CY1119906T1 - Πολυμερικες συζευξεις οπιοειδων ανταγωνιστων - Google Patents
Πολυμερικες συζευξεις οπιοειδων ανταγωνιστωνInfo
- Publication number
- CY1119906T1 CY1119906T1 CY20181100170T CY181100170T CY1119906T1 CY 1119906 T1 CY1119906 T1 CY 1119906T1 CY 20181100170 T CY20181100170 T CY 20181100170T CY 181100170 T CY181100170 T CY 181100170T CY 1119906 T1 CY1119906 T1 CY 1119906T1
- Authority
- CY
- Cyprus
- Prior art keywords
- competitors
- optional
- polymer
- opioid
- provides
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 abstract 3
- 239000003401 opiate antagonist Substances 0.000 abstract 2
- 206010010774 Constipation Diseases 0.000 abstract 1
- 206010028813 Nausea Diseases 0.000 abstract 1
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 239000003887 narcotic antagonist Substances 0.000 abstract 1
- 230000008693 nausea Effects 0.000 abstract 1
- 239000000014 opioid analgesic Substances 0.000 abstract 1
- 229940005483 opioid analgesics Drugs 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33040001P | 2001-10-18 | 2001-10-18 | |
| PCT/US2002/033325 WO2003032990A2 (en) | 2001-10-18 | 2002-10-18 | Polymer conjugates of opioid antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119906T1 true CY1119906T1 (el) | 2018-06-27 |
Family
ID=23289594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100170T CY1119906T1 (el) | 2001-10-18 | 2018-02-12 | Πολυμερικες συζευξεις οπιοειδων ανταγωνιστων |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US7056500B2 (enExample) |
| EP (3) | EP2939696B1 (enExample) |
| JP (2) | JP4814488B2 (enExample) |
| KR (2) | KR100974842B1 (enExample) |
| AU (1) | AU2002360284B2 (enExample) |
| CA (1) | CA2463938C (enExample) |
| CY (1) | CY1119906T1 (enExample) |
| DK (2) | DK1436012T3 (enExample) |
| ES (2) | ES2569262T3 (enExample) |
| LT (1) | LT1436012T (enExample) |
| MX (1) | MXPA04003597A (enExample) |
| PT (2) | PT2939696E (enExample) |
| SI (2) | SI1436012T1 (enExample) |
| WO (1) | WO2003032990A2 (enExample) |
Families Citing this family (84)
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| US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
| ES2275561T3 (es) * | 1999-10-04 | 2007-06-16 | Nektar Therapeutics Al, Corporation | Neuropeptidos estabilizados por polimeros. |
| SI1436012T1 (en) | 2001-10-18 | 2018-03-30 | Nektar Therapeutics | Polymer conjugates of opioid antagonists |
| CA2473526C (en) | 2002-01-18 | 2013-10-22 | Biogen Idec Ma Inc. | Polyalkylene polymer compounds and uses thereof |
| JP2006522817A (ja) * | 2003-04-08 | 2006-10-05 | プロジェニックス ファーマシューティカルズ，インコーポレーテッド | 過敏性腸症候群を処置するための末梢オピオイドアンタゴニスト、特にメチルナルトレキソンの使用 |
| US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
| ES2528631T3 (es) * | 2003-04-08 | 2015-02-11 | Progenics Pharmaceuticals, Inc. | Formulaciones farmacéuticas que contienen metilnaltrexona |
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| GB0314472D0 (en) | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
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| CN101171010B (zh) | 2005-03-07 | 2014-09-17 | 芝加哥大学 | 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途 |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
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| CN101466381B (zh) | 2006-04-21 | 2012-11-14 | 尼克塔治疗公司 | 吗啡酮的立体选择性还原 |
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| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
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2002
- 2002-10-18 SI SI200231089T patent/SI1436012T1/en unknown
- 2002-10-18 AU AU2002360284A patent/AU2002360284B2/en active Active
- 2002-10-18 EP EP15172363.2A patent/EP2939696B1/en not_active Expired - Lifetime
- 2002-10-18 MX MXPA04003597A patent/MXPA04003597A/es active IP Right Grant
- 2002-10-18 US US10/274,296 patent/US7056500B2/en not_active Expired - Lifetime
- 2002-10-18 DK DK02795531.9T patent/DK1436012T3/en active
- 2002-10-18 PT PT151723632T patent/PT2939696E/pt unknown
- 2002-10-18 PT PT2795531T patent/PT1436012T/pt unknown
- 2002-10-18 EP EP02795531.9A patent/EP1436012B1/en not_active Expired - Lifetime
- 2002-10-18 CA CA2463938A patent/CA2463938C/en not_active Expired - Lifetime
- 2002-10-18 SI SI200231072A patent/SI2939696T1/sl unknown
- 2002-10-18 LT LTEP02795531.9T patent/LT1436012T/lt unknown
- 2002-10-18 ES ES15172363.2T patent/ES2569262T3/es not_active Expired - Lifetime
- 2002-10-18 DK DK15172363.2T patent/DK2939696T3/en active
- 2002-10-18 JP JP2003535793A patent/JP4814488B2/ja not_active Expired - Lifetime
- 2002-10-18 EP EP10007224A patent/EP2236161A1/en not_active Withdrawn
- 2002-10-18 KR KR1020047005735A patent/KR100974842B1/ko not_active Expired - Lifetime
- 2002-10-18 ES ES02795531.9T patent/ES2654819T3/es not_active Expired - Lifetime
- 2002-10-18 KR KR1020097025168A patent/KR101009309B1/ko not_active Expired - Lifetime
- 2002-10-18 WO PCT/US2002/033325 patent/WO2003032990A2/en not_active Ceased
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- 2006-01-17 US US11/332,964 patent/US7662365B2/en not_active Expired - Lifetime
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2009
- 2009-04-30 JP JP2009111653A patent/JP5570137B2/ja not_active Expired - Lifetime
- 2009-10-06 US US12/574,335 patent/US8349307B2/en not_active Expired - Fee Related
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2012
- 2012-11-29 US US13/689,640 patent/US8617530B2/en not_active Expired - Lifetime
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2018
- 2018-02-12 CY CY20181100170T patent/CY1119906T1/el unknown
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