ES2153046T3 - Radicales libres a base de heterociclil-metilo utilizados como agentes intensificadores de imagen. - Google Patents
Radicales libres a base de heterociclil-metilo utilizados como agentes intensificadores de imagen.Info
- Publication number
- ES2153046T3 ES2153046T3 ES95931302T ES95931302T ES2153046T3 ES 2153046 T3 ES2153046 T3 ES 2153046T3 ES 95931302 T ES95931302 T ES 95931302T ES 95931302 T ES95931302 T ES 95931302T ES 2153046 T3 ES2153046 T3 ES 2153046T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- sup
- radicals
- water solubilizing
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003254 radicals Chemical class 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- 230000003381 solubilizing effect Effects 0.000 abstract 3
- 241000282693 Cercopithecidae Species 0.000 abstract 2
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 2
- -1 HYDROXYL GROUP Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
- C07B61/02—Generation of organic free radicals; Organic free radicals per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Pyridine Compounds (AREA)
- Cosmetics (AREA)
Abstract
LA INVENCION PROPONE NOVEDOSOS RADICALES LIBRES PERSISTENTES UTILES EN RMI OVERHAUSER QUE SON RADICALES TRIARILMETILO CON AL MENOS UN GRUPO ARILO DE FORMULA (1) O (2), DONDE CADA X, QUE PUEDEN SER IGUALES O DIFERENTES, ES UN ATOMO DE OXIGENO O AZUFRE O UN GRUPO CO O S(O) SUB,N} (DONDE N ES DE 1 A 3) CON LA CONDICION DE QUE AL MENOS UN GRUPO X SEA UN ATOMO DE AZUFRE O UN GRUPO S(O) SUB,N}; R SUP,1} ES UN ATOMO DE HIDROGENO O UN GRUPO DE FORMULA SOLUBILIZADOR EN AGUA, Y AR SUP,2} REPRESENTA UN ANILLO AROMATICO DE 5 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDO POR UN GRUPO M SOLUBILIZADOR EN AGUA; Y CADA UNO DE LOS GRUPOS R SUP,7}, QUE PUEDEN SER IGUALES O DIFERENTES, ES UN ATOMO DE HIDROGENO O UN GRUPO HIDROCARBURO O UN GRUPO M SOLUBILIZADOR EN AGUA, O DOS GRUPOS R SUP,7} JUNTO CON EL ATOMO AL QUE ESTAN ENLAZADOS REPRESENTAN UN GRUPO CARBONILO O UN CICLOALQUILIDENO DE 5 A 8 MIEMBROS, MONO QUILIDENO O MONO ICIO, Y CUANDO R SUP,7} NO ES HIDROGENO ESTA OPCIONALMENTE SUSTITUIDO POR UN GRUPO HIDROXILO,UN GRUPO ACILOXI O ALQUILO OPCIONALMENTE ALCOXILADO Y OPCIONALMENTE HIDROXILADO O UN GRUPO M SOLUBILIZADOR EN AGUA. LOS RADICALES NOVEDOSOS PRESENTAN BUENA ESTABILIDAD, TIEMPOS DE RELAJACION LARGOS Y BUENA RELAJABILIDAD.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/467,273 US5728370A (en) | 1993-04-02 | 1995-06-06 | Free Radicals |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2153046T3 true ES2153046T3 (es) | 2001-02-16 |
Family
ID=23855069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95931302T Expired - Lifetime ES2153046T3 (es) | 1995-06-06 | 1995-09-08 | Radicales libres a base de heterociclil-metilo utilizados como agentes intensificadores de imagen. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5728370A (es) |
EP (1) | EP0832054B1 (es) |
JP (1) | JP4054376B2 (es) |
KR (1) | KR19990022477A (es) |
CN (1) | CN1193952A (es) |
AT (1) | ATE198313T1 (es) |
AU (1) | AU709532B2 (es) |
CA (1) | CA2222331A1 (es) |
CZ (1) | CZ390197A3 (es) |
DE (1) | DE69519752T2 (es) |
ES (1) | ES2153046T3 (es) |
HU (1) | HUT78020A (es) |
NO (1) | NO975758D0 (es) |
NZ (1) | NZ292582A (es) |
PL (1) | PL323919A1 (es) |
WO (1) | WO1996039367A1 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6063360A (en) * | 1993-04-02 | 2000-05-16 | Nycomed Imaging A/S | Free radicals comprising benzodithiole derivatives |
GB9704669D0 (en) * | 1997-03-06 | 1997-04-23 | Nycomed Imaging As | Free radicals |
AU6506598A (en) * | 1997-03-06 | 1998-09-22 | Nycomed Imaging As | Triarylmethyl free radicals as image enhancing agents |
US7122736B2 (en) * | 2001-08-16 | 2006-10-17 | Midwest Research Institute | Method and apparatus for fabricating a thin-film solar cell utilizing a hot wire chemical vapor deposition technique |
US7351402B2 (en) * | 2003-08-21 | 2008-04-01 | Massachusetts Institute Of Technology | Polarizing agents for dynamic nuclear polarization |
JP5367265B2 (ja) | 2004-07-30 | 2013-12-11 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 組成物の製造方法、組成物及びその使用 |
AU2005267670B2 (en) * | 2004-07-30 | 2011-03-03 | Ge Healthcare As | Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process |
WO2007064226A2 (en) | 2005-12-01 | 2007-06-07 | Ge Healthcare As | Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion |
EP1960001A2 (en) | 2005-12-08 | 2008-08-27 | Koninklijke Philips Electronics N.V. | System and method for monitoring in vivo drug release using overhauser-enhanced nmr |
ES2393750T3 (es) * | 2005-12-16 | 2012-12-27 | Ge Healthcare As | Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas |
EP2018545A4 (en) | 2006-05-12 | 2011-03-09 | Massachusetts Inst Technology | BIRADIC POLARIZERS FOR DYNAMIC NUCLEAR POLARIZATION |
ES2432393T3 (es) | 2006-08-30 | 2013-12-03 | Ge Healthcare As | Procedimiento de polarización nuclear dinámica (PND), y compuestos y composiciones para su uso en el procedimiento |
EP2072061A1 (en) | 2007-12-19 | 2009-06-24 | GE Healthcare Limited | Composition and method for generating a metabolic profile using 13C-MR detection |
US8697034B2 (en) | 2008-10-10 | 2014-04-15 | The Board Of Regents Of The University Of Texas System | Hyperpolarized 89-yttrium and methods relating thereto |
US8968703B2 (en) | 2009-09-10 | 2015-03-03 | Ge Healthcare Limited | 13C-MR detection using hyperpolarised 13C-fructose |
WO2011124672A1 (en) | 2010-04-08 | 2011-10-13 | Bracco Imaging Spa | Process for preparing hyperpolarized substrates and method for mri |
FR2967158A1 (fr) | 2010-11-08 | 2012-05-11 | Phosphoenix Sarl | Nouveaux radicaux triarylmethyle: leur preparation et application |
AU2012277481B2 (en) * | 2011-06-30 | 2016-10-06 | Godavari Biorefineries Limited | Synthesis of cleistanthin A an derivatives thereof |
US9511154B2 (en) | 2011-10-12 | 2016-12-06 | Bracco Imaging S.P.A. | Process for the preparation of hyperpolarized derivatives for use in MRI analysis |
US9693828B2 (en) | 2011-12-05 | 2017-07-04 | Bracco Imaging S.P.A. | Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis |
US8715621B2 (en) | 2012-03-15 | 2014-05-06 | Massachusetts Institute Of Technology | Radical polarizing agents for dynamic nuclear polarization |
US9925280B2 (en) | 2012-04-02 | 2018-03-27 | Bracco Imaging S.P.A. | Hyperpolarized amino acids |
US9381257B2 (en) | 2012-07-13 | 2016-07-05 | Bracco Imaging S.P.A. | Triarylmethyl radicals |
WO2014192894A1 (ja) * | 2013-05-29 | 2014-12-04 | 国立大学法人九州大学 | 生体における酸化還元反応を検出する方法 |
CN103951613A (zh) * | 2014-04-21 | 2014-07-30 | 南开大学 | 用于蛋白质顺磁标记的dtpa类似物的设计与合成 |
CN104610138A (zh) * | 2015-01-09 | 2015-05-13 | 南开大学 | 用于蛋白质顺磁标记的乙二胺四乙酸类探针的合成方法 |
WO2019018655A1 (en) * | 2017-07-19 | 2019-01-24 | West Virginia University | SYNTHESIS OF BIOCOMPATIBLE TRITYLE RADICALS FOR APPLICATIONS AS HYPERPOLARIZATION AGENTS |
DE102017122275B4 (de) * | 2017-09-26 | 2021-03-11 | Universität Potsdam | Fluoreszenzfarbstoffe basierend auf Benzo[1,2-d:4,5- d']bis([1,3]dithiol) |
DE102018126261A1 (de) | 2018-10-22 | 2020-04-23 | Universität Bielefeld | Tritylverbindungen vom Finland-Typ |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69112384T2 (de) * | 1990-02-12 | 1996-03-28 | Nycomed Innovation Ab | Triarylmethyl-radikale und die anwendung von inerten kohlenstofffreien radikalen in mri. |
WO1992021017A1 (en) * | 1991-05-23 | 1992-11-26 | Unger Evan C | Liposoluble compounds for magnetic resonance imaging |
US5435991A (en) * | 1991-08-09 | 1995-07-25 | Nycomed Innovation Ab | Use of persistent heterocyclic free-radicals in magnetic resonance imaging |
GB9117258D0 (en) * | 1991-08-09 | 1991-09-25 | Hafslund Nycomed Innovation | Use of radicals |
GB9307027D0 (en) * | 1993-04-02 | 1993-05-26 | Nycomed Innovation Ab | Free radicals |
-
1995
- 1995-06-06 US US08/467,273 patent/US5728370A/en not_active Expired - Fee Related
- 1995-09-08 WO PCT/GB1995/002151 patent/WO1996039367A1/en not_active Application Discontinuation
- 1995-09-08 HU HU9802729A patent/HUT78020A/hu unknown
- 1995-09-08 NZ NZ292582A patent/NZ292582A/xx unknown
- 1995-09-08 JP JP51933896A patent/JP4054376B2/ja not_active Expired - Lifetime
- 1995-09-08 ES ES95931302T patent/ES2153046T3/es not_active Expired - Lifetime
- 1995-09-08 KR KR1019970708958A patent/KR19990022477A/ko not_active Application Discontinuation
- 1995-09-08 DE DE69519752T patent/DE69519752T2/de not_active Expired - Lifetime
- 1995-09-08 EP EP95931302A patent/EP0832054B1/en not_active Expired - Lifetime
- 1995-09-08 CA CA002222331A patent/CA2222331A1/en not_active Abandoned
- 1995-09-08 AT AT95931302T patent/ATE198313T1/de not_active IP Right Cessation
- 1995-09-08 PL PL95323919A patent/PL323919A1/xx unknown
- 1995-09-08 CZ CZ973901A patent/CZ390197A3/cs unknown
- 1995-09-08 AU AU34790/95A patent/AU709532B2/en not_active Ceased
-
1996
- 1996-09-08 CN CN95197926A patent/CN1193952A/zh active Pending
-
1997
- 1997-12-05 NO NO975758A patent/NO975758D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE69519752D1 (de) | 2001-02-01 |
JP4054376B2 (ja) | 2008-02-27 |
EP0832054B1 (en) | 2000-12-27 |
CZ390197A3 (cs) | 1998-06-17 |
NO975758L (no) | 1997-12-05 |
JPH11505510A (ja) | 1999-05-21 |
ATE198313T1 (de) | 2001-01-15 |
CA2222331A1 (en) | 1996-12-12 |
NO975758D0 (no) | 1997-12-05 |
NZ292582A (en) | 1998-12-23 |
WO1996039367A1 (en) | 1996-12-12 |
DE69519752T2 (de) | 2001-08-02 |
PL323919A1 (en) | 1998-04-27 |
AU3479095A (en) | 1996-12-24 |
HUT78020A (hu) | 1999-05-28 |
CN1193952A (zh) | 1998-09-23 |
US5728370A (en) | 1998-03-17 |
AU709532B2 (en) | 1999-09-02 |
EP0832054A1 (en) | 1998-04-01 |
KR19990022477A (ko) | 1999-03-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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