PL323919A1 - Free heterocyclic methyl radicals as agent improving imaging - Google Patents
Free heterocyclic methyl radicals as agent improving imagingInfo
- Publication number
- PL323919A1 PL323919A1 PL95323919A PL32391995A PL323919A1 PL 323919 A1 PL323919 A1 PL 323919A1 PL 95323919 A PL95323919 A PL 95323919A PL 32391995 A PL32391995 A PL 32391995A PL 323919 A1 PL323919 A1 PL 323919A1
- Authority
- PL
- Poland
- Prior art keywords
- methyl radicals
- radicals
- improving imaging
- agent improving
- free heterocyclic
- Prior art date
Links
- 238000003384 imaging method Methods 0.000 title 1
- 239000002872 contrast media Substances 0.000 abstract 2
- 229940039231 contrast media Drugs 0.000 abstract 2
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 125000005039 triarylmethyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
- C07B61/02—Generation of organic free radicals; Organic free radicals per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Pyridine Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/467,273 US5728370A (en) | 1993-04-02 | 1995-06-06 | Free Radicals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL323919A1 true PL323919A1 (en) | 1998-04-27 |
Family
ID=23855069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL95323919A PL323919A1 (en) | 1995-06-06 | 1995-09-08 | Free heterocyclic methyl radicals as agent improving imaging |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5728370A (de) |
| EP (1) | EP0832054B1 (de) |
| JP (1) | JP4054376B2 (de) |
| KR (1) | KR19990022477A (de) |
| CN (1) | CN1193952A (de) |
| AT (1) | ATE198313T1 (de) |
| AU (1) | AU709532B2 (de) |
| CA (1) | CA2222331A1 (de) |
| CZ (1) | CZ390197A3 (de) |
| DE (1) | DE69519752T2 (de) |
| ES (1) | ES2153046T3 (de) |
| HU (1) | HUT78020A (de) |
| NO (1) | NO975758L (de) |
| NZ (1) | NZ292582A (de) |
| PL (1) | PL323919A1 (de) |
| WO (1) | WO1996039367A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9704669D0 (en) * | 1997-03-06 | 1997-04-23 | Nycomed Imaging As | Free radicals |
| US6063360A (en) * | 1993-04-02 | 2000-05-16 | Nycomed Imaging A/S | Free radicals comprising benzodithiole derivatives |
| DE69815305T2 (de) * | 1997-03-06 | 2004-04-29 | Amersham Health As | Triarylmethylfreie radikale als bildverbesserungsmittel |
| US7122736B2 (en) * | 2001-08-16 | 2006-10-17 | Midwest Research Institute | Method and apparatus for fabricating a thin-film solar cell utilizing a hot wire chemical vapor deposition technique |
| US7351402B2 (en) * | 2003-08-21 | 2008-04-01 | Massachusetts Institute Of Technology | Polarizing agents for dynamic nuclear polarization |
| PL1797102T3 (pl) | 2004-07-30 | 2015-10-30 | Ge Healthcare As | Kompozycja zawierająca rodnik triarylometylowy przydatna w diagnostyce metodą MRI |
| ES2545377T3 (es) * | 2004-07-30 | 2015-09-10 | Ge Healthcare As | Radicales y su uso como agentes paramagnéticos en un proceso de polarización nuclear dinámica |
| KR20130116383A (ko) | 2005-12-01 | 2013-10-23 | 지이 헬스케어 에이에스 | 트리틸 라디칼 및 상자성 금속 이온을 사용하는 동적 핵 분극화 방법 |
| EP1960001A2 (de) | 2005-12-08 | 2008-08-27 | Koninklijke Philips Electronics N.V. | System und verfahren zur überwachung einer in-vivo-wirkstofffreisetzung über overhauser-erweiterte kernspinresonanz |
| JP5102221B2 (ja) * | 2005-12-16 | 2012-12-19 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 過分極カルボン酸塩の製造方法 |
| US7985594B2 (en) | 2006-05-12 | 2011-07-26 | Massachusetts Institute Of Technology | Biradical polarizing agents for dynamic nuclear polarization |
| US8273874B2 (en) | 2006-08-30 | 2012-09-25 | Ge Healthcare As | Method of dynamic nuclear polarisation (DNP) and compounds and compositions for use in the method |
| EP2072061A1 (de) | 2007-12-19 | 2009-06-24 | GE Healthcare Limited | Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR |
| US8697034B2 (en) | 2008-10-10 | 2014-04-15 | The Board Of Regents Of The University Of Texas System | Hyperpolarized 89-yttrium and methods relating thereto |
| EP2476009A1 (de) | 2009-09-10 | 2012-07-18 | GE Healthcare UK Limited | 13c-mr-detektion mit hyperpolarisierter 13-c-fructose |
| EP2555803B1 (de) | 2010-04-08 | 2018-09-12 | Bracco Imaging S.p.A | Verfahren zur herstellung von hyperpolarisierten substraten und mri-verfahren |
| FR2967158A1 (fr) | 2010-11-08 | 2012-05-11 | Phosphoenix Sarl | Nouveaux radicaux triarylmethyle: leur preparation et application |
| MX357509B (es) * | 2011-06-30 | 2018-07-12 | Godavari Biorefineries Ltd | Sintesis de cleistantina a y derivados de la misma. |
| WO2013053839A1 (en) | 2011-10-12 | 2013-04-18 | Bracco Imaging Spa | Process for the preparation of hyperpolarized derivatives for use in mri analysis |
| WO2013083535A1 (en) | 2011-12-05 | 2013-06-13 | Bracco Imaging Spa | Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis |
| US8715621B2 (en) | 2012-03-15 | 2014-05-06 | Massachusetts Institute Of Technology | Radical polarizing agents for dynamic nuclear polarization |
| EP2833924B1 (de) | 2012-04-02 | 2019-05-08 | Bracco Imaging S.p.A | Hyperpolarisierte aminosäuren |
| EP2872520B1 (de) * | 2012-07-13 | 2016-09-14 | Bracco Imaging S.p.A | Triarylmethyl-radikale |
| WO2014192894A1 (ja) * | 2013-05-29 | 2014-12-04 | 国立大学法人九州大学 | 生体における酸化還元反応を検出する方法 |
| CN103951613A (zh) * | 2014-04-21 | 2014-07-30 | 南开大学 | 用于蛋白质顺磁标记的dtpa类似物的设计与合成 |
| CN104610138A (zh) * | 2015-01-09 | 2015-05-13 | 南开大学 | 用于蛋白质顺磁标记的乙二胺四乙酸类探针的合成方法 |
| WO2019018655A1 (en) * | 2017-07-19 | 2019-01-24 | West Virginia University | SYNTHESIS OF BIOCOMPATIBLE TRITYLE RADICALS FOR APPLICATIONS AS HYPERPOLARIZATION AGENTS |
| DE102017122275B4 (de) * | 2017-09-26 | 2021-03-11 | Universität Potsdam | Fluoreszenzfarbstoffe basierend auf Benzo[1,2-d:4,5- d']bis([1,3]dithiol) |
| DE102018126261A1 (de) | 2018-10-22 | 2020-04-23 | Universität Bielefeld | Tritylverbindungen vom Finland-Typ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU651570B2 (en) * | 1990-02-12 | 1994-07-28 | Hafslund Nycomed Innovation Ab | Triarylmethyl radicals and the use of inert carbon free radicals in MRI |
| JPH06507904A (ja) * | 1991-05-23 | 1994-09-08 | イマアーレクス・フアーマシユーチカル・コーポレーシヨン | 磁気共鳴画像形成用の油脂可溶化合物 |
| GB9117258D0 (en) * | 1991-08-09 | 1991-09-25 | Hafslund Nycomed Innovation | Use of radicals |
| DK0662004T3 (da) * | 1991-08-09 | 1998-10-19 | Nycomed Innovation Ab | Anvendelse af stabile frie radikaler ved magnetiskresonans-billeddannnelse |
| GB9307027D0 (en) * | 1993-04-02 | 1993-05-26 | Nycomed Innovation Ab | Free radicals |
-
1995
- 1995-06-06 US US08/467,273 patent/US5728370A/en not_active Expired - Fee Related
- 1995-09-08 PL PL95323919A patent/PL323919A1/xx unknown
- 1995-09-08 WO PCT/GB1995/002151 patent/WO1996039367A1/en not_active Application Discontinuation
- 1995-09-08 CZ CZ973901A patent/CZ390197A3/cs unknown
- 1995-09-08 EP EP95931302A patent/EP0832054B1/de not_active Expired - Lifetime
- 1995-09-08 AT AT95931302T patent/ATE198313T1/de not_active IP Right Cessation
- 1995-09-08 HU HU9802729A patent/HUT78020A/hu unknown
- 1995-09-08 CA CA002222331A patent/CA2222331A1/en not_active Abandoned
- 1995-09-08 DE DE69519752T patent/DE69519752T2/de not_active Expired - Lifetime
- 1995-09-08 NZ NZ292582A patent/NZ292582A/xx unknown
- 1995-09-08 KR KR1019970708958A patent/KR19990022477A/ko not_active Application Discontinuation
- 1995-09-08 ES ES95931302T patent/ES2153046T3/es not_active Expired - Lifetime
- 1995-09-08 JP JP51933896A patent/JP4054376B2/ja not_active Expired - Lifetime
- 1995-09-08 AU AU34790/95A patent/AU709532B2/en not_active Ceased
-
1996
- 1996-09-08 CN CN95197926A patent/CN1193952A/zh active Pending
-
1997
- 1997-12-05 NO NO975758A patent/NO975758L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2153046T3 (es) | 2001-02-16 |
| JP4054376B2 (ja) | 2008-02-27 |
| EP0832054A1 (de) | 1998-04-01 |
| JPH11505510A (ja) | 1999-05-21 |
| CN1193952A (zh) | 1998-09-23 |
| HUT78020A (hu) | 1999-05-28 |
| NO975758D0 (no) | 1997-12-05 |
| DE69519752T2 (de) | 2001-08-02 |
| KR19990022477A (ko) | 1999-03-25 |
| US5728370A (en) | 1998-03-17 |
| AU709532B2 (en) | 1999-09-02 |
| DE69519752D1 (de) | 2001-02-01 |
| NO975758L (no) | 1997-12-05 |
| EP0832054B1 (de) | 2000-12-27 |
| AU3479095A (en) | 1996-12-24 |
| CZ390197A3 (cs) | 1998-06-17 |
| NZ292582A (en) | 1998-12-23 |
| ATE198313T1 (de) | 2001-01-15 |
| WO1996039367A1 (en) | 1996-12-12 |
| CA2222331A1 (en) | 1996-12-12 |
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