AR103242A1 - Compuestos co-agonistas de gip y glp-1 - Google Patents
Compuestos co-agonistas de gip y glp-1Info
- Publication number
- AR103242A1 AR103242A1 ARP150104252A ARP150104252A AR103242A1 AR 103242 A1 AR103242 A1 AR 103242A1 AR P150104252 A ARP150104252 A AR P150104252A AR P150104252 A ARP150104252 A AR P150104252A AR 103242 A1 AR103242 A1 AR 103242A1
- Authority
- AR
- Argentina
- Prior art keywords
- gip
- glp
- agonist compounds
- diabetes
- peptide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/645—Secretins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Compuestos miméticos del péptido de incretina dual que agoniza los receptores para tanto el polipéptido insulinotrópico dependiente de la glucosa humana (GIP) y péptido-1 similar al glucagón (GLP-1), y pueden ser útiles para tratar diabetes mellitus tipo 2 (T2D).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562101488P | 2015-01-09 | 2015-01-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR103242A1 true AR103242A1 (es) | 2017-04-26 |
Family
ID=55315708
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150104252A AR103242A1 (es) | 2015-01-09 | 2015-12-22 | Compuestos co-agonistas de gip y glp-1 |
Country Status (45)
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106456589B (zh) | 2013-12-18 | 2020-07-07 | 斯克利普斯研究所 | 修饰的治疗剂、订合的肽脂质缀合物及其组合物 |
TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
WO2018104263A1 (en) | 2016-12-06 | 2018-06-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of enhancing the potency of incretin-based drugs in subjects in need thereof |
JOP20180028A1 (ar) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
EP3624828A4 (en) | 2017-05-18 | 2021-03-03 | Merck Sharp & Dohme Corp. | PHARMACEUTICAL FORMULATION WITH INCRETIN-INSULIN CONJUGATES |
TWI744579B (zh) * | 2017-12-21 | 2021-11-01 | 美商美國禮來大藥廠 | 腸促胰島素(incretin)類似物及其用途 |
TWI810937B (zh) * | 2017-12-21 | 2023-08-01 | 美商美國禮來大藥廠 | 腸促胰島素(incretin)類似物及其用途 |
WO2019140030A1 (en) | 2018-01-12 | 2019-07-18 | Eli Lilly And Company | Combination therapy |
BR112020022027A2 (pt) * | 2018-05-04 | 2021-02-02 | Novo Nordisk A/S | derivados de gip e seus usos |
TWI705820B (zh) * | 2018-06-22 | 2020-10-01 | 美商美國禮來大藥廠 | Gip/glp1促效劑組合物 |
IL308674A (en) * | 2018-07-23 | 2024-01-01 | Lilly Co Eli | Methods of using a GIP/GLP1 co-agonist for diabetes |
CN112469731A (zh) * | 2018-07-23 | 2021-03-09 | 伊莱利利公司 | Gip/glp1共激动剂化合物 |
MA53390A (fr) * | 2018-07-23 | 2021-06-02 | Lilly Co Eli | Procédés d'utilisation d'un co-agoniste de gip/glp1 pour une thérapie |
JP6564539B1 (ja) | 2018-09-14 | 2019-08-21 | 長瀬産業株式会社 | スルホン酸化合物によるペプチド精製方法 |
WO2020067575A1 (en) | 2018-09-24 | 2020-04-02 | Takeda Pharmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
TWI799680B (zh) * | 2019-01-29 | 2023-04-21 | 美商美國禮來大藥廠 | 製備gip/glp1雙重促效劑之方法 |
US11845801B2 (en) | 2019-06-12 | 2023-12-19 | AskGene Pharma, Inc. | IL-15 prodrugs and methods of use thereof |
TWI764209B (zh) * | 2019-08-01 | 2022-05-11 | 美商美國禮來大藥廠 | Gipr促效劑化合物 |
WO2021034815A1 (en) | 2019-08-19 | 2021-02-25 | Eli Lilly And Company | Methods of making incretin analogs |
KR20210040818A (ko) | 2019-10-04 | 2021-04-14 | 한미약품 주식회사 | 글루카곤, 및 glp-1 수용체 및 gip 수용체 이중 작용제를 포함하는 조성물 및 이의 치료학적 용도 |
CN110684082B (zh) * | 2019-10-08 | 2021-12-10 | 江苏诺泰澳赛诺生物制药股份有限公司 | Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途 |
AR120714A1 (es) * | 2019-12-18 | 2022-03-09 | Lilly Co Eli | Análogos de incretina y sus usos |
AR121093A1 (es) | 2020-01-23 | 2022-04-20 | Lilly Co Eli | Compuestos coagonistas de gip / glp1 |
TW202228762A (zh) * | 2020-01-30 | 2022-08-01 | 美商美國禮來大藥廠 | 提派肽(tirzepatide)之治療用途 |
CN111253475B (zh) * | 2020-02-18 | 2021-03-09 | 江苏诺泰澳赛诺生物制药股份有限公司 | Glp-1激动多肽化合物及其盐与合成方法及用途 |
MX2022011089A (es) | 2020-03-06 | 2022-10-03 | Sanofi Sa | Peptidos como agonistas selectivos del receptor de gip. |
CN113493503B (zh) * | 2020-04-08 | 2022-08-05 | 浙江道尔生物科技有限公司 | 一种肠促胰岛素类似物及其制备方法和用途 |
TW202216746A (zh) | 2020-06-22 | 2022-05-01 | 印度商太陽製藥工業有限公司 | 長效型glp-1/gip雙重促效劑 |
EP4185606A1 (en) | 2020-07-22 | 2023-05-31 | Novo Nordisk A/S | Glp-1 and gip receptor co-agonists |
US20220177538A1 (en) * | 2020-07-22 | 2022-06-09 | Novo Nordisk A/S | Co-agonists at glp-1 and gip receptors suitable for oral delivery |
EP4222176A4 (en) * | 2020-09-30 | 2024-02-28 | Beijing Ql Biopharmaceutical Co Ltd | POLYPEPTIDE CONJUGATES AND METHODS OF USE |
EP4204440A1 (en) | 2020-10-17 | 2023-07-05 | Sun Pharmaceutical Industries Limited | Glp-1/gip dual agonists |
JP2023552362A (ja) * | 2020-12-02 | 2023-12-15 | ドンバオ パープル スター (ハンチョウ) バイオファーマシューティカル シーオー.,エルティーディー. | ラクタム修飾を含むポリペプチド化合物 |
EP4281464A1 (en) * | 2021-01-20 | 2023-11-29 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
EP4294423A1 (en) * | 2021-02-17 | 2023-12-27 | Eli Lilly and Company | Gip/glp1 dual agonist therapeutic methods |
EP4294419A2 (en) | 2021-02-17 | 2023-12-27 | Eli Lilly And Co. | Tirzepatide therapeutic methods |
US20240150425A1 (en) * | 2021-03-25 | 2024-05-09 | Brightgene Bio-Medical Technology Co., Ltd. | Gip and glp-1 dual receptor agonist, pharmaceutical composition, and use |
JP2024511107A (ja) * | 2021-03-25 | 2024-03-12 | ブライトジーン バイオ-メディカル テクノロジー カンパニー リミテッド | Gipとglp-1の二重受容体作動薬、医薬組成物および使用 |
MX2023013144A (es) | 2021-05-07 | 2023-11-28 | Eli Lilly And Company | Tableta erosionable. |
WO2022247950A1 (zh) * | 2021-05-28 | 2022-12-01 | 广东众生睿创生物科技有限公司 | 多肽的制备及其应用 |
CA3222051A1 (en) * | 2021-06-01 | 2022-12-08 | Nanjing Zhihe Medicine Technology Co., Ltd. | Polypeptide derivative having effect of dual targeted activation of glp-1r and gipr, preparation method therefor, and use thereof |
WO2022262825A1 (zh) * | 2021-06-18 | 2022-12-22 | 南京明德新药研发有限公司 | 含内酰胺桥的多肽化合物 |
CN118159552A (zh) | 2021-09-06 | 2024-06-07 | 赛诺菲 | 作为强效的且选择性的gip受体激动剂的新肽 |
KR20240055145A (ko) * | 2021-09-15 | 2024-04-26 | 바이킹 테라퓨틱스 인코포레이티드 | 대사 및 간 장애의 치료를 위한 조성물 및 방법 |
EP4299057A1 (en) | 2022-06-30 | 2024-01-03 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
WO2023084118A1 (en) | 2021-11-15 | 2023-05-19 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
EP4180060A1 (en) | 2021-11-15 | 2023-05-17 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
WO2023089594A1 (en) | 2021-11-22 | 2023-05-25 | Sun Pharmaceutical Industries Limited | Process for the preparation of tirzepatide or pharmaceutically acceptable salt thereof |
TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
WO2023193727A1 (zh) * | 2022-04-07 | 2023-10-12 | 广东众生睿创生物科技有限公司 | 多肽在制备治疗和/或预防糖尿病及肥胖症及其相关疾病药物中的制药用途 |
WO2024006662A1 (en) | 2022-06-30 | 2024-01-04 | Eli Lilly And Company | Tirzepatide compositions and use |
EP4299052A1 (en) | 2022-06-30 | 2024-01-03 | Adocia | Solid compositions comprising a peptide or a protein and a permeation enhancer |
EP4299071A1 (en) | 2022-07-01 | 2024-01-03 | Adocia | Compositions comprising a peptide or a protein and an acylated amino acid |
CN117402219A (zh) * | 2022-07-13 | 2024-01-16 | 杭州中美华东制药有限公司 | Glp-1/gip双激动剂及其制备方法和用途 |
WO2024020388A1 (en) * | 2022-07-20 | 2024-01-25 | Viking Therapeutics, Inc. | Pharmaceutical formulations and methods for the treatment of metabolic and liver disorders |
WO2024050289A1 (en) | 2022-08-29 | 2024-03-07 | Eli Lilly And Company | Compositions for oral delivery |
WO2024059674A1 (en) | 2022-09-15 | 2024-03-21 | Eli Lilly And Company | Gip and glp-1 dual agonist compounds |
WO2024061310A1 (zh) * | 2022-09-23 | 2024-03-28 | 博瑞生物医药(苏州)股份有限公司 | 一种glp-1和gip双受体激动剂药物组合物及其用途 |
WO2024077149A2 (en) | 2022-10-05 | 2024-04-11 | Eli Lilly And Company | Peptides for incretin synthesis |
CN117756913A (zh) * | 2022-11-07 | 2024-03-26 | 内蒙古博睿精创科技有限公司 | 一种新型长效多肽化合物、组合物及其应用 |
WO2024112617A2 (en) | 2022-11-21 | 2024-05-30 | Eli Lilly And Company | Process for preparing a gip/glp1 dual agonist |
CN116832141B (zh) * | 2023-06-06 | 2024-02-09 | 诺博泰科(成都)生物科技有限公司 | 一种用于治疗糖尿病的glp-1、gip和gcg受体三激动多肽化合物 |
CN116693652B (zh) * | 2023-08-02 | 2024-01-05 | 北京惠之衡生物科技有限公司 | 一种glp-1/gip受体双重激动剂衍生物及其制备方法和应用 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050272652A1 (en) * | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
US20080171695A1 (en) * | 2005-02-02 | 2008-07-17 | Novo Nordisk A/S | Insulin Derivatives |
US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
CN102170895A (zh) * | 2008-08-07 | 2011-08-31 | 益普生制药股份有限公司 | 葡萄糖依赖性促胰岛素多肽类似物 |
ES2561208T3 (es) | 2008-09-12 | 2016-02-25 | Novo Nordisk A/S | Método de acilación de un péptido o una proteína |
CN101367873B (zh) * | 2008-10-08 | 2011-05-04 | 南开大学 | 一种改构的胰高血糖素样肽-1的类似物和修饰物及其应用 |
PE20120332A1 (es) | 2008-12-19 | 2012-04-14 | Univ Indiana Res & Tech Corp | Profarmacos de peptido de la superfamilia de glucagon basado en amida |
GB0917072D0 (en) * | 2009-09-29 | 2009-11-11 | Univ Ulster | Peptide analogues of glucagon for diabetes therapy |
US8551946B2 (en) | 2010-01-27 | 2013-10-08 | Indiana University Research And Technology Corporation | Glucagon antagonist-GIP agonist conjugates and compositions for the treatment of metabolic disorders and obesity |
AR080592A1 (es) * | 2010-03-26 | 2012-04-18 | Lilly Co Eli | Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso |
KR101091041B1 (ko) * | 2010-07-29 | 2011-12-09 | 고려대학교 산학협력단 | 새로운 재조합 글루코스 의존성 인슐린분비 펩타이드(rcGIP) 작용제 및 그 용도 |
CN103458920B (zh) | 2010-12-22 | 2016-07-06 | 印第安那大学科技研究公司 | 表现出gip受体活性的胰高血糖素类似物 |
CN103402536A (zh) * | 2010-12-22 | 2013-11-20 | 马克迪亚生物科技公司 | 用gip和glp-1受体活性的基于胰高血糖素的肽来治疗代谢异常和肥胖的方法 |
US9790262B2 (en) | 2011-04-05 | 2017-10-17 | Longevity Biotech, Inc. | Compositions comprising glucagon analogs and methods of making and using the same |
KR102002783B1 (ko) | 2011-06-10 | 2019-07-24 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | 포도당 의존성 인슐리노트로핀 폴리펩타이드 유사물질, 이의 약학적 조성물 및 응용 |
JP6058646B2 (ja) | 2011-06-15 | 2017-01-11 | ノヴォ ノルディスク アー/エス | 多置換インスリン |
JP6352806B2 (ja) * | 2011-09-23 | 2018-07-04 | ノヴォ ノルディスク アー/エス | 新規のグルカゴン類似体 |
JP2015502380A (ja) * | 2011-12-23 | 2015-01-22 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
EP2844669B1 (en) * | 2012-05-03 | 2018-08-01 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
JP6311708B2 (ja) | 2012-06-21 | 2018-04-18 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | Gip受容体活性を示すグルカゴンアナローグ |
EP2908845A1 (en) | 2012-10-17 | 2015-08-26 | Novo Nordisk Health Care AG | Fatty acid acylated amino acids for growth hormone delivery |
EP2934569A1 (en) | 2012-12-21 | 2015-10-28 | Sanofi | Exendin-4 derivatives |
PE20151770A1 (es) * | 2013-05-28 | 2015-12-11 | Takeda Pharmaceutical | Compuesto peptidico |
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2015
- 2015-01-09 JO JOP/2020/0119A patent/JOP20200119A1/ar unknown
- 2015-12-22 JO JOP/2015/0334A patent/JO3575B1/ar active
- 2015-12-22 TW TW104143220A patent/TWI582109B/zh active
- 2015-12-22 AR ARP150104252A patent/AR103242A1/es unknown
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2016
- 2016-01-05 KR KR1020177018584A patent/KR101957620B1/ko active IP Right Grant
- 2016-01-05 MA MA41315A patent/MA41315B1/fr unknown
- 2016-01-05 KR KR1020217037823A patent/KR20210145311A/ko not_active Application Discontinuation
- 2016-01-05 ES ES16703620T patent/ES2747928T3/es active Active
- 2016-01-05 US US14/987,791 patent/US9474780B2/en active Active
- 2016-01-05 MY MYPI2017702464A patent/MY193616A/en unknown
- 2016-01-05 PE PE2017001142A patent/PE20170954A1/es unknown
- 2016-01-05 CN CN201680005007.XA patent/CN107207576B/zh active Active
- 2016-01-05 WO PCT/US2016/012124 patent/WO2016111971A1/en active Application Filing
- 2016-01-05 PL PL16703620T patent/PL3242887T3/pl unknown
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