PL372619A1 - Pierwotne i proksymalne wątrobowe komórki macierzyste - Google Patents

Pierwotne i proksymalne wątrobowe komórki macierzyste

Info

Publication number
PL372619A1
PL372619A1 PL03372619A PL37261903A PL372619A1 PL 372619 A1 PL372619 A1 PL 372619A1 PL 03372619 A PL03372619 A PL 03372619A PL 37261903 A PL37261903 A PL 37261903A PL 372619 A1 PL372619 A1 PL 372619A1
Authority
PL
Poland
Prior art keywords
primitive
stem cells
hepatic stem
proximal hepatic
proximal
Prior art date
Application number
PL03372619A
Other languages
English (en)
Inventor
Lola Reid
Nicholas G. Moss
Mark E. Furth
John W. Ludlow
Andrew T. Bruce
Original Assignee
University Of North Carolina At Chapel Hill
Incara Cell Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of North Carolina At Chapel Hill, Incara Cell Technologies, Inc. filed Critical University Of North Carolina At Chapel Hill
Publication of PL372619A1 publication Critical patent/PL372619A1/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
PL03372619A 2002-03-15 2003-03-14 Pierwotne i proksymalne wątrobowe komórki macierzyste PL372619A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36536102P 2002-03-15 2002-03-15

Publications (1)

Publication Number Publication Date
PL372619A1 true PL372619A1 (pl) 2005-07-25

Family

ID=28042021

Family Applications (1)

Application Number Title Priority Date Filing Date
PL03372619A PL372619A1 (pl) 2002-03-15 2003-03-14 Pierwotne i proksymalne wątrobowe komórki macierzyste

Country Status (18)

Country Link
US (4) US7413897B2 (pl)
EP (2) EP1490480B1 (pl)
JP (2) JP4723811B2 (pl)
KR (1) KR101119878B1 (pl)
CN (3) CN1742082B (pl)
AU (2) AU2003233399B2 (pl)
CA (1) CA2479510C (pl)
CY (1) CY1118167T1 (pl)
DK (1) DK1490480T3 (pl)
ES (1) ES2569951T3 (pl)
HK (1) HK1209783A1 (pl)
HU (1) HUE032238T2 (pl)
IL (1) IL164048A0 (pl)
MX (1) MXPA04009031A (pl)
PL (1) PL372619A1 (pl)
RU (1) RU2327479C2 (pl)
SI (1) SI1490480T1 (pl)
WO (1) WO2003078588A2 (pl)

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IL164048A0 (en) * 2002-03-15 2005-12-18 Univ North Carolina Primitive and proximal hepatic stemcells
WO2007083504A1 (ja) * 2003-08-01 2007-07-26 Norimasa Nakamura スキャフォールドフリー自己組織性三次元人工組織（Ｓｃａｆｆｏｌｄ－ｆｒｅｅ Ｓｅｌｆ－Ｏｒｇａｎｉｚｅｄ ３Ｄ ｓｙｎｔｈｅｔｉｃ ｔｉｓｓｕｅ）
JP4522994B2 (ja) 2003-08-01 2010-08-11 憲正 中村 スキャフォールドフリー自己組織性三次元人工組織（Ｓｃａｆｆｏｌｄ−ｆｒｅｅＳｅｌｆ−Ｏｒｇａｎｉｚｅｄ３Ｄｓｙｎｔｈｅｔｉｃｔｉｓｓｕｅ）
US7670596B2 (en) * 2004-04-23 2010-03-02 Bioe, Inc. Multi-lineage progenitor cells
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
WO2006126219A1 (en) 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
CN101384705A (zh) 2005-11-16 2009-03-11 北卡罗来纳大学教堂山分校 用于肝祖细胞扩增或分化的细胞外基质组分
US20070148141A1 (en) * 2005-12-22 2007-06-28 Vesta Therapeutics Inc. Method of using hepatic progenitors in treating liver dysfunction
EP2019858B1 (en) * 2006-04-17 2012-06-13 BioE LLC Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
EP2019859A4 (en) * 2006-04-25 2009-11-25 Univ Louisiana State ADULPTED ADULPTED STEM CELLS DERIVED FOR USE IN HEPATIC REGENERATION
PT2029725T (pt) 2006-05-26 2018-04-12 Univ North Carolina Chapel Hill Precursores de células hepáticas estreladas e métodos para isolar as mesmas
IN2010KN00157A (pl) * 2007-06-15 2015-08-28 Univ North Carolina
CN101835479A (zh) * 2007-07-25 2010-09-15 佰欧益有限公司 多系祖细胞分化为软骨细胞
US20100087000A1 (en) * 2008-05-02 2010-04-08 Vesta Therapeutics, Inc. Hepatic progenitor cell and method of isolating same
JP5822287B2 (ja) * 2008-05-14 2015-11-24 公立大学法人横浜市立大学 ヒト肝幹細胞、その調製方法、分化誘導方法及び利用方法
WO2009143241A2 (en) * 2008-05-21 2009-11-26 Bioe, Inc. Differentiation of multi-lineage progenitor cells to pancreatic cells
TW201000110A (en) * 2008-05-22 2010-01-01 Vesta Therapeutics Inc Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells
US20100227393A1 (en) * 2009-03-06 2010-09-09 Eric Lagasse Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder
JP5936547B2 (ja) * 2009-10-30 2016-06-22 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 肝外胆樹からの多能性幹細胞およびそれらを単離する方法
US9341550B2 (en) * 2010-11-19 2016-05-17 On-Chip Biotechnologies Co., Ltd. Method for detecting low concentrations of specific cell from high concentrations of cell populations, and method for collecting and analyzing detected cell
JP6158175B2 (ja) * 2011-05-27 2017-07-05 デピュイ・シンセス・プロダクツ・インコーポレイテッド バイオ人工近位尿細管システム及びその使用方法
KR20140102730A (ko) 2011-12-08 2014-08-22 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 포유류 태아 폐 세포와 이를 치료용으로 사용하는 방법
CN104508122A (zh) * 2012-06-20 2015-04-08 赛璐拉有限公司 用于处理细胞群体的材料和方法
JP6510162B2 (ja) * 2013-01-21 2019-05-08 テルモ株式会社 シート状細胞培養物の製造方法
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
ES2767062T3 (es) * 2013-09-19 2020-06-16 Univ Leland Stanford Junior Métodos y composiciones para producir células similares a hepatocitos
JP6643993B2 (ja) 2013-12-16 2020-02-12 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング 膵島様細胞構造体及びそれを調製する方法
JP6595157B2 (ja) * 2014-03-04 2019-10-23 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム
US10179896B2 (en) 2015-05-12 2019-01-15 Baker Group, LLP Method and system for a bioartificial organ
US10683484B2 (en) 2015-06-12 2020-06-16 National University Of Singapore Derivation of hepatic stem cells and mature liver cell types and uses thereof
EP3310388B1 (en) 2015-06-18 2021-10-06 Yeda Research and Development Co., Ltd. Conditioning protocols and use of same for tissue regeneration
CN105483077A (zh) * 2015-12-24 2016-04-13 福州市传染病医院 一种提高肝细胞增殖活性的细胞培养方法
JP2019134682A (ja) * 2016-06-01 2019-08-15 国立研究開発法人医薬基盤・健康・栄養研究所 肝幹細胞様細胞の調製方法
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
US20190231932A1 (en) * 2018-01-26 2019-08-01 Polarityte, Inc. Complex living interface-coordinated self-assembling materials (clicsam)
EP4293109A1 (en) 2022-06-14 2023-12-20 Upside Foods, Inc. Non-skeletal muscle-derived cells as a source of suspension capable myogenic cells for cultured foods

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IL164048A0 (en) * 2002-03-15 2005-12-18 Univ North Carolina Primitive and proximal hepatic stemcells

Also Published As

Publication number Publication date
AU2003233399B2 (en) 2008-03-20
SI1490480T1 (sl) 2016-06-30
JP4723811B2 (ja) 2011-07-13
RU2327479C2 (ru) 2008-06-27
US7413897B2 (en) 2008-08-19
AU2008202656B2 (en) 2011-03-17
HK1209783A1 (en) 2016-04-08
US20070099297A1 (en) 2007-05-03
EP1490480B1 (en) 2016-02-03
CY1118167T1 (el) 2017-06-28
RU2005125598A (ru) 2006-01-27
CN1742082B (zh) 2015-01-21
IL164048A0 (en) 2005-12-18
EP3023491A1 (en) 2016-05-25
EP1490480A4 (en) 2006-06-14
ES2569951T3 (es) 2016-05-13
US20170096641A1 (en) 2017-04-06
AU2008202656A8 (en) 2011-12-15
AU2008202656A1 (en) 2008-07-10
KR101119878B1 (ko) 2012-03-09
AU2008202656B8 (en) 2011-12-15
MXPA04009031A (es) 2005-12-12
KR20060010693A (ko) 2006-02-02
US20040018621A1 (en) 2004-01-29
AU2003233399A1 (en) 2003-09-29
WO2003078588A3 (en) 2004-04-01
EP1490480A2 (en) 2004-12-29
CA2479510A1 (en) 2003-09-25
US8691523B2 (en) 2014-04-08
HUE032238T2 (en) 2017-09-28
CA2479510C (en) 2019-10-29
JP5463271B2 (ja) 2014-04-09
DK1490480T3 (en) 2016-04-11
WO2003078588A2 (en) 2003-09-25
JP2011087591A (ja) 2011-05-06
CN1742082A (zh) 2006-03-01
WO2003078588A9 (en) 2003-12-11
US20140302601A1 (en) 2014-10-09
JP2005520513A (ja) 2005-07-14
CN104630129A (zh) 2015-05-20

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