PL3536797T3 - Wzmocniona ekspresja transgenu i przetwarzanie - Google Patents

Wzmocniona ekspresja transgenu i przetwarzanie

Info

Publication number
PL3536797T3
PL3536797T3 PL19153376.9T PL19153376T PL3536797T3 PL 3536797 T3 PL3536797 T3 PL 3536797T3 PL 19153376 T PL19153376 T PL 19153376T PL 3536797 T3 PL3536797 T3 PL 3536797T3
Authority
PL
Poland
Prior art keywords
processing
transgene expression
enhanced transgene
enhanced
expression
Prior art date
Application number
PL19153376.9T
Other languages
English (en)
Polish (pl)
Inventor
Valérie LE FOURN
Nicolas Mermod
Alexandre Regamey
Montse BUCETA
Déborah LEY
Niamh HARRAGHY
Kaja KOSTYRKO
Pierre-Alain GIRO
David Calabrese
Original Assignee
Selexis S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selexis S.A. filed Critical Selexis S.A.
Publication of PL3536797T3 publication Critical patent/PL3536797T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • C12N2800/106Plasmid DNA for vertebrates
    • C12N2800/107Plasmid DNA for vertebrates for mammalian
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/90Vectors containing a transposable element
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/46Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
PL19153376.9T 2013-02-01 2014-02-01 Wzmocniona ekspresja transgenu i przetwarzanie PL3536797T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361759802P 2013-02-01 2013-02-01
US201361800244P 2013-03-15 2013-03-15
US201361806634P 2013-03-29 2013-03-29

Publications (1)

Publication Number Publication Date
PL3536797T3 true PL3536797T3 (pl) 2023-09-11

Family

ID=50239688

Family Applications (2)

Application Number Title Priority Date Filing Date
PL19153376.9T PL3536797T3 (pl) 2013-02-01 2014-02-01 Wzmocniona ekspresja transgenu i przetwarzanie
PL14708935T PL2951309T3 (pl) 2013-02-01 2014-02-01 Wzmocniona ekspresja transgenu i przetwarzanie

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL14708935T PL2951309T3 (pl) 2013-02-01 2014-02-01 Wzmocniona ekspresja transgenu i przetwarzanie

Country Status (20)

Country Link
US (1) US11898154B2 (enExample)
EP (2) EP2951309B1 (enExample)
JP (1) JP6563816B2 (enExample)
KR (1) KR102235603B1 (enExample)
CN (2) CN120718957A (enExample)
AU (2) AU2014210856B2 (enExample)
CA (1) CA2898878C (enExample)
DK (2) DK2951309T3 (enExample)
ES (2) ES2717175T3 (enExample)
FI (1) FI3536797T3 (enExample)
HU (2) HUE061494T2 (enExample)
IL (1) IL240198B (enExample)
LT (1) LT2951309T (enExample)
PL (2) PL3536797T3 (enExample)
PT (2) PT3536797T (enExample)
RU (1) RU2711505C9 (enExample)
SG (2) SG11201505487UA (enExample)
SI (1) SI2951309T1 (enExample)
WO (1) WO2014118619A2 (enExample)
ZA (1) ZA201506419B (enExample)

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CN105154473B (zh) * 2015-09-30 2019-03-01 上海细胞治疗研究院 一种高效安全的转座子整合系统及其用途
JP6871679B2 (ja) * 2016-03-23 2021-05-12 国立大学法人 岡山大学 遺伝子発現用カセット及びその産生物
WO2017061354A1 (ja) * 2015-10-06 2017-04-13 国立大学法人 岡山大学 遺伝子発現用カセット及びその産生物
JP2017070224A (ja) * 2015-10-06 2017-04-13 国立大学法人 岡山大学 遺伝子発現用カセット及びその産生物
SG11201805132YA (en) 2015-12-24 2018-07-30 Selexis Sa Improved eukaryotic cells for protein manufacturing and methods of making them
ITUA20161610A1 (it) * 2016-03-14 2017-09-14 Angela Anna Messina Composto peptidico farmacologicamente attivo, procedimento per la sua preparazione e suo uso.
EP3219800A1 (en) * 2016-03-15 2017-09-20 Max-Delbrück-Centrum Für Molekulare Medizin A transposon-based transfection system for primary cells
EP3219803A1 (en) * 2016-03-15 2017-09-20 Max-Delbrück-Centrum für Molekulare Medizin Enhanced sleeping beauty transposons, kits and methods of transposition
JP6959942B2 (ja) * 2016-05-03 2021-11-05 ロンザ リミテッドLonza Limited タンパク質生成のための脂質代謝のモジュレーション
CN109790539A (zh) * 2016-10-03 2019-05-21 第一三共株式会社 Hspa5基因的启动子
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KR102523318B1 (ko) 2016-12-16 2023-04-18 비-모젠 바이오테크놀로지스, 인크. 증진된 hAT 패밀리 트랜스포존 매개 유전자 전달 및 연관된 조성물, 시스템, 및 방법
WO2018224162A1 (en) * 2017-06-09 2018-12-13 Biontech Rna Pharmaceuticals Gmbh Methods for characterizing loss of antigen presentation
JP7240749B2 (ja) * 2017-09-29 2023-03-16 ベスファジェン・インコーポレイテッド 心不全の予防または治療のための医薬組成物
CN109929839B (zh) * 2017-12-18 2021-02-12 华东师范大学 拆分型单碱基基因编辑系统及其应用
CN108504692B (zh) * 2018-03-26 2021-07-23 安徽大学 一种基因敲除cho细胞株的构建方法及其在治疗性重组蛋白表达中的应用
EP3794128A1 (en) * 2018-05-18 2021-03-24 Sorbonne Universite Molecular tools and methods for transgene integration and their transposition dependent expression
EP3810764A2 (en) 2018-06-21 2021-04-28 B-Mogen Biotechnologies, Inc. Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods
RU2686102C1 (ru) * 2018-08-07 2019-04-24 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Рекомбинантный вектор для создания плазмидных генетических конструкций, обладающих повышенной длительностью экспрессии целевых генов
EP3847261A1 (en) * 2018-09-05 2021-07-14 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft A method for engineering synthetic cis-regulatory dna
US20210380661A1 (en) * 2018-10-16 2021-12-09 Texas Tech University System Method to Express, Purify, and Biotinylate Eukaryotic Cell-Derived Major Histocompatibility Complexes
WO2020084528A1 (en) 2018-10-24 2020-04-30 Selexis Sa Expression systems, recombinant cells and uses thereof
US12404527B2 (en) * 2018-12-24 2025-09-02 Selexs S.A. Characterization and inactivation of endogenous retroviruses in chinese hamster ovary cells
US20220088158A1 (en) 2019-01-23 2022-03-24 Aceragen, Inc. Method of ameliorating a pro-inflammatory immunophenotype in farber disease subjects by repeated administration of a recombinant human acid ceramidase
IT201900002321A1 (it) * 2019-02-18 2020-08-18 Univ Degli Studi Padova Peptidi con attivita' antitumorale
EP3946596A4 (en) * 2019-03-27 2022-12-21 Phoenix Tissue Repair, Inc. SYSTEMS AND METHODS OF PRODUCING COLLAGEN COMPOSITIONS 7
CN110006866B (zh) * 2019-04-16 2022-04-22 杭州迈尔德生物科技有限公司 一种阿片类活性物质的通用检测方法及其检测试剂盒
WO2020228721A1 (en) * 2019-05-13 2020-11-19 Lin Mei Chun Method and kit for monitoring cancer
CN114514324A (zh) * 2019-10-10 2022-05-17 加利福尼亚州立大学董事会 稳定哺乳动物细胞的方法
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CN112813099A (zh) * 2019-11-15 2021-05-18 上海细胞治疗集团有限公司 一种在活化的t细胞中具有高活性的启动子
CN110863008B (zh) * 2019-11-22 2020-10-16 昆明学院 Mar序列调控弱启动子构建高效表达载体的方法
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BR112022016617A2 (pt) * 2020-02-19 2022-11-22 Wuxi Biologics Ireland Ltd Ácido nucleico, vetor, vetor de transposon, sistema de expressão, ácido nucleico isolado, método para gerar uma célula, célula, método de expressão de uma proteína, proteína, composiçao farmacêutica, sistema de expressão, linhagem celular
CN111500629B (zh) * 2020-04-17 2021-11-19 安徽中盛溯源生物科技有限公司 一种高表达层粘连蛋白-511变体的方法及其应用
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CN116440269B (zh) * 2022-01-10 2024-02-09 华中农业大学 Slc35a1基因作为靶点在防治猪流行性腹泻病中的应用
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Also Published As

Publication number Publication date
SG11201505487UA (en) 2015-08-28
CN120718957A (zh) 2025-09-30
IL240198A0 (en) 2015-09-24
JP6563816B2 (ja) 2019-08-21
US11898154B2 (en) 2024-02-13
FI3536797T3 (fi) 2023-03-23
WO2014118619A3 (en) 2014-10-30
RU2711505C2 (ru) 2020-01-17
SI2951309T1 (sl) 2019-04-30
US20150361451A1 (en) 2015-12-17
SG10201803758XA (en) 2018-06-28
PT3536797T (pt) 2023-03-15
PT2951309T (pt) 2019-04-03
CA2898878A1 (en) 2014-08-07
EP3536797B1 (en) 2023-01-04
EP3536797A1 (en) 2019-09-11
ZA201506419B (en) 2017-02-22
KR102235603B1 (ko) 2021-04-05
AU2014210856A1 (en) 2015-07-30
ES2717175T3 (es) 2019-06-19
RU2015127667A (ru) 2017-03-06
HK1216323A1 (en) 2016-11-04
IL240198B (en) 2019-10-31
HUE043103T2 (hu) 2019-08-28
ES2940433T3 (es) 2023-05-08
DK2951309T3 (en) 2019-04-23
CA2898878C (en) 2020-04-28
EP2951309B1 (en) 2019-01-30
EP2951309A2 (en) 2015-12-09
KR20150123803A (ko) 2015-11-04
LT2951309T (lt) 2019-03-25
JP2016504922A (ja) 2016-02-18
DK3536797T3 (da) 2023-04-03
DK3536797T5 (da) 2024-09-02
CN105073995A (zh) 2015-11-18
AU2014210856B2 (en) 2019-10-24
WO2014118619A2 (en) 2014-08-07
AU2019250224B2 (en) 2022-05-12
HUE061494T2 (hu) 2023-07-28
RU2711505C9 (ru) 2020-08-12
PL2951309T3 (pl) 2019-06-28
AU2019250224A1 (en) 2019-11-07

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