PL3242887T3 - Związki koagonistyczne GIP i GLP-1 - Google Patents
Związki koagonistyczne GIP i GLP-1Info
- Publication number
- PL3242887T3 PL3242887T3 PL16703620T PL16703620T PL3242887T3 PL 3242887 T3 PL3242887 T3 PL 3242887T3 PL 16703620 T PL16703620 T PL 16703620T PL 16703620 T PL16703620 T PL 16703620T PL 3242887 T3 PL3242887 T3 PL 3242887T3
- Authority
- PL
- Poland
- Prior art keywords
- gip
- glp
- agonist compounds
- agonist
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/645—Secretins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Child & Adolescent Psychology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562101488P | 2015-01-09 | 2015-01-09 | |
| PCT/US2016/012124 WO2016111971A1 (en) | 2015-01-09 | 2016-01-05 | Gip and glp-1 co-agonist compounds |
| EP16703620.1A EP3242887B1 (en) | 2015-01-09 | 2016-01-05 | Gip and glp-1 co-agonist compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3242887T3 true PL3242887T3 (pl) | 2020-02-28 |
Family
ID=55315708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16703620T PL3242887T3 (pl) | 2015-01-09 | 2016-01-05 | Związki koagonistyczne GIP i GLP-1 |
Country Status (46)
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2933701C (en) | 2013-12-18 | 2022-05-31 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| US11285180B2 (en) | 2016-12-06 | 2022-03-29 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods of enhancing the potency of incretin-based drugs in subjects in need thereof |
| JOP20180028A1 (ar) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
| US11590237B2 (en) | 2017-05-18 | 2023-02-28 | Merck Sharp & Dohme Llc | Pharmaceutical formulation comprising incretin-insulin conjugates |
| TWI847306B (zh) | 2017-08-24 | 2024-07-01 | 丹麥商諾佛 儂迪克股份有限公司 | Ｇｌｐ-１組成物及其用途 |
| AR113486A1 (es) * | 2017-12-21 | 2020-05-06 | Lilly Co Eli | Análogos de incretina y sus usos |
| TWI767095B (zh) * | 2017-12-21 | 2022-06-11 | 美商美國禮來大藥廠 | 腸促胰島素(incretin)類似物及其用途 |
| WO2019140030A1 (en) | 2018-01-12 | 2019-07-18 | Eli Lilly And Company | Combination therapy |
| EP4299118A3 (en) | 2018-02-02 | 2024-04-10 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant |
| CA3094167A1 (en) | 2018-03-22 | 2019-09-26 | Viking Therapeutics, Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
| TWI707865B (zh) * | 2018-05-04 | 2020-10-21 | 丹麥商諾佛 儂迪克股份有限公司 | Gip衍生物及其用途 |
| TWI705820B (zh) | 2018-06-22 | 2020-10-01 | 美商美國禮來大藥廠 | Gip/glp1促效劑組合物 |
| WO2020023386A1 (en) * | 2018-07-23 | 2020-01-30 | Eli Lilly And Company | Gip/glp1 co-agonist compounds |
| MA53390A (fr) * | 2018-07-23 | 2021-06-02 | Lilly Co Eli | Procédés d'utilisation d'un co-agoniste de gip/glp1 pour une thérapie |
| MA53378A (fr) | 2018-07-23 | 2021-06-02 | Lilly Co Eli | Procédé d'utilisation d'un co-agoniste de gip/glp1 contre le diabète |
| WO2020023702A1 (en) | 2018-07-25 | 2020-01-30 | AskGene Pharma, Inc. | Novel il-21 prodrugs and methods of use thereof |
| JP6564539B1 (ja) | 2018-09-14 | 2019-08-21 | 長瀬産業株式会社 | スルホン酸化合物によるペプチド精製方法 |
| EP3856339A1 (en) | 2018-09-24 | 2021-08-04 | Takeda Pharmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
| WO2020117962A1 (en) | 2018-12-05 | 2020-06-11 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| TWI799680B (zh) * | 2019-01-29 | 2023-04-21 | 美商美國禮來大藥廠 | 製備gip/glp1雙重促效劑之方法 |
| WO2020252264A1 (en) | 2019-06-12 | 2020-12-17 | AskGene Pharma, Inc. | Novel il-15 prodrugs and methods of use thereof |
| GB201908424D0 (en) | 2019-06-12 | 2019-07-24 | Imp College Innovations Ltd | Novel compounds |
| AR119471A1 (es) * | 2019-08-01 | 2021-12-22 | Lilly Co Eli | Compuestos agonistas de gipr |
| JP2022545200A (ja) | 2019-08-19 | 2022-10-26 | イーライ リリー アンド カンパニー | インクレチン類似体を作製する方法 |
| CN114786706A (zh) * | 2019-10-04 | 2022-07-22 | 韩美药品株式会社 | 胰高血糖素、包含glp-1受体和gip受体双重激动剂的组合物、及其治疗用途 |
| CN110684082B (zh) * | 2019-10-08 | 2021-12-10 | 江苏诺泰澳赛诺生物制药股份有限公司 | Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途 |
| AR120714A1 (es) * | 2019-12-18 | 2022-03-09 | Lilly Co Eli | Análogos de incretina y sus usos |
| MX2022009149A (es) * | 2020-01-23 | 2022-12-15 | Lilly Co Eli | Compuestos coagonistas de gip/glp1. |
| TW202228762A (zh) * | 2020-01-30 | 2022-08-01 | 美商美國禮來大藥廠 | 提派肽(tirzepatide)之治療用途 |
| CN111253475B (zh) * | 2020-02-18 | 2021-03-09 | 江苏诺泰澳赛诺生物制药股份有限公司 | Glp-1激动多肽化合物及其盐与合成方法及用途 |
| JP7544838B2 (ja) | 2020-03-06 | 2024-09-03 | サノフイ | 選択的ｇｉｐ受容体アゴニストとしてのペプチド |
| CN113493503B (zh) * | 2020-04-08 | 2022-08-05 | 浙江道尔生物科技有限公司 | 一种肠促胰岛素类似物及其制备方法和用途 |
| TW202216746A (zh) | 2020-06-22 | 2022-05-01 | 印度商太陽製藥工業有限公司 | 長效型ｇｌｐ－１／ｇｉｐ雙重促效劑 |
| AU2021304762B2 (en) * | 2020-07-06 | 2024-05-02 | Vitalixir (Beijing) Co., Ltd | Novel polypeptide and therapeutic use thereof |
| CA3184717A1 (en) | 2020-07-22 | 2022-01-27 | Patrick J. KNERR | Co-agonists at glp-1 and gip receptors suitable for oral delivery |
| WO2022018185A1 (en) | 2020-07-22 | 2022-01-27 | Novo Nordisk A/S | Glp-1 and gip receptor co-agonists |
| JP2023545684A (ja) * | 2020-09-30 | 2023-10-31 | ベイジン キューエル バイオファーマシューティカル カンパニー，リミテッド | ポリペプチドコンジュゲートおよび使用の方法 |
| WO2022080986A1 (ko) | 2020-10-16 | 2022-04-21 | 한미약품 주식회사 | Glp-1/gip 이중작용제, 이의 지속형 결합체, 및 이를 포함하는 약학적 조성물 |
| EP4204440A1 (en) * | 2020-10-17 | 2023-07-05 | Sun Pharmaceutical Industries Limited | Glp-1/gip dual agonists |
| CN116615222A (zh) * | 2020-12-02 | 2023-08-18 | 东宝紫星(杭州)生物医药有限公司 | 含内酰胺修饰的多肽类化合物 |
| EP4281464A4 (en) | 2021-01-20 | 2025-01-01 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
| CA3208208A1 (en) | 2021-02-17 | 2022-08-25 | Mathijs Christiaan Michael BUNCK | Tirzepatide therapeutic methods |
| WO2022177744A1 (en) * | 2021-02-17 | 2022-08-25 | Eli Lilly And Company | Gip/glp1 dual agonist therapeutic methods |
| EP4317179B1 (en) | 2021-03-25 | 2025-10-29 | BrightGene Bio-Medical Technology Co., Ltd. | Gip and glp-1 dual receptor agonist, pharmaceutical composition, and use |
| US12215133B2 (en) * | 2021-03-25 | 2025-02-04 | Brightgene Bio-Medical Technology Co., Ltd. | GIP and GLP-1 dual receptor agonist, pharmaceutical composition, and use |
| MX2023013144A (es) | 2021-05-07 | 2023-11-28 | Lilly Co Eli | Tableta erosionable. |
| CN117980325A (zh) | 2021-05-13 | 2024-05-03 | 卡莫特治疗学股份有限公司 | G-蛋白偶联受体的调节剂 |
| CN117866048A (zh) * | 2021-05-28 | 2024-04-12 | 广东众生睿创生物科技有限公司 | 多肽的制备及其应用 |
| WO2022253202A1 (zh) * | 2021-06-01 | 2022-12-08 | 南京知和医药科技有限公司 | 一种glp-1r和gipr双重靶向激动作用的多肽衍生物及其制备方法和用途 |
| CN117794946A (zh) | 2021-06-09 | 2024-03-29 | 斯克利普斯研究所 | 长效双重gip/glp-1肽缀合物及使用方法 |
| WO2022262825A1 (zh) * | 2021-06-18 | 2022-12-22 | 南京明德新药研发有限公司 | 含内酰胺桥的多肽化合物 |
| CA3230915A1 (en) | 2021-09-06 | 2023-03-09 | Thomas Boehme | New peptides as potent and selective gip receptor agonists |
| JP7642830B2 (ja) | 2021-09-15 | 2025-03-10 | バイキング・セラピューティクス・インコーポレイテッド | 代謝及び肝臓障害の処置のための組成物及び方法 |
| EP4180060A1 (en) | 2021-11-15 | 2023-05-17 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
| US20250000948A1 (en) | 2021-11-15 | 2025-01-02 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
| EP4299057A1 (en) | 2022-06-30 | 2024-01-03 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
| WO2023089594A1 (en) | 2021-11-22 | 2023-05-25 | Sun Pharmaceutical Industries Limited | Process for the preparation of tirzepatide or pharmaceutically acceptable salt thereof |
| TW202330584A (zh) * | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
| CN118843640A (zh) * | 2022-04-07 | 2024-10-25 | 广东众生睿创生物科技有限公司 | 多肽在制备治疗和/或预防糖尿病及肥胖症及其相关疾病药物中的制药用途 |
| CN116947978A (zh) * | 2022-04-19 | 2023-10-27 | 北京惠之衡生物科技有限公司 | 一种glp-1和gip受体共激动多肽衍生物及其盐和制剂 |
| EP4547218A1 (en) | 2022-06-30 | 2025-05-07 | Eli Lilly And Company | Tirzepatide compositions and use |
| EP4299052A1 (en) | 2022-06-30 | 2024-01-03 | Adocia | Solid compositions comprising a peptide or a protein and a permeation enhancer |
| EP4299071A1 (en) | 2022-07-01 | 2024-01-03 | Adocia | Compositions comprising a peptide or a protein and an acylated amino acid |
| CN119522233A (zh) * | 2022-07-13 | 2025-02-25 | 杭州中美华东制药有限公司 | Glp-1/gip双激动剂及其制备方法和用途 |
| CA3262093A1 (en) * | 2022-07-20 | 2024-01-25 | Viking Therapeutics, Inc. | Pharmaceutical Formulations and Methods for the Treatment of Metabolic and Liver Disorders |
| EP4580608A1 (en) | 2022-08-29 | 2025-07-09 | Eli Lilly And Company | Compositions for oral delivery |
| JP2025531200A (ja) | 2022-09-15 | 2025-09-19 | イーライ リリー アンド カンパニー | Ｇｉｐ及びｇｌｐ－１二重アゴニスト化合物 |
| KR20250073361A (ko) * | 2022-09-23 | 2025-05-27 | 브라이트제네 피티이. 엘티디. | Glp-1 및 gip 이중 수용체 작용제 약학적 조성물 및 그 용도 |
| KR20250096895A (ko) | 2022-10-05 | 2025-06-27 | 일라이 릴리 앤드 캄파니 | 인크레틴 합성을 위한 펩티드 |
| AU2023365820A1 (en) * | 2022-10-19 | 2025-05-01 | Eli Lilly And Company | Preserved gip/glp agonist compositions |
| WO2024098718A1 (zh) * | 2022-11-07 | 2024-05-16 | 内蒙古博睿精创科技有限公司 | 一种新型长效多肽化合物、组合物及其应用 |
| KR20250110330A (ko) | 2022-11-21 | 2025-07-18 | 일라이 릴리 앤드 캄파니 | Gip/glp1 이중 효능제의 제조 방법 |
| WO2024128882A1 (ko) | 2022-12-16 | 2024-06-20 | 주식회사 펩트론 | Glp-1 수용체 작용제 또는 이의 약학적으로 허용가능한 염을 포함하는 서방형 미립구 및 이의 용도 |
| AU2023414623A1 (en) | 2022-12-29 | 2025-06-26 | Eli Lilly And Company | Processes and intermediates for preparing tirzepatide |
| AU2023415591A1 (en) | 2022-12-30 | 2025-08-14 | Algipharma As | Compositions and methods to increase the systemic bioavailability of a polypeptide therapeutic agent undergoing oral administration |
| PE20252287A1 (es) | 2023-01-31 | 2025-09-18 | Lilly Co Eli | Agonistas del trirreceptor gip/glp1/gcg y usos de estos |
| WO2024165571A2 (en) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| KR20250159046A (ko) * | 2023-03-15 | 2025-11-07 | 바이킹 테라퓨틱스 인코포레이티드 | 대사 및 간 장애의 치료를 위한 약학 조성물 및 방법 |
| CN118684758A (zh) * | 2023-03-23 | 2024-09-24 | 上海民为生物技术有限公司 | 肠促胰岛素类似物及其应用 |
| CN121001735A (zh) | 2023-03-31 | 2025-11-21 | 伊莱利利公司 | 用于治疗t2d的替尔泊肽 |
| CN121002051A (zh) * | 2023-04-11 | 2025-11-21 | 上海多米瑞生物技术有限公司 | 肠促胰素类似物及其制备方法和应用 |
| TW202500575A (zh) * | 2023-05-21 | 2025-01-01 | 美商卡默療法股份有限公司 | 具有或不具有體重相關合併症之過重或肥胖成人之治療 |
| CN116832141B (zh) * | 2023-06-06 | 2024-02-09 | 诺博泰科(成都)生物科技有限公司 | 一种用于治疗糖尿病的glp-1、gip和gcg受体三激动多肽化合物 |
| KR20260022948A (ko) | 2023-06-09 | 2026-02-20 | 썬 파마슈티컬 인더스트리스 리미티드 | Glp-1/gip 이중 수용체 작용제, glp-1/gcg 이중 수용체 작용제, 및 glp-1/gip/gcg 삼중 수용체 작용제 |
| AR132977A1 (es) | 2023-06-15 | 2025-08-13 | Novo Nordisk As | Formulaciones farmacéuticas que comprenden una ciclodextrina |
| TW202517291A (zh) | 2023-06-30 | 2025-05-01 | 丹麥商西蘭製藥公司 | 組合療法 |
| CN116693652B (zh) * | 2023-08-02 | 2024-01-05 | 北京惠之衡生物科技有限公司 | 一种glp-1/gip受体双重激动剂衍生物及其制备方法和应用 |
| WO2025069009A1 (en) | 2023-09-29 | 2025-04-03 | Graviton Bioscience Bv | Rock2 inhibitors in the treatment of obesity |
| CN117646017A (zh) * | 2023-11-02 | 2024-03-05 | 中国人民解放军海军军医大学 | Gip/glp-1双激动剂多肽编码基因、及其重组乳酸菌和应用 |
| TW202521100A (zh) | 2023-11-17 | 2025-06-01 | 美商雅沛尼美德公司（德拉瓦州公司） | 使用ｇｌｐ－１受體促效劑及第二活性劑之組合治療睡眠呼吸中止之方法及組合物 |
| TW202540155A (zh) | 2023-11-30 | 2025-10-16 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1、gip及澱粉素受體之三重促效劑 |
| WO2025125576A2 (en) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| CN120173084A (zh) * | 2023-12-20 | 2025-06-20 | 深圳翰宇药业股份有限公司 | 一种替尔泊肽的合成方法 |
| WO2025133348A1 (en) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| EP4686757A1 (en) | 2024-07-31 | 2026-02-04 | e-therapeutics PLC | Inhibitors of expression and/or function |
| TW202535911A (zh) * | 2024-01-12 | 2025-09-16 | 大陸商杭州中美華東製藥有限公司 | 長效glp-1/gip雙激動劑的藥物組合物 |
| WO2025163674A1 (en) * | 2024-01-30 | 2025-08-07 | Msn Laboratories Private Limited, R&D Center | Process for the preparation of tirzepatide |
| WO2025185605A1 (en) * | 2024-03-05 | 2025-09-12 | Beijing Ql Biopharmaceutical Co., Ltd. | Polypeptide conjugates and methods of uses |
| WO2025191149A1 (en) | 2024-03-15 | 2025-09-18 | Krka, D.D., Novo Mesto | Pharmaceutical composition comprising dual gip and glp-1 receptor agonist |
| WO2025196502A1 (en) | 2024-03-20 | 2025-09-25 | North Carolina Agricultural & Technical State University | Choline kinase inhibitors as a therapeutic treatment for obesity |
| WO2025237168A1 (zh) * | 2024-05-11 | 2025-11-20 | 石药集团百克(山东)生物制药股份有限公司 | Gipr和glp-1r共激动多肽及其用途 |
| WO2025240560A2 (en) | 2024-05-15 | 2025-11-20 | Rose Pharma Inc. | Glp-1 formulations and their uses |
| CN118440155B (zh) * | 2024-07-11 | 2024-11-22 | 中国药科大学 | 一种双激动多肽化合物及其医药用途 |
| US12434008B1 (en) | 2025-02-26 | 2025-10-07 | Genzyme Corporation | Lock ring for a medicament delivery device |
| US12465697B1 (en) | 2025-02-26 | 2025-11-11 | Genzyme Corporation | Medicament delivery device |
| US12539367B1 (en) | 2025-02-26 | 2026-02-03 | Genzyme Corporation | Medicament delivery device |
| US12420017B1 (en) | 2025-02-26 | 2025-09-23 | Genzyme Corporation | Damping device for a medicament delivery device |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050272652A1 (en) * | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
| JP5410020B2 (ja) * | 2005-02-02 | 2014-02-05 | ノヴォ ノルディスク アー／エス | インスリン誘導体 |
| US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
| KR20130133104A (ko) * | 2008-08-07 | 2013-12-05 | 입센 파마 에스.에이.에스 | 포도당 의존적인 인슐린 분비 자극성 폴리펩타이드 유사체 |
| CN106317164A (zh) | 2008-09-12 | 2017-01-11 | 诺沃—诺迪斯克有限公司 | 酰化肽或蛋白的方法 |
| CN101367873B (zh) * | 2008-10-08 | 2011-05-04 | 南开大学 | 一种改构的胰高血糖素样肽-1的类似物和修饰物及其应用 |
| AU2009327418A1 (en) | 2008-12-19 | 2010-06-24 | Indiana University Research And Technology Corporation | Amide based glucagon superfamily peptide prodrugs |
| GB0917072D0 (en) * | 2009-09-29 | 2009-11-11 | Univ Ulster | Peptide analogues of glucagon for diabetes therapy |
| RU2012136450A (ru) | 2010-01-27 | 2014-03-10 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Конъюгаты антагонист глюкагона - агонист gip и композиции для лечения метаболических расстройств и ожирения |
| AR080592A1 (es) | 2010-03-26 | 2012-04-18 | Lilly Co Eli | Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso |
| KR101091041B1 (ko) * | 2010-07-29 | 2011-12-09 | 고려대학교 산학협력단 | 새로운 재조합 글루코스 의존성 인슐린분비 펩타이드(ｒｃＧＩＰ) 작용제 및 그 용도 |
| SG191252A1 (en) * | 2010-12-22 | 2013-07-31 | Marcadia Biotech Inc | Methods for treating metabolic disorders and obesity with gip and glp-1 receptor-active glucagon-based peptides |
| CA2821766A1 (en) | 2010-12-22 | 2012-06-28 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting gip receptor activity |
| DK2694095T3 (en) | 2011-04-05 | 2018-05-28 | Longevity Biotech Inc | COMPOSITIONS COMPREHENSIVE GLUCAGON ANALOGS AND METHODS FOR PREPARING AND USING THE SAME |
| WO2012167744A1 (en) | 2011-06-10 | 2012-12-13 | Beijing Hanmi Pharmaceutical Co., Ltd. | Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof |
| CN103596584B (zh) | 2011-06-15 | 2016-12-14 | 诺沃—诺迪斯克有限公司 | 多取代的胰岛素 |
| JP6352806B2 (ja) * | 2011-09-23 | 2018-07-04 | ノヴォ ノルディスク アー／エス | 新規のグルカゴン類似体 |
| SG11201403377QA (en) * | 2011-12-23 | 2014-07-30 | Zealand Pharma As | Glucagon analogues |
| WO2013164483A1 (en) * | 2012-05-03 | 2013-11-07 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
| RU2015101697A (ru) * | 2012-06-21 | 2016-08-10 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Аналоги глюкагона, обладающие активностью рецептора gip |
| CN104955472A (zh) | 2012-10-17 | 2015-09-30 | 诺和诺德保健股份有限公司 | 用于生长激素递送的脂肪酸酰化的氨基酸 |
| SG10201705097PA (en) | 2012-12-21 | 2017-07-28 | Sanofi Sa | Functionalized exendin-4 derivatives |
| LT3004155T (lt) | 2013-05-28 | 2021-12-27 | Takeda Pharmaceutical Company Limited | Peptidų junginys |
-
2015
- 2015-01-09 JO JOP/2020/0119A patent/JOP20200119A1/ar unknown
- 2015-12-22 TW TW104143220A patent/TWI582109B/zh active
- 2015-12-22 AR ARP150104252A patent/AR103242A1/es active IP Right Grant
- 2015-12-22 JO JOP/2015/0334A patent/JO3575B1/ar active
-
2016
- 2016-01-05 KR KR1020217037823A patent/KR20210145311A/ko not_active Ceased
- 2016-01-05 RS RS20191110A patent/RS59146B1/sr unknown
- 2016-01-05 EA EA202090392A patent/EA202090392A3/ru unknown
- 2016-01-05 MD MDE20170269 patent/MD3242887T2/ro unknown
- 2016-01-05 NZ NZ771043A patent/NZ771043A/en unknown
- 2016-01-05 KR KR1020237004037A patent/KR20230023822A/ko not_active Ceased
- 2016-01-05 CA CA2973352A patent/CA2973352C/en active Active
- 2016-01-05 MY MYPI2017702464A patent/MY193616A/en unknown
- 2016-01-05 US US14/987,791 patent/US9474780B2/en active Active
- 2016-01-05 AU AU2016205435A patent/AU2016205435B2/en active Active
- 2016-01-05 CR CR20170310A patent/CR20170310A/es unknown
- 2016-01-05 KR KR1020197006498A patent/KR102330764B1/ko active Active
- 2016-01-05 LT LT16703620T patent/LT3242887T/lt unknown
- 2016-01-05 NZ NZ771547A patent/NZ771547A/en unknown
- 2016-01-05 ME MEP-2019-238A patent/ME03494B/me unknown
- 2016-01-05 JP JP2016549352A patent/JP6219534B2/ja active Active
- 2016-01-05 EA EA201791281A patent/EA031591B1/ru unknown
- 2016-01-05 HR HRP20191614 patent/HRP20191614T1/hr unknown
- 2016-01-05 MX MX2017008927A patent/MX382753B/es unknown
- 2016-01-05 SG SG11201705603YA patent/SG11201705603YA/en unknown
- 2016-01-05 KR KR1020247028815A patent/KR20240135032A/ko active Pending
- 2016-01-05 DK DK16703620.1T patent/DK3242887T3/da active
- 2016-01-05 IL IL281545A patent/IL281545B2/en unknown
- 2016-01-05 IL IL320236A patent/IL320236A/en unknown
- 2016-01-05 EP EP19188718.1A patent/EP3597662A1/en active Pending
- 2016-01-05 KR KR1020177018584A patent/KR101957620B1/ko active Active
- 2016-01-05 EA EA201892057A patent/EA035055B1/ru unknown
- 2016-01-05 PE PE2017001142A patent/PE20170954A1/es unknown
- 2016-01-05 PH PH1/2017/501252A patent/PH12017501252B1/en unknown
- 2016-01-05 TN TN2017000198A patent/TN2017000198A1/en unknown
- 2016-01-05 WO PCT/US2016/012124 patent/WO2016111971A1/en not_active Ceased
- 2016-01-05 CN CN201680005007.XA patent/CN107207576B/zh active Active
- 2016-01-05 NZ NZ732000A patent/NZ732000A/en unknown
- 2016-01-05 CN CN202011598548.2A patent/CN112608377B/zh active Active
- 2016-01-05 SI SI201630358T patent/SI3242887T1/sl unknown
- 2016-01-05 HU HUE16703620A patent/HUE045860T2/hu unknown
- 2016-01-05 ES ES16703620T patent/ES2747928T3/es active Active
- 2016-01-05 MA MA050422A patent/MA50422A/fr unknown
- 2016-01-05 EP EP16703620.1A patent/EP3242887B1/en active Active
- 2016-01-05 PT PT167036201T patent/PT3242887T/pt unknown
- 2016-01-05 MA MA41315A patent/MA41315B1/fr unknown
- 2016-01-05 PL PL16703620T patent/PL3242887T3/pl unknown
- 2016-05-01 UA UAA201707109A patent/UA118239C2/uk unknown
-
2017
- 2017-05-24 IL IL252499A patent/IL252499B/en active IP Right Grant
- 2017-06-01 SV SV2017005453A patent/SV2017005453A/es unknown
- 2017-06-08 ZA ZA2017/03930A patent/ZA201703930B/en unknown
- 2017-06-22 DO DO2017000153A patent/DOP2017000153A/es unknown
- 2017-07-03 CL CL2017001760A patent/CL2017001760A1/es unknown
- 2017-07-05 CO CONC2017/0006737A patent/CO2017006737A2/es unknown
- 2017-07-05 MX MX2021005835A patent/MX2021005835A/es unknown
- 2017-07-07 EC ECIEPI201743648A patent/ECSP17043648A/es unknown
- 2017-09-27 JP JP2017186721A patent/JP6545766B2/ja active Active
-
2019
- 2019-06-19 JP JP2019113638A patent/JP6754867B2/ja active Active
- 2019-09-12 CY CY20191100957T patent/CY1122028T1/el unknown
-
2020
- 2020-08-04 IL IL276492A patent/IL276492B/en active IP Right Grant
-
2023
- 2023-01-31 FR FR23C1006C patent/FR23C1006I2/fr active Active
- 2023-01-31 HU HUS2300006C patent/HUS2300006I1/hu unknown
- 2023-01-31 LT LTPA2023504C patent/LTC3242887I2/lt unknown
- 2023-01-31 CY CY2023003C patent/CY2023003I2/el unknown
- 2023-02-02 FI FIC20230005C patent/FIC20230005I1/fi unknown
- 2023-02-02 NO NO2023005C patent/NO2023005I1/no unknown
- 2023-02-03 LU LU00296C patent/LUC00296I2/fr unknown
- 2023-02-07 NL NL301217C patent/NL301217I2/nl unknown
-
2024
- 2024-02-15 AR ARP240100340A patent/AR131857A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL276492B (en) | Co-agonistic compounds for gip and glp-1 | |
| IL285231A (en) | Co-agonistic compounds for glucagon and glp-1 | |
| GB201411332D0 (en) | Core positioning | |
| GB2564479B (en) | Pool | |
| GB201501593D0 (en) | New compounds and processes | |
| GB2550676B (en) | Structural Support-Frameworks | |
| GB2532933B (en) | Temporary enclosures | |
| GB2540645B (en) | Starter | |
| GB201509671D0 (en) | Web-winding core | |
| GB201517685D0 (en) | Velcro | |
| GB201517698D0 (en) | Velcro | |
| GB201516922D0 (en) | New processes and compounds | |
| GB201514845D0 (en) | Portable feeder | |
| GB201514285D0 (en) | Velcro | |
| GB201410682D0 (en) | Web-winding core | |
| AU357500S (en) | Alu table | |
| AU357508S (en) | Alu table | |
| AU357412S (en) | Alu table | |
| AU357411S (en) | Alu table | |
| AU357410S (en) | Alu table | |
| AU357409S (en) | Alu table | |
| AU357204S (en) | Alu table |