PT2694075T - Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco - Google Patents

Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco

Info

Publication number
PT2694075T
PT2694075T PT127646057T PT12764605T PT2694075T PT 2694075 T PT2694075 T PT 2694075T PT 127646057 T PT127646057 T PT 127646057T PT 12764605 T PT12764605 T PT 12764605T PT 2694075 T PT2694075 T PT 2694075T
Authority
PT
Portugal
Prior art keywords
phosphoinositide
kinase inhibitor
binding moiety
zinc binding
zinc
Prior art date
Application number
PT127646057T
Other languages
English (en)
Portuguese (pt)
Inventor
Qian Changgeng
Zhai Haixiao
Cai Xiong
Lai Chengjung
Bao Rudi
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Publication of PT2694075T publication Critical patent/PT2694075T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT127646057T 2011-04-01 2012-03-30 Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco PT2694075T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161470849P 2011-04-01 2011-04-01
US201161559489P 2011-11-14 2011-11-14

Publications (1)

Publication Number Publication Date
PT2694075T true PT2694075T (pt) 2016-07-11

Family

ID=46931927

Family Applications (2)

Application Number Title Priority Date Filing Date
PT127646057T PT2694075T (pt) 2011-04-01 2012-03-30 Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco
PT16166266T PT3111938T (pt) 2011-04-01 2012-03-30 Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT16166266T PT3111938T (pt) 2011-04-01 2012-03-30 Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco

Country Status (29)

Country Link
US (7) US8710219B2 (OSRAM)
EP (2) EP2694075B1 (OSRAM)
JP (3) JP6242331B2 (OSRAM)
KR (2) KR20180108848A (OSRAM)
CN (2) CN103582483B (OSRAM)
AU (1) AU2012236367B2 (OSRAM)
BR (1) BR112013025340B1 (OSRAM)
CA (1) CA2830822C (OSRAM)
CL (1) CL2013002823A1 (OSRAM)
CY (2) CY1117785T1 (OSRAM)
DK (2) DK3111938T3 (OSRAM)
EA (1) EA022434B9 (OSRAM)
ES (2) ES2733128T3 (OSRAM)
HR (2) HRP20160545T1 (OSRAM)
HU (2) HUE028910T2 (OSRAM)
IL (2) IL228588A (OSRAM)
LT (1) LT3111938T (OSRAM)
ME (2) ME03523B (OSRAM)
MX (1) MX340577B (OSRAM)
PE (1) PE20141382A1 (OSRAM)
PL (2) PL2694075T3 (OSRAM)
PT (2) PT2694075T (OSRAM)
RS (2) RS54903B1 (OSRAM)
SG (2) SG10201602569RA (OSRAM)
SI (2) SI2694075T1 (OSRAM)
SM (2) SMT201900435T1 (OSRAM)
TW (1) TWI571469B (OSRAM)
WO (1) WO2012135571A1 (OSRAM)
ZA (2) ZA201307082B (OSRAM)

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CA2749228C (en) * 2009-01-08 2016-05-17 Curis, Inc. Phosphoinositide 3-kinase inhibitors with a zinc binding moiety
SI2694075T1 (sl) * 2011-04-01 2016-07-29 Curis, Inc. Fosfoinozitid 3-kinazni inhibitor z delom, ki veže cink
EP3045453A1 (en) 2011-11-14 2016-07-20 Cephalon, Inc. Uracil derivatives as axl and c-met kinase inhibitors
CN104725301A (zh) * 2013-12-20 2015-06-24 北京蓝贝望生物医药科技股份有限公司 一种1,2-二氢吡啶-2-酮衍生物的制备方法
WO2016169417A1 (zh) * 2015-04-21 2016-10-27 成都金瑞长青生物科技有限公司 嘌呤基-n-羟基嘧啶甲酰胺衍生物及其制备方法和用途
CN109476710B (zh) * 2016-07-19 2021-11-23 国立植物基因组研究所 抗真菌病原体的新蛋白质
MX2019004842A (es) * 2016-11-02 2019-06-20 Curis Inc Terapia de combinación con un inhibidor fosfoinositida 3-cinasa con un resto de unión a cinc.
CA3081815A1 (en) * 2017-11-06 2019-05-09 Cold Spring Harbor Laboratory Method and compositions for forming a copper-containing complex and uses thereof
BR112021004371A2 (pt) * 2018-09-11 2021-05-25 Curis Inc. terapia em combinação com um inibidor de fosfoinositídeo 3-quinase com uma porção de ligação a zinco
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WO2023212574A1 (en) * 2022-04-26 2023-11-02 Olivia Szu Hsieh Lee Nakaya Compositions and methods for modulating rhythmic activity of pacemaker cardiomyocytes

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Also Published As

Publication number Publication date
US11654136B2 (en) 2023-05-23
US9249156B2 (en) 2016-02-02
TWI571469B (zh) 2017-02-21
US20220168284A1 (en) 2022-06-02
MX340577B (es) 2016-07-13
SI2694075T1 (sl) 2016-07-29
RS54903B1 (sr) 2016-10-31
WO2012135571A1 (en) 2012-10-04
IL248597B (en) 2018-04-30
EA022434B1 (ru) 2015-12-30
SMT201900435T1 (it) 2019-09-09
EP3111938B1 (en) 2019-05-08
IL228588A0 (en) 2013-12-31
HRP20191091T1 (hr) 2019-09-20
CY1117785T1 (el) 2017-05-17
SI3111938T1 (sl) 2019-08-30
IL228588A (en) 2016-11-30
EA201301114A1 (ru) 2014-04-30
US20170304279A1 (en) 2017-10-26
LT3111938T (lt) 2019-06-25
SG193563A1 (en) 2013-11-29
AU2012236367A1 (en) 2013-04-18
CN105461736B (zh) 2018-06-12
EA022434B9 (ru) 2016-02-29
JP2018052987A (ja) 2018-04-05
SG10201602569RA (en) 2016-05-30
CY1121825T1 (el) 2020-07-31
ES2733128T3 (es) 2019-11-27
AU2012236367B2 (en) 2014-10-09
ES2577982T3 (es) 2016-07-19
KR20140023333A (ko) 2014-02-26
CN103582483B (zh) 2016-02-17
ME02451B (me) 2016-09-20
DK3111938T3 (da) 2019-07-01
KR20180108848A (ko) 2018-10-04
US20140243330A1 (en) 2014-08-28
PT3111938T (pt) 2019-07-10
CL2013002823A1 (es) 2014-04-11
CA2830822A1 (en) 2012-10-04
ME03523B (me) 2020-04-20
RS59219B1 (sr) 2019-10-31
HK1194969A1 (zh) 2014-10-31
MX2013011132A (es) 2014-03-12
PL2694075T3 (pl) 2016-09-30
ZA201406167B (en) 2015-03-25
PL3111938T3 (pl) 2019-09-30
TW201247678A (en) 2012-12-01
SMT201600179B (it) 2016-08-31
NZ705039A (en) 2016-03-31
EP2694075A1 (en) 2014-02-12
EP2694075A4 (en) 2014-10-01
JP2014509653A (ja) 2014-04-21
US10111864B2 (en) 2018-10-30
CN103582483A (zh) 2014-02-12
US9657032B2 (en) 2017-05-23
HUE028910T2 (en) 2017-01-30
HUE045041T2 (hu) 2019-12-30
US20200215039A1 (en) 2020-07-09
CA2830822C (en) 2018-10-02
HRP20160545T1 (hr) 2016-06-17
EP3111938A1 (en) 2017-01-04
DK2694075T3 (en) 2016-08-01
US8710219B2 (en) 2014-04-29
PE20141382A1 (es) 2014-11-04
BR112013025340A2 (pt) 2016-12-13
JP6242331B2 (ja) 2017-12-06
US10543197B2 (en) 2020-01-28
CN105461736A (zh) 2016-04-06
IL248597A0 (en) 2016-12-29
US20190091211A1 (en) 2019-03-28
ZA201307082B (en) 2015-04-29
BR112013025340B1 (pt) 2021-12-21
US20130090335A1 (en) 2013-04-11
NZ615586A (en) 2015-02-27
JP6275784B2 (ja) 2018-02-07
JP2016188255A (ja) 2016-11-04
US20160185796A1 (en) 2016-06-30
EP2694075B1 (en) 2016-04-27
US11135205B2 (en) 2021-10-05
KR101902325B1 (ko) 2018-09-28

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