DE60225943D1 - Topoisomerase-giftmittel - Google Patents

Topoisomerase-giftmittel

Info

Publication number
DE60225943D1
DE60225943D1 DE60225943T DE60225943T DE60225943D1 DE 60225943 D1 DE60225943 D1 DE 60225943D1 DE 60225943 T DE60225943 T DE 60225943T DE 60225943 T DE60225943 T DE 60225943T DE 60225943 D1 DE60225943 D1 DE 60225943D1
Authority
DE
Germany
Prior art keywords
sub
formula
topoisomerase
compounds
gift funds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60225943T
Other languages
English (en)
Other versions
DE60225943T2 (de
Inventor
Edmond J Lavoie
Alexander L Ruchelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Application granted granted Critical
Publication of DE60225943D1 publication Critical patent/DE60225943D1/de
Publication of DE60225943T2 publication Critical patent/DE60225943T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
DE60225943T 2001-11-14 2002-11-14 Topoisomerase-giftmittel Expired - Lifetime DE60225943T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33305001P 2001-11-14 2001-11-14
US333050P 2001-11-14
PCT/US2002/036477 WO2003047505A2 (en) 2001-11-14 2002-11-14 Topoisomerase poison agents

Publications (2)

Publication Number Publication Date
DE60225943D1 true DE60225943D1 (de) 2008-05-15
DE60225943T2 DE60225943T2 (de) 2009-01-29

Family

ID=23301042

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60225943T Expired - Lifetime DE60225943T2 (de) 2001-11-14 2002-11-14 Topoisomerase-giftmittel

Country Status (6)

Country Link
US (1) US6964964B2 (de)
EP (1) EP1453506B1 (de)
AT (1) ATE390923T1 (de)
AU (1) AU2002364953A1 (de)
DE (1) DE60225943T2 (de)
WO (1) WO2003047505A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2467279A1 (en) * 2001-11-14 2003-06-26 Edmond J. Lavoie Solubilized topoisomerase poison agents
WO2003047505A2 (en) 2001-11-14 2003-06-12 Rutgers, The State University Topoisomerase poison agents
SI1465625T1 (sl) 2001-11-14 2010-06-30 Univ Rutgers Solubilizirani topoizomerazni strupi
EP1453812B1 (de) 2001-11-14 2008-08-20 Rutgers, The State University Cytotoxische mittel
AU2003265406A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted topoisomerase agents
WO2004014906A2 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
US6992088B2 (en) 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
CA2510337C (en) 2002-11-12 2013-01-08 Rutgers, The State University Of New Jersey Topoisomerase-targeting agents
JP5773888B2 (ja) 2009-03-06 2015-09-02 ラットガーズ，ザ・ステート・ユニバーシティ・オブ・ニュージャージー 癌治療に用いられるメチレンジオキシベンゾ［ｉ］フェナントリジン誘導体
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
CN109071557A (zh) * 2016-02-04 2018-12-21 珀杜研究基金会 抗癌剂indotecan和indimitecan的前药
WO2017160898A1 (en) 2016-03-15 2017-09-21 Purdue Research Foundation Aza-a-ring indenoisoquinoline topoisomerase i poisons
CN109219610A (zh) 2016-04-04 2019-01-15 新泽西州立拉特格斯大学 拓扑异构酶毒物
CA3047992A1 (en) 2016-12-22 2018-06-28 Purdue Research Foundation Azaindenoisoquinoline compounds and uses thereof

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2981731A (en) 1961-04-25 Acridine derivatives
US2985661A (en) 1956-02-06 1961-05-23 American Cyanamid Co Preparation of 2(omicron-aminophenyl)-benzimidazole
US2915523A (en) 1956-12-03 1959-12-01 Parke Davis & Co Benzacridine compounds
US3272707A (en) 1964-07-17 1966-09-13 Smith Kline French Lab Pharmaceutical compositions and methods for their use
CH420044A (de) 1964-09-01 1967-03-15 Ciba Geigy Verwendung von neuen Azol-Derivaten als optische Aufheller für textile organische Materialien
US3267107A (en) 1964-09-17 1966-08-16 American Home Prod 3-(4'-5'-methylenedioxy-phenyl)-7, 8-dimethoxy-1, 2, 3, 4,-tetrahydroisoquinolines
US3849561A (en) 1964-10-20 1974-11-19 S Naruto Anti-peptic ulcer substance from corydalis tubers
DE1670684A1 (de) 1966-04-01 1970-12-03 Hoechst Ag Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten
US3542782A (en) 1967-03-15 1970-11-24 Sandoz Ag 5,6-dihydro-8h-isoquino(1,2-b)quinazolines
JPS4942700A (de) 1972-08-25 1974-04-22
US3912740A (en) 1974-02-28 1975-10-14 Us Health Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds
PT73763B (fr) 1981-10-01 1983-10-26 Quatrum Empresa Nacional De Qu Procede pour la preparation de nouveaux epoxides d'alkaloides benzofenantridiniques et de compositions pharmaceutiques qui les contiennent
US5153178A (en) 1982-05-14 1992-10-06 Maroko Peter R Compositions and method of treatment for improving circulatory performance
US4761417A (en) 1982-05-14 1988-08-02 Maroko Peter R Compounds, compositions and method of treatments for improving circulatory performance
US4980344A (en) 1982-05-14 1990-12-25 Maroko Peter R Compositions for improving circulatory performance
IE55519B1 (en) 1982-05-14 1990-10-10 Maroko Peter R Use of a protoberberine alkaloid and composition containing same
US4749708A (en) 1982-05-14 1988-06-07 Maroko Peter R Composition for improving circulatory performance
JPS61130289A (ja) 1984-11-29 1986-06-18 Ss Pharmaceut Co Ltd １３−プロピルベルベリンの塩
FR2595356B1 (fr) 1986-03-05 1991-05-24 Pasteur Strasbourg Universite Derives des nitro ou aminobenzyltetrahydroisoquinoleines, procedes d'obtention, compositions pharmaceutiques les contenant, proprietes pharmacologiques et applications
US5244903A (en) 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
SU1530628A1 (ru) 1987-11-20 1989-12-23 Ленинградский Технологический Институт Им.Ленсовета Тригидрохлорид 2-[2-фенил-5(6)-бензимидазолил]-N-(3-диметиламинопропил)-5(6)-бензимидазолкарбоксамида в качестве флуоресцентного красител дл исследовани ДНК
US5153753A (en) * 1989-04-12 1992-10-06 Ricoh Company, Ltd. Active matrix-type liquid crystal display containing a horizontal MIM device with inter-digital conductors
US5106863A (en) 1990-03-26 1992-04-21 Ortho Pharmaceutical Corporation Substituted imidazole and pyridine derivatives
US5135934A (en) 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
US5126351A (en) 1991-01-24 1992-06-30 Glaxo Inc. Antitumor compounds
US5223506A (en) 1991-06-04 1993-06-29 Glaxo Inc. Cyclic antitumor compounds
US5428040A (en) 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
CA2150235A1 (en) 1993-09-28 1995-04-06 Fumio Suzuki A novel tetracyclic compound
HUP9900071A3 (en) 1995-05-17 2002-01-28 Univ Rutgers Tribenzimidazoles useful as topoisomerase i inhibitors, pharmaceutical compositions containing them and their use
US5767142A (en) 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5807874A (en) 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
HUP9900413A3 (en) 1996-02-12 2002-02-28 Univ Rutgers Use of coralyne derivatives, new coralyne derivatives and use thereof, pharmaceutical compositions containing these new coralyne derivatives
US5770617A (en) 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
PL332416A1 (en) 1996-09-23 1999-09-13 Rutgers Substituted heterocyclic compounds as anticarcinogenic agents
US6140328A (en) 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
AU765135B2 (en) 1998-10-14 2003-09-11 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Novel indenoisoquinolines as antineoplastic agents
US6740650B2 (en) * 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
JP2003513079A (ja) 1999-10-29 2003-04-08 ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー 複素環式細胞傷害剤
SI1465625T1 (sl) 2001-11-14 2010-06-30 Univ Rutgers Solubilizirani topoizomerazni strupi
CA2467279A1 (en) 2001-11-14 2003-06-26 Edmond J. Lavoie Solubilized topoisomerase poison agents
WO2003047505A2 (en) 2001-11-14 2003-06-12 Rutgers, The State University Topoisomerase poison agents
EP1453812B1 (de) 2001-11-14 2008-08-20 Rutgers, The State University Cytotoxische mittel
AU2003265406A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted topoisomerase agents

Also Published As

Publication number Publication date
AU2002364953A1 (en) 2003-06-17
ATE390923T1 (de) 2008-04-15
EP1453506B1 (de) 2008-04-02
DE60225943T2 (de) 2009-01-29
US20050010046A1 (en) 2005-01-13
EP1453506A2 (de) 2004-09-08
US6964964B2 (en) 2005-11-15
AU2002364953A8 (en) 2003-06-17
EP1453506A4 (de) 2005-06-08
WO2003047505A3 (en) 2003-09-04
WO2003047505A2 (en) 2003-06-12

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Legal Events

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8364 No opposition during term of opposition