ATE194845T1 - Von peptiden abgeleitete komplexbildner für radionuklide - Google Patents
Von peptiden abgeleitete komplexbildner für radionuklideInfo
- Publication number
- ATE194845T1 ATE194845T1 AT95916539T AT95916539T ATE194845T1 AT E194845 T1 ATE194845 T1 AT E194845T1 AT 95916539 T AT95916539 T AT 95916539T AT 95916539 T AT95916539 T AT 95916539T AT E194845 T1 ATE194845 T1 AT E194845T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- complex formers
- radionuclides
- derived
- radionuclides derived
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000002738 chelating agent Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/279,155 US5662885A (en) | 1994-07-22 | 1994-07-22 | Peptide derived radionuclide chelators |
PCT/CA1995/000249 WO1996003427A1 (en) | 1994-07-22 | 1995-04-28 | Peptide derived radionuclide chelators |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE194845T1 true ATE194845T1 (de) | 2000-08-15 |
Family
ID=23067872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95916539T ATE194845T1 (de) | 1994-07-22 | 1995-04-28 | Von peptiden abgeleitete komplexbildner für radionuklide |
Country Status (11)
Country | Link |
---|---|
US (3) | US5662885A (de) |
EP (1) | EP0772628B1 (de) |
JP (1) | JP3753734B2 (de) |
CN (1) | CN1158133A (de) |
AT (1) | ATE194845T1 (de) |
AU (1) | AU700772B2 (de) |
CA (1) | CA2194551A1 (de) |
DE (1) | DE69518083T2 (de) |
HU (1) | HUT77137A (de) |
NO (1) | NO970273L (de) |
WO (1) | WO1996003427A1 (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
US7238340B1 (en) | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
US5804158A (en) * | 1995-05-31 | 1998-09-08 | Resolution Pharmaceuticals Inc. | Sequestered imaging agents |
WO2000036136A1 (en) * | 1998-12-14 | 2000-06-22 | Palatin Technologies, Inc. | Metallopeptide combinatorial libraries and applications |
US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
US5688489A (en) * | 1995-09-15 | 1997-11-18 | Resolution Pharmaceuticals, Inc. | Non-receptor mediated imaging agents |
FR2748747B1 (fr) * | 1996-05-20 | 1998-08-07 | Centre Nat Rech Scient | Particules virales recombinantes comportant un peptide ayant des proprietes de masquage et de demasquage vis-a-vis d'un mecanisme biologique |
CA2257856A1 (en) * | 1996-06-10 | 1997-12-18 | G.D. Searle & Co. | Radiopharmaceutical compositions capable of localizing at sites of thrombus |
CA2346154A1 (en) | 2001-05-02 | 2002-11-02 | University Of Missouri | Gastrin receptor-avid peptide conjugates |
EP0977579B1 (de) | 1997-04-22 | 2009-03-11 | Curator Of The University Of Missouri | Konjugate aus peptiden, die liganden von gastrinrezeptoren sind |
US6017511A (en) * | 1997-05-30 | 2000-01-25 | Resolution Pharmaceuticals Inc. | Glycopeptide-chelator conjugates |
WO1999010016A1 (en) * | 1997-08-21 | 1999-03-04 | Resolution Pharmaceuticals Inc. | Combinatorial library |
WO1999033863A1 (en) * | 1997-12-24 | 1999-07-08 | Resolution Pharmaceuticals Inc. | Peptide chelators that predominately form a single stereoisomeric species upon coordination to a metal center |
US6334996B1 (en) * | 1997-12-24 | 2002-01-01 | Resolution Pharmaceuticals Inc. | Chelators that predominantely form a single stereoisomeric species upon coordination to a metal center |
JP2002510705A (ja) | 1998-04-03 | 2002-04-09 | デュポン ファーマシューティカルズ カンパニー | 感染および炎症の撮像、ならびに癌の撮像および治療のための放射性医薬品 |
CA2351547A1 (en) * | 1998-08-31 | 2000-03-09 | Gryphon Sciences | Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides |
AU5142899A (en) * | 1999-02-17 | 2000-09-04 | Resolution Pharmaceuticals Inc. | Immobilized labeling compounds and methods |
US6544279B1 (en) | 2000-08-09 | 2003-04-08 | Incept, Llc | Vascular device for emboli, thrombus and foreign body removal and methods of use |
US7482425B2 (en) | 1999-08-26 | 2009-01-27 | Amylin Pharmaceuticals, Inc. | Compositions for lipid matrix-assisted chemical ligation |
US7109167B2 (en) | 2000-06-02 | 2006-09-19 | Bracco International B.V. | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
US8263739B2 (en) * | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
US7311893B2 (en) * | 2000-07-25 | 2007-12-25 | Neurochem (International) Limited | Amyloid targeting imaging agents and uses thereof |
US7422733B2 (en) * | 2000-11-29 | 2008-09-09 | Bracco International B.V. | Linkable sialyl Lewis X analogs |
US7893223B2 (en) | 2001-07-17 | 2011-02-22 | Bracco Imaging S.P.A. | Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
ES2506142T3 (es) | 2002-03-01 | 2014-10-13 | Dyax Corp. | Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico |
US7850947B2 (en) | 2003-01-13 | 2010-12-14 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
WO2004062574A2 (en) | 2003-01-13 | 2004-07-29 | Bracco Imaging S.P.A. | Improved linkers for radiopharmaceutical compounds |
US7611692B2 (en) | 2003-01-13 | 2009-11-03 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
US7922998B2 (en) | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
US8420050B2 (en) | 2003-01-13 | 2013-04-16 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
EP1603935A4 (de) | 2003-03-03 | 2007-03-21 | Dyax Corp | SPEZIFISCH AN HGF-REZEPTOR (cMet) BINDENDE PEPTIDE UND DEREN VERWENDUNG |
AU2004259028C1 (en) * | 2003-07-24 | 2009-12-24 | Bracco Imaging S.P.A. | Stable radiopharmaceutical compositions and methods for preparation |
DK1737889T3 (da) | 2004-10-19 | 2011-01-03 | Lonza Ag | Fremgangsmåde til fastfase-peptidsyntese |
EP1700608A1 (de) | 2005-03-10 | 2006-09-13 | Schering AG | Chelate für radioaktiv markierte Konjugate mit einer stabilisierenden Seitenkette |
CN101558081B (zh) | 2006-12-11 | 2014-08-20 | 伯拉考成像股份公司 | 用于诊断和治疗应用的纤维蛋白结合肽缀合体 |
CA2713872A1 (en) * | 2008-02-21 | 2009-08-27 | Burnham Institute For Medical Research | Methods and compositions related to peptides and proteins with c-terminal elements |
EP2147684A1 (de) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Selektiv gegen Metallproteasen wirkende Diagnosemittel |
US20120045393A1 (en) | 2009-03-17 | 2012-02-23 | Linder Karen E | Lhrh-ii peptide analogs |
JP5906184B2 (ja) | 2009-06-22 | 2016-04-20 | バーナム インスティテュート フォー メディカル リサーチ | C末端エレメントを有するペプチドおよびタンパク質を使用する方法および組成物 |
WO2015171543A1 (en) | 2014-05-05 | 2015-11-12 | California Institute Of Technology | Mutant akt-specific capture agents, compositions, and methods of using and making |
CN108290927B (zh) | 2015-07-15 | 2022-06-24 | 加州理工学院 | Il-17f-特异性捕获剂、组合物以及使用和制造的方法 |
IL260957B2 (en) | 2016-02-09 | 2023-11-01 | Bracco Suisse Sa | Chimeric, Recombinant Protein Glycoprotein Selectin-P Ligand-1 (PSGL-1) Conjugates, Preparations Containing Them and Uses Thereof |
CN115109120A (zh) | 2016-04-04 | 2022-09-27 | 英蒂分子公司 | Cd8-特异性捕获剂、组合物及使用和制备方法 |
US11884707B2 (en) | 2016-09-29 | 2024-01-30 | Regeneron Pharmaceuticals, Inc. | Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same |
US11358982B2 (en) | 2016-11-01 | 2022-06-14 | Ohio State Innovation Foundation | Methods for the iodination of biomolecules |
WO2018232345A1 (en) | 2017-06-15 | 2018-12-20 | Indi Molecular, Inc. | Il-17f and il-17a-specific capture agents, compositions, and methods of using and making |
WO2020097531A1 (en) | 2018-11-08 | 2020-05-14 | Indi Molecular, Inc. | Theranostic capture agents, compositions, and methods of using and making |
US20200291391A1 (en) | 2019-03-12 | 2020-09-17 | Indi Molecular, Inc. | Cross-linked epitopes and methods of use thereof |
WO2020236969A1 (en) | 2019-05-20 | 2020-11-26 | Indi Molecular, Inc. | Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1) |
US11414460B2 (en) | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
KR20240040769A (ko) | 2021-07-26 | 2024-03-28 | 아비나스 오퍼레이션스, 인코포레이티드 | 이작용성 화합물을 제조하는 방법 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4390528A (en) * | 1981-11-16 | 1983-06-28 | Research Corporation | Tuftsinyl-tuftsin |
US4980147A (en) * | 1984-06-25 | 1990-12-25 | University Of Utah Research Foundation | Radiolabeled technetium chelates for use in renal function determinations |
FR2575753B1 (fr) * | 1985-01-07 | 1987-02-20 | Adir | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5187264A (en) * | 1986-05-28 | 1993-02-16 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
ES2017088B3 (es) * | 1986-05-28 | 1991-01-01 | Mallinckrodt Inc (A Missouri Corporation) | Quelatos de tecnecio a utilizar para determinar la funcion renal. |
US5082930A (en) * | 1986-05-29 | 1992-01-21 | Mallinckrodt Medical, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
FR2610934B1 (fr) * | 1987-02-13 | 1989-05-05 | Adir | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5091514A (en) * | 1987-03-26 | 1992-02-25 | Neorx Corporation | Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy |
US4965392A (en) * | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
FR2616663B1 (fr) * | 1987-06-16 | 1989-08-18 | Adir | Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5021567A (en) * | 1987-09-24 | 1991-06-04 | Abbott Laboratories | 8-hydroxyquinoline chelating agents |
US5202451A (en) * | 1988-02-17 | 1993-04-13 | Neorx Corporation | Anchimeric radiometal chelating compounds |
US5202109A (en) * | 1988-06-10 | 1993-04-13 | Neorx Corporation | Conjugates for bone imaging and bone cancer therapy |
IT1230712B (it) * | 1989-02-10 | 1991-10-29 | Sclavo Spa | Composizione per vaccini |
WO1990009172A1 (en) * | 1989-02-16 | 1990-08-23 | Pfizer Inc. | Phosphorus containing renin inhibitors |
US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
US5248764A (en) * | 1989-06-16 | 1993-09-28 | Merck Frosst Canada, Inc. | Chelate derivatives of atrial natriuretic factor (ANF) |
US5028593A (en) * | 1989-08-15 | 1991-07-02 | Board Of Regents, The University Of Texas System | Tuftsin analogs |
IT1232311B (it) * | 1989-09-04 | 1992-01-28 | Sclavo Spa | Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare. |
US5175257A (en) * | 1989-12-29 | 1992-12-29 | Neorx Corporation | Radiolabeled proteins for diagnostic or therapeutic use |
EP0454302A3 (en) * | 1990-03-30 | 1992-10-14 | Banyu Pharmaceutical Co., Ltd. | Tuftsin derivatives |
US5112594A (en) * | 1991-04-04 | 1992-05-12 | Mallinckrodt Medical, Inc. | Kit for preparing a technetium-99m myocardial imaging agent |
WO1992013572A1 (en) * | 1991-02-08 | 1992-08-20 | Diatech, Inc. | TECHNETIUM-99m LABELED POLYPEPTIDES FOR IMAGING |
WO1992019274A1 (en) * | 1991-05-08 | 1992-11-12 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
DE69231586T2 (de) * | 1992-01-03 | 2001-07-19 | Rhomed Inc | Pharmazeutische anwendungen auf der basis von peptid-metall-ionen |
GB9209641D0 (en) * | 1992-05-02 | 1992-06-17 | Johnson Matthey Plc | Improvements in radiolabelling |
AU7261994A (en) * | 1993-07-19 | 1995-02-20 | Resolution Pharmaceuticals Inc. | Hydrazino-type radionuclide chelators having an n3s configuration |
CA2175557A1 (en) * | 1993-11-16 | 1995-05-26 | Alfred Pollak | Immobilized labelling method |
US5480970A (en) * | 1993-12-22 | 1996-01-02 | Resolution Pharmaceuticals | Metal chelators |
US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
US5804158A (en) * | 1995-05-31 | 1998-09-08 | Resolution Pharmaceuticals Inc. | Sequestered imaging agents |
-
1994
- 1994-07-22 US US08/279,155 patent/US5662885A/en not_active Expired - Lifetime
-
1995
- 1995-04-28 US US08/612,842 patent/US5976495A/en not_active Expired - Lifetime
- 1995-04-28 EP EP95916539A patent/EP0772628B1/de not_active Expired - Lifetime
- 1995-04-28 CA CA002194551A patent/CA2194551A1/en not_active Abandoned
- 1995-04-28 AU AU23011/95A patent/AU700772B2/en not_active Ceased
- 1995-04-28 AT AT95916539T patent/ATE194845T1/de not_active IP Right Cessation
- 1995-04-28 JP JP50532396A patent/JP3753734B2/ja not_active Expired - Fee Related
- 1995-04-28 DE DE69518083T patent/DE69518083T2/de not_active Expired - Lifetime
- 1995-04-28 CN CN95195127A patent/CN1158133A/zh active Pending
- 1995-04-28 WO PCT/CA1995/000249 patent/WO1996003427A1/en not_active Application Discontinuation
- 1995-04-28 HU HU9700196A patent/HUT77137A/hu unknown
-
1996
- 1996-08-28 US US08/703,988 patent/US5780006A/en not_active Expired - Lifetime
-
1997
- 1997-01-21 NO NO970273A patent/NO970273L/no unknown
Also Published As
Publication number | Publication date |
---|---|
DE69518083T2 (de) | 2001-03-22 |
WO1996003427A1 (en) | 1996-02-08 |
NO970273L (no) | 1997-03-12 |
NO970273D0 (no) | 1997-01-21 |
JP3753734B2 (ja) | 2006-03-08 |
EP0772628A1 (de) | 1997-05-14 |
US5976495A (en) | 1999-11-02 |
EP0772628B1 (de) | 2000-07-19 |
US5780006A (en) | 1998-07-14 |
DE69518083D1 (de) | 2000-08-24 |
JPH10502931A (ja) | 1998-03-17 |
CN1158133A (zh) | 1997-08-27 |
AU2301195A (en) | 1996-02-22 |
US5662885A (en) | 1997-09-02 |
CA2194551A1 (en) | 1996-02-08 |
HUT77137A (hu) | 1998-03-02 |
AU700772B2 (en) | 1999-01-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |