KR101009309B1 - 아편양 길항제의 중합체 공액 - Google Patents
아편양 길항제의 중합체 공액 Download PDFInfo
- Publication number
- KR101009309B1 KR101009309B1 KR1020097025168A KR20097025168A KR101009309B1 KR 101009309 B1 KR101009309 B1 KR 101009309B1 KR 1020097025168 A KR1020097025168 A KR 1020097025168A KR 20097025168 A KR20097025168 A KR 20097025168A KR 101009309 B1 KR101009309 B1 KR 101009309B1
- Authority
- KR
- South Korea
- Prior art keywords
- polymer
- opioid
- delete delete
- poly
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (26)
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 제 13 항에 있어서, 상기 아편양 효현제가 알펜타닐, 브레마조신, 부프레노르핀, 부토르판올, 코데인, 시클라조신, 데조신, 디아세틸모르핀, 디히드로코데인, 펜타닐, 히드로코돈, 히드로모르폰, 레보르판올, 메페리딘 (페티딘), 메타돈, 모르핀, 날부핀, 노스카핀, 옥시코돈, 옥시모르폰, 파파베린, 펜타조신, 페티딘, 페나조신, 프로피람, 프로폭시펜, 수펜타닐, 테바인 및 트라마돌로 이루어지는 군으로부터 선택되는 조성물.
- 삭제
- 삭제
- 삭제
- 삭제
- 제 13 항에 있어서, POLY 가 하기 식인 조성물:CH3O-(CH2CH2O)n-CH2CH2-[식 중, 하첨자 n 은 2 내지 45 이다].
- 제 19 항에 있어서, 하첨자 n 이 2 내지 20 인 조성물.
- 제 13 항에 있어서, POLY 가 100 Da 내지 500 Da 의 분자량을 갖는 조성물.
- 제 13 항에 있어서, X 가 -NHC(O)- 인 조성물.
- 제 13 항에 있어서, X 가 -NH- 인 조성물.
- 제 13 항에 있어서, X 가 -O- 인 조성물.
- 제 13 항에 있어서, X 가 -S- 인 조성물.
- 제 13 항에 있어서, X 가 -NHC(O)NH- 인 조성물.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33040001P | 2001-10-18 | 2001-10-18 | |
US60/330,400 | 2001-10-18 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020047005735A Division KR100974842B1 (ko) | 2001-10-18 | 2002-10-18 | 아편양 길항제의 중합체 공액 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20090130155A KR20090130155A (ko) | 2009-12-17 |
KR101009309B1 true KR101009309B1 (ko) | 2011-01-18 |
Family
ID=23289594
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020047005735A KR100974842B1 (ko) | 2001-10-18 | 2002-10-18 | 아편양 길항제의 중합체 공액 |
KR1020097025168A KR101009309B1 (ko) | 2001-10-18 | 2002-10-18 | 아편양 길항제의 중합체 공액 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020047005735A KR100974842B1 (ko) | 2001-10-18 | 2002-10-18 | 아편양 길항제의 중합체 공액 |
Country Status (15)
Country | Link |
---|---|
US (4) | US7056500B2 (ko) |
EP (3) | EP2939696B1 (ko) |
JP (2) | JP4814488B2 (ko) |
KR (2) | KR100974842B1 (ko) |
AU (1) | AU2002360284B2 (ko) |
CA (1) | CA2463938C (ko) |
CY (1) | CY1119906T1 (ko) |
DK (2) | DK1436012T3 (ko) |
ES (2) | ES2569262T3 (ko) |
HK (1) | HK1215171A1 (ko) |
LT (1) | LT1436012T (ko) |
MX (1) | MXPA04003597A (ko) |
PT (2) | PT1436012T (ko) |
SI (2) | SI2939696T1 (ko) |
WO (1) | WO2003032990A2 (ko) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6274591B1 (en) * | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
AU782298B2 (en) * | 1999-10-04 | 2005-07-14 | Nektar Therapeutics | Polymer stabilized neuropeptides |
DK1436012T3 (en) | 2001-10-18 | 2018-01-22 | Nektar Therapeutics | Polymer Conjugates of Opioid Antagonists |
EP1476181B1 (en) * | 2002-01-18 | 2016-03-23 | Biogen MA Inc. | Polyalkylene polymer compounds and uses thereof |
EP2368554B1 (en) | 2003-04-08 | 2014-12-24 | Progenics Pharmaceuticals, Inc. | Pharmaceutical formulations containing methylnaltrexone |
EP1617846A1 (en) * | 2003-04-08 | 2006-01-25 | Progenics Pharmaceuticals, Inc. | The use of peripheral opiois antagonists, especially methylnaltrexone to treat irritable bowel syndrome |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
WO2004091665A1 (en) * | 2003-04-08 | 2004-10-28 | Progenics Pharmaceuticals, Inc. | Combination therapy for constipation comprising a laxative and a peripheral opioid antagonist |
GB0314472D0 (en) | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
US7482376B2 (en) | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
WO2005044836A2 (de) | 2003-11-05 | 2005-05-19 | Genovoxx Gmbh | Makromolekulare nukleotidverbindungen und methoden zu deren anwendung |
AU2014280956B2 (en) * | 2003-12-16 | 2016-09-22 | Nektar Therapeutics | Chemically modified small molecules |
ES2733764T3 (es) * | 2003-12-16 | 2019-12-02 | Nektar Therapeutics | Método para la preparación de oligo etilenglicol monodisperso |
US20060182692A1 (en) | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
AU2005229001A1 (en) * | 2004-03-23 | 2005-10-13 | Amgen Inc. | Chemically modified protein compositions and methods |
US7495098B2 (en) * | 2004-06-08 | 2009-02-24 | Mallinckrodt Inc | Extraction of alkaloids from opium |
JPWO2006064780A1 (ja) * | 2004-12-14 | 2008-06-12 | 塩野義製薬株式会社 | 便秘治療剤 |
MX2007008756A (es) * | 2005-01-20 | 2007-09-27 | Progenics Pharm Inc | Uso de metilnaltrexona y compuestos relacionados para el tratamiento de disfuncion gastrointestinal postoperatoria. |
US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
US9662390B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
US20080194611A1 (en) * | 2005-06-03 | 2008-08-14 | Alverdy John C | Modulation of Cell Barrier Dysfunction |
NZ572252A (en) | 2006-04-21 | 2011-09-30 | Nektar Therapeutics | Stereoselective reduction of a morphinone |
SG172633A1 (en) | 2006-05-26 | 2011-07-28 | Pharmacofore Inc | Controlled release of phenolic opioids |
JP2010509227A (ja) * | 2006-11-07 | 2010-03-25 | ネクター セラピューティックス エイエル,コーポレイション | オピオイド作動薬およびオピオイド拮抗薬の用量形態および同時投与 |
WO2008064353A2 (en) * | 2006-11-22 | 2008-05-29 | Progenics Pharmaceuticals, Inc. | 7,8-saturated-4,5-epoxy-morphinanium analogs |
WO2008101187A2 (en) * | 2007-02-16 | 2008-08-21 | Pharmacofore, Inc. | Pro-drugs of peripheral phenolic opioid antagonists |
KR101508617B1 (ko) * | 2007-02-28 | 2015-04-06 | 세리나 쎄라퓨틱스, 인코포레이티드 | 활성화된 폴리옥사졸린 및 이를 포함하는 조성물 |
US20140011964A1 (en) | 2007-02-28 | 2014-01-09 | Serina Therapeutics, Inc. | Activated Polyoxazolines and Conjugates and Compositions Comprising the Same |
US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
SI2134371T1 (sl) * | 2007-03-12 | 2015-04-30 | Nektar Therapeutics | Konjugati agonista oligomer-opioid |
EP3263571B2 (en) | 2007-03-29 | 2023-08-23 | Progenics Pharmaceuticals, Inc. | Crystal form of (r)-n-methylnaltrexone bromide and uses thereof |
PE20130480A1 (es) | 2007-03-29 | 2013-05-08 | Progenics Pharm Inc | Compuestos heterociclicos como antagonistas del receptor opioide periferico |
MX2009010515A (es) | 2007-03-29 | 2009-10-19 | Wyeth Corp | Antagonistas del receptor opioide periferico y usos de los mismos. |
EP2214672B1 (en) * | 2007-10-18 | 2012-10-17 | Aiko Biotechnology | Combination analgesic employing opioid and neutral antagonist |
US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
CA2713568C (en) | 2008-02-06 | 2016-09-20 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
EP2278966B1 (en) | 2008-03-21 | 2019-10-09 | The University of Chicago | Treatment with opioid antagonists and mtor inhibitors |
EA201001643A1 (ru) * | 2008-05-07 | 2011-06-30 | Нектар Терапеутикс | Пероральное введение периферически действующих опиоидных антагонистов |
WO2010002576A1 (en) | 2008-07-01 | 2010-01-07 | University Of Chicago | Particles containing an opioid receptor antagonist and methods of use |
EP2331140B1 (en) | 2008-08-11 | 2018-07-04 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
CA2734333A1 (en) * | 2008-09-16 | 2010-03-25 | Nektar Therapeutics | Pegylated opioids with low potential for abuse |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
NZ598783A (en) * | 2009-09-18 | 2013-07-26 | Adolor Corp | Use of opioid receptor antagonist for gastrointestinal tract disorders |
US9315860B2 (en) | 2009-10-26 | 2016-04-19 | Genovoxx Gmbh | Conjugates of nucleotides and method for the application thereof |
EA029096B1 (ru) | 2010-03-11 | 2018-02-28 | Вайет Ллк | Твердая лекарственная форма для перорального введения, содержащая метилналтрексон |
JP6034789B2 (ja) | 2010-09-30 | 2016-11-30 | アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag | 結晶性ナロキソール−peg接合体 |
US20140371258A1 (en) | 2010-12-17 | 2014-12-18 | Nektar Therapeutics | Water-Soluble Polymer Conjugates of Topotecan |
JP5899241B2 (ja) | 2010-12-21 | 2016-04-06 | ネクター セラピューティクス | ペメトレキセドベースの化合物のマルチアームポリマープロドラッグコンジュゲート |
US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
WO2012088445A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
MX348933B (es) * | 2011-11-07 | 2017-07-03 | Nektar Therapeutics | Composiciones, formas de dosificacion y coadministracion de un compuesto agonista opioide y un compuesto analgesico. |
EP2895157A4 (en) * | 2012-09-11 | 2016-07-13 | Univ Massachusetts | NETWORKED POLYMER NANOBAU GROUPS AND USES THEREOF |
PT2914599T (pt) | 2012-10-30 | 2018-01-08 | Nektar Therapeutics | Forma de sal sólida de alfa-6-mpeg6-o-hidroxicodona como agonistas opioides e suas utilizações |
US8637538B1 (en) | 2012-12-14 | 2014-01-28 | Trevi Therapeutics, Inc. | Methods for treatment of pruritis |
US20140179727A1 (en) | 2012-12-14 | 2014-06-26 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
US8987289B2 (en) | 2012-12-14 | 2015-03-24 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
WO2015023675A2 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
MX2016013829A (es) * | 2014-04-28 | 2017-05-12 | Orphomed Inc | Dimeros activos farmaceuticamente ligados a traves de grupos hidroxilo fenolicos. |
US9707184B2 (en) | 2014-07-17 | 2017-07-18 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
CA2964628A1 (en) | 2014-10-20 | 2016-04-28 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
WO2016064914A1 (en) * | 2014-10-20 | 2016-04-28 | Elysium Therapeutics, Inc. | Diversion-resistant opioid formulations |
US10449190B2 (en) | 2015-04-27 | 2019-10-22 | John K. Thottathil | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof |
US10017519B2 (en) | 2015-04-27 | 2018-07-10 | 3St Research Llc | Alpha-hydroxy carboxylic acid and derivatives and other GRAS based prodrugs of oxycodone and uses thereof |
US10226456B2 (en) * | 2015-04-27 | 2019-03-12 | 3St Research Llc | Methods and compositions for preventing opioid abuse |
US11066366B2 (en) | 2015-09-03 | 2021-07-20 | Allegheny-Singer Research Institute | Hydrophilic fentanyl derivatives |
CN107033154B (zh) * | 2016-02-02 | 2020-02-04 | 上海瀚迈生物医药科技有限公司 | 阿片受体拮抗剂缀合物及其应用 |
EP3416644A4 (en) * | 2016-02-18 | 2020-01-29 | Virginia Commonwealth University | NANOPARTICLE-CONJUGATED SYNTHETIC OPIOID PRODRUGS AND METHOD FOR THE USE THEREOF |
CN108210933B (zh) * | 2016-12-22 | 2021-05-04 | 北京键凯科技股份有限公司 | 一种地佐辛与聚乙二醇的结合物 |
EP3654977A4 (en) | 2017-07-20 | 2021-06-09 | Suzhou Runxindatai Pharmaceutics Ltd Co. | SUSTAINABLE RELEASE, ABUSE RESISTANT OPIOID PRODRUGS |
AU2019309913A1 (en) | 2018-07-23 | 2021-03-11 | Trevi Therapeutics, Inc. | Treatment of chronic cough, breathlessness and dyspnea |
WO2020205537A1 (en) * | 2019-03-29 | 2020-10-08 | Allegheny Singer Research Institute | Covalent modification and controlled delivery of mu opioid receptor antagonists |
WO2024134619A1 (en) | 2022-12-23 | 2024-06-27 | Sintalica S.R.L. | Non-hallucinogenic tryptamine compounds, preparation, pharmaceutical compositions and uses thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996021469A1 (en) * | 1995-01-10 | 1996-07-18 | Shearwater Polymers, Inc. | Multi-armed, monofunctional, and hydrolytically stable derivatives of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
WO1999045964A1 (en) * | 1998-03-12 | 1999-09-16 | Shearwater Polymers, Incorporated | Poly(ethylene glycol) derivatives with proximal reactive groups |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2433883C2 (de) * | 1973-07-20 | 1986-03-27 | Research Corp., New York, N.Y. | Verwendung von physiologisch aktiven Polypeptiden |
US4457933A (en) | 1980-01-24 | 1984-07-03 | Bristol-Myers Company | Prevention of analgesic abuse |
US4864781A (en) * | 1981-06-17 | 1989-09-12 | Emblin Robert T | Multiple panel metal roofing system with overlapping panel edges |
US4366159A (en) * | 1981-09-08 | 1982-12-28 | Michael Richard Magruder | Nalbuphine-narcotic analgesic composition and method of producing analgesia |
FR2514644A1 (fr) | 1981-10-19 | 1983-04-22 | Sanofi Sa | Composition pharmaceutique a action antagoniste peripherique des opiaces |
US4587046A (en) | 1982-05-18 | 1986-05-06 | The Regents Of The University Of California | Drug-carrier conjugates |
EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
US4730048A (en) * | 1985-12-12 | 1988-03-08 | Regents Of The University Of Minnesota | Gut-selective opiates |
US4806556A (en) * | 1985-12-12 | 1989-02-21 | Regents Of The University Of Minnesota | Gut-selective opiates |
US4719215A (en) * | 1986-03-07 | 1988-01-12 | University Of Chicago | Quaternary derivatives of noroxymorphone which relieve nausea and emesis |
US4861781A (en) | 1986-03-07 | 1989-08-29 | The University Of Chicago | Quaternary derivatives of noroxymorphone which relieve nausea and emesis |
US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
US5102887A (en) | 1989-02-17 | 1992-04-07 | Arch Development Corporation | Method for reducing emesis and nausea induced by the administration of an emesis causing agent |
DK0386644T3 (da) * | 1989-03-10 | 1997-10-13 | Hoffmann La Roche | Reagenser til bestemmelse af lægemidler |
JPH0383914A (ja) * | 1989-08-18 | 1991-04-09 | W R Grace & Co | ドラッグキャリアー |
US5130126A (en) | 1990-07-09 | 1992-07-14 | Nippon Oil & Fats Co., Ltd. | Polymer-drug conjugate and a method of producing it |
US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
JP2829794B2 (ja) * | 1991-02-08 | 1998-12-02 | エスエス製薬 株式会社 | 徐放性経口投与型プラノプロフェン製剤 |
US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
US5270328A (en) * | 1991-03-29 | 1993-12-14 | Eli Lilly And Company | Peripherally selective piperidine opioid antagonists |
US5250542A (en) * | 1991-03-29 | 1993-10-05 | Eli Lilly And Company | Peripherally selective piperidine carboxylate opioid antagonists |
US5281698A (en) | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
WO1993024476A1 (en) | 1992-06-04 | 1993-12-09 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
US5321095A (en) * | 1993-02-02 | 1994-06-14 | Enzon, Inc. | Azlactone activated polyalkylene oxides |
EP0689424B1 (en) | 1993-03-17 | 1998-10-14 | Minnesota Mining And Manufacturing Company | Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid |
US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
US5434171A (en) | 1993-12-08 | 1995-07-18 | Eli Lilly And Company | Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates |
US5629384A (en) | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
US5650234A (en) | 1994-09-09 | 1997-07-22 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
AU2059297A (en) * | 1996-03-12 | 1997-10-01 | Alza Corporation | Composition and dosage form comprising opioid antagonist |
US6214966B1 (en) * | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
DE19651551C2 (de) * | 1996-12-11 | 2000-02-03 | Klinge Co Chem Pharm Fab | Opioidantagonisthaltige galenische Formulierung |
US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
US5972954A (en) | 1997-11-03 | 1999-10-26 | Arch Development Corporation | Use of methylnaltrexone and related compounds |
HU1500214D0 (hu) * | 1997-12-22 | 2002-03-28 | Euro Celtique Sa | Opioid agonista és antagonista hatóanyagot tartalmazó gyógyszerkészítmény |
US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
US6703381B1 (en) | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
EP0995757A3 (en) | 1998-08-26 | 2002-05-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Bivalent inhibitors of the proteasome |
US7060708B2 (en) | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
US6380405B1 (en) | 1999-09-13 | 2002-04-30 | Nobex Corporation | Taxane prodrugs |
US6451806B2 (en) * | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
AU781839B2 (en) | 1999-12-22 | 2005-06-16 | Nektar Therapeutics | Sterically hindered derivatives of water soluble polymers |
US6413507B1 (en) | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
OA12215A (en) * | 2000-02-08 | 2006-05-09 | Euro Celtique Sa | Tamper-resistant oral opioid agonist formulations. |
WO2001062299A2 (en) | 2000-02-28 | 2001-08-30 | Shearwater Corporation | Water-soluble polymer conjugates of artelinic acid |
ATE326222T1 (de) * | 2000-03-15 | 2006-06-15 | Wolfgang Sadee | Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauch |
US7829074B2 (en) | 2001-10-18 | 2010-11-09 | Nektar Therapeutics | Hydroxypatite-targeting poly(ethylene glycol) and related polymers |
EP1355671A2 (en) | 2000-11-30 | 2003-10-29 | Nektar Therapeutics Al, Corporation | Water-soluble polymer conjugates of triazine derivatives |
DK1362053T3 (da) | 2001-02-20 | 2008-03-10 | Enzon Inc | Terminalt forgrenede polymere linkere og polymere konjugater indeholdende disse |
ES2361148T3 (es) | 2001-05-11 | 2011-06-14 | Endo Pharmaceuticals Inc. | Forma de dosificación de opioides de liberación controlada resistente al abuso. |
US6858580B2 (en) | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6756354B2 (en) | 2001-09-05 | 2004-06-29 | Deanna Jean Nelson | Therapeutic compositions containing oligo (ethylene glycol)-terminated 1,2-dithiolanes and their conjugates |
US20030054030A1 (en) * | 2001-09-13 | 2003-03-20 | Gary Gordon | Method and compositions for the treatment of pruritus |
DK1436012T3 (en) | 2001-10-18 | 2018-01-22 | Nektar Therapeutics | Polymer Conjugates of Opioid Antagonists |
AU2002342193B2 (en) | 2001-10-29 | 2006-10-26 | Nektar Therapeutics Al, Corporation | Polymer conjugates of protein kinase C inhibitors |
MXPA04004025A (es) | 2001-10-30 | 2004-07-08 | Nektar Therapeutics Al Corp | Conjugados polimericos de acido retinoico solubles en agua. |
CA2822457C (en) | 2001-12-14 | 2016-03-08 | The University Of Wyoming | Methods and compositions for controlled resease of drugs |
EP2266590A3 (en) | 2002-02-22 | 2011-04-20 | Shire LLC | Active agent delivery sytems and methods for protecting and administering active agents |
MXPA05009757A (es) | 2003-03-13 | 2005-12-05 | Controlled Chemicals Inc | Conjugados de oxicodona con menor potencial de abuso y duracion de accion extendida. |
US20060182692A1 (en) | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
ES2733764T3 (es) | 2003-12-16 | 2019-12-02 | Nektar Therapeutics | Método para la preparación de oligo etilenglicol monodisperso |
EP1695700A1 (en) | 2005-02-28 | 2006-08-30 | Euro-Celtique S.A. | Dosage form containing oxycodone and naloxone |
NZ572252A (en) | 2006-04-21 | 2011-09-30 | Nektar Therapeutics | Stereoselective reduction of a morphinone |
JP2010509227A (ja) | 2006-11-07 | 2010-03-25 | ネクター セラピューティックス エイエル,コーポレイション | オピオイド作動薬およびオピオイド拮抗薬の用量形態および同時投与 |
PL2197429T3 (pl) * | 2007-09-03 | 2016-09-30 | Kompozycje w postaci cząstek do dostarczania słabo rozpuszczalnych leków | |
KR102612902B1 (ko) | 2016-04-22 | 2023-12-18 | 삼성디스플레이 주식회사 | 투명 전도막 및 이를 포함하는 전자 소자 |
-
2002
- 2002-10-18 DK DK02795531.9T patent/DK1436012T3/en active
- 2002-10-18 EP EP15172363.2A patent/EP2939696B1/en not_active Expired - Lifetime
- 2002-10-18 SI SI200231072A patent/SI2939696T1/sl unknown
- 2002-10-18 US US10/274,296 patent/US7056500B2/en not_active Expired - Lifetime
- 2002-10-18 SI SI200231089T patent/SI1436012T1/en unknown
- 2002-10-18 JP JP2003535793A patent/JP4814488B2/ja not_active Expired - Lifetime
- 2002-10-18 LT LTEP02795531.9T patent/LT1436012T/lt unknown
- 2002-10-18 ES ES15172363.2T patent/ES2569262T3/es not_active Expired - Lifetime
- 2002-10-18 ES ES02795531.9T patent/ES2654819T3/es not_active Expired - Lifetime
- 2002-10-18 DK DK15172363.2T patent/DK2939696T3/en active
- 2002-10-18 EP EP10007224A patent/EP2236161A1/en not_active Withdrawn
- 2002-10-18 PT PT2795531T patent/PT1436012T/pt unknown
- 2002-10-18 AU AU2002360284A patent/AU2002360284B2/en active Active
- 2002-10-18 WO PCT/US2002/033325 patent/WO2003032990A2/en active Application Filing
- 2002-10-18 MX MXPA04003597A patent/MXPA04003597A/es active IP Right Grant
- 2002-10-18 CA CA2463938A patent/CA2463938C/en not_active Expired - Lifetime
- 2002-10-18 PT PT151723632T patent/PT2939696E/pt unknown
- 2002-10-18 EP EP02795531.9A patent/EP1436012B1/en not_active Expired - Lifetime
- 2002-10-18 KR KR1020047005735A patent/KR100974842B1/ko active IP Right Grant
- 2002-10-18 KR KR1020097025168A patent/KR101009309B1/ko active IP Right Grant
-
2006
- 2006-01-17 US US11/332,964 patent/US7662365B2/en not_active Expired - Lifetime
-
2009
- 2009-04-30 JP JP2009111653A patent/JP5570137B2/ja not_active Expired - Lifetime
- 2009-10-06 US US12/574,335 patent/US8349307B2/en not_active Expired - Lifetime
-
2012
- 2012-11-29 US US13/689,640 patent/US8617530B2/en not_active Expired - Lifetime
-
2016
- 2016-03-17 HK HK16103153.9A patent/HK1215171A1/zh not_active IP Right Cessation
-
2018
- 2018-02-12 CY CY20181100170T patent/CY1119906T1/el unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996021469A1 (en) * | 1995-01-10 | 1996-07-18 | Shearwater Polymers, Inc. | Multi-armed, monofunctional, and hydrolytically stable derivatives of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
WO1999045964A1 (en) * | 1998-03-12 | 1999-09-16 | Shearwater Polymers, Incorporated | Poly(ethylene glycol) derivatives with proximal reactive groups |
Non-Patent Citations (2)
Title |
---|
Advanced Drug Delivery Reviews 16(2/3): 157-182 (1995) |
J. Controlled Release 16: 43-52(1991) |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101009309B1 (ko) | 아편양 길항제의 중합체 공액 | |
AU2002360284A1 (en) | Polymer conjugates of opioid antagonists | |
ES2629696T3 (es) | Profármacos poliméricos multibrazo | |
JP5827123B2 (ja) | 乱用の可能性が低いpeg化オピオイド | |
JP5837491B2 (ja) | オリゴマー−オピオイドアゴニスト抱合体 | |
KR20080110910A (ko) | 모르피논의 입체선택적 환원 | |
WO2003037384A2 (en) | Polymer conjugates of protein kinase c inhibitors | |
AU2002342193A1 (en) | Polymer conjugates of protein kinase C inhibitors | |
US20090156629A1 (en) | Indenoisoquinoline-releasable polymer conjugates | |
MXPA06003108A (en) | Multi-arm polymer prodrugs |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A107 | Divisional application of patent | ||
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
N231 | Notification of change of applicant | ||
E90F | Notification of reason for final refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20131223 Year of fee payment: 4 |
|
FPAY | Annual fee payment |
Payment date: 20141230 Year of fee payment: 5 |
|
FPAY | Annual fee payment |
Payment date: 20151217 Year of fee payment: 6 |
|
FPAY | Annual fee payment |
Payment date: 20161220 Year of fee payment: 7 |
|
FPAY | Annual fee payment |
Payment date: 20171219 Year of fee payment: 8 |
|
FPAY | Annual fee payment |
Payment date: 20181226 Year of fee payment: 9 |
|
FPAY | Annual fee payment |
Payment date: 20191217 Year of fee payment: 10 |