ME03494B - Spojevi koji su suagonisti gip i glp-1 - Google Patents
Spojevi koji su suagonisti gip i glp-1Info
- Publication number
- ME03494B ME03494B MEP-2019-238A MEP2019238A ME03494B ME 03494 B ME03494 B ME 03494B ME P2019238 A MEP2019238 A ME P2019238A ME 03494 B ME03494 B ME 03494B
- Authority
- ME
- Montenegro
- Prior art keywords
- gip
- glp
- agonist compounds
- agonist
- compounds
- Prior art date
Links
- 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/645—Secretins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Child & Adolescent Psychology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562101488P | 2015-01-09 | 2015-01-09 | |
| EP16703620.1A EP3242887B1 (en) | 2015-01-09 | 2016-01-05 | Gip and glp-1 co-agonist compounds |
| PCT/US2016/012124 WO2016111971A1 (en) | 2015-01-09 | 2016-01-05 | Gip and glp-1 co-agonist compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME03494B true ME03494B (me) | 2020-01-20 |
Family
ID=55315708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2019-238A ME03494B (me) | 2015-01-09 | 2016-01-05 | Spojevi koji su suagonisti gip i glp-1 |
Country Status (46)
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4212180A1 (en) | 2013-12-18 | 2023-07-19 | The Scripps Research Institute | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| WO2018104263A1 (en) | 2016-12-06 | 2018-06-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of enhancing the potency of incretin-based drugs in subjects in need thereof |
| JOP20180028A1 (ar) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
| US11590237B2 (en) | 2017-05-18 | 2023-02-28 | Merck Sharp & Dohme Llc | Pharmaceutical formulation comprising incretin-insulin conjugates |
| KR102665710B1 (ko) | 2017-08-24 | 2024-05-14 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 그 용도 |
| TWI767095B (zh) * | 2017-12-21 | 2022-06-11 | 美商美國禮來大藥廠 | 腸促胰島素(incretin)類似物及其用途 |
| AR113486A1 (es) * | 2017-12-21 | 2020-05-06 | Lilly Co Eli | Análogos de incretina y sus usos |
| WO2019140030A1 (en) | 2018-01-12 | 2019-07-18 | Eli Lilly And Company | Combination therapy |
| KR102647171B1 (ko) | 2018-02-02 | 2024-03-15 | 노보 노르디스크 에이/에스 | Glp-1 작용제 및 n-(8-(2-하이드록시벤조일)아미노)카프릴산의 염을 포함하는 고형 조성물 |
| AU2019238090B2 (en) | 2018-03-22 | 2024-08-01 | Viking Therapeutics, Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
| MA52483A (fr) * | 2018-05-04 | 2021-03-10 | Novo Nordisk As | Dérivés de gip et leurs utilisations |
| TWI705820B (zh) * | 2018-06-22 | 2020-10-01 | 美商美國禮來大藥廠 | Gip/glp1促效劑組合物 |
| KR20210031533A (ko) * | 2018-07-23 | 2021-03-19 | 일라이 릴리 앤드 캄파니 | Gip/glp1 공효능제 화합물 |
| EP3826662B9 (en) * | 2018-07-23 | 2025-02-19 | Eli Lilly and Company | Method of using a gip/glp1 co-agonist for diabetes |
| TW202432173A (zh) | 2018-07-23 | 2024-08-16 | 美商美國禮來大藥廠 | 使用gip/glp1共促效劑之療法 |
| WO2020023702A1 (en) | 2018-07-25 | 2020-01-30 | AskGene Pharma, Inc. | Novel il-21 prodrugs and methods of use thereof |
| JP6564539B1 (ja) | 2018-09-14 | 2019-08-21 | 長瀬産業株式会社 | スルホン酸化合物によるペプチド精製方法 |
| WO2020067575A1 (en) | 2018-09-24 | 2020-04-02 | Takeda Pharmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
| US12102646B2 (en) | 2018-12-05 | 2024-10-01 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| TWI799680B (zh) * | 2019-01-29 | 2023-04-21 | 美商美國禮來大藥廠 | 製備gip/glp1雙重促效劑之方法 |
| US11845801B2 (en) | 2019-06-12 | 2023-12-19 | AskGene Pharma, Inc. | IL-15 prodrugs and methods of use thereof |
| GB201908424D0 (en) | 2019-06-12 | 2019-07-24 | Imp College Innovations Ltd | Novel compounds |
| AR119471A1 (es) * | 2019-08-01 | 2021-12-22 | Lilly Co Eli | Compuestos agonistas de gipr |
| MY201700A (en) | 2019-08-19 | 2024-03-13 | Lilly Co Eli | Methods of making incretin analogs |
| US20230000950A1 (en) * | 2019-10-04 | 2023-01-05 | Hanmi Pharm. Co., Ltd. | Composition comprising glucagon and glp-1 and gip receptor dual agonist and therapeutic use of same |
| CN110684082B (zh) * | 2019-10-08 | 2021-12-10 | 江苏诺泰澳赛诺生物制药股份有限公司 | Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途 |
| TWI795698B (zh) * | 2019-12-18 | 2023-03-11 | 美商美國禮來大藥廠 | 腸促胰島素(incretin)類似物及其用途 |
| US20230265151A1 (en) | 2020-01-23 | 2023-08-24 | Eli Lilly And Company | Gip/glp1 co-agonist compounds |
| TW202140058A (zh) | 2020-01-30 | 2021-11-01 | 美商美國禮來大藥廠 | 提派肽（ｔｉｒｚｅｐａｔｉｄｅ）之治療用途 |
| CN111253475B (zh) * | 2020-02-18 | 2021-03-09 | 江苏诺泰澳赛诺生物制药股份有限公司 | Glp-1激动多肽化合物及其盐与合成方法及用途 |
| JP7544838B2 (ja) | 2020-03-06 | 2024-09-03 | サノフイ | 選択的ｇｉｐ受容体アゴニストとしてのペプチド |
| CN113493503B (zh) * | 2020-04-08 | 2022-08-05 | 浙江道尔生物科技有限公司 | 一种肠促胰岛素类似物及其制备方法和用途 |
| TW202216746A (zh) * | 2020-06-22 | 2022-05-01 | 印度商太陽製藥工業有限公司 | 長效型ｇｌｐ－１／ｇｉｐ雙重促效劑 |
| WO2022007805A1 (zh) * | 2020-07-06 | 2022-01-13 | 鸿绪生物医药科技（北京）有限公司 | 新型多肽及其治疗用途 |
| TW202315883A (zh) | 2020-07-22 | 2023-04-16 | 丹麥商諾佛 儂迪克股份有限公司 | 適用於口服的glp-1及gip受體共促效劑 |
| CA3184723A1 (en) * | 2020-07-22 | 2022-01-27 | Patrick J. KNERR | Glp-1 and gip receptor co-agonists |
| CA3193453A1 (en) * | 2020-09-30 | 2022-04-07 | Beijing Ql Biopharmaceutical Co., Ltd. | Polypeptide conjugates and methods of uses |
| CN116419765A (zh) * | 2020-10-16 | 2023-07-11 | 韩美药品株式会社 | Glp-1/gip双重激动剂、其长效缀合物，以及包括其的药物组合物 |
| AU2021361263A1 (en) * | 2020-10-17 | 2023-02-16 | Sun Pharmaceutical Industries Limited | GLP-1/GIP dual agonists |
| KR20230116894A (ko) * | 2020-12-02 | 2023-08-04 | 둥바오 퍼플 스타 (항저우) 바이오파마슈티컬 컴퍼니 리미티드 | 락탐 변형을 포함한 폴리펩타이드계 화합물 |
| WO2022159395A1 (en) * | 2021-01-20 | 2022-07-28 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
| CA3208208A1 (en) | 2021-02-17 | 2022-08-25 | Mathijs Christiaan Michael BUNCK | Tirzepatide therapeutic methods |
| WO2022177744A1 (en) * | 2021-02-17 | 2022-08-25 | Eli Lilly And Company | Gip/glp1 dual agonist therapeutic methods |
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| US12215133B2 (en) * | 2021-03-25 | 2025-02-04 | Brightgene Bio-Medical Technology Co., Ltd. | GIP and GLP-1 dual receptor agonist, pharmaceutical composition, and use |
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| CN117866050A (zh) * | 2021-05-28 | 2024-04-12 | 广东众生睿创生物科技有限公司 | 多肽的制备及其应用 |
| CN117440964A (zh) * | 2021-06-01 | 2024-01-23 | 南京知和医药科技有限公司 | 一种glp-1r和gipr双重靶向激动作用的多肽衍生物及其制备方法和用途 |
| KR20240032010A (ko) | 2021-06-09 | 2024-03-08 | 더 스크립스 리서치 인스티튜트 | 장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법 |
| TW202302624A (zh) * | 2021-06-18 | 2023-01-16 | 大陸商廣東眾生睿創生物科技有限公司 | 含內醯胺橋的多肽化合物 |
| WO2023031455A1 (en) | 2021-09-06 | 2023-03-09 | Sanofi Sa | New peptides as potent and selective gip receptor agonists |
| EP4259647A4 (en) | 2021-09-15 | 2025-03-26 | Viking Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC AND LIVER DISEASES |
| EP4433093A1 (en) | 2021-11-15 | 2024-09-25 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
| EP4299057A1 (en) | 2022-06-30 | 2024-01-03 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
| EP4180060A1 (en) | 2021-11-15 | 2023-05-17 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
| WO2023089594A1 (en) | 2021-11-22 | 2023-05-25 | Sun Pharmaceutical Industries Limited | Process for the preparation of tirzepatide or pharmaceutically acceptable salt thereof |
| TW202330584A (zh) * | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
| KR20240170837A (ko) * | 2022-04-07 | 2024-12-04 | 광둥 레이노벤트 바이오테크 컴퍼니 리미티드 | 당뇨병 및 비만 및 관련 질환의 치료 및/또는 예방을 위한 약물의 제조에서의 폴리펩티드의 약학적 용도 |
| CN116947978A (zh) * | 2022-04-19 | 2023-10-27 | 北京惠之衡生物科技有限公司 | 一种glp-1和gip受体共激动多肽衍生物及其盐和制剂 |
| EP4299052A1 (en) | 2022-06-30 | 2024-01-03 | Adocia | Solid compositions comprising a peptide or a protein and a permeation enhancer |
| JP2025521770A (ja) | 2022-06-30 | 2025-07-10 | イーライ リリー アンド カンパニー | チルゼパチド組成物及び使用 |
| EP4299071A1 (en) | 2022-07-01 | 2024-01-03 | Adocia | Compositions comprising a peptide or a protein and an acylated amino acid |
| AU2023305663A1 (en) | 2022-07-13 | 2025-02-20 | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. | Glp-1/gip dual agonist, and preparation method therefor and use thereof |
| IL318334A (en) * | 2022-07-20 | 2025-03-01 | Viking Therapeutics Inc | Pharmaceutical formulations and methods for treating metabolic and liver disorders |
| CA3266547A1 (en) | 2022-08-29 | 2024-03-07 | Eli Lilly And Company | COMPOSITIONS FOR ORAL ADMINISTRATION |
| JP2025531200A (ja) | 2022-09-15 | 2025-09-19 | イーライ リリー アンド カンパニー | Ｇｉｐ及びｇｌｐ－１二重アゴニスト化合物 |
| WO2024061310A1 (zh) * | 2022-09-23 | 2024-03-28 | 博瑞生物医药（苏州）股份有限公司 | 一种glp-1和gip双受体激动剂药物组合物及其用途 |
| AU2023356357A1 (en) | 2022-10-05 | 2025-04-24 | Eli Lilly And Company | Peptides for incretin synthesis |
| JP2025535379A (ja) * | 2022-10-19 | 2025-10-24 | イーライ リリー アンド カンパニー | 保存されたｇｉｐ／ｇｌｐアゴニスト組成物 |
| CN117756913B (zh) * | 2022-11-07 | 2025-05-09 | 内蒙古博睿精创科技有限公司 | 一种新型长效多肽化合物、组合物及其应用 |
| CN120569401A (zh) | 2022-11-21 | 2025-08-29 | 伊莱利利公司 | 制备gip/glp1双重激动剂的方法 |
| WO2024128882A1 (ko) | 2022-12-16 | 2024-06-20 | 주식회사 펩트론 | Glp-1 수용체 작용제 또는 이의 약학적으로 허용가능한 염을 포함하는 서방형 미립구 및 이의 용도 |
| AU2023414623A1 (en) | 2022-12-29 | 2025-06-26 | Eli Lilly And Company | Processes and intermediates for preparing tirzepatide |
| KR20250141711A (ko) | 2022-12-30 | 2025-09-29 | 알지파마 에이에스 | 경구 투여되는 폴리펩타이드 치료제의 전신 생체이용률을 증가시키는 조성물 및 방법 |
| US20240270821A1 (en) | 2023-01-31 | 2024-08-15 | Eli Lilly And Company | Gip/glp1/gcg tri-receptor agonists and uses thereof |
| WO2024165571A2 (en) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| AR132137A1 (es) * | 2023-03-15 | 2025-05-28 | Viking Therapeutics Inc | Composiciones farmacéuticas y métodos para el tratamiento de trastornos metabólicos y hepáticos |
| CN118684758A (zh) * | 2023-03-23 | 2024-09-24 | 上海民为生物技术有限公司 | 肠促胰岛素类似物及其应用 |
| CN121001735A (zh) | 2023-03-31 | 2025-11-21 | 伊莱利利公司 | 用于治疗t2d的替尔泊肽 |
| CN121002051A (zh) * | 2023-04-11 | 2025-11-21 | 上海多米瑞生物技术有限公司 | 肠促胰素类似物及其制备方法和应用 |
| CN121398835A (zh) * | 2023-05-21 | 2026-01-23 | 卡莫特治疗学股份有限公司 | 患有或未患有体重相关合并症的超重或肥胖成年人的治疗 |
| CN116832141B (zh) * | 2023-06-06 | 2024-02-09 | 诺博泰科(成都)生物科技有限公司 | 一种用于治疗糖尿病的glp-1、gip和gcg受体三激动多肽化合物 |
| CN121285571A (zh) | 2023-06-09 | 2026-01-06 | 太阳医药工业有限公司 | Glp-1/gip双重、glp-1/gcg双重和glp-1/gip/gcg三重受体激动剂 |
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| CN121443305A (zh) | 2023-06-30 | 2026-01-30 | 西兰制药公司 | 组合治疗 |
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