PT100245B - Sequencia de adn que codifica um derivado de factor viii humano recombinante, biologicamente activo, vector de expressao recombinante, celula hospedeira, processo de producao de um derivado de factor vii e derivado de factor viii - Google Patents
Sequencia de adn que codifica um derivado de factor viii humano recombinante, biologicamente activo, vector de expressao recombinante, celula hospedeira, processo de producao de um derivado de factor vii e derivado de factor viii Download PDFInfo
- Publication number
- PT100245B PT100245B PT100245A PT10024592A PT100245B PT 100245 B PT100245 B PT 100245B PT 100245 A PT100245 A PT 100245A PT 10024592 A PT10024592 A PT 10024592A PT 100245 B PT100245 B PT 100245B
- Authority
- PT
- Portugal
- Prior art keywords
- factor viii
- derivative
- kda
- human factor
- dna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9100799A SE468050C (sv) | 1991-03-15 | 1991-03-15 | Rekombinant derivat av human faktor VIII |
Publications (2)
Publication Number | Publication Date |
---|---|
PT100245A PT100245A (pt) | 1993-07-30 |
PT100245B true PT100245B (pt) | 1999-08-31 |
Family
ID=20382191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT100245A PT100245B (pt) | 1991-03-15 | 1992-03-13 | Sequencia de adn que codifica um derivado de factor viii humano recombinante, biologicamente activo, vector de expressao recombinante, celula hospedeira, processo de producao de um derivado de factor vii e derivado de factor viii |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0533862B1 ( ) |
JP (1) | JP2655752B2 ( ) |
AR (1) | AR247590A1 ( ) |
AT (1) | ATE186055T1 ( ) |
AU (1) | AU650730B2 ( ) |
CA (1) | CA2081659C ( ) |
DE (1) | DE69230206T2 ( ) |
DK (1) | DK0533862T3 ( ) |
ES (1) | ES2137182T3 ( ) |
FI (1) | FI107539B ( ) |
GR (1) | GR3032468T3 ( ) |
IE (1) | IE920814A1 ( ) |
NO (1) | NO308174B1 ( ) |
PT (1) | PT100245B ( ) |
SE (1) | SE468050C ( ) |
WO (1) | WO1992016557A1 ( ) |
ZA (1) | ZA921882B ( ) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5595886A (en) * | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
US6060447A (en) * | 1987-05-19 | 2000-05-09 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
US5744446A (en) * | 1992-04-07 | 1998-04-28 | Emory University | Hybrid human/animal factor VIII |
US5663060A (en) * | 1992-04-07 | 1997-09-02 | Emory University | Hybrid human/animal factor VIII |
US5364771A (en) * | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
US5888974A (en) * | 1992-04-07 | 1999-03-30 | Emory University | Hybrid human/animal factor VIII |
KR950702635A (ko) | 1992-07-31 | 1995-07-29 | 크리스틴 헬렌 수덴 | 감쇠 박테리아에서 재조합 융합 단백질의 발현(Expression of recombinant fusion proteins in attenuated bacteria) |
SE9300509D0 (sv) * | 1993-02-16 | 1993-02-16 | Kabi Pharmacia Ab | Peg treatment |
SE504074C2 (sv) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
GB9401787D0 (en) * | 1994-01-31 | 1994-03-23 | Medeva Holdings Bv | Vaccine compositions |
SE9303601D0 (sv) * | 1993-11-01 | 1993-11-01 | Kabi Pharmacia Ab | Improved cell cultivation method and medium |
SE9403915D0 (sv) * | 1994-11-14 | 1994-11-14 | Annelie Almstedt | Process A |
US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
US6197526B1 (en) * | 1999-01-04 | 2001-03-06 | Dyax Corp. | Polypeptides for binding human factor VIII and fragments of human factor VIII |
US7112438B2 (en) | 1999-01-04 | 2006-09-26 | Dyax Corp. | Binding molecules for human factor VIII and factor VIII-like proteins |
EP1038959A1 (en) * | 1999-03-17 | 2000-09-27 | Aventis Behring Gesellschaft mit beschränkter Haftung | Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX |
EP1048726B1 (en) * | 1999-04-27 | 2006-07-26 | Négrier, Claude | Modified factor VIII cDNA |
SE9901379D0 (sv) | 1999-04-19 | 1999-04-19 | Pharmacia & Upjohn Ab | Receptor structures |
EP1233064A1 (en) * | 2001-02-09 | 2002-08-21 | Aventis Behring Gesellschaft mit beschränkter Haftung | Modified factor VIII cDNA and its use for the production of factor VIII |
EP1284290A1 (en) * | 2001-08-08 | 2003-02-19 | Aventis Behring GmbH | Increase of the expression levels of factor VIII by insertion of spliceable nucleotide sequences into factor VIII cDNA |
EP1283263A1 (en) * | 2001-08-08 | 2003-02-12 | Aventis Behring GmbH | Modified cDNA for high expression levels of factor VIII and its derivatives |
JP5054975B2 (ja) | 2003-09-30 | 2012-10-24 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | アデノ随伴ウイルス(aav)の同源系統群、配列、それらを含有するベクターおよびそれらの用途 |
EP3603676A1 (en) | 2005-04-07 | 2020-02-05 | The Trustees of the University of Pennsylvania | Method of increasing the function of an aav vector |
WO2006108590A1 (en) * | 2005-04-14 | 2006-10-19 | Csl Behring Gmbh | Modified coagulation factor viii with enhanced stability and its derivates |
US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
CN102869779A (zh) | 2010-03-29 | 2013-01-09 | 宾夕法尼亚大学托管会 | 药理学诱导的转基因消融系统 |
BRPI1105317A2 (pt) | 2011-01-24 | 2013-04-30 | Fundacco Hemoct De Ribeirco Preto | produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1 |
AU2012219380B2 (en) | 2011-02-17 | 2017-04-13 | The Trustees Of The University Of Pennsylvania | Compositions and methods for altering tissue specificity and improving AAV9-mediated gene transfer |
US9719106B2 (en) | 2013-04-29 | 2017-08-01 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof |
CN105017410B (zh) * | 2014-04-18 | 2018-06-08 | 北京诺思兰德生物技术股份有限公司 | 一种b区部分缺失型重组人凝血因子ⅷ |
EP3283126B1 (en) | 2015-04-16 | 2019-11-06 | Emory University | Recombinant promoters and vectors for protein expression in liver and use thereof |
JP7382138B2 (ja) * | 2016-10-03 | 2023-11-16 | 第一三共株式会社 | Hspa5遺伝子のプロモーター |
JP2023537070A (ja) | 2020-08-07 | 2023-08-30 | アミカス セラピューティックス インコーポレイテッド | 小胞を標的とするタンパク質及びその使用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1200773A (en) * | 1980-02-29 | 1986-02-18 | William J. Rutter | Expression linkers |
JPS62181786A (ja) * | 1985-08-12 | 1987-08-10 | シンテツクス(ユ−・エス・エイ)インコ−ポレイテツド | 融合蛋白質の製造法 |
US4935233A (en) * | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
US5451521A (en) * | 1986-05-29 | 1995-09-19 | Genetics Institute, Inc. | Procoagulant proteins |
IL83192A (en) * | 1986-07-18 | 1992-11-15 | Gist Brocades Nv | Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies |
NZ219516A (en) * | 1987-02-10 | 1991-02-26 | Wellcome Found | Fusion proteins of hbcag (hepatitis b virus core antigen) |
DE3720246A1 (de) * | 1987-06-19 | 1988-12-29 | Behringwerke Ag | Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet |
KR960701899A (ko) * | 1989-11-17 | 1996-03-28 | 안네 제케르 | 인자 viii:c활성을 갖는 단백질 복합체 및 그의 제조 |
SE465222C5 (sv) * | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
CA2078721A1 (en) * | 1991-09-24 | 1993-03-25 | Hiroshi Yonemura | Process for preparing human coagulation factor viii protein complex |
-
1991
- 1991-03-15 SE SE9100799A patent/SE468050C/sv not_active IP Right Cessation
-
1992
- 1992-03-11 WO PCT/SE1992/000150 patent/WO1992016557A1/en active IP Right Grant
- 1992-03-11 CA CA002081659A patent/CA2081659C/en not_active Expired - Lifetime
- 1992-03-11 AT AT92905708T patent/ATE186055T1/de active
- 1992-03-11 AU AU13513/92A patent/AU650730B2/en not_active Expired
- 1992-03-11 DE DE69230206T patent/DE69230206T2/de not_active Expired - Lifetime
- 1992-03-11 DK DK92905708T patent/DK0533862T3/da active
- 1992-03-11 ES ES92905708T patent/ES2137182T3/es not_active Expired - Lifetime
- 1992-03-11 EP EP92905708A patent/EP0533862B1/en not_active Expired - Lifetime
- 1992-03-11 JP JP4505642A patent/JP2655752B2/ja not_active Expired - Lifetime
- 1992-03-13 AR AR92321933A patent/AR247590A1/es active
- 1992-03-13 PT PT100245A patent/PT100245B/pt not_active IP Right Cessation
- 1992-03-13 IE IE081492A patent/IE920814A1/en not_active IP Right Cessation
- 1992-03-13 ZA ZA921882A patent/ZA921882B/xx unknown
- 1992-11-11 FI FI925131A patent/FI107539B/fi not_active IP Right Cessation
- 1992-11-13 NO NO924395A patent/NO308174B1/no not_active IP Right Cessation
-
2000
- 2000-01-25 GR GR20000400162T patent/GR3032468T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI925131A (fi) | 1992-11-11 |
JP2655752B2 (ja) | 1997-09-24 |
PT100245A (pt) | 1993-07-30 |
SE468050B (sv) | 1992-10-26 |
NO308174B1 (no) | 2000-08-07 |
ATE186055T1 (de) | 1999-11-15 |
GR3032468T3 (en) | 2000-05-31 |
SE468050C (sv) | 1998-04-27 |
EP0533862A1 (en) | 1993-03-31 |
SE9100799D0 (sv) | 1991-03-15 |
FI925131A0 (fi) | 1992-11-11 |
AU1351392A (en) | 1992-10-21 |
SE9100799L (sv) | 1992-09-16 |
ES2137182T3 (es) | 1999-12-16 |
IE920814A1 (en) | 1992-09-23 |
NO924395L (no) | 1993-01-13 |
WO1992016557A1 (en) | 1992-10-01 |
EP0533862B1 (en) | 1999-10-27 |
AU650730B2 (en) | 1994-06-30 |
CA2081659C (en) | 2002-06-25 |
DK0533862T3 (da) | 2000-01-17 |
JPH05507420A (ja) | 1993-10-28 |
DE69230206D1 (de) | 1999-12-02 |
NO924395D0 (no) | 1992-11-13 |
CA2081659A1 (en) | 1992-09-16 |
DE69230206T2 (de) | 2000-05-18 |
AR247590A1 (es) | 1995-01-31 |
FI107539B (fi) | 2001-08-31 |
ZA921882B (en) | 1992-11-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB1A | Laying open of patent application |
Effective date: 19930322 |
|
FG3A | Patent granted, date of granting |
Effective date: 19990521 |
|
PC3A | Transfer or assignment |
Free format text: 20020108 BIOVITRUM AB SE |
|
PD3A | Change of proprietorship |
Owner name: PHARMACIA AKTIEBOLAG Effective date: 20020108 |
|
MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20131121 |
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MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20140521 |