PL370137A1 - 3-Cyjanochinoliny jako inhibitory kinaz EGF-R i HER2 - Google Patents
3-Cyjanochinoliny jako inhibitory kinaz EGF-R i HER2Info
- Publication number
- PL370137A1 PL370137A1 PL02370137A PL37013702A PL370137A1 PL 370137 A1 PL370137 A1 PL 370137A1 PL 02370137 A PL02370137 A PL 02370137A PL 37013702 A PL37013702 A PL 37013702A PL 370137 A1 PL370137 A1 PL 370137A1
- Authority
- PL
- Poland
- Prior art keywords
- cyanoquinolines
- egf
- inhibitors
- her2 kinases
- her2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33356801P | 2001-11-27 | 2001-11-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL370137A1 true PL370137A1 (pl) | 2005-05-16 |
Family
ID=23303345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL02370137A PL370137A1 (pl) | 2001-11-27 | 2002-11-26 | 3-Cyjanochinoliny jako inhibitory kinaz EGF-R i HER2 |
Country Status (24)
Country | Link |
---|---|
US (1) | US6821988B2 (pl) |
EP (1) | EP1448531B1 (pl) |
JP (1) | JP2005514384A (pl) |
KR (1) | KR20050044599A (pl) |
CN (1) | CN1659145A (pl) |
AR (1) | AR037438A1 (pl) |
AT (1) | ATE370123T1 (pl) |
AU (1) | AU2002359489B2 (pl) |
BR (1) | BR0214485A (pl) |
CA (1) | CA2467573A1 (pl) |
CO (1) | CO5580828A2 (pl) |
DE (1) | DE60221886D1 (pl) |
EC (1) | ECSP045122A (pl) |
HU (1) | HUP0402228A2 (pl) |
IL (1) | IL161921A0 (pl) |
MX (1) | MXPA04004969A (pl) |
NO (1) | NO20042634L (pl) |
NZ (1) | NZ533118A (pl) |
PL (1) | PL370137A1 (pl) |
RU (1) | RU2309150C2 (pl) |
TW (1) | TW200300348A (pl) |
UA (1) | UA77469C2 (pl) |
WO (1) | WO2003050090A1 (pl) |
ZA (1) | ZA200405025B (pl) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60134679D1 (de) | 2000-10-20 | 2008-08-14 | Eisai R&D Man Co Ltd | Stickstoff enthaltende aromatische Heterozyklen |
EP2280003B1 (en) | 2002-07-15 | 2014-04-02 | Symphony Evolution, Inc. | Process for preparing receptor-type kinase modulators |
AU2004266572A1 (en) * | 2003-08-01 | 2005-03-03 | Wyeth Holdings Corporation | Use of combination of an epidermal growth factor receptor kinase inhibitor and cytotoxic agents for treatment and inhibition of cancer |
CA2537978C (en) * | 2003-09-15 | 2011-08-02 | Wyeth | Substituted quinolines as protein tyrosine kinase enzyme inhibitors |
US7399865B2 (en) * | 2003-09-15 | 2008-07-15 | Wyeth | Protein tyrosine kinase enzyme inhibitors |
US7365203B2 (en) * | 2003-09-15 | 2008-04-29 | Wyeth | Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile |
SI2213661T1 (sl) * | 2003-09-26 | 2011-11-30 | Exelixis Inc | c-Met modulatorji in postopki uporabe |
US7781591B2 (en) | 2006-06-13 | 2010-08-24 | Wyeth Llc | Substituted 3-cyanopyridines as protein kinase inhibitors |
EP1683785B1 (en) | 2003-11-11 | 2013-10-16 | Eisai R&D Management Co., Ltd. | Urea derivative and process for producing the same |
CA2575466A1 (en) | 2004-08-13 | 2006-02-23 | Genentech, Inc. | Thiazole based inhibitors of atp-utilizing enzymes |
ES2322175T3 (es) | 2004-09-17 | 2009-06-17 | EISAI R&D MANAGEMENT CO., LTD. | Composicion medicinal con estabilidad mejorada y gelificacion reducida. |
TW200616612A (en) * | 2004-10-08 | 2006-06-01 | Wyeth Corp | Method for the teatment of polycystic kidney disease field of invention |
DE602006021142D1 (de) | 2005-02-03 | 2011-05-19 | Gen Hospital Corp | Verfahren zur behandlung von gefitinib-resistentem krebs |
GB0509227D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Intracellular enzyme inhibitors |
US7624279B2 (en) * | 2005-06-29 | 2009-11-24 | Lenovo Singapore Pte. Ltd. | System and method for secure O.S. boot from password-protected HDD |
JP4989476B2 (ja) | 2005-08-02 | 2012-08-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を検定する方法 |
EP1942937A1 (en) | 2005-11-04 | 2008-07-16 | Wyeth | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
CN104706637A (zh) | 2006-05-18 | 2015-06-17 | 卫材R&D管理有限公司 | 针对甲状腺癌的抗肿瘤剂 |
RU2008139079A (ru) * | 2006-06-13 | 2010-07-20 | Вайет (Us) | Замещенные 3-цианопиридины в качестве ингибиторов протеинкиназы |
CN101511793B (zh) | 2006-08-28 | 2011-08-03 | 卫材R&D管理有限公司 | 针对未分化型胃癌的抗肿瘤剂 |
WO2008093855A1 (ja) | 2007-01-29 | 2008-08-07 | Eisai R & D Management Co., Ltd. | 未分化型胃癌治療用組成物 |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
CA2704000C (en) | 2007-11-09 | 2016-12-13 | Eisai R&D Management Co., Ltd. | Combination of anti-angiogenic substance and anti-tumor platinum complex |
WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
NZ616613A (en) | 2008-06-17 | 2015-05-29 | Wyeth Llc | Antineoplastic combinations containing hki-272 and vinorelbine |
AU2009279771B2 (en) | 2008-08-04 | 2015-05-14 | Wyeth Llc | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
ITMI20082336A1 (it) * | 2008-12-29 | 2010-06-30 | Univ Parma | Composti inibitori irreversibili di egfr con attivita' antiproliferativa |
EP2387563B2 (en) | 2009-01-16 | 2022-04-27 | Exelixis, Inc. | Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quinolin-4-yl]oxy}phenyl-n' - (4 -fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer |
HUE061640T2 (hu) | 2009-04-06 | 2023-07-28 | Wyeth Llc | Gyógykezelési rendszer mellrákhoz neratinib alkalmazásával |
UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
NZ599762A (en) | 2009-11-09 | 2014-07-25 | Wyeth Llc | Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea |
AU2011264209B2 (en) * | 2010-06-09 | 2014-08-07 | Tianjin Hemay Oncology Pharmaceutical Co., Ltd | Cyanoquinoline derivatives |
EP2586443B1 (en) | 2010-06-25 | 2016-03-16 | Eisai R&D Management Co., Ltd. | Antitumor agent using compounds having kinase inhibitory effect in combination |
CN103313713B (zh) * | 2010-08-26 | 2014-12-31 | 和谐进化股份有限公司 | 受体型激酶调节剂和多囊性肾病的治疗方法 |
CA2816957A1 (en) | 2010-11-07 | 2012-05-10 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
CN102675287A (zh) * | 2011-03-11 | 2012-09-19 | 江苏恒瑞医药股份有限公司 | (e)-n-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2r)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可药用的盐、其制备方法及其在医药上的应用 |
AU2012246490B2 (en) | 2011-04-18 | 2016-08-04 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
US9945862B2 (en) | 2011-06-03 | 2018-04-17 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
US9334239B2 (en) | 2012-12-21 | 2016-05-10 | Eisai R&D Management Co., Ltd. | Amorphous form of quinoline derivative, and method for producing same |
CN103214489B (zh) * | 2013-02-25 | 2016-10-26 | 中国人民解放军第二军医大学 | 一类具有抗肿瘤活性的多靶点激酶抑制剂及其制备方法 |
AU2014266223B2 (en) | 2013-05-14 | 2020-06-25 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
CN103304494B (zh) * | 2013-06-20 | 2015-05-27 | 河北大学 | 茚(1,2-b)喹喔啉-11-酮肟衍生物及其制备方法和用途 |
PL3524595T3 (pl) | 2014-08-28 | 2022-10-31 | Eisai R&D Management Co., Ltd. | Pochodna chinoliny o wysokiej czystości i sposób jej wytwarzania |
HUE064614T2 (hu) | 2015-02-25 | 2024-04-28 | Eisai R&D Man Co Ltd | Eljárás egy kinolin-származék keserû ízének elnyomására |
KR20240064733A (ko) | 2015-03-04 | 2024-05-13 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
BR112017027227B1 (pt) | 2015-06-16 | 2023-12-12 | Eisai R&D Management Co., Ltd | Agente anti-câncer |
WO2016210345A1 (en) * | 2015-06-25 | 2016-12-29 | The California Institute For Biomedical Research | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 |
US20190016703A1 (en) * | 2015-12-30 | 2019-01-17 | Dana-Farber Cancer Institute, Inc. | Bifunctional compounds for her3 degradation and methods of use |
CN107141293B (zh) * | 2016-03-01 | 2022-09-23 | 上海医药集团股份有限公司 | 一种含氮杂环化合物、制备方法、中间体、组合物和应用 |
HRP20231191T1 (hr) | 2017-07-28 | 2024-02-02 | Yuhan Corporation | Postupak za proizvodnju n-(5-((4-(4-((dimetilamino)metil)-3-fenil-1h-pirazol-1-il)pirimidin-2-il)amino)-4-metoksi-2-morfolinofenil)akrilamida putem reakcije odgovarajućeg amina s 3-halo-propionilkloridom |
CN110452232A (zh) * | 2019-09-17 | 2019-11-15 | 北京振东光明药物研究院有限公司 | 阿法替尼杂质化合物及其制备方法与应用 |
CN111995618B (zh) * | 2020-09-02 | 2021-06-11 | 重庆医科大学 | 一种来那替尼杂质g的制备方法 |
CN111943933B (zh) * | 2020-09-02 | 2021-05-28 | 重庆医科大学 | 一种来那替尼杂质d的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR19990082463A (ko) * | 1996-02-13 | 1999-11-25 | 돈 리사 로얄 | 혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체 |
UA73073C2 (uk) * | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
US6235740B1 (en) * | 1997-08-25 | 2001-05-22 | Bristol-Myers Squibb Co. | Imidazoquinoxaline protein tyrosine kinase inhibitors |
CA2344169C (en) * | 1998-09-29 | 2011-07-19 | American Cyanamid Company | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors |
SI2253620T1 (sl) * | 1998-09-29 | 2014-06-30 | Wyeth Holdings Llc | Substituirani 3-cianokinolini kot inhibitorji protein tirozin-kinaz |
GB9910577D0 (en) * | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
ATE353320T1 (de) * | 1999-12-29 | 2007-02-15 | Wyeth Corp | Tricyclische proteinkinasehemmer |
US7067532B2 (en) * | 2000-11-02 | 2006-06-27 | Astrazeneca | Substituted quinolines as antitumor agents |
-
2002
- 2002-11-26 RU RU2004119414/04A patent/RU2309150C2/ru not_active IP Right Cessation
- 2002-11-26 DE DE60221886T patent/DE60221886D1/de not_active Expired - Lifetime
- 2002-11-26 AT AT02794031T patent/ATE370123T1/de not_active IP Right Cessation
- 2002-11-26 CN CN028275381A patent/CN1659145A/zh active Pending
- 2002-11-26 UA UA20040605019A patent/UA77469C2/uk unknown
- 2002-11-26 WO PCT/US2002/037918 patent/WO2003050090A1/en active IP Right Grant
- 2002-11-26 IL IL16192102A patent/IL161921A0/xx unknown
- 2002-11-26 PL PL02370137A patent/PL370137A1/pl not_active Application Discontinuation
- 2002-11-26 TW TW091134370A patent/TW200300348A/zh unknown
- 2002-11-26 CA CA002467573A patent/CA2467573A1/en not_active Abandoned
- 2002-11-26 AR ARP020104543A patent/AR037438A1/es not_active Application Discontinuation
- 2002-11-26 JP JP2003551115A patent/JP2005514384A/ja not_active Ceased
- 2002-11-26 MX MXPA04004969A patent/MXPA04004969A/es active IP Right Grant
- 2002-11-26 BR BR0214485-9A patent/BR0214485A/pt not_active IP Right Cessation
- 2002-11-26 NZ NZ533118A patent/NZ533118A/en unknown
- 2002-11-26 AU AU2002359489A patent/AU2002359489B2/en not_active Ceased
- 2002-11-26 HU HU0402228A patent/HUP0402228A2/hu unknown
- 2002-11-26 EP EP02794031A patent/EP1448531B1/en not_active Expired - Lifetime
- 2002-11-26 US US10/305,438 patent/US6821988B2/en not_active Expired - Fee Related
- 2002-11-26 KR KR1020047007951A patent/KR20050044599A/ko not_active Application Discontinuation
-
2004
- 2004-05-25 CO CO04048181A patent/CO5580828A2/es not_active Application Discontinuation
- 2004-05-26 EC EC2004005122A patent/ECSP045122A/es unknown
- 2004-06-23 NO NO20042634A patent/NO20042634L/no not_active Application Discontinuation
- 2004-06-24 ZA ZA200405025A patent/ZA200405025B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2467573A1 (en) | 2003-06-19 |
RU2004119414A (ru) | 2006-02-27 |
AR037438A1 (es) | 2004-11-10 |
CN1659145A (zh) | 2005-08-24 |
US20030149056A1 (en) | 2003-08-07 |
RU2309150C2 (ru) | 2007-10-27 |
EP1448531A1 (en) | 2004-08-25 |
AU2002359489A1 (en) | 2003-06-23 |
CO5580828A2 (es) | 2005-11-30 |
US6821988B2 (en) | 2004-11-23 |
WO2003050090A1 (en) | 2003-06-19 |
ECSP045122A (es) | 2004-07-23 |
BR0214485A (pt) | 2004-09-14 |
DE60221886D1 (de) | 2007-09-27 |
ATE370123T1 (de) | 2007-09-15 |
NZ533118A (en) | 2006-07-28 |
ZA200405025B (en) | 2006-12-27 |
JP2005514384A (ja) | 2005-05-19 |
AU2002359489B2 (en) | 2008-10-30 |
UA77469C2 (en) | 2006-12-15 |
HUP0402228A2 (hu) | 2005-02-28 |
KR20050044599A (ko) | 2005-05-12 |
MXPA04004969A (es) | 2004-08-11 |
NO20042634L (no) | 2004-06-23 |
EP1448531B1 (en) | 2007-08-15 |
TW200300348A (en) | 2003-06-01 |
IL161921A0 (en) | 2005-11-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL161921A0 (en) | 3-Cyanoquinolines as inhibitors of egf-r and her2 kinases | |
HK1160859A1 (en) | Inhibitors of tyrosine kinases | |
IL161576A0 (en) | Benzimidazoles and analogues and their use as protein kinases inhibitors | |
EP1363702A4 (en) | PROCESS FOR INHIBITING KINASES | |
HK1053832A1 (zh) | 蛋白激酶抑制劑 | |
MXPA03006420A (es) | Diaminotiazoles. | |
PT1562589E (pt) | Diaminotriazoles úteis como inibidores de proteína-quinases | |
HK1076598A1 (en) | Substituted quinazoline derivatives as inhibitors of aurora kinases | |
HK1072545A1 (en) | Novel inhibitors of kinases | |
HK1061854A1 (en) | Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors | |
AU2003256297A1 (en) | Benzimidazoles and benzothiazoles as inhibitors of map kinase | |
EP1372654A4 (en) | QUINOLINE INHIBITORS OF HYAK1 AND HYAK3 KINASES | |
PL369742A1 (pl) | Inhibitory kinaz cyklinozależnych oraz związane znimi kompozycje i zastosowania | |
AU2002337913A1 (en) | Glycosulfopeptide inhibitors and methods of use thereof | |
MXPA03009257A (es) | Derivados de isoxaxol como inhibidores de src y otras proteinas cinasas. | |
AU2003210983A8 (en) | Kinase inhibitors and methods of use thereof | |
IL145397A0 (en) | Compositions and methods for treatment of cancer | |
HUP0401641A3 (en) | Use of substituted diazonine derivatives as phosphorodiesterase iv inhibitors | |
MXPA03006423A (es) | Naftostirilos. | |
AU2002306845A1 (en) | Telomerase inhibitors and methods of their use | |
ZA200305379B (en) | Diaminothiazoles and their use as inhibitors of cyclin-dependent kinase. | |
AU2002303336A1 (en) | Isoxaxole derivatives as inhibitors of src and other protein kinases | |
AU2002317319A1 (en) | Quinoline derivatives and their use as tyrosine kinase inhibitors | |
ZA200500492B (en) | Novel inhibitors of kinases | |
AU2002345712A1 (en) | Isoxazolyl-pyrimidines as inhibitors of src and lck protein kinases |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |