DE69519752T2 - Freie heterocyclische Methylradikale als Bildverbesserungsmittel - Google Patents

Freie heterocyclische Methylradikale als Bildverbesserungsmittel

Info

Publication number
DE69519752T2
DE69519752T2 DE69519752T DE69519752T DE69519752T2 DE 69519752 T2 DE69519752 T2 DE 69519752T2 DE 69519752 T DE69519752 T DE 69519752T DE 69519752 T DE69519752 T DE 69519752T DE 69519752 T2 DE69519752 T2 DE 69519752T2
Authority
DE
Germany
Prior art keywords
methyl radicals
radicals
image enhancer
free heterocyclic
heterocyclic methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69519752T
Other languages
English (en)
Other versions
DE69519752D1 (de
Inventor
Sven Andersson
Anna Rydbeck
Rolf Servin
Lars-Goran Wistrand
Finn Radner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Publication of DE69519752D1 publication Critical patent/DE69519752D1/de
Application granted granted Critical
Publication of DE69519752T2 publication Critical patent/DE69519752T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C07B61/02—Generation of organic free radicals; Organic free radicals per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pyridine Compounds (AREA)
  • Cosmetics (AREA)
DE69519752T 1995-06-06 1995-09-08 Freie heterocyclische Methylradikale als Bildverbesserungsmittel Expired - Lifetime DE69519752T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/467,273 US5728370A (en) 1993-04-02 1995-06-06 Free Radicals
PCT/GB1995/002151 WO1996039367A1 (en) 1994-03-31 1995-09-08 Heterocyclic methyl free radicals as image enhancing agents

Publications (2)

Publication Number Publication Date
DE69519752D1 DE69519752D1 (de) 2001-02-01
DE69519752T2 true DE69519752T2 (de) 2001-08-02

Family

ID=23855069

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69519752T Expired - Lifetime DE69519752T2 (de) 1995-06-06 1995-09-08 Freie heterocyclische Methylradikale als Bildverbesserungsmittel

Country Status (16)

Country Link
US (1) US5728370A (de)
EP (1) EP0832054B1 (de)
JP (1) JP4054376B2 (de)
KR (1) KR19990022477A (de)
CN (1) CN1193952A (de)
AT (1) ATE198313T1 (de)
AU (1) AU709532B2 (de)
CA (1) CA2222331A1 (de)
CZ (1) CZ390197A3 (de)
DE (1) DE69519752T2 (de)
ES (1) ES2153046T3 (de)
HU (1) HUT78020A (de)
NO (1) NO975758D0 (de)
NZ (1) NZ292582A (de)
PL (1) PL323919A1 (de)
WO (1) WO1996039367A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US6063360A (en) * 1993-04-02 2000-05-16 Nycomed Imaging A/S Free radicals comprising benzodithiole derivatives
ES2201462T3 (es) * 1997-03-06 2004-03-16 Amersham Health As Radicales libres de triarilmetilo como agentes mejoradores de la imagen.
US7122736B2 (en) * 2001-08-16 2006-10-17 Midwest Research Institute Method and apparatus for fabricating a thin-film solar cell utilizing a hot wire chemical vapor deposition technique
US7351402B2 (en) * 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
KR20070063504A (ko) * 2004-07-30 2007-06-19 지이 헬스케어 에이에스 조성물의 제조 방법, 조성물 및 그의 용도
RU2374253C2 (ru) * 2004-07-30 2009-11-27 Джи-И Хелткер АС Радикалы и их применение в качестве парамагнитных агентов в процессе динамической поляризации ядер
KR101372173B1 (ko) 2005-12-01 2014-03-07 지이 헬스케어 에이에스 트리틸 라디칼 및 상자성 금속 이온을 사용하는 동적 핵분극화 방법
US20090004114A1 (en) 2005-12-08 2009-01-01 Koninklijke Philips Electronics N. V. System and Method for Monitoring in Vivo Drug Release Using Overhauser-Enhanced Nmr
JP5102221B2 (ja) * 2005-12-16 2012-12-19 ジーイー・ヘルスケア・アクスイェ・セルスカプ 過分極カルボン酸塩の製造方法
US7985594B2 (en) 2006-05-12 2011-07-26 Massachusetts Institute Of Technology Biradical polarizing agents for dynamic nuclear polarization
KR101502180B1 (ko) 2006-08-30 2015-03-12 지이 헬스케어 에이에스 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물
EP2902041A1 (de) 2007-12-19 2015-08-05 GE Healthcare Limited Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR
US8697034B2 (en) 2008-10-10 2014-04-15 The Board Of Regents Of The University Of Texas System Hyperpolarized 89-yttrium and methods relating thereto
SG179067A1 (en) 2009-09-10 2012-04-27 Ge Healthcare Ltd 13c-mr detection using hyperpolarised 13c-fructose
EP2555803B1 (de) 2010-04-08 2018-09-12 Bracco Imaging S.p.A Verfahren zur herstellung von hyperpolarisierten substraten und mri-verfahren
FR2967158A1 (fr) 2010-11-08 2012-05-11 Phosphoenix Sarl Nouveaux radicaux triarylmethyle: leur preparation et application
AU2012277481B2 (en) * 2011-06-30 2016-10-06 Godavari Biorefineries Limited Synthesis of cleistanthin A an derivatives thereof
EP2766050B1 (de) 2011-10-12 2018-09-05 Bracco Imaging S.p.A Verfahren zur herstellung von hyperpolarisierten derivaten zur verwendung bei der mri-analyse
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
US8715621B2 (en) 2012-03-15 2014-05-06 Massachusetts Institute Of Technology Radical polarizing agents for dynamic nuclear polarization
WO2013149935A1 (en) 2012-04-02 2013-10-10 Bracco Imaging Spa Hyperpolarized amino acids
EP2872520B1 (de) * 2012-07-13 2016-09-14 Bracco Imaging S.p.A Triarylmethyl-radikale
US20160216351A1 (en) * 2013-05-29 2016-07-28 Kyushu University, National University Corporation Method for detecting oxidation/reduction reaction in vivo
CN103951613A (zh) * 2014-04-21 2014-07-30 南开大学 用于蛋白质顺磁标记的dtpa类似物的设计与合成
CN104610138A (zh) * 2015-01-09 2015-05-13 南开大学 用于蛋白质顺磁标记的乙二胺四乙酸类探针的合成方法
WO2019018655A1 (en) * 2017-07-19 2019-01-24 West Virginia University SYNTHESIS OF BIOCOMPATIBLE TRITYLE RADICALS FOR APPLICATIONS AS HYPERPOLARIZATION AGENTS
DE102017122275B4 (de) * 2017-09-26 2021-03-11 Universität Potsdam Fluoreszenzfarbstoffe basierend auf Benzo[1,2-d:4,5- d']bis([1,3]dithiol)
DE102018126261A1 (de) 2018-10-22 2020-04-23 Universität Bielefeld Tritylverbindungen vom Finland-Typ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2075818A1 (en) * 1990-02-12 1991-08-13 Mikkel Joergensen Triarylmethyl radicals and the use of inert carbon free radicals in mri
CA2102605A1 (en) * 1991-05-23 1992-11-24 Evan C. Unger Liposoluble compounds for magnetic resonance imaging
WO1993002711A1 (en) * 1991-08-09 1993-02-18 Nycomed Innovation Ab Use of persistent free-radicals in magnetic resonance imaging
GB9117258D0 (en) * 1991-08-09 1991-09-25 Hafslund Nycomed Innovation Use of radicals
GB9307027D0 (en) * 1993-04-02 1993-05-26 Nycomed Innovation Ab Free radicals

Also Published As

Publication number Publication date
NO975758L (no) 1997-12-05
AU3479095A (en) 1996-12-24
ES2153046T3 (es) 2001-02-16
CN1193952A (zh) 1998-09-23
CA2222331A1 (en) 1996-12-12
DE69519752D1 (de) 2001-02-01
PL323919A1 (en) 1998-04-27
JP4054376B2 (ja) 2008-02-27
KR19990022477A (ko) 1999-03-25
NO975758D0 (no) 1997-12-05
JPH11505510A (ja) 1999-05-21
EP0832054A1 (de) 1998-04-01
US5728370A (en) 1998-03-17
HUT78020A (hu) 1999-05-28
AU709532B2 (en) 1999-09-02
WO1996039367A1 (en) 1996-12-12
ATE198313T1 (de) 2001-01-15
CZ390197A3 (cs) 1998-06-17
NZ292582A (en) 1998-12-23
EP0832054B1 (de) 2000-12-27

Similar Documents

Publication Publication Date Title
DE69519752T2 (de) Freie heterocyclische Methylradikale als Bildverbesserungsmittel
DE69410466T2 (de) Verfahren und zusammensetzungen zur erhöhung des bild-kontrastes
DE69518083T2 (de) Von peptiden abgeleitete komplexbildner für radionuklide
NO984543L (no) Bioaktiverte diagnostiske imaging kontrastmidler
DE69112384D1 (de) Triarylmethyl-radikale und die anwendung von inerten kohlenstofffreien radikalen in mri.
NO854765L (no) Anvendelse av ferromagnetiske partikler i kontrastmidler for nmr-avbildning og kontrastmidler.
NO991688L (no) Administrerbare sammensetninger og fremgangsmÕter til magnetisk resonansavbildning
DE69326379D1 (de) Kinematographische Bilderzeugung mittels magnetischer Resonanz
AU589428B2 (en) Lymphographic imaging method and kit
DE69330726T2 (de) Anordnungen zur Anzeige von Bildern von Objekten
DK0772610T3 (da) Dihydrobenzofuraner
DE60239552D1 (de) Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasser
ES2033077T3 (es) Medios de contraste que contienen radicales libres estables.
DE69312171D1 (de) Nichtmagnetisches Einzelkomponenten Entwicklungssystem für Graustufenbilder
DE69332215T2 (de) Bilderzeugung mittels magnetischer Resonanz
DE69407848D1 (de) Magnetanordnung für die Bilderzeugung mittels magnetischer Resonanz
DE69523681D1 (de) Anordnungen von Gradientenspulen für Gerät zur Bilderzeugung durch magnetische Resonanz
ATE167665T1 (de) Hydroxamat- und hydrazidderivate von polyaminen und ihre medizinische verwendung als chelatierende wirkstoffe
ATE108026T1 (de) Verfahren zur bilderzeugung mittels magnetischer resonanz.
ATE337559T1 (de) Kombinierung komplexer bilder von flüssigem material, aufgenommen durch bilderzeugung mit magnetischer resonanz
BR9508435A (pt) Quelentes macrocíclicos seus quelatos e usos dos mesmos no campo diagnóstico
DE69116556D1 (de) Abgeschirmte gradientspule für nmr-abbildung
ATE148459T1 (de) Spiro(cycloalkylbenzen-1,1'-(1',2',3',4'- tetrahydroisoquinoline)> mit neuroprotektiven eigenschaften
IT1249314B (it) Mezzi di contrasto per l'imaging del miocardo e della milza
ATA137394A (de) Spulenanordnung zur erzeugung eines elektromagnetischen wanderfeldes für therapeutische zwecke

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE AS, OSLO, NO

8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS RECHTSANWAELTE PATENTANWAELTE, 80539 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB

R082 Change of representative

Ref document number: 832054

Country of ref document: EP

Representative=s name: J D REYNOLDS & CO., GB