BR0214485A - 3-cianoquinolinas como inibidores de egf-r e her2 quinases - Google Patents

3-cianoquinolinas como inibidores de egf-r e her2 quinases

Info

Publication number
BR0214485A
BR0214485A BR0214485-9A BR0214485A BR0214485A BR 0214485 A BR0214485 A BR 0214485A BR 0214485 A BR0214485 A BR 0214485A BR 0214485 A BR0214485 A BR 0214485A
Authority
BR
Brazil
Prior art keywords
egf
inhibitors
cyanoquinolines
her2 kinases
her2
Prior art date
Application number
BR0214485-9A
Other languages
English (en)
Inventor
Allan Wissner
Hwei-Ru Tsou
Middleton Brawner Floyd Jr
Bernard Dean Johnson
Elsebe Geral Overbeek-Klumpers
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0214485A publication Critical patent/BR0214485A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"3-CIANOQUINOLINAS COMO INIBIDORES DE EGF-R E HER2 QUINASES". A presente invenção fornece compostos da fórmula (I), representados pela estrutura em que G~ 1~, G~ 2~, G~ 3~, G~ 4~, Z, X e n estão definidos no presente relatório, ou um sal farmaceuticamente aceitável dos mesmos, que são úteis como agentes antineoplásticos e no tratamento de doença renal policística.
BR0214485-9A 2001-11-27 2002-11-26 3-cianoquinolinas como inibidores de egf-r e her2 quinases BR0214485A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33356801P 2001-11-27 2001-11-27
PCT/US2002/037918 WO2003050090A1 (en) 2001-11-27 2002-11-26 3-cyanoquinolines as inhibitors of egf-r and her2 kinases

Publications (1)

Publication Number Publication Date
BR0214485A true BR0214485A (pt) 2004-09-14

Family

ID=23303345

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0214485-9A BR0214485A (pt) 2001-11-27 2002-11-26 3-cianoquinolinas como inibidores de egf-r e her2 quinases

Country Status (24)

Country Link
US (1) US6821988B2 (pt)
EP (1) EP1448531B1 (pt)
JP (1) JP2005514384A (pt)
KR (1) KR20050044599A (pt)
CN (1) CN1659145A (pt)
AR (1) AR037438A1 (pt)
AT (1) ATE370123T1 (pt)
AU (1) AU2002359489B2 (pt)
BR (1) BR0214485A (pt)
CA (1) CA2467573A1 (pt)
CO (1) CO5580828A2 (pt)
DE (1) DE60221886D1 (pt)
EC (1) ECSP045122A (pt)
HU (1) HUP0402228A2 (pt)
IL (1) IL161921A0 (pt)
MX (1) MXPA04004969A (pt)
NO (1) NO20042634L (pt)
NZ (1) NZ533118A (pt)
PL (1) PL370137A1 (pt)
RU (1) RU2309150C2 (pt)
TW (1) TW200300348A (pt)
UA (1) UA77469C2 (pt)
WO (1) WO2003050090A1 (pt)
ZA (1) ZA200405025B (pt)

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WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
KR20180128078A (ko) 2008-06-17 2018-11-30 와이어쓰 엘엘씨 Ｈｋｉ-272 및 비노렐빈을 함유하는 항신생물성 조합물
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ITMI20082336A1 (it) * 2008-12-29 2010-06-30 Univ Parma Composti inibitori irreversibili di egfr con attivita' antiproliferativa
TWI447108B (zh) 2009-01-16 2014-08-01 Exelixis Inc Ｎ－（４－｛〔６，７雙（甲氧基）喹啉－４－基〕氧基｝苯基）－ｎ’－（４－氟苯基）環丙烷－１，１－二甲醯胺之蘋果酸鹽及其結晶型
HUE061640T2 (hu) 2009-04-06 2023-07-28 Wyeth Llc Gyógykezelési rendszer mellrákhoz neratinib alkalmazásával
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
CN107441058A (zh) 2009-11-09 2017-12-08 惠氏有限责任公司 包衣药物球状体及消除或减少病症如呕吐和腹泻的用途
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Also Published As

Publication number Publication date
PL370137A1 (en) 2005-05-16
AU2002359489B2 (en) 2008-10-30
EP1448531B1 (en) 2007-08-15
ZA200405025B (en) 2006-12-27
RU2309150C2 (ru) 2007-10-27
ECSP045122A (es) 2004-07-23
TW200300348A (en) 2003-06-01
RU2004119414A (ru) 2006-02-27
NO20042634L (no) 2004-06-23
US6821988B2 (en) 2004-11-23
DE60221886D1 (de) 2007-09-27
NZ533118A (en) 2006-07-28
ATE370123T1 (de) 2007-09-15
WO2003050090A1 (en) 2003-06-19
HUP0402228A2 (hu) 2005-02-28
CO5580828A2 (es) 2005-11-30
US20030149056A1 (en) 2003-08-07
EP1448531A1 (en) 2004-08-25
CN1659145A (zh) 2005-08-24
UA77469C2 (en) 2006-12-15
CA2467573A1 (en) 2003-06-19
AU2002359489A1 (en) 2003-06-23
MXPA04004969A (es) 2004-08-11
AR037438A1 (es) 2004-11-10
KR20050044599A (ko) 2005-05-12
IL161921A0 (en) 2005-11-20
JP2005514384A (ja) 2005-05-19

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.