DE69519752D1 - Heterocyclische methylfreie radikale als biloverbesserungsmittel - Google Patents

Heterocyclische methylfreie radikale als biloverbesserungsmittel

Info

Publication number
DE69519752D1
DE69519752D1 DE69519752T DE69519752T DE69519752D1 DE 69519752 D1 DE69519752 D1 DE 69519752D1 DE 69519752 T DE69519752 T DE 69519752T DE 69519752 T DE69519752 T DE 69519752T DE 69519752 D1 DE69519752 D1 DE 69519752D1
Authority
DE
Germany
Prior art keywords
free radicals
bilo
improvement agent
heterocyclic methyl
radicals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69519752T
Other languages
English (en)
Other versions
DE69519752T2 (de
Inventor
Sven Andersson
Anna Rydbeck
Rolf Servin
Lars-Goran Wistrand
Finn Radner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Application granted granted Critical
Publication of DE69519752D1 publication Critical patent/DE69519752D1/de
Publication of DE69519752T2 publication Critical patent/DE69519752T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C07B61/02—Generation of organic free radicals; Organic free radicals per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cosmetics (AREA)
  • Pyridine Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
DE69519752T 1995-06-06 1995-09-08 Freie heterocyclische Methylradikale als Bildverbesserungsmittel Expired - Lifetime DE69519752T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/467,273 US5728370A (en) 1993-04-02 1995-06-06 Free Radicals
PCT/GB1995/002151 WO1996039367A1 (en) 1994-03-31 1995-09-08 Heterocyclic methyl free radicals as image enhancing agents

Publications (2)

Publication Number Publication Date
DE69519752D1 true DE69519752D1 (de) 2001-02-01
DE69519752T2 DE69519752T2 (de) 2001-08-02

Family

ID=23855069

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69519752T Expired - Lifetime DE69519752T2 (de) 1995-06-06 1995-09-08 Freie heterocyclische Methylradikale als Bildverbesserungsmittel

Country Status (16)

Country Link
US (1) US5728370A (de)
EP (1) EP0832054B1 (de)
JP (1) JP4054376B2 (de)
KR (1) KR19990022477A (de)
CN (1) CN1193952A (de)
AT (1) ATE198313T1 (de)
AU (1) AU709532B2 (de)
CA (1) CA2222331A1 (de)
CZ (1) CZ390197A3 (de)
DE (1) DE69519752T2 (de)
ES (1) ES2153046T3 (de)
HU (1) HUT78020A (de)
NO (1) NO975758L (de)
NZ (1) NZ292582A (de)
PL (1) PL323919A1 (de)
WO (1) WO1996039367A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US6063360A (en) * 1993-04-02 2000-05-16 Nycomed Imaging A/S Free radicals comprising benzodithiole derivatives
ES2201462T3 (es) * 1997-03-06 2004-03-16 Amersham Health As Radicales libres de triarilmetilo como agentes mejoradores de la imagen.
US7122736B2 (en) * 2001-08-16 2006-10-17 Midwest Research Institute Method and apparatus for fabricating a thin-film solar cell utilizing a hot wire chemical vapor deposition technique
US7351402B2 (en) * 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
KR20070063504A (ko) 2004-07-30 2007-06-19 지이 헬스케어 에이에스 조성물의 제조 방법, 조성물 및 그의 용도
JP5535435B2 (ja) 2004-07-30 2014-07-02 ジーイー・ヘルスケア・アクスイェ・セルスカプ ラジカル及び、ｄｎｐ処理における常磁性試薬としてのその使用
WO2007064226A2 (en) 2005-12-01 2007-06-07 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
EP1960001A2 (de) 2005-12-08 2008-08-27 Koninklijke Philips Electronics N.V. System und verfahren zur überwachung einer in-vivo-wirkstofffreisetzung über overhauser-erweiterte kernspinresonanz
ES2393750T3 (es) * 2005-12-16 2012-12-27 Ge Healthcare As Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas
US7985594B2 (en) 2006-05-12 2011-07-26 Massachusetts Institute Of Technology Biradical polarizing agents for dynamic nuclear polarization
CN101506179B (zh) 2006-08-30 2012-08-22 通用电气医疗集团股份有限公司 动态核极化(dnp)的方法及用于所述方法的化合物和组合物
EP2902041A1 (de) 2007-12-19 2015-08-05 GE Healthcare Limited Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR
US8697034B2 (en) 2008-10-10 2014-04-15 The Board Of Regents Of The University Of Texas System Hyperpolarized 89-yttrium and methods relating thereto
EP2476009A1 (de) 2009-09-10 2012-07-18 GE Healthcare UK Limited 13c-mr-detektion mit hyperpolarisierter 13-c-fructose
JP5758982B2 (ja) 2010-04-08 2015-08-05 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 過分極基質の製造方法およびｍｒｉのための方法
FR2967158A1 (fr) 2010-11-08 2012-05-11 Phosphoenix Sarl Nouveaux radicaux triarylmethyle: leur preparation et application
IN2014MN00174A (de) * 2011-06-30 2015-06-19 Godavari Biorefineries Ltd
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
US8715621B2 (en) 2012-03-15 2014-05-06 Massachusetts Institute Of Technology Radical polarizing agents for dynamic nuclear polarization
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids
US9381257B2 (en) 2012-07-13 2016-07-05 Bracco Imaging S.P.A. Triarylmethyl radicals
WO2014192894A1 (ja) * 2013-05-29 2014-12-04 国立大学法人九州大学 生体における酸化還元反応を検出する方法
CN103951613A (zh) * 2014-04-21 2014-07-30 南开大学 用于蛋白质顺磁标记的dtpa类似物的设计与合成
CN104610138A (zh) * 2015-01-09 2015-05-13 南开大学 用于蛋白质顺磁标记的乙二胺四乙酸类探针的合成方法
WO2019018655A1 (en) * 2017-07-19 2019-01-24 West Virginia University SYNTHESIS OF BIOCOMPATIBLE TRITYLE RADICALS FOR APPLICATIONS AS HYPERPOLARIZATION AGENTS
DE102017122275B4 (de) * 2017-09-26 2021-03-11 Universität Potsdam Fluoreszenzfarbstoffe basierend auf Benzo[1,2-d:4,5- d']bis([1,3]dithiol)
DE102018126261A1 (de) 2018-10-22 2020-04-23 Universität Bielefeld Tritylverbindungen vom Finland-Typ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU651570B2 (en) * 1990-02-12 1994-07-28 Hafslund Nycomed Innovation Ab Triarylmethyl radicals and the use of inert carbon free radicals in MRI
WO1992021017A1 (en) * 1991-05-23 1992-11-26 Unger Evan C Liposoluble compounds for magnetic resonance imaging
US5435991A (en) * 1991-08-09 1995-07-25 Nycomed Innovation Ab Use of persistent heterocyclic free-radicals in magnetic resonance imaging
GB9117258D0 (en) * 1991-08-09 1991-09-25 Hafslund Nycomed Innovation Use of radicals
GB9307027D0 (en) * 1993-04-02 1993-05-26 Nycomed Innovation Ab Free radicals

Also Published As

Publication number Publication date
KR19990022477A (ko) 1999-03-25
CA2222331A1 (en) 1996-12-12
ATE198313T1 (de) 2001-01-15
EP0832054B1 (de) 2000-12-27
AU709532B2 (en) 1999-09-02
AU3479095A (en) 1996-12-24
JP4054376B2 (ja) 2008-02-27
EP0832054A1 (de) 1998-04-01
DE69519752T2 (de) 2001-08-02
JPH11505510A (ja) 1999-05-21
NO975758D0 (no) 1997-12-05
US5728370A (en) 1998-03-17
WO1996039367A1 (en) 1996-12-12
NO975758L (no) 1997-12-05
CZ390197A3 (cs) 1998-06-17
HUT78020A (hu) 1999-05-28
ES2153046T3 (es) 2001-02-16
PL323919A1 (en) 1998-04-27
CN1193952A (zh) 1998-09-23
NZ292582A (en) 1998-12-23

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE AS, OSLO, NO

8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS RECHTSANWAELTE PATENTANWAELTE, 80539 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB

R082 Change of representative

Ref document number: 832054

Country of ref document: EP

Representative=s name: J D REYNOLDS & CO., GB