114A (ja) * | 2017-10-06 | 2020-12-10 | ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー | 癌の処置および予防のためctla−4を標的とするdnaモノクローナル抗体 |
JP7227237B2 (ja) * | 2017-10-10 | 2023-02-21 | グリットストーン バイオ インコーポレイテッド | ホットスポットを利用した新生抗原の特定 |
EP3707245A1 (en) * | 2017-11-06 | 2020-09-16 | Ludwig Institute for Cancer Research Ltd | Method for expansion of lymphocytes |
WO2019094396A1 (en) * | 2017-11-07 | 2019-05-16 | Nektar Therapeutics | Immunotherapeutic combination for treating cancer |
AU2018373154A1 (en) | 2017-11-22 | 2020-07-02 | Gritstone Bio, Inc. | Reducing junction epitope presentation for neoantigens |
CN109682978B (zh) * | 2017-11-30 | 2020-07-03 | 四川康德赛医疗科技有限公司 | 一种肿瘤突变肽mhc亲和力预测方法及其应用 |
TW201930340A (zh) | 2017-12-18 | 2019-08-01 | 美商尼恩醫療公司 | 新抗原及其用途 |
CN111818943A (zh) | 2018-01-04 | 2020-10-23 | 伊科尼克治疗公司 | 抗组织因子抗体、抗体-药物缀合物及相关方法 |
US11573230B2 (en) | 2018-01-26 | 2023-02-07 | Nantcell, Inc. | Rapid verification of virus particle production for a personalized vaccine |
US20210046177A1 (en) | 2018-01-26 | 2021-02-18 | Nantcell, Inc. | Compositions and methods for combination cancer vaccine and immunologic adjuvant therapy |
CN108491689B (zh) * | 2018-02-01 | 2019-07-09 | 杭州纽安津生物科技有限公司 | 基于转录组的肿瘤新抗原鉴定方法 |
KR20200127001A (ko) * | 2018-02-27 | 2020-11-09 | 그릿스톤 온콜로지, 인코포레이티드 | 범-대립유전자 모델을 갖는 신생항원 동정 |
WO2019210055A2 (en) | 2018-04-26 | 2019-10-31 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
US20210361755A1 (en) * | 2018-05-25 | 2021-11-25 | The Wistar Institute | Tumor-specific neoantigens and methods of using the same |
EP3806888B1 (en) | 2018-06-12 | 2024-01-31 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
CA3106574A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Arid1a, cdkn2a, kmt2b, kmt2d, tp53 and pten vaccines for cancer |
US20210213116A1 (en) | 2018-07-26 | 2021-07-15 | Frame Pharmaceuticals B.V. | Cancer vaccines for kidney cancer |
CA3106573A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Cancer vaccines for colorectal cancer |
WO2020022897A1 (en) * | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Method of preparing subject-specific immunogenic compositions based on a neo open-reading-frame peptide database |
US20210187088A1 (en) | 2018-07-26 | 2021-06-24 | Frame Pharmaceuticals B.V. | Cancer vaccines for uterine cancer |
CA3106564A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Cancer vaccines for breast cancer |
CN109021062B (zh) * | 2018-08-06 | 2021-08-20 | 倍而达药业(苏州)有限公司 | 一种肿瘤新抗原的筛选方法 |
CA3109539A1 (en) | 2018-08-31 | 2020-03-05 | Guardant Health, Inc. | Microsatellite instability detection in cell-free dna |
US11945850B2 (en) | 2018-09-17 | 2024-04-02 | Immatics Biotechnologies Gmbh | B*44 restricted peptides for use in immunotherapy against cancers and related methods |
WO2020061499A1 (en) | 2018-09-21 | 2020-03-26 | Berkeley Lights, Inc. | Functionalized well plate, methods of preparation and use thereof |
WO2020097466A1 (en) | 2018-11-08 | 2020-05-14 | Neximmune, Inc. | T cell compositions with improved phenotypic properties |
WO2020131586A2 (en) | 2018-12-17 | 2020-06-25 | The Broad Institute, Inc. | Methods for identifying neoantigens |
CN109706065A (zh) * | 2018-12-29 | 2019-05-03 | 深圳裕策生物科技有限公司 | 肿瘤新生抗原负荷检测装置及存储介质 |
EP3927354A1 (en) | 2019-02-20 | 2021-12-29 | Rubius Therapeutics, Inc. | Engineered erythroid cells including loadable antigen-presenting polypeptides and methods of use |
CN111621564B (zh) * | 2019-02-28 | 2022-03-25 | 武汉大学 | 一种鉴定有效肿瘤新抗原的方法 |
US20220130489A1 (en) * | 2019-03-12 | 2022-04-28 | Syntekabio,Inc. | System and method for providing neoantigen immunotherapy information by using artificial-intelligence-model-based molecular dynamics big data |
JP2022533861A (ja) * | 2019-05-03 | 2022-07-26 | ギレム リチャード | がんにおける新抗原 |
US20220220472A1 (en) * | 2019-05-06 | 2022-07-14 | The Regents Of The University Of Michigan | Targeted therapy |
CA3140019A1 (en) | 2019-05-30 | 2020-12-03 | Gritstone Bio, Inc. | Modified adenoviruses |
CN112011833B (zh) * | 2019-05-30 | 2024-04-26 | 上海桀蒙生物技术有限公司 | 筛选和分离肿瘤新生抗原的方法 |
CN110322925B (zh) * | 2019-07-18 | 2021-09-03 | 杭州纽安津生物科技有限公司 | 一种预测融合基因产生新生抗原的方法 |
CN110706747B (zh) * | 2019-09-17 | 2021-09-07 | 北京橡鑫生物科技有限公司 | 检测肿瘤新生抗原多肽的方法和装置 |
EP4038222A4 (en) | 2019-10-02 | 2023-10-18 | Arizona Board of Regents on behalf of Arizona State University | METHODS AND COMPOSITIONS FOR IDENTIFYING NEOANTIGENS FOR USE IN THE TREATMENT AND PREVENTION OF CANCER |
US11920202B2 (en) | 2020-04-09 | 2024-03-05 | University Of Connecticut | Unbiased identification of tumor rejection mediating neoepitopes |
WO2021252904A1 (en) | 2020-06-11 | 2021-12-16 | Massachusetts Institute Of Technology | Ribonucleoprotein approach to boost the sting signaling for cancer immunotherapy |
WO2022032196A2 (en) | 2020-08-06 | 2022-02-10 | Gritstone Bio, Inc. | Multiepitope vaccine cassettes |
IL300564A (en) | 2020-08-13 | 2023-04-01 | Biontech Us Inc | Preparations and methods for the production of T cells |
US20230323431A1 (en) * | 2020-08-31 | 2023-10-12 | World Biotech Regenerative Medical Group Limited | Personalized Immunogenic Compositions and Methods for Producing and Using Same |
KR102552632B1 (ko) * | 2020-11-06 | 2023-07-06 | 사회복지법인 삼성생명공익재단 | 중추신경계 림프종을 진단하기 위한 마커, 이를 포함하는 중추신경계 림프종 진단 키트 및 중추신경계 림프종을 진단하는 방법 |
JP2024517793A (ja) | 2021-04-30 | 2024-04-23 | ティゲン・ファーマ・ソシエテ・アノニム | 単一容器リンパ球拡大 |
EP4392140A1 (en) | 2021-08-24 | 2024-07-03 | BioNTech SE | In vitro transcription technologies |
CN115772564B (zh) * | 2021-09-08 | 2023-08-18 | 广州市基准医疗有限责任公司 | 用于辅助检测肺癌体细胞atm基因融合突变的甲基化生物标记物及其应用 |
WO2023068931A1 (en) | 2021-10-21 | 2023-04-27 | Curevac Netherlands B.V. | Cancer neoantigens |
WO2023177655A1 (en) | 2022-03-14 | 2023-09-21 | Generation Bio Co. | Heterologous prime boost vaccine compositions and methods of use |
WO2024077256A1 (en) | 2022-10-07 | 2024-04-11 | The General Hospital Corporation | Methods and compositions for high-throughput discovery ofpeptide-mhc targeting binding proteins |
WO2024083345A1 (en) | 2022-10-21 | 2024-04-25 | BioNTech SE | Methods and uses associated with liquid compositions |
WO2024097864A1 (en) | 2022-11-02 | 2024-05-10 | Tigen Pharma Sa | Expansion of lymphocytes |
Family Cites Families (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
GB8311018D0 (en) | 1983-04-22 | 1983-05-25 | Amersham Int Plc | Detecting mutations in dna |
US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
US4844893A (en) | 1986-10-07 | 1989-07-04 | Scripps Clinic And Research Foundation | EX vivo effector cell activation for target cell killing |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
FR2650840B1 (fr) | 1989-08-11 | 1991-11-29 | Bertin & Cie | Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications |
AU625013B2 (en) | 1989-11-03 | 1992-06-25 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
IL105914A0 (en) | 1992-06-04 | 1993-10-20 | Univ California | Methods and compositions for in vivo gene therapy |
WO2001000225A1 (en) * | 1999-06-29 | 2001-01-04 | Epimmune Inc. | Hla binding peptides and their uses |
US9340577B2 (en) | 1992-08-07 | 2016-05-17 | Epimmune Inc. | HLA binding motifs and peptides and their uses |
US5589406A (en) | 1993-07-30 | 1996-12-31 | Ag Technology Co., Ltd. | Method of making TFT display |
US6071890A (en) | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
WO2000020587A2 (en) | 1998-10-05 | 2000-04-13 | Ludwig Institute For Cancer Research | Cancer associated antigens and uses therefor |
NO309798B1 (no) | 1999-04-30 | 2001-04-02 | Targovax As | Peptidblanding, samt farmasoytisk sammensetning og kreftvaksine som innbefatter peptidblandingen |
BR0010322A (pt) * | 1999-05-06 | 2002-04-09 | Univ Wake Forest | Vetor de expressão, vacina e seu método de uso para eliciar uma resposta imune dirigida contra um antìgeno em um mamìfero |
EP1250351B1 (en) * | 2000-01-28 | 2005-11-30 | Statens Serum Institut | Methods to identify ctl epitopes of hiv |
ES2537074T3 (es) * | 2001-09-06 | 2015-06-02 | Agensys, Inc. | Ácido nucleico y proteína correspondiente denominados STEAP-1 útiles en el tratamiento y la detección de cáncer |
ATE519115T1 (de) | 2002-06-13 | 2011-08-15 | Merck Patent Gmbh | Verfahren für die identifizierung von allo- antigenen und ihre verwendung für krebstherapie und transplantation |
US20080274129A1 (en) * | 2003-04-18 | 2008-11-06 | Fikes John D | Hla-A2 Tumor Associated Antigen Peptides and Compositions |
US20060008468A1 (en) * | 2004-06-17 | 2006-01-12 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
US7220549B2 (en) | 2004-12-30 | 2007-05-22 | Helicos Biosciences Corporation | Stabilizing a nucleic acid for nucleic acid sequencing |
US7283337B2 (en) | 2005-03-04 | 2007-10-16 | Headway Technologies, Inc. | Abutted exchange bias design for sensor stabilization |
CN101213297B (zh) | 2005-05-09 | 2013-02-13 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及单独使用或与其它免疫治疗剂联合使用抗pd-1抗体来治疗癌症的方法 |
US20070112754A1 (en) | 2005-11-15 | 2007-05-17 | Honeywell International Inc. | Method and apparatus for identifying data of interest in a database |
EP1994181A4 (en) | 2006-02-27 | 2010-05-19 | Univ Arizona | IDENTIFICATION AND USE OF NOVOPEPTIDES FOR THE TREATMENT OF CANCER |
EP2007423A2 (en) * | 2006-04-05 | 2008-12-31 | Pfizer Products Incorporated | Ctla4 antibody combination therapy |
US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
KR101323540B1 (ko) | 2007-02-07 | 2013-10-29 | 사이단호진한다이비세이부쯔뵤우겐큐우카이 | 암의 치료제 |
JP5932217B2 (ja) | 2007-07-12 | 2016-06-08 | ジーアイティーアール, インコーポレイテッド | Gitr結合分子を使用する併用療法 |
ES2537323T3 (es) | 2007-08-20 | 2015-06-05 | Oncotherapy Science, Inc. | Péptido CDCA1 y agente farmacéutico que lo comprende |
US20090220980A1 (en) | 2007-12-28 | 2009-09-03 | John Wayne Cancer Institute | Use of methylation status of mint loci and tumor-related genes as a marker for melanoma and breast cancer |
WO2009102909A2 (en) * | 2008-02-15 | 2009-08-20 | Board Of Regents, The University Of Texas System | Anti-cancer vaccines |
AU2009292996B2 (en) * | 2008-09-22 | 2015-04-23 | Baylor College Of Medicine | Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptor adapters |
US8369279B2 (en) | 2010-03-10 | 2013-02-05 | Broadcom Corporation | Method and system for iterative multiple frequency hypothesis testing with cell-ID detection in an E-UTRA/LTE UE receiver |
EP2509583B1 (en) | 2009-12-10 | 2019-05-15 | Merck Patent GmbH | Pharmaceutical composition comprising oligopeptides, preferably cilengitide |
US9023802B2 (en) | 2009-12-14 | 2015-05-05 | Immatics Biotechnologies Gmbh | HLA-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof |
GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
KR102095670B1 (ko) | 2010-05-14 | 2020-03-31 | 더 제너럴 하스피톨 코포레이션 | 종양 특이적 신생항원을 확인하는 조성물 및 방법 |
RU2621640C2 (ru) | 2010-06-02 | 2017-06-06 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | Способы лечения рака мочевого пузыря |
EP2663651B1 (en) | 2011-01-14 | 2018-06-20 | Genefirst Limited | Methods, compositions, and kits for determing the presence/absence of a variant nucleic acid sequence |
WO2013026027A1 (en) | 2011-08-18 | 2013-02-21 | Nestec S.A. | Compositions and methods for detecting allelic variants |
JP2015517798A (ja) | 2012-02-15 | 2015-06-25 | ジャンセン ダイアグノスティックス,エルエルシー | 低頻度変異を検出するための高感度な方法 |
BR122022015975B1 (pt) | 2012-05-15 | 2024-01-02 | Bristol-Myers Squibb Company | Anticorpos monoclonais, kit para o tratamento de um indivíduo afligido com um câncer, processo para medir pd-l1 membranoso em células tumorais isoladas e uso do anticorpo ou uma porção que se liga ao antígeno do mesmo |
WO2014150924A2 (en) | 2013-03-15 | 2014-09-25 | The Broad Institute, Inc. | Accurate typing of hla through exome sequencing |
AU2015268982B2 (en) | 2014-06-05 | 2021-11-04 | Kling Biotherapeutics B.V. | Means and methods for determining T cell recognition |
PL3198026T3 (pl) | 2014-08-07 | 2020-05-18 | Pharmassist Ltd | Metody określania mutacji genu pik3ca w próbce |
EP3280738A4 (en) | 2015-04-08 | 2019-01-02 | Nantomics, LLC | Cancer neoepitopes |
CN108138221B (zh) | 2015-05-10 | 2021-11-05 | 康代思锐公司 | 用于检测核酸的超高灵敏度探针 |
TWI750122B (zh) | 2015-06-09 | 2021-12-21 | 美商博德研究所有限公司 | 用於贅瘤疫苗之調配物及其製備方法 |
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