DK1436012T3 - Polymer Conjugates of Opioid Antagonists - Google Patents
Polymer Conjugates of Opioid Antagonists Download PDFInfo
- Publication number
- DK1436012T3 DK1436012T3 DK02795531.9T DK02795531T DK1436012T3 DK 1436012 T3 DK1436012 T3 DK 1436012T3 DK 02795531 T DK02795531 T DK 02795531T DK 1436012 T3 DK1436012 T3 DK 1436012T3
- Authority
- DK
- Denmark
- Prior art keywords
- polymer
- pharmaceutical composition
- opioid
- conjugate
- group
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title claims abstract description 181
- 239000003887 narcotic antagonist Substances 0.000 title abstract description 14
- 239000003401 opiate antagonist Substances 0.000 claims abstract description 78
- -1 poly(ethylene glycol) Polymers 0.000 claims abstract description 72
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 61
- 230000000694 effects Effects 0.000 claims abstract description 46
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 24
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- 239000003402 opiate agonist Substances 0.000 claims description 22
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- 150000003839 salts Chemical class 0.000 claims description 16
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- 125000005842 heteroatom Chemical group 0.000 claims description 13
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 11
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Applications Claiming Priority (2)
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|---|---|---|---|
| US33040001P | 2001-10-18 | 2001-10-18 | |
| PCT/US2002/033325 WO2003032990A2 (en) | 2001-10-18 | 2002-10-18 | Polymer conjugates of opioid antagonists |
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| DK02795531.9T DK1436012T3 (en) | 2001-10-18 | 2002-10-18 | Polymer Conjugates of Opioid Antagonists |
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| DK15172363.2T DK2939696T3 (en) | 2001-10-18 | 2002-10-18 | Polymer Conjugates of Opioid Antagonists |
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| EP (3) | EP1436012B1 (enExample) |
| JP (2) | JP4814488B2 (enExample) |
| KR (2) | KR101009309B1 (enExample) |
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| CY (1) | CY1119906T1 (enExample) |
| DK (2) | DK2939696T3 (enExample) |
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| MX (1) | MXPA04003597A (enExample) |
| PT (2) | PT2939696E (enExample) |
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