PT2939696E - Conjugados poliméricos de antagonistas de opióides - Google Patents
Conjugados poliméricos de antagonistas de opióides Download PDFInfo
- Publication number
- PT2939696E PT2939696E PT151723632T PT15172363T PT2939696E PT 2939696 E PT2939696 E PT 2939696E PT 151723632 T PT151723632 T PT 151723632T PT 15172363 T PT15172363 T PT 15172363T PT 2939696 E PT2939696 E PT 2939696E
- Authority
- PT
- Portugal
- Prior art keywords
- polymer
- conjugate
- opioid
- formula
- poly
- Prior art date
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- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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Landscapes
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- Medicinal Preparation (AREA)
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| US33040001P | 2001-10-18 | 2001-10-18 |
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| PT2939696E true PT2939696E (pt) | 2016-06-17 |
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| PT2795531T PT1436012T (pt) | 2001-10-18 | 2002-10-18 | Conjugados poliméricos de antagonistas de opióides |
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| US6274591B1 (en) * | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
| US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
| ES2275561T3 (es) * | 1999-10-04 | 2007-06-16 | Nektar Therapeutics Al, Corporation | Neuropeptidos estabilizados por polimeros. |
| SI1436012T1 (en) | 2001-10-18 | 2018-03-30 | Nektar Therapeutics | Polymer conjugates of opioid antagonists |
| CA2473526C (en) | 2002-01-18 | 2013-10-22 | Biogen Idec Ma Inc. | Polyalkylene polymer compounds and uses thereof |
| JP2006522817A (ja) * | 2003-04-08 | 2006-10-05 | プロジェニックス ファーマシューティカルズ，インコーポレーテッド | 過敏性腸症候群を処置するための末梢オピオイドアンタゴニスト、特にメチルナルトレキソンの使用 |
| US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
| ES2528631T3 (es) * | 2003-04-08 | 2015-02-11 | Progenics Pharmaceuticals, Inc. | Formulaciones farmacéuticas que contienen metilnaltrexona |
| MXPA05010821A (es) * | 2003-04-08 | 2006-03-30 | Progenics Pharm Inc | Terapia de combinacion para constipacion que comprende un laxante y un antagonista opioide periferico. |
| GB0314472D0 (en) | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
| US7482376B2 (en) * | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
| EP1725572B1 (de) | 2003-11-05 | 2017-05-31 | AGCT GmbH | Makromolekulare nukleotidverbindungen und methoden zu deren anwendung |
| AU2014280956B2 (en) * | 2003-12-16 | 2016-09-22 | Nektar Therapeutics | Chemically modified small molecules |
| US20060182692A1 (en) * | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
| PL1694363T3 (pl) * | 2003-12-16 | 2014-07-31 | Nektar Therapeutics | Monodyspersyjne kompozycje PEGylowanego naloksolu |
| EP1744786A2 (en) * | 2004-03-23 | 2007-01-24 | Amgen Inc. | Chemically modified protein compositions and methods |
| CN1964976A (zh) * | 2004-06-08 | 2007-05-16 | 马林克罗特公司 | 从鸦片中提取生物碱 |
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