MXPA04004969A - 3-cianoquinolinas como inhibidores del receptor del factor de crecimiento epidermico y her2 cinasas. - Google Patents

3-cianoquinolinas como inhibidores del receptor del factor de crecimiento epidermico y her2 cinasas.

Info

Publication number
MXPA04004969A
MXPA04004969A MXPA04004969A MXPA04004969A MXPA04004969A MX PA04004969 A MXPA04004969 A MX PA04004969A MX PA04004969 A MXPA04004969 A MX PA04004969A MX PA04004969 A MXPA04004969 A MX PA04004969A MX PA04004969 A MXPA04004969 A MX PA04004969A
Authority
MX
Mexico
Prior art keywords
cyanoquinolines
egf
inhibitors
her2 kinases
her2
Prior art date
Application number
MXPA04004969A
Other languages
English (en)
Inventor
Brawner Floyd Middleton Jr
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA04004969A publication Critical patent/MXPA04004969A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Esta invencion proporciona compuestos de formula (I), ver formula (I); representados por la estructura en donde G1, G2, G3, G4, Z, X y n son como se definen en la presente, o una sal farmaceuticamente aceptable del mismo los cuales son utiles cono agentes antineoplasticos y en el tratamiento de enfermedad renal poliquistica.
MXPA04004969A 2001-11-27 2002-11-26 3-cianoquinolinas como inhibidores del receptor del factor de crecimiento epidermico y her2 cinasas. MXPA04004969A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33356801P 2001-11-27 2001-11-27
PCT/US2002/037918 WO2003050090A1 (en) 2001-11-27 2002-11-26 3-cyanoquinolines as inhibitors of egf-r and her2 kinases

Publications (1)

Publication Number Publication Date
MXPA04004969A true MXPA04004969A (es) 2004-08-11

Family

ID=23303345

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04004969A MXPA04004969A (es) 2001-11-27 2002-11-26 3-cianoquinolinas como inhibidores del receptor del factor de crecimiento epidermico y her2 cinasas.

Country Status (24)

Country Link
US (1) US6821988B2 (es)
EP (1) EP1448531B1 (es)
JP (1) JP2005514384A (es)
KR (1) KR20050044599A (es)
CN (1) CN1659145A (es)
AR (1) AR037438A1 (es)
AT (1) ATE370123T1 (es)
AU (1) AU2002359489B2 (es)
BR (1) BR0214485A (es)
CA (1) CA2467573A1 (es)
CO (1) CO5580828A2 (es)
DE (1) DE60221886D1 (es)
EC (1) ECSP045122A (es)
HU (1) HUP0402228A2 (es)
IL (1) IL161921A0 (es)
MX (1) MXPA04004969A (es)
NO (1) NO20042634L (es)
NZ (1) NZ533118A (es)
PL (1) PL370137A1 (es)
RU (1) RU2309150C2 (es)
TW (1) TW200300348A (es)
UA (1) UA77469C2 (es)
WO (1) WO2003050090A1 (es)
ZA (1) ZA200405025B (es)

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US7365203B2 (en) * 2003-09-15 2008-04-29 Wyeth Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile
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JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
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WO2007146376A2 (en) * 2006-06-13 2007-12-21 Wyeth Substituted 3-cyanopyridines as protein kinase inhibitors
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CA2704000C (en) 2007-11-09 2016-12-13 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
EP2915532B1 (en) 2008-06-17 2016-10-19 Wyeth LLC Antineoplastic combinations containing hki-272 and vinorelbine
JP5681108B2 (ja) 2008-08-04 2015-03-04 ワイス・エルエルシー ４−アニリノ−３−シアノキノリンとカペシタビンの抗新生物薬の組合せ
ITMI20082336A1 (it) * 2008-12-29 2010-06-30 Univ Parma Composti inibitori irreversibili di egfr con attivita' antiproliferativa
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RU2011139363A (ru) 2009-04-06 2013-05-20 ВАЙЕТ ЭлЭлСи Схема лечения рака молочной железы с использованием нератиниба
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
CA2780332C (en) 2009-11-09 2018-01-30 Wyeth Llc Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
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US9012458B2 (en) 2010-06-25 2015-04-21 Eisai R&D Management Co., Ltd. Antitumor agent using compounds having kinase inhibitory effect in combination
AU2011293315A1 (en) * 2010-08-26 2013-03-14 Symphony Evolution, Inc. Use of a receptor-type kinase modulator for treating polycystic kidney disease
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Also Published As

Publication number Publication date
ECSP045122A (es) 2004-07-23
HUP0402228A2 (hu) 2005-02-28
AU2002359489A1 (en) 2003-06-23
CO5580828A2 (es) 2005-11-30
KR20050044599A (ko) 2005-05-12
NZ533118A (en) 2006-07-28
EP1448531A1 (en) 2004-08-25
JP2005514384A (ja) 2005-05-19
NO20042634L (no) 2004-06-23
AU2002359489B2 (en) 2008-10-30
ATE370123T1 (de) 2007-09-15
AR037438A1 (es) 2004-11-10
UA77469C2 (en) 2006-12-15
WO2003050090A1 (en) 2003-06-19
BR0214485A (pt) 2004-09-14
US20030149056A1 (en) 2003-08-07
PL370137A1 (en) 2005-05-16
CA2467573A1 (en) 2003-06-19
TW200300348A (en) 2003-06-01
CN1659145A (zh) 2005-08-24
EP1448531B1 (en) 2007-08-15
ZA200405025B (en) 2006-12-27
DE60221886D1 (de) 2007-09-27
RU2309150C2 (ru) 2007-10-27
US6821988B2 (en) 2004-11-23
RU2004119414A (ru) 2006-02-27
IL161921A0 (en) 2005-11-20

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