PT1900362E - Derivados de alfa-aminoamida úteis no tratamento de perturbações aditivas - Google Patents

Derivados de alfa-aminoamida úteis no tratamento de perturbações aditivas Download PDF

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Publication number
PT1900362E
PT1900362E PT07022078T PT07022078T PT1900362E PT 1900362 E PT1900362 E PT 1900362E PT 07022078 T PT07022078 T PT 07022078T PT 07022078 T PT07022078 T PT 07022078T PT 1900362 E PT1900362 E PT 1900362E
Authority
PT
Portugal
Prior art keywords
benzylamino
propanamide
fluorobenzyloxy
cocaine
methyl
Prior art date
Application number
PT07022078T
Other languages
English (en)
Portuguese (pt)
Inventor
Luca Benatti
Ruggero Fariello
Patricia Salvati
Florian Thaler
Claudia Besana
Elena Barbanti
Emanuela Izzo
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Publication of PT1900362E publication Critical patent/PT1900362E/pt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
PT07022078T 2004-04-22 2005-04-19 Derivados de alfa-aminoamida úteis no tratamento de perturbações aditivas PT1900362E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04009532A EP1588704A1 (en) 2004-04-22 2004-04-22 Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders

Publications (1)

Publication Number Publication Date
PT1900362E true PT1900362E (pt) 2011-03-09

Family

ID=34924693

Family Applications (2)

Application Number Title Priority Date Filing Date
PT07022078T PT1900362E (pt) 2004-04-22 2005-04-19 Derivados de alfa-aminoamida úteis no tratamento de perturbações aditivas
PT05736365T PT1737438E (pt) 2004-04-22 2005-04-19 Derivados de alfa-aminoamida úteis no tratamento da síndrome das pernas inquietas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT05736365T PT1737438E (pt) 2004-04-22 2005-04-19 Derivados de alfa-aminoamida úteis no tratamento da síndrome das pernas inquietas

Country Status (25)

Country Link
US (2) US8445513B2 (da)
EP (3) EP1588704A1 (da)
JP (1) JP5020069B2 (da)
KR (2) KR101195819B1 (da)
CN (1) CN1942179B (da)
AT (2) ATE405256T1 (da)
AU (1) AU2005235428B2 (da)
BR (2) BRPI0509976B8 (da)
CA (1) CA2563674C (da)
CY (2) CY1108494T1 (da)
DE (2) DE602005009162D1 (da)
DK (2) DK1737438T3 (da)
ES (2) ES2313330T3 (da)
HR (2) HRP20080593T3 (da)
IL (1) IL178732A (da)
ME (2) ME02324B (da)
MX (1) MXPA06012163A (da)
NO (2) NO337900B1 (da)
NZ (1) NZ550664A (da)
PL (2) PL1737438T3 (da)
PT (2) PT1900362E (da)
RS (2) RS50667B (da)
RU (1) RU2403030C2 (da)
SI (2) SI1900362T1 (da)
WO (1) WO2005102300A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
DK1423168T3 (da) 2001-09-03 2006-05-15 Newron Pharm Spa Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
ES2339021T3 (es) * 2003-08-25 2010-05-14 Newron Pharmaceuticals S.P.A. Derivados de alfa-aminoamida utiles como agentes antiinflamatorios.
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
US20080096965A1 (en) * 2004-09-10 2008-04-24 Newron Pharmaceuticals S.P.A. (Halobenzyloxy) Benzylamino-Propanamides as Sodium and/or Calcium Channel Selective Modulators
JP2008519811A (ja) * 2004-11-10 2008-06-12 オリオン コーポレーション 下肢静止不能症候群の治療
BRPI0620239B8 (pt) * 2005-12-22 2021-05-25 Newron Pharm Spa derivados de 2-feniletilamino.
JP5769923B2 (ja) * 2006-04-03 2015-08-26 テバ ファーマシューティカル インダストリーズ リミティド レストレスレッグス症候群の治療のためのラサギリンの使用
EP1870097A1 (en) 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
EA017123B1 (ru) * 2006-06-19 2012-10-30 Ньюрон Фармасьютикалс С.П.А. Способ получения 2-[4-(3- и 2-фторбензилокси)бензиламино]пропанамидов
GB0706630D0 (en) * 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
JP5440496B2 (ja) 2007-06-15 2014-03-12 ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー 置換2−[2−(フェニル)エチルアミノ]アルカンアミド誘導体ならびにナトリウムおよび/またはカルシウムチャネル調節剤としてのこれらの使用
MX2010006278A (es) * 2007-12-11 2010-08-31 Newron Pharm Spa Proceso para produccion de 2-[4-(3- o 2-fluorobenciloxi)bencilamin o]propanamidas con un alto grado de pureza.
JP5736175B2 (ja) * 2007-12-19 2015-06-17 ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー 精神障害の治療に有用なα−アミノアミド誘導体
EP2314569A1 (en) 2009-10-22 2011-04-27 Merck Patent GmbH Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof
EP2563355B1 (en) 2010-04-27 2016-06-08 Newron Pharmaceuticals S.p.A. Process for the production of ralfinamide methanesulfonate salts or their R-enantiomers
US11278651B2 (en) * 2018-10-17 2022-03-22 Gambro Lundia Ab Membrane and device for treating restless leg syndrome
CN114667963B (zh) * 2020-12-24 2024-04-26 中国科学院脑科学与智能技术卓越创新中心 一种非人灵长类动物药物成瘾性评估的装置

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GB1140748A (en) 1966-06-23 1969-01-22 Ici Ltd New carboxylic acid derivatives
US4049663A (en) 1972-06-06 1977-09-20 Allen & Hanburys Limited Ethylene diamine derivatives
FR2480747A1 (fr) 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
US4935429A (en) * 1985-10-25 1990-06-19 Dackis Charles A Method of treating psychostimulant addiction
US4970200A (en) 1988-03-01 1990-11-13 Schering Aktiengesellschaft Agent for treatment of Parkinson's disease
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US5221536A (en) 1990-05-07 1993-06-22 Alza Corporation Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
EP0520325A1 (de) * 1991-06-28 1992-12-30 F.Hoffmann-La Roche & Co. Aktiengesellschaft Verwendung von Monoaminoxidase-B-Hemmern zur Verhütung und Behandlung von Entzugserscheinungen nach Alkohol- und Drogenmissbrauch
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JP2005060370A (ja) * 2003-07-25 2005-03-10 Kyowa Hakko Kogyo Co Ltd 医薬組成物
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EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders

Also Published As

Publication number Publication date
HK1099216A1 (en) 2007-08-10
US8697738B2 (en) 2014-04-15
IL178732A0 (en) 2007-05-15
DE602005009162D1 (de) 2008-10-02
DE602005025941D1 (de) 2011-02-24
DK1737438T3 (da) 2008-12-08
NZ550664A (en) 2010-08-27
HRP20080593T3 (en) 2008-12-31
IL178732A (en) 2013-01-31
BR122020004541B1 (pt) 2021-11-09
AU2005235428B2 (en) 2010-03-18
EP1900362A2 (en) 2008-03-19
PL1737438T3 (pl) 2009-01-30
EP1900362B1 (en) 2011-01-12
ME01219B (me) 2013-06-20
RS51791B (sr) 2011-12-31
ME02324B (me) 2016-06-20
JP2007533691A (ja) 2007-11-22
BRPI0509976A (pt) 2007-10-16
CY1111656T1 (el) 2015-10-07
RU2403030C2 (ru) 2010-11-10
CN1942179B (zh) 2010-08-11
WO2005102300A1 (en) 2005-11-03
CN1942179A (zh) 2007-04-04
EP1737438A1 (en) 2007-01-03
NO337900B1 (no) 2016-07-04
ATE494890T1 (de) 2011-01-15
PT1737438E (pt) 2008-12-22
RS50667B (sr) 2010-06-30
EP1737438B1 (en) 2008-08-20
DK1900362T3 (da) 2011-05-09
RU2006137079A (ru) 2008-04-27
CA2563674C (en) 2012-12-18
KR20070042914A (ko) 2007-04-24
NO338870B1 (no) 2016-10-31
KR101195819B1 (ko) 2012-11-05
JP5020069B2 (ja) 2012-09-05
HRP20110230T1 (hr) 2011-04-30
ES2313330T3 (es) 2009-03-01
BRPI0509976B1 (pt) 2020-10-06
EP1588704A1 (en) 2005-10-26
MXPA06012163A (es) 2007-01-17
CA2563674A1 (en) 2005-11-03
BRPI0509976B8 (pt) 2021-05-25
KR20120028399A (ko) 2012-03-22
US20130217747A1 (en) 2013-08-22
NO20064732L (no) 2006-11-22
AU2005235428A1 (en) 2005-11-03
SI1737438T1 (sl) 2008-12-31
ES2357559T3 (es) 2011-04-27
PL1900362T3 (pl) 2011-06-30
US8445513B2 (en) 2013-05-21
SI1900362T1 (sl) 2011-03-31
KR101238377B1 (ko) 2013-03-04
US20070203182A1 (en) 2007-08-30
NO20150971L (no) 2006-11-22
ATE405256T1 (de) 2008-09-15
CY1108494T1 (el) 2014-04-09
EP1900362A3 (en) 2009-04-01

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