ME03494B - Spojevi koji su suagonisti gip i glp-1 - Google Patents

Spojevi koji su suagonisti gip i glp-1

Info

Publication number
ME03494B
ME03494B MEP-2019-238A MEP2019238A ME03494B ME 03494 B ME03494 B ME 03494B ME P2019238 A MEP2019238 A ME P2019238A ME 03494 B ME03494 B ME 03494B
Authority
ME
Montenegro
Prior art keywords
gip
glp
agonist compounds
agonist
compounds
Prior art date
Application number
MEP-2019-238A
Other languages
German (de)
English (en)
French (fr)
Inventor
Jorge Alsina-Fernandez
Bengt Krister Bokvist
Tamer Coskun
Robert Chadwick Cummins
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55315708&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME03494(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ME03494B publication Critical patent/ME03494B/me

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/645Secretins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
MEP-2019-238A 2015-01-09 2016-01-05 Spojevi koji su suagonisti gip i glp-1 ME03494B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562101488P 2015-01-09 2015-01-09
EP16703620.1A EP3242887B1 (en) 2015-01-09 2016-01-05 Gip and glp-1 co-agonist compounds
PCT/US2016/012124 WO2016111971A1 (en) 2015-01-09 2016-01-05 Gip and glp-1 co-agonist compounds

Publications (1)

Publication Number Publication Date
ME03494B true ME03494B (me) 2020-01-20

Family

ID=55315708

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2019-238A ME03494B (me) 2015-01-09 2016-01-05 Spojevi koji su suagonisti gip i glp-1

Country Status (45)

Country Link
US (1) US9474780B2 (me)
EP (2) EP3597662A1 (me)
JP (3) JP6219534B2 (me)
KR (5) KR101957620B1 (me)
CN (2) CN107207576B (me)
AR (1) AR103242A1 (me)
AU (1) AU2016205435B2 (me)
CA (1) CA2973352C (me)
CL (1) CL2017001760A1 (me)
CO (1) CO2017006737A2 (me)
CR (1) CR20170310A (me)
CY (2) CY1122028T1 (me)
DK (1) DK3242887T3 (me)
DO (1) DOP2017000153A (me)
EA (3) EA035055B1 (me)
EC (1) ECSP17043648A (me)
ES (1) ES2747928T3 (me)
FI (1) FIC20230005I1 (me)
FR (1) FR23C1006I2 (me)
HR (1) HRP20191614T1 (me)
HU (2) HUE045860T2 (me)
IL (3) IL252499B (me)
JO (2) JOP20200119A1 (me)
LT (2) LT3242887T (me)
MA (2) MA50422A (me)
MD (1) MD3242887T2 (me)
ME (1) ME03494B (me)
MX (2) MX2017008927A (me)
MY (1) MY193616A (me)
NL (1) NL301217I2 (me)
NO (1) NO2023005I1 (me)
NZ (1) NZ732000A (me)
PE (1) PE20170954A1 (me)
PH (1) PH12017501252A1 (me)
PL (1) PL3242887T3 (me)
PT (1) PT3242887T (me)
RS (1) RS59146B1 (me)
SG (1) SG11201705603YA (me)
SI (1) SI3242887T1 (me)
SV (1) SV2017005453A (me)
TN (1) TN2017000198A1 (me)
TW (1) TWI582109B (me)
UA (1) UA118239C2 (me)
WO (1) WO2016111971A1 (me)
ZA (1) ZA201703930B (me)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6572497B2 (ja) 2013-12-18 2019-09-11 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、ステープル留めされたペプチド脂質複合体、及びそれらの組成物
TWI622596B (zh) 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
US11285180B2 (en) 2016-12-06 2022-03-29 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods of enhancing the potency of incretin-based drugs in subjects in need thereof
JOP20180028A1 (ar) 2017-03-31 2019-01-30 Takeda Pharmaceuticals Co مركب ببتيد
WO2018213151A1 (en) * 2017-05-18 2018-11-22 Merck Sharp & Dohme Corp. Pharmaceutical formulation comprising incretin-insulin conjugates
TWI767095B (zh) * 2017-12-21 2022-06-11 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
AR113486A1 (es) * 2017-12-21 2020-05-06 Lilly Co Eli Análogos de incretina y sus usos
WO2019140030A1 (en) * 2018-01-12 2019-07-18 Eli Lilly And Company Combination therapy
WO2019149880A1 (en) 2018-02-02 2019-08-08 Novo Nordisk A/S Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant
JP6818940B2 (ja) * 2018-05-04 2021-01-27 ノヴォ ノルディスク アー/エス Gip誘導体およびその使用
TWI705820B (zh) * 2018-06-22 2020-10-01 美商美國禮來大藥廠 Gip/glp1促效劑組合物
TWI735917B (zh) * 2018-07-23 2021-08-11 美商美國禮來大藥廠 Gip/glp1共促效劑化合物
WO2020023388A1 (en) * 2018-07-23 2020-01-30 Eli Lilly And Company Method of using a gip/glp1 co-agonist for diabetes
EP3826716A1 (en) * 2018-07-23 2021-06-02 Eli Lilly and Company Methods of using a gip/glp1 co-agonist for therapy
JP6564539B1 (ja) 2018-09-14 2019-08-21 長瀬産業株式会社 スルホン酸化合物によるペプチド精製方法
EP3856339A1 (en) 2018-09-24 2021-08-04 Takeda Pharmaceutical Company Limited Gip receptor agonist peptide compounds and uses thereof
JP2022510691A (ja) 2018-12-05 2022-01-27 バイキング・セラピューティクス・インコーポレイテッド 線維症及び炎症の処置のための組成物
TWI799680B (zh) * 2019-01-29 2023-04-21 美商美國禮來大藥廠 製備gip/glp1雙重促效劑之方法
WO2020252264A1 (en) 2019-06-12 2020-12-17 AskGene Pharma, Inc. Novel il-15 prodrugs and methods of use thereof
AR119471A1 (es) 2019-08-01 2021-12-22 Lilly Co Eli Compuestos agonistas de gipr
AU2020334993B2 (en) 2019-08-19 2023-07-13 Eli Lilly And Company Methods of making incretin analogs
EP4043026A4 (en) 2019-10-04 2024-01-10 Hanmi Pharm. Co., Ltd. GLUCAGON, GLP-1 RECEPTOR AND DGIP RECEPTOR DUAL AGONIST COMPOSITION AND THERAPEUTIC USE THEREOF
CN110684082B (zh) * 2019-10-08 2021-12-10 江苏诺泰澳赛诺生物制药股份有限公司 Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途
AR120714A1 (es) * 2019-12-18 2022-03-09 Lilly Co Eli Análogos de incretina y sus usos
CA3165430A1 (en) 2020-01-23 2021-07-29 Jorge Alsina-Fernandez Gip/glp1 co-agonist compounds
TW202140058A (zh) * 2020-01-30 2021-11-01 美商美國禮來大藥廠 提派肽(tirzepatide)之治療用途
CN111253475B (zh) * 2020-02-18 2021-03-09 江苏诺泰澳赛诺生物制药股份有限公司 Glp-1激动多肽化合物及其盐与合成方法及用途
KR20220145888A (ko) 2020-03-06 2022-10-31 사노피 선택적 gip 수용체 작용제로서의 펩티드
CN113493503B (zh) * 2020-04-08 2022-08-05 浙江道尔生物科技有限公司 一种肠促胰岛素类似物及其制备方法和用途
TW202216746A (zh) 2020-06-22 2022-05-01 印度商太陽製藥工業有限公司 長效型glp-1/gip雙重促效劑
JP2023534130A (ja) 2020-07-22 2023-08-08 ノヴォ ノルディスク アー/エス Glp-1受容体およびgip受容体共作動薬
MX2023000303A (es) 2020-07-22 2023-02-09 Novo Nordisk As Coagonistas de los receptores del peptido 1 similar al glucagon (glp-1) y del polipeptido insulinotropico dependiente de glucosa (gip) adecuados para el suministro oral.
CA3193453A1 (en) * 2020-09-30 2022-04-07 Beijing Ql Biopharmaceutical Co., Ltd. Polypeptide conjugates and methods of uses
BR112023003668A2 (pt) 2020-10-17 2023-04-25 Sun Pharmaceutical Ind Ltd Agonistas duplos de glp-1/gip
MX2023006419A (es) * 2020-12-02 2023-08-15 Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd Compuestos polipéptidos modificados con lactama.
MX2023008330A (es) * 2021-01-20 2024-01-18 Viking Therapeutics Inc Agonistas del receptor dual gip/glp-1 de molécula pequeña, composiciones farmacéuticas y preparación de las mismas para usarse en el tratamiento de trastornos metabólicos y hepáticos.
WO2022177744A1 (en) * 2021-02-17 2022-08-25 Eli Lilly And Company Gip/glp1 dual agonist therapeutic methods
EP4294419A2 (en) 2021-02-17 2023-12-27 Eli Lilly And Co. Tirzepatide therapeutic methods
KR20230160369A (ko) * 2021-03-25 2023-11-23 브라이트제네 바이오-메디컬 테크놀로지 코., 엘티디. Gip 및 glp-1의 이중 수용체 작용제, 약물 조성물 및 용도
US20240150425A1 (en) * 2021-03-25 2024-05-09 Brightgene Bio-Medical Technology Co., Ltd. Gip and glp-1 dual receptor agonist, pharmaceutical composition, and use
JP2024518058A (ja) 2021-05-07 2024-04-24 イーライ リリー アンド カンパニー 浸食性錠剤
KR20230154234A (ko) * 2021-05-28 2023-11-07 광둥 레이노벤트 바이오테크 컴퍼니 리미티드 폴리펩티드의 제조 및 이의 용도
EP4345105A1 (en) * 2021-06-01 2024-04-03 Nanjing Zhine Medicine Technology Co., Ltd. Polypeptide derivative having effect of dual targeted activation of glp-1r and gipr, preparation method therefor, and use thereof
WO2022262825A1 (zh) * 2021-06-18 2022-12-22 南京明德新药研发有限公司 含内酰胺桥的多肽化合物
CA3230915A1 (en) 2021-09-06 2023-03-09 Thomas Boehme New peptides as potent and selective gip receptor agonists
US20240239843A1 (en) * 2021-09-15 2024-07-18 Viking Therapeutics, Inc. Compositions and methods for the treatment of metabolic and liver disorders
EP4433093A1 (en) 2021-11-15 2024-09-25 Adocia Solid compositions comprising a peptide or a protein and an acylated amino acid
EP4180060A1 (en) 2021-11-15 2023-05-17 Adocia Solid compositions comprising a peptide or a protein and an acylated amino acid
EP4299057A1 (en) 2022-06-30 2024-01-03 Adocia Solid compositions comprising a peptide or a protein and an acylated amino acid
EP4436991A1 (en) 2021-11-22 2024-10-02 Sun Pharmaceutical Industries Limited Process for the preparation of tirzepatide or pharmaceutically acceptable salt thereof
TW202330584A (zh) 2022-01-20 2023-08-01 丹麥商諾佛 儂迪克股份有限公司 前藥及其用途
WO2023193727A1 (zh) * 2022-04-07 2023-10-12 广东众生睿创生物科技有限公司 多肽在制备治疗和/或预防糖尿病及肥胖症及其相关疾病药物中的制药用途
EP4299052A1 (en) 2022-06-30 2024-01-03 Adocia Solid compositions comprising a peptide or a protein and a permeation enhancer
WO2024006662A1 (en) 2022-06-30 2024-01-04 Eli Lilly And Company Tirzepatide compositions and use
EP4299071A1 (en) 2022-07-01 2024-01-03 Adocia Compositions comprising a peptide or a protein and an acylated amino acid
WO2024012472A1 (zh) * 2022-07-13 2024-01-18 杭州中美华东制药有限公司 Glp-1/gip双激动剂及其制备方法和用途
WO2024020388A1 (en) * 2022-07-20 2024-01-25 Viking Therapeutics, Inc. Pharmaceutical formulations and methods for the treatment of metabolic and liver disorders
WO2024050289A1 (en) 2022-08-29 2024-03-07 Eli Lilly And Company Compositions for oral delivery
WO2024059674A1 (en) * 2022-09-15 2024-03-21 Eli Lilly And Company Gip and glp-1 dual agonist compounds
TW202412835A (zh) * 2022-09-23 2024-04-01 大陸商博瑞生物醫藥(蘇州)股份有限公司 一種glp-1和gip雙受體激動劑藥物組合物及其用途
WO2024077149A2 (en) 2022-10-05 2024-04-11 Eli Lilly And Company Peptides for incretin synthesis
WO2024098718A1 (zh) * 2022-11-07 2024-05-16 内蒙古博睿精创科技有限公司 一种新型长效多肽化合物、组合物及其应用
WO2024112617A2 (en) 2022-11-21 2024-05-30 Eli Lilly And Company Process for preparing a gip/glp1 dual agonist
WO2024145638A2 (en) 2022-12-29 2024-07-04 Eli Lilly And Company Processes and intermediates for preparing tirzepatide
WO2024141760A1 (en) 2022-12-30 2024-07-04 Algipharma As Compositions and methods to increase the systemic bioavailability of a polypeptide therapeutic agent undergoing oral administration
US20240270821A1 (en) 2023-01-31 2024-08-15 Eli Lilly And Company Gip/glp1/gcg tri-receptor agonists and uses thereof
WO2024165571A2 (en) 2023-02-06 2024-08-15 E-Therapeutics Plc Inhibitors of expression and/or function
WO2024192219A1 (en) * 2023-03-15 2024-09-19 Viking Therapeutics, Inc. Pharmaceutical compositions and methods for the treatment of metabolic and liver disorders
CN118684758A (zh) * 2023-03-23 2024-09-24 上海民为生物技术有限公司 肠促胰岛素类似物及其应用
WO2024206552A1 (en) 2023-03-31 2024-10-03 Eli Lilly And Company Tirzepatide for use in treating t2d
CN116832141B (zh) * 2023-06-06 2024-02-09 诺博泰科(成都)生物科技有限公司 一种用于治疗糖尿病的glp-1、gip和gcg受体三激动多肽化合物
CN116693652B (zh) * 2023-08-02 2024-01-05 北京惠之衡生物科技有限公司 一种glp-1/gip受体双重激动剂衍生物及其制备方法和应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050272652A1 (en) * 1999-03-29 2005-12-08 Gault Victor A Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
EP2292653B1 (en) 2005-02-02 2014-05-21 Novo Nordisk A/S Novel insulin derivatives
US20100317057A1 (en) 2007-12-28 2010-12-16 Novo Nordisk A/S Semi-recombinant preparation of glp-1 analogues
US9072703B2 (en) * 2008-08-07 2015-07-07 Ipsen Pharma S.A.S. Glucose-dependent insulinotropic polypeptide analogues
JP5591243B2 (ja) 2008-09-12 2014-09-17 ノボ・ノルデイスク・エー/エス ペプチド又はタンパク質のアシル化の方法
CN101367873B (zh) * 2008-10-08 2011-05-04 南开大学 一种改构的胰高血糖素样肽-1的类似物和修饰物及其应用
WO2010071807A1 (en) 2008-12-19 2010-06-24 Indiana University Research And Technology Corporation Amide based glucagon superfamily peptide prodrugs
GB0917072D0 (en) * 2009-09-29 2009-11-11 Univ Ulster Peptide analogues of glucagon for diabetes therapy
EP2528618A4 (en) 2010-01-27 2015-05-27 Univ Indiana Res & Tech Corp GLUCAGON ANTAGONISTE AND GIP AGONISTS CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES AND ADIPOSITAS
AR080592A1 (es) * 2010-03-26 2012-04-18 Lilly Co Eli Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso
KR101091041B1 (ko) * 2010-07-29 2011-12-09 고려대학교 산학협력단 새로운 재조합 글루코스 의존성 인슐린분비 펩타이드(rcGIP) 작용제 및 그 용도
EP2654774A4 (en) * 2010-12-22 2015-07-01 Marcadia Biotech Inc METHOD FOR THE TREATMENT OF METABOLISM DISEASES AND ADIPOSITAS WITH GIP AND GLP-1 RECEPTOR ACTIVE PUCIDIDES ON GLUCAGON BASIS
CN103458920B (zh) 2010-12-22 2016-07-06 印第安那大学科技研究公司 表现出gip受体活性的胰高血糖素类似物
WO2012138941A1 (en) 2011-04-05 2012-10-11 Longevity Biotech, Inc. Compositions comprising glucagon analogs and methods of making and using the same
EP2718317B1 (en) 2011-06-10 2018-11-14 Beijing Hanmi Pharmaceutical Co., Ltd. Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof
US9260503B2 (en) 2011-06-15 2016-02-16 Novo Nordisk A/S Multi-substituted insulins
TWI596110B (zh) * 2011-09-23 2017-08-21 諾佛 儂迪克股份有限公司 新穎升糖素類似物
AU2012357739A1 (en) * 2011-12-23 2014-07-03 Boehringer Ingelheim International Gmbh Glucagon analogues
NZ702333A (en) 2012-05-03 2017-06-30 Zealand Pharma As Gip-glp-1 dual agonist compounds and methods
RU2015101697A (ru) 2012-06-21 2016-08-10 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Аналоги глюкагона, обладающие активностью рецептора gip
JP2015536314A (ja) 2012-10-17 2015-12-21 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 成長ホルモン送達のための脂肪酸アシル化アミノ酸
HUE035803T2 (en) 2012-12-21 2018-05-28 Sanofi Sa Dual GLP1 / GIP or trigonal GLP1 / GIP / glucagon agonists
ES2900744T3 (es) 2013-05-28 2022-03-18 Takeda Pharmaceuticals Co Compuesto de péptidos

Also Published As

Publication number Publication date
PL3242887T3 (pl) 2020-02-28
JP2017507124A (ja) 2017-03-16
CA2973352C (en) 2019-03-26
TW201636362A (zh) 2016-10-16
ES2747928T3 (es) 2020-03-12
EA031591B1 (ru) 2019-01-31
SV2017005453A (es) 2018-08-27
EA201892057A1 (ru) 2019-02-28
EA202090392A3 (ru) 2020-08-31
KR102330764B1 (ko) 2021-11-25
US9474780B2 (en) 2016-10-25
JOP20200119A1 (ar) 2017-06-16
EP3597662A1 (en) 2020-01-22
ZA201703930B (en) 2019-06-26
UA118239C2 (uk) 2018-12-10
MA41315B1 (fr) 2019-11-29
HUE045860T2 (hu) 2020-01-28
RS59146B1 (sr) 2019-09-30
JP2019203000A (ja) 2019-11-28
CN107207576B (zh) 2020-11-24
CN107207576A (zh) 2017-09-26
KR20170092661A (ko) 2017-08-11
MX2021005835A (es) 2021-07-15
TN2017000198A1 (en) 2018-10-19
MA50422A (fr) 2020-08-26
EP3242887A1 (en) 2017-11-15
JP6754867B2 (ja) 2020-09-16
MD3242887T2 (ro) 2019-11-30
CY2023003I2 (el) 2023-06-09
SI3242887T1 (sl) 2019-10-30
JP6219534B2 (ja) 2017-10-25
JP6545766B2 (ja) 2019-07-17
IL281545A (en) 2021-05-31
SG11201705603YA (en) 2017-08-30
KR20210145311A (ko) 2021-12-01
KR20190026967A (ko) 2019-03-13
BR112017010596A2 (pt) 2018-03-06
HRP20191614T1 (hr) 2019-12-13
EA201791281A1 (ru) 2017-11-30
AU2016205435A1 (en) 2017-06-08
PT3242887T (pt) 2019-10-29
FR23C1006I2 (fr) 2024-01-05
CY2023003I1 (el) 2023-03-24
EA202090392A2 (ru) 2020-05-31
IL252499A0 (en) 2017-07-31
DOP2017000153A (es) 2017-07-15
KR20240135032A (ko) 2024-09-10
JP2018052933A (ja) 2018-04-05
NO2023005I1 (no) 2023-02-02
NZ732000A (en) 2018-11-30
MY193616A (en) 2022-10-20
FR23C1006I1 (fr) 2023-03-24
CL2017001760A1 (es) 2018-03-16
LTPA2023504I1 (me) 2023-02-27
MX2017008927A (es) 2017-10-11
CY1122028T1 (el) 2020-10-14
KR20230023822A (ko) 2023-02-17
PH12017501252A1 (en) 2017-10-30
AR103242A1 (es) 2017-04-26
PE20170954A1 (es) 2017-07-13
LT3242887T (lt) 2019-11-11
NZ748274A (en) 2022-03-25
NL301217I1 (me) 2023-02-15
IL276492A (en) 2020-09-30
NL301217I2 (nl) 2023-04-04
EA035055B1 (ru) 2020-04-22
CN112608377B (zh) 2024-02-13
ECSP17043648A (es) 2017-11-30
HUS2300006I1 (hu) 2023-02-28
IL276492B (en) 2021-04-29
CN112608377A (zh) 2021-04-06
KR101957620B1 (ko) 2019-03-13
AU2016205435B2 (en) 2018-03-29
MA41315A (fr) 2017-11-15
WO2016111971A1 (en) 2016-07-14
CR20170310A (es) 2017-08-17
DK3242887T3 (da) 2019-09-02
IL252499B (en) 2020-08-31
FIC20230005I1 (fi) 2023-02-02
JO3575B1 (ar) 2020-07-05
TWI582109B (zh) 2017-05-11
CO2017006737A2 (es) 2017-09-29
CA2973352A1 (en) 2016-07-14
US20160199438A1 (en) 2016-07-14
EP3242887B1 (en) 2019-08-14

Similar Documents

Publication Publication Date Title
HUS2300006I1 (hu) GIP és GLP-1 ko-agonista vegyületek
IL285231A (en) Co-agonistic compounds for glucagon and glp-1
GB201411332D0 (en) Core positioning
GB201501593D0 (en) New compounds and processes
GB2540645B (en) Starter
GB2532933B (en) Temporary enclosures
GB201517685D0 (en) Velcro
GB201517698D0 (en) Velcro
GB201516922D0 (en) New processes and compounds
GB201514845D0 (en) Portable feeder
GB201509671D0 (en) Web-winding core
GB201514285D0 (en) Velcro
GB201410682D0 (en) Web-winding core
AU357508S (en) Alu table
AU357500S (en) Alu table
AU357409S (en) Alu table
AU357411S (en) Alu table
AU357412S (en) Alu table
AU357410S (en) Alu table
AU357204S (en) Alu table