EA200901344A1 - Фолат-конъюгаты и соответствующие комплексы хелатов металлов для применения для диагностической визуализации и лучевой терапии - Google Patents

Фолат-конъюгаты и соответствующие комплексы хелатов металлов для применения для диагностической визуализации и лучевой терапии

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Publication number
EA200901344A1
EA200901344A1 EA200901344A EA200901344A EA200901344A1 EA 200901344 A1 EA200901344 A1 EA 200901344A1 EA 200901344 A EA200901344 A EA 200901344A EA 200901344 A EA200901344 A EA 200901344A EA 200901344 A1 EA200901344 A1 EA 200901344A1
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Eurasian Patent Office
Prior art keywords
conjugates
folat
radiotherapy
application
metal chelate
Prior art date
Application number
EA200901344A
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English (en)
Inventor
Рудольф Мозер
Роже Шибли
Кристина Магдалена Мюллер
Виола Грён
Урс Михель
Кристоф Спарр
Томас Лейтон Миндт
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Мерк Эпрова Аг
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Application filed by Мерк Эпрова Аг filed Critical Мерк Эпрова Аг
Publication of EA200901344A1 publication Critical patent/EA200901344A1/ru

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    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
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    • A—HUMAN NECESSITIES
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    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
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Abstract

Настоящее изобретение относится к новым фолат-конъюгатам формулы Iгде F представляет собой фолат или его производное, Z, Z, Zпредставляют собой независимо друг от друга С или N, S-Zпредставляют собой независимо друг от друга простую связь или спейсер, R, Rи Rпредставляют собой донорные группы и/или другую группу F, Rпредставляет собой необязательно другую группу F и n представляет собой 1 или 2. Изобретение также охватывает соответствующие комплексы хелатов металлов, а также их фармацевтические композиции, и их применения для диагностической визуализации и лучевой терапии.
EA200901344A 2007-04-11 2008-04-11 Фолат-конъюгаты и соответствующие комплексы хелатов металлов для применения для диагностической визуализации и лучевой терапии EA200901344A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07105980 2007-04-11
PCT/EP2008/054409 WO2008125618A1 (en) 2007-04-11 2008-04-11 Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy

Publications (1)

Publication Number Publication Date
EA200901344A1 true EA200901344A1 (ru) 2010-04-30

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EA200901344A EA200901344A1 (ru) 2007-04-11 2008-04-11 Фолат-конъюгаты и соответствующие комплексы хелатов металлов для применения для диагностической визуализации и лучевой терапии

Country Status (12)

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US (2) US20100143249A1 (ru)
EP (1) EP2146995A1 (ru)
JP (2) JP5710246B2 (ru)
KR (2) KR101605426B1 (ru)
CN (1) CN101646672B (ru)
AU (1) AU2008237935B2 (ru)
CA (1) CA2670385C (ru)
EA (1) EA200901344A1 (ru)
HK (1) HK1138571A1 (ru)
IL (1) IL201250A0 (ru)
WO (1) WO2008125618A1 (ru)
ZA (1) ZA200903483B (ru)

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WO2008125618A1 (en) * 2007-04-11 2008-10-23 Merck Eprova Ag Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy
US8236284B1 (en) * 2008-04-02 2012-08-07 University Of Central Florida Research Foundation, Inc. Multimodal, multifunctional polymer coated nanoparticles
FR2942227B1 (fr) * 2009-02-13 2011-04-15 Guerbet Sa Utilisation de tampons pour la complexation de radionucleides
WO2011084571A2 (en) 2009-12-16 2011-07-14 Mallinckrodt Inc. Azide derivatives for phototherapy
KR102036199B1 (ko) * 2011-08-17 2019-10-24 메르크 앤드 씨에 알부민-결합 개체들의 폴레이트 공액체들
CN104379585B (zh) 2012-05-08 2018-07-06 默克及其合伙人公司 18f-标记的叶酸/抗叶酸剂类似物
CN107207418A (zh) * 2015-02-06 2017-09-26 森普拉制药公司 4‑叠氮基丁胺和制备方法
WO2020256210A1 (ko) 2019-06-20 2020-12-24 주식회사 쿼드마이너 네트워크 포렌식 시스템 및 이를 이용한 네트워크 포렌식 방법

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US6093382A (en) * 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
DE60231868D1 (de) 2001-04-24 2009-05-20 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
CN101648028B (zh) * 2002-05-06 2012-11-21 恩多塞特公司 维生素-定向的显象剂
EP1618380B1 (en) * 2003-04-29 2009-12-30 Universität Zürich N epsilon AND/OR N alpha DERIVATIZED, METAL AND ORGANIC PROTECTED L-HISTIDINE FOR COUPLING TO BIOMOLECULES FOR HIGHLY EFFICIENT LABELING WITH (M(OH2)3(CO)3)+ BY FAC COORDINATION
US9265746B2 (en) * 2006-05-31 2016-02-23 Merck & Cie Method for cell-specific targeting
WO2008125618A1 (en) * 2007-04-11 2008-10-23 Merck Eprova Ag Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy

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CN101646672B (zh) 2015-08-19
JP5876527B2 (ja) 2016-03-02
EP2146995A1 (en) 2010-01-27
IL201250A0 (en) 2010-05-31
KR101605426B1 (ko) 2016-03-22
KR20100016330A (ko) 2010-02-12
ZA200903483B (en) 2010-04-28
AU2008237935A1 (en) 2008-10-23
CN101646672A (zh) 2010-02-10
WO2008125618A1 (en) 2008-10-23
CA2670385C (en) 2016-01-12
JP2014193889A (ja) 2014-10-09
JP5710246B2 (ja) 2015-04-30
KR20150140415A (ko) 2015-12-15
CA2670385A1 (en) 2008-10-23
US20170128599A1 (en) 2017-05-11
AU2008237935B2 (en) 2014-03-27
US20100143249A1 (en) 2010-06-10
JP2010523626A (ja) 2010-07-15
HK1138571A1 (zh) 2010-08-27

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