TWI571469B - 具有鋅結合位的磷脂醯肌醇3-激酶抑制劑 - Google Patents

具有鋅結合位的磷脂醯肌醇3-激酶抑制劑 Download PDF

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TWI571469B
TWI571469B TW101111283A TW101111283A TWI571469B TW I571469 B TWI571469 B TW I571469B TW 101111283 A TW101111283 A TW 101111283A TW 101111283 A TW101111283 A TW 101111283A TW I571469 B TWI571469 B TW I571469B
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compound
cancer
tumor
group
disease
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TW101111283A
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TW201247678A (en
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蔡雄
翟海嘯
賴正榮
錢長庚
包如迪
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古利斯股份有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW101111283A 2011-04-01 2012-03-30 具有鋅結合位的磷脂醯肌醇3-激酶抑制劑 TWI571469B (zh)

Applications Claiming Priority (2)

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US201161470849P 2011-04-01 2011-04-01
US201161559489P 2011-11-14 2011-11-14

Publications (2)

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TW201247678A TW201247678A (en) 2012-12-01
TWI571469B true TWI571469B (zh) 2017-02-21

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Country Status (29)

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US (7) US8710219B2 (OSRAM)
EP (2) EP3111938B1 (OSRAM)
JP (3) JP6242331B2 (OSRAM)
KR (2) KR101902325B1 (OSRAM)
CN (2) CN103582483B (OSRAM)
AU (1) AU2012236367B2 (OSRAM)
BR (1) BR112013025340B1 (OSRAM)
CA (1) CA2830822C (OSRAM)
CL (1) CL2013002823A1 (OSRAM)
CY (2) CY1117785T1 (OSRAM)
DK (2) DK2694075T3 (OSRAM)
EA (1) EA022434B9 (OSRAM)
ES (2) ES2577982T3 (OSRAM)
HR (2) HRP20160545T1 (OSRAM)
HU (2) HUE045041T2 (OSRAM)
IL (2) IL228588A (OSRAM)
LT (1) LT3111938T (OSRAM)
ME (2) ME02451B (OSRAM)
MX (1) MX340577B (OSRAM)
PE (1) PE20141382A1 (OSRAM)
PL (2) PL2694075T3 (OSRAM)
PT (2) PT2694075T (OSRAM)
RS (2) RS59219B1 (OSRAM)
SG (2) SG193563A1 (OSRAM)
SI (2) SI3111938T1 (OSRAM)
SM (2) SMT201900435T1 (OSRAM)
TW (1) TWI571469B (OSRAM)
WO (1) WO2012135571A1 (OSRAM)
ZA (2) ZA201307082B (OSRAM)

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EA023521B1 (ru) 2011-11-14 2016-06-30 Сефалон, Инк. ПРОИЗВОДНЫЕ УРАЦИЛА В КАЧЕСТВЕ ИНГИБИТОРОВ AXL И c-MET КИНАЗЫ
CN104725301A (zh) * 2013-12-20 2015-06-24 北京蓝贝望生物医药科技股份有限公司 一种1,2-二氢吡啶-2-酮衍生物的制备方法
CN107849045B (zh) * 2015-04-21 2019-12-24 贵州百灵企业集团制药股份有限公司 嘌呤基-n-羟基嘧啶甲酰胺衍生物及其制备方法和用途
US11142552B2 (en) * 2016-07-19 2021-10-12 National Institute Of Plant Genome Research Protein against fungal pathogens
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HRP20191091T1 (hr) 2019-09-20
EP2694075A1 (en) 2014-02-12
US20190091211A1 (en) 2019-03-28
US9249156B2 (en) 2016-02-02
CA2830822C (en) 2018-10-02
EP2694075A4 (en) 2014-10-01
CA2830822A1 (en) 2012-10-04
US20140243330A1 (en) 2014-08-28
PT2694075T (pt) 2016-07-11
AU2012236367B2 (en) 2014-10-09
EP2694075B1 (en) 2016-04-27
IL248597B (en) 2018-04-30
JP2016188255A (ja) 2016-11-04
JP2014509653A (ja) 2014-04-21
RS54903B1 (sr) 2016-10-31
CL2013002823A1 (es) 2014-04-11
US20130090335A1 (en) 2013-04-11
KR101902325B1 (ko) 2018-09-28
US11654136B2 (en) 2023-05-23
DK3111938T3 (da) 2019-07-01
RS59219B1 (sr) 2019-10-31
PE20141382A1 (es) 2014-11-04
PL2694075T3 (pl) 2016-09-30
ZA201307082B (en) 2015-04-29
US10111864B2 (en) 2018-10-30
HK1194969A1 (zh) 2014-10-31
US20200215039A1 (en) 2020-07-09
BR112013025340A2 (pt) 2016-12-13
CN105461736B (zh) 2018-06-12
ME03523B (me) 2020-04-20
SG10201602569RA (en) 2016-05-30
CN103582483A (zh) 2014-02-12
HUE028910T2 (en) 2017-01-30
HUE045041T2 (hu) 2019-12-30
BR112013025340B1 (pt) 2021-12-21
KR20140023333A (ko) 2014-02-26
EP3111938A1 (en) 2017-01-04
ZA201406167B (en) 2015-03-25
PT3111938T (pt) 2019-07-10
JP6242331B2 (ja) 2017-12-06
SMT201900435T1 (it) 2019-09-09
CY1117785T1 (el) 2017-05-17
KR20180108848A (ko) 2018-10-04
CN105461736A (zh) 2016-04-06
SI2694075T1 (sl) 2016-07-29
AU2012236367A1 (en) 2013-04-18
US9657032B2 (en) 2017-05-23
JP6275784B2 (ja) 2018-02-07
US20220168284A1 (en) 2022-06-02
IL228588A (en) 2016-11-30
ME02451B (me) 2016-09-20
TW201247678A (en) 2012-12-01
MX340577B (es) 2016-07-13
NZ705039A (en) 2016-03-31
CN103582483B (zh) 2016-02-17
IL248597A0 (en) 2016-12-29
US11135205B2 (en) 2021-10-05
DK2694075T3 (en) 2016-08-01
ES2577982T3 (es) 2016-07-19
SG193563A1 (en) 2013-11-29
EA022434B9 (ru) 2016-02-29
LT3111938T (lt) 2019-06-25
EA201301114A1 (ru) 2014-04-30
US10543197B2 (en) 2020-01-28
SMT201600179B (it) 2016-08-31
WO2012135571A1 (en) 2012-10-04
SI3111938T1 (sl) 2019-08-30
HRP20160545T1 (hr) 2016-06-17
CY1121825T1 (el) 2020-07-31
NZ615586A (en) 2015-02-27
EP3111938B1 (en) 2019-05-08
US20170304279A1 (en) 2017-10-26
ES2733128T3 (es) 2019-11-27
EA022434B1 (ru) 2015-12-30
MX2013011132A (es) 2014-03-12
US8710219B2 (en) 2014-04-29
PL3111938T3 (pl) 2019-09-30
US20160185796A1 (en) 2016-06-30
JP2018052987A (ja) 2018-04-05
IL228588A0 (en) 2013-12-31

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