ATE435035T1 - Verbesserte linker für radiopharmazeutische verbindungen - Google Patents

Verbesserte linker für radiopharmazeutische verbindungen

Info

Publication number
ATE435035T1
ATE435035T1 AT03808615T AT03808615T ATE435035T1 AT E435035 T1 ATE435035 T1 AT E435035T1 AT 03808615 T AT03808615 T AT 03808615T AT 03808615 T AT03808615 T AT 03808615T AT E435035 T1 ATE435035 T1 AT E435035T1
Authority
AT
Austria
Prior art keywords
compounds
diagnostic
methods
therapeutic moiety
linker
Prior art date
Application number
AT03808615T
Other languages
English (en)
Inventor
Haen Christoph De
Adrian Nunn
Rolf Swenson
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of ATE435035T1 publication Critical patent/ATE435035T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0493—Steroids, e.g. cholesterol, testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT03808615T 2003-01-13 2003-12-24 Verbesserte linker für radiopharmazeutische verbindungen ATE435035T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43972203P 2003-01-13 2003-01-13
PCT/US2003/041656 WO2004062574A2 (en) 2003-01-13 2003-12-24 Improved linkers for radiopharmaceutical compounds

Publications (1)

Publication Number Publication Date
ATE435035T1 true ATE435035T1 (de) 2009-07-15

Family

ID=32713508

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03808615T ATE435035T1 (de) 2003-01-13 2003-12-24 Verbesserte linker für radiopharmazeutische verbindungen

Country Status (9)

Country Link
US (2) US7989417B2 (de)
EP (1) EP1583564B1 (de)
JP (1) JP4610345B2 (de)
CN (1) CN100534535C (de)
AT (1) ATE435035T1 (de)
AU (1) AU2003303714B2 (de)
CA (1) CA2512310C (de)
DE (1) DE60328226D1 (de)
WO (1) WO2004062574A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
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US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7922998B2 (en) * 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
ATE435035T1 (de) * 2003-01-13 2009-07-15 Bracco Imaging Spa Verbesserte linker für radiopharmazeutische verbindungen
RU2006126637A (ru) * 2003-12-24 2008-01-27 Бракко Имэджинг С.П.А. (It) Улучшенные производные пептида, высвобождающего гастрит
US8029766B2 (en) * 2004-06-18 2011-10-04 Elmaleh David R Intravascular imaging device and uses thereof
US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
KR101653182B1 (ko) * 2006-04-19 2016-09-01 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 세포 영상화 및 치료를 위한 조성물 및 방법
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
EP2606911A1 (de) * 2007-02-16 2013-06-26 KTB Tumorforschungsgesellschaft mbH Rezeptor- und antigengerichtete Prodrug
WO2008144728A1 (en) * 2007-05-21 2008-11-27 Bracco Imaging S.P.A. Conjugates which bind a blood protein such as human serum albumin and methods of using the same in diagnostic and therapeutic applications
EP2895204B1 (de) 2012-09-13 2020-10-21 Provincial Health Services Authority Gegen bradykinin-rezeptor-b1 gerichtete zusammensetzung zur medizinischen bildgebung von krebs und anderen erkrankungen
CN104744568B (zh) * 2013-12-25 2018-02-23 华东理工大学 对神经激肽‑1受体蛋白特异性识别的p物质多肽探针及其制备与应用
GB201417067D0 (en) 2014-09-26 2014-11-12 South African Nuclear Energy Radiopharmaceutical conjugate
US20190029637A1 (en) * 2016-01-29 2019-01-31 The Regents Of The University Of California A wearable sensor, and method, to monitor anti-coagulation therapy
CN109970834A (zh) * 2019-02-27 2019-07-05 郑州明泽医药科技有限公司 一种氢化可的松琥珀酸钠的制备方法
CN112067556B (zh) * 2020-09-29 2021-08-17 湖北鑫英泰系统技术股份有限公司 一种油浸式设备油气检测方法及装置

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US4988496A (en) 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
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GB2355009A (en) * 1999-07-30 2001-04-11 Univ Glasgow Peptides conjugated to bile acids/salts
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ATE435035T1 (de) * 2003-01-13 2009-07-15 Bracco Imaging Spa Verbesserte linker für radiopharmazeutische verbindungen

Also Published As

Publication number Publication date
CN1738652A (zh) 2006-02-22
US20060241018A1 (en) 2006-10-26
US20110280802A1 (en) 2011-11-17
JP2006513247A (ja) 2006-04-20
CA2512310C (en) 2012-09-25
WO2004062574A2 (en) 2004-07-29
CA2512310A1 (en) 2004-07-29
US7989417B2 (en) 2011-08-02
CN100534535C (zh) 2009-09-02
JP4610345B2 (ja) 2011-01-12
EP1583564A2 (de) 2005-10-12
EP1583564A4 (de) 2007-06-13
EP1583564B1 (de) 2009-07-01
DE60328226D1 (de) 2009-08-13
AU2003303714A1 (en) 2004-08-10
WO2004062574A3 (en) 2005-04-14
WO2004062574A9 (en) 2005-05-26
AU2003303714B2 (en) 2009-02-19

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