NO970273L - Peptid-avledete radionuklid-chelatorer - Google Patents

Peptid-avledete radionuklid-chelatorer

Info

Publication number
NO970273L
NO970273L NO970273A NO970273A NO970273L NO 970273 L NO970273 L NO 970273L NO 970273 A NO970273 A NO 970273A NO 970273 A NO970273 A NO 970273A NO 970273 L NO970273 L NO 970273L
Authority
NO
Norway
Prior art keywords
alkyl
carboxyl
hydroxyl
amino
halogen
Prior art date
Application number
NO970273A
Other languages
English (en)
Other versions
NO970273D0 (no
Inventor
Alfred Pollak
Anne Goodbody
Original Assignee
Resolution Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23067872&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO970273(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Resolution Pharm Inc filed Critical Resolution Pharm Inc
Publication of NO970273D0 publication Critical patent/NO970273D0/no
Publication of NO970273L publication Critical patent/NO970273L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer radionuklid-chelatorer med formel (I) som kan brukes for å danne bilder av steder av diagnostisk interesse inne i kroppen, og hvor X er en lineær eller forgrenet, mettet eller umettet C,.4alkylkjede som eventuelt er avbrutt av ett eller to heteroatomer valgt fra N, O og S; og som eventuelt er substituert med minst en gruppe valgt fra halogen, hydroksyl, amnio, karboksyl, C,^alkyl, aryl og C(0)Z; Y er H eller en substituent definert ved X; X og Y kan tilsammen danne en 5- eller 6-leddet mettet eller umettet heterocyklisk ring, eventuelt substituert med minst en gruppe valgt fra halogen, hydroksyl, amino, karboksyl, okso, Ci^alkyl, aryl og C(0)Z; R' til og med R" er valgt uavhengig fra hverandre fra H; karboksyl; C,^alkyl; Ci^^alkyl substituert med en gruppe valgt fra hydroksyl, amino, sulfhydryl, halogen, karboksyl, C,^alkoksykarbonyl og aminokarbonyl, en alfakarbonsidekjede av en D- eller L- aminosyre forskjellig fra prolin; og C(0)Z; R' og R^ er uavhengig av hverandre valgt fra H; karboksyl; amino; C,^alkyl; Ci^^alkyl substituert med hydroksyl, karboksyl eller amino; og C(0)Z; R' er valgt fra H og en svovelbeskyttende gruppe, og Z er valgt fra hydroksyl, Ci^alkoksy og et målsøkende molekyl.
NO970273A 1994-07-22 1997-01-21 Peptid-avledete radionuklid-chelatorer NO970273L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/279,155 US5662885A (en) 1994-07-22 1994-07-22 Peptide derived radionuclide chelators
PCT/CA1995/000249 WO1996003427A1 (en) 1994-07-22 1995-04-28 Peptide derived radionuclide chelators

Publications (2)

Publication Number Publication Date
NO970273D0 NO970273D0 (no) 1997-01-21
NO970273L true NO970273L (no) 1997-03-12

Family

ID=23067872

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970273A NO970273L (no) 1994-07-22 1997-01-21 Peptid-avledete radionuklid-chelatorer

Country Status (11)

Country Link
US (3) US5662885A (no)
EP (1) EP0772628B1 (no)
JP (1) JP3753734B2 (no)
CN (1) CN1158133A (no)
AT (1) ATE194845T1 (no)
AU (1) AU700772B2 (no)
CA (1) CA2194551A1 (no)
DE (1) DE69518083T2 (no)
HU (1) HUT77137A (no)
NO (1) NO970273L (no)
WO (1) WO1996003427A1 (no)

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Also Published As

Publication number Publication date
EP0772628A1 (en) 1997-05-14
WO1996003427A1 (en) 1996-02-08
ATE194845T1 (de) 2000-08-15
US5780006A (en) 1998-07-14
US5976495A (en) 1999-11-02
DE69518083D1 (de) 2000-08-24
EP0772628B1 (en) 2000-07-19
JP3753734B2 (ja) 2006-03-08
DE69518083T2 (de) 2001-03-22
CN1158133A (zh) 1997-08-27
HUT77137A (hu) 1998-03-02
AU700772B2 (en) 1999-01-14
JPH10502931A (ja) 1998-03-17
US5662885A (en) 1997-09-02
AU2301195A (en) 1996-02-22
CA2194551A1 (en) 1996-02-08
NO970273D0 (no) 1997-01-21

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