JP2655752B2 - 組換えヒト第▲ｖｉｉｉ▼因子誘導体 - Google Patents

組換えヒト第▲ｖｉｉｉ▼因子誘導体

Info

Publication number
JP2655752B2
JP2655752B2 JP4505642A JP50564292A JP2655752B2 JP 2655752 B2 JP2655752 B2 JP 2655752B2 JP 4505642 A JP4505642 A JP 4505642A JP 50564292 A JP50564292 A JP 50564292A JP 2655752 B2 JP2655752 B2 JP 2655752B2
Authority
JP
Japan
Prior art keywords
factor viii
kda
polypeptides
linker
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP4505642A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05507420A (ja
Inventor
アルムステツト，アンネリエ・ベー
ヘルストレム，エーバ・マリア
リンド，ペーテル
ユング，カテリーネ
サンドベルイ，ヘレーナ・インガ
スピラ，ヤツク
シドウ―ベツクマン，モーナ
ビマン，ヘレーナ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Kabi Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia AB filed Critical Kabi Pharmacia AB
Publication of JPH05507420A publication Critical patent/JPH05507420A/ja
Application granted granted Critical
Publication of JP2655752B2 publication Critical patent/JP2655752B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP4505642A 1991-03-15 1992-03-11 組換えヒト第▲ｖｉｉｉ▼因子誘導体 Expired - Lifetime JP2655752B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9100799A SE468050C (sv) 1991-03-15 1991-03-15 Rekombinant derivat av human faktor VIII
SE9100799-7 1991-03-15
PCT/SE1992/000150 WO1992016557A1 (en) 1991-03-15 1992-03-11 Recombinant human factor viii derivatives

Publications (2)

Publication Number Publication Date
JPH05507420A JPH05507420A (ja) 1993-10-28
JP2655752B2 true JP2655752B2 (ja) 1997-09-24

Family

ID=20382191

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4505642A Expired - Lifetime JP2655752B2 (ja) 1991-03-15 1992-03-11 組換えヒト第▲ｖｉｉｉ▼因子誘導体

Country Status (17)

Country Link
EP (1) EP0533862B1 ( )
JP (1) JP2655752B2 ( )
AR (1) AR247590A1 ( )
AT (1) ATE186055T1 ( )
AU (1) AU650730B2 ( )
CA (1) CA2081659C ( )
DE (1) DE69230206T2 ( )
DK (1) DK0533862T3 ( )
ES (1) ES2137182T3 ( )
FI (1) FI107539B ( )
GR (1) GR3032468T3 ( )
IE (1) IE920814A1 ( )
NO (1) NO308174B1 ( )
PT (1) PT100245B ( )
SE (1) SE468050C ( )
WO (1) WO1992016557A1 ( )
ZA (1) ZA921882B ( )

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595886A (en) * 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5364771A (en) * 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5663060A (en) * 1992-04-07 1997-09-02 Emory University Hybrid human/animal factor VIII
US5744446A (en) * 1992-04-07 1998-04-28 Emory University Hybrid human/animal factor VIII
KR950702635A (ko) 1992-07-31 1995-07-29 크리스틴 헬렌 수덴 감쇠 박테리아에서 재조합 융합 단백질의 발현(Expression of recombinant fusion proteins in attenuated bacteria)
SE9300509D0 (sv) * 1993-02-16 1993-02-16 Kabi Pharmacia Ab Peg treatment
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
GB9401787D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
SE9303601D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Improved cell cultivation method and medium
SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
EP1038959A1 (en) 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
EP1048726B1 (en) * 1999-04-27 2006-07-26 Négrier, Claude Modified factor VIII cDNA
SE9901379D0 (sv) 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
EP1233064A1 (en) * 2001-02-09 2002-08-21 Aventis Behring Gesellschaft mit beschränkter Haftung Modified factor VIII cDNA and its use for the production of factor VIII
EP1284290A1 (en) * 2001-08-08 2003-02-19 Aventis Behring GmbH Increase of the expression levels of factor VIII by insertion of spliceable nucleotide sequences into factor VIII cDNA
EP1283263A1 (en) * 2001-08-08 2003-02-12 Aventis Behring GmbH Modified cDNA for high expression levels of factor VIII and its derivatives
CN102199626B (zh) 2003-09-30 2015-06-24 宾夕法尼亚大学托管会 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用
CN101203613B (zh) 2005-04-07 2012-12-12 宾夕法尼亚大学托管会 增强腺相关病毒载体功能的方法
CA2604299A1 (en) * 2005-04-14 2006-10-19 Csl Behring Gmbh Modified coagulation factor viii with enhanced stability and its derivates
MX342858B (es) 2010-03-29 2016-10-13 The Trustees Of The Univ Of Pennsylvania * Sistema de ablacion transgenica inducida farmacologicamente.
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
EP2675902B1 (en) 2011-02-17 2019-03-27 The Trustees Of The University Of Pennsylvania Compositions and methods for altering tissue specificity and improving aav9-mediated gene transfer
US9719106B2 (en) 2013-04-29 2017-08-01 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
CN105017410B (zh) * 2014-04-18 2018-06-08 北京诺思兰德生物技术股份有限公司 一种b区部分缺失型重组人凝血因子ⅷ
CN115074366A (zh) 2015-04-16 2022-09-20 埃默里大学 用于肝脏中蛋白质表达的重组启动子和载体及其用途
KR102553990B1 (ko) 2016-10-03 2023-07-10 다이이찌 산쿄 가부시키가이샤 Hspa5 유전자의 프로모터
KR20230042754A (ko) 2020-08-07 2023-03-29 아미쿠스 세라퓨틱스, 인코포레이티드 소포 표적화 단백질 및 이의 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
JPS62181786A (ja) * 1985-08-12 1987-08-10 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド 融合蛋白質の製造法
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5451521A (en) * 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
NO872932L (no) * 1986-07-18 1988-01-19 Gist Brocades Nv Fremgangsmaate for fremstilling av proteiner med faktorviiiaktivitet ved hjelp av mikrobielle vertsceller, eksprimeringsvektorer, vertsceller, antibiotika.
NZ219516A (en) * 1987-02-10 1991-02-26 Wellcome Found Fusion proteins of hbcag (hepatitis b virus core antigen)
DE3720246A1 (de) * 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
KR927003812A (ko) * 1989-11-17 1992-12-18 노보 노르디스크 아크티에 셀스카브 인자 viii:c 활성을 갖는 단백질 복합체 및 그의 제조
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
蛋白質核酸酵素，Ｖｏｌ．３５，Ｎｏ．１４，Ｐ．２６７１−２６８７（１９９０）

Also Published As

Publication number Publication date
CA2081659A1 (en) 1992-09-16
AR247590A1 (es) 1995-01-31
NO924395D0 (no) 1992-11-13
AU1351392A (en) 1992-10-21
NO924395L (no) 1993-01-13
PT100245B (pt) 1999-08-31
IE920814A1 (en) 1992-09-23
SE468050C (sv) 1998-04-27
WO1992016557A1 (en) 1992-10-01
SE9100799L (sv) 1992-09-16
DE69230206D1 (de) 1999-12-02
DE69230206T2 (de) 2000-05-18
FI925131A0 (fi) 1992-11-11
AU650730B2 (en) 1994-06-30
SE9100799D0 (sv) 1991-03-15
EP0533862A1 (en) 1993-03-31
PT100245A (pt) 1993-07-30
NO308174B1 (no) 2000-08-07
ES2137182T3 (es) 1999-12-16
EP0533862B1 (en) 1999-10-27
SE468050B (sv) 1992-10-26
DK0533862T3 (da) 2000-01-17
FI107539B (fi) 2001-08-31
JPH05507420A (ja) 1993-10-28
FI925131A (fi) 1992-11-11
ZA921882B (en) 1992-11-25
ATE186055T1 (de) 1999-11-15
GR3032468T3 (en) 2000-05-31
CA2081659C (en) 2002-06-25

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