DE69840647D1 - Konjugate aus peptiden, die liganden von gastrinrezeptoren sind - Google Patents

Konjugate aus peptiden, die liganden von gastrinrezeptoren sind

Info

Publication number
DE69840647D1
DE69840647D1 DE69840647T DE69840647T DE69840647D1 DE 69840647 D1 DE69840647 D1 DE 69840647D1 DE 69840647 T DE69840647 T DE 69840647T DE 69840647 T DE69840647 T DE 69840647T DE 69840647 D1 DE69840647 D1 DE 69840647D1
Authority
DE
Germany
Prior art keywords
conjugates
ligands
peptides
gastrin receptors
gastrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69840647T
Other languages
English (en)
Inventor
Timothy Hoffman
Wynn A Volkert
Li Ning
Gary Sieckman
Chrys A Higgenbotham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Missouri System
Original Assignee
University of Missouri System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Missouri System filed Critical University of Missouri System
Application granted granted Critical
Publication of DE69840647D1 publication Critical patent/DE69840647D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0073—Rhodium compounds
    • C07F15/008—Rhodium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57572—Gastrin releasing peptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69840647T 1997-04-22 1998-04-22 Konjugate aus peptiden, die liganden von gastrinrezeptoren sind Expired - Lifetime DE69840647D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4404997P 1997-04-22 1997-04-22
PCT/US1998/007990 WO1998047524A1 (en) 1997-04-22 1998-04-22 Gastrin receptor-avid peptide conjugates

Publications (1)

Publication Number Publication Date
DE69840647D1 true DE69840647D1 (de) 2009-04-23

Family

ID=21930254

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69840647T Expired - Lifetime DE69840647D1 (de) 1997-04-22 1998-04-22 Konjugate aus peptiden, die liganden von gastrinrezeptoren sind

Country Status (6)

Country Link
US (4) US6200546B1 (de)
EP (1) EP0977579B1 (de)
JP (1) JP2002506424A (de)
CA (1) CA2283854A1 (de)
DE (1) DE69840647D1 (de)
WO (1) WO1998047524A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2346154A1 (en) * 2001-05-02 2002-11-02 University Of Missouri Gastrin receptor-avid peptide conjugates
DE69840647D1 (de) * 1997-04-22 2009-04-23 Curator Of The University Of M Konjugate aus peptiden, die liganden von gastrinrezeptoren sind
US6866837B2 (en) * 1998-06-05 2005-03-15 Mallinckrodt Inc. Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors
JP2002537274A (ja) * 1999-02-17 2002-11-05 ブラッコ インターナショナル ベスローテン フエンノートシャップ 固定化した標識配合物および方法
GR1003661B (el) * 2000-05-25 2001-09-05 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ
EP1385556A4 (de) * 2001-05-02 2005-10-19 Univ Missouri System At Columb Peptid-konjugate mit affinität für gastrin-rezeptoren
MXPA04002621A (es) 2001-09-21 2004-07-08 Univ Tulane Conjugados de analogos de somatostatina o bombesina para diagnostico o terapeuticos y usos de los mismos.
CA2478543A1 (en) * 2001-10-26 2003-04-26 The Uab Research Foundation Multidrug multiligand conjugates for targeted drug delivery
DE60331049D1 (de) 2002-03-01 2010-03-11 Univ Tulane Konjugate von zytotoxischen mitteln und biologisch aktiven peptiden
WO2003092743A1 (en) * 2002-05-03 2003-11-13 Bracco Imaging S.P.A. Radiopharmaceutical formulations
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US20080008649A1 (en) * 2003-01-13 2008-01-10 Bracco Imaging S.P.A. Gastrin Releasing Peptide Compounds
ATE435035T1 (de) * 2003-01-13 2009-07-15 Bracco Imaging Spa Verbesserte linker für radiopharmazeutische verbindungen
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7922998B2 (en) * 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) * 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US20060239923A1 (en) * 2003-01-13 2006-10-26 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
CA2783275A1 (en) * 2003-07-24 2005-02-03 Bracco Imaging S.P.A. Stable radiopharmaceutical compositions and methods for their preparation
AU2004273057C1 (en) 2003-09-08 2011-06-30 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Non-peptide agonists and antagonists of adrenomedullin and gastrin releasing peptide
US20080051315A1 (en) * 2003-12-11 2008-02-28 Eric Kandel Grp Receptor-Related Methods for the Treating and Preventing Fear-Related Disorders
US8084493B1 (en) 2005-01-04 2011-12-27 Gp Medical, Inc. Pharmaceutical composition of peptide drug and enzyme-inhibition compounds
EP1898958A2 (de) * 2005-05-31 2008-03-19 INBIOS S.r.l. Supramolekulare aggregate mit cheliermitteln und bioaktiven peptiden als effektive und selektive abgabewerkzeuge für arzneimittel und kontrastmittel bei mrt oder in der nuklearmedizin
EP1985624A3 (de) * 2007-04-23 2008-12-24 Bayer Schering Pharma Aktiengesellschaft Einschrittiges Verfahren zur Radiofluorierung von biologisch aktiven Verbindungen oder Biomolekülen
US20100028912A1 (en) * 2006-12-20 2010-02-04 Bracco Imaging S.P.A. Imaging using radioactive monocations in combination with a receptor binding ligand that stimulates the influx of cations
EP2100900A1 (de) 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin-analoge Peptid-antagonistische Konjugate
US20100015058A1 (en) * 2008-06-25 2010-01-21 Stanford University Radiolabeled bbn-rgd heterodimers for cancer targeting

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL245621A (de) * 1957-09-25
NL106889C (de) * 1957-09-25 1900-01-01
US3523103A (en) * 1965-06-08 1970-08-04 Liner Technology Inc Process for polyurethane formation and catalysts therefor
US3836488A (en) * 1970-10-06 1974-09-17 Dow Chemical Co Tris(2-(dimethylamino)ethyl)amine as catalyst for the preparation of polyurethanes
US4119585A (en) * 1977-05-10 1978-10-10 M&T Chemicals Inc. Process for preparing rigid polyurethane foams using latent catalysts
US5534497A (en) 1986-05-28 1996-07-09 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
FR2630444B1 (fr) * 1988-04-21 1990-09-07 Rhone Poulenc Chimie Composes d'etain utilisables notamment comme catalyseurs latents pour la preparation de polyurethannes
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
CA2032499C (en) 1989-07-20 2002-05-14 Rainer Albert Polypeptide derivatives
US5686410A (en) * 1989-07-20 1997-11-11 Novartis Ag Polypeptide derivatives
US5217955A (en) 1989-09-15 1993-06-08 Biomeasure, Inc. Treatment of cancer with peptide analog of bombesin, grp, litorin or neuromedin
JPH05506981A (ja) * 1989-10-24 1993-10-14 バーレックス　ラボラトリーズ　インコーポレイテイド ガストリン放出ペプチド受容体
US5834433A (en) * 1990-07-26 1998-11-10 Merrell Pharmaceuticals Inc. Compounds and pharmaceutical uses of peptides of bombesin and GRP
US5620959A (en) 1990-07-31 1997-04-15 Glaxo Wellcome Inc. Bombesin antagonists
US5244883A (en) 1990-11-29 1993-09-14 The Administrators Of The Tulane Educational Fund Nonapeptide bombesin antagonists
US5369094A (en) 1990-11-29 1994-11-29 The Administrators Of The Tulane Educational Fund Polypeptide bombesin antagonists
ATE156492T1 (de) * 1991-05-23 1997-08-15 Merrell Pharma Inc Bombesinanaloge
CA2129032A1 (en) * 1992-02-07 1993-08-19 Judson V. Edwards Phenylalanine analogs of bombesin
US5491174A (en) * 1992-10-09 1996-02-13 The Dow Chemical Company Process for preparation of polyurethanes utilizing novel catalysts
US5620955A (en) 1993-06-18 1997-04-15 Peptide Technologies Corporation Bombesin receptor antagonists and uses thereof
NZ270267A (en) * 1993-12-30 1997-03-24 Hoechst Ag 3-hydroxypyridin-2yl (and -quinolin-2-yl) carboxamide derivatives and pharmaceutical compositions
US5662885A (en) 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
CA2346154A1 (en) * 2001-05-02 2002-11-02 University Of Missouri Gastrin receptor-avid peptide conjugates
DE69840647D1 (de) * 1997-04-22 2009-04-23 Curator Of The University Of M Konjugate aus peptiden, die liganden von gastrinrezeptoren sind

Also Published As

Publication number Publication date
EP0977579A1 (de) 2000-02-09
US7147838B2 (en) 2006-12-12
US6921526B2 (en) 2005-07-26
US20050163710A1 (en) 2005-07-28
EP0977579B1 (de) 2009-03-11
EP0977579A4 (de) 2002-10-02
US6200546B1 (en) 2001-03-13
JP2002506424A (ja) 2002-02-26
US20020176819A1 (en) 2002-11-28
WO1998047524A1 (en) 1998-10-29
US20070065362A1 (en) 2007-03-22
CA2283854A1 (en) 1998-10-29

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Legal Events

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