DE69518083T2 - Von peptiden abgeleitete komplexbildner für radionuklide - Google Patents
Von peptiden abgeleitete komplexbildner für radionuklideInfo
- Publication number
- DE69518083T2 DE69518083T2 DE69518083T DE69518083T DE69518083T2 DE 69518083 T2 DE69518083 T2 DE 69518083T2 DE 69518083 T DE69518083 T DE 69518083T DE 69518083 T DE69518083 T DE 69518083T DE 69518083 T2 DE69518083 T2 DE 69518083T2
- Authority
- DE
- Germany
- Prior art keywords
- peptides
- imagers
- complex
- radionuclides
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000002738 chelating agent Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/279,155 US5662885A (en) | 1994-07-22 | 1994-07-22 | Peptide derived radionuclide chelators |
PCT/CA1995/000249 WO1996003427A1 (en) | 1994-07-22 | 1995-04-28 | Peptide derived radionuclide chelators |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69518083D1 DE69518083D1 (de) | 2000-08-24 |
DE69518083T2 true DE69518083T2 (de) | 2001-03-22 |
Family
ID=23067872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69518083T Expired - Lifetime DE69518083T2 (de) | 1994-07-22 | 1995-04-28 | Von peptiden abgeleitete komplexbildner für radionuklide |
Country Status (11)
Country | Link |
---|---|
US (3) | US5662885A (de) |
EP (1) | EP0772628B1 (de) |
JP (1) | JP3753734B2 (de) |
CN (1) | CN1158133A (de) |
AT (1) | ATE194845T1 (de) |
AU (1) | AU700772B2 (de) |
CA (1) | CA2194551A1 (de) |
DE (1) | DE69518083T2 (de) |
HU (1) | HUT77137A (de) |
NO (1) | NO970273L (de) |
WO (1) | WO1996003427A1 (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7238340B1 (en) | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
US5804158A (en) * | 1995-05-31 | 1998-09-08 | Resolution Pharmaceuticals Inc. | Sequestered imaging agents |
US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
US5688489A (en) * | 1995-09-15 | 1997-11-18 | Resolution Pharmaceuticals, Inc. | Non-receptor mediated imaging agents |
FR2748747B1 (fr) * | 1996-05-20 | 1998-08-07 | Centre Nat Rech Scient | Particules virales recombinantes comportant un peptide ayant des proprietes de masquage et de demasquage vis-a-vis d'un mecanisme biologique |
WO1997047329A2 (en) * | 1996-06-10 | 1997-12-18 | G.D. Searle & Co. | Radiopharmaceutical compositions capable of localizing at sites of thrombus |
DE69840647D1 (de) | 1997-04-22 | 2009-04-23 | Curator Of The University Of M | Konjugate aus peptiden, die liganden von gastrinrezeptoren sind |
US7060247B2 (en) | 1997-04-22 | 2006-06-13 | The Curators Of The University Of Missouri | Gastrin receptor-avid peptide conjugates |
US6017511A (en) * | 1997-05-30 | 2000-01-25 | Resolution Pharmaceuticals Inc. | Glycopeptide-chelator conjugates |
AU8849398A (en) * | 1997-08-21 | 1999-03-16 | Resolution Pharmaceuticals Inc. | Combinatorial library |
EP1047708B1 (de) * | 1997-12-24 | 2007-09-26 | Bracco International B.V. | Peptide chelatoren die nach der koordination mit einem metall zu einem vorherrschenden einzel-stereoisomeren führen |
US6334996B1 (en) * | 1997-12-24 | 2002-01-01 | Resolution Pharmaceuticals Inc. | Chelators that predominantely form a single stereoisomeric species upon coordination to a metal center |
JP2002510705A (ja) | 1998-04-03 | 2002-04-09 | デュポン ファーマシューティカルズ カンパニー | 感染および炎症の撮像、ならびに癌の撮像および治療のための放射性医薬品 |
WO2000012536A2 (en) * | 1998-08-31 | 2000-03-09 | Gryphon Sciences | Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides |
JP2002536295A (ja) * | 1998-12-14 | 2002-10-29 | パラチン テクノロジーズ, インク. | 金属ペプチド組合せライブラリ及びその利用法 |
CA2362860A1 (en) * | 1999-02-17 | 2000-08-24 | Bracco International B.V. | Immobilized labeling compounds and methods |
US6544279B1 (en) | 2000-08-09 | 2003-04-08 | Incept, Llc | Vascular device for emboli, thrombus and foreign body removal and methods of use |
US7482425B2 (en) | 1999-08-26 | 2009-01-27 | Amylin Pharmaceuticals, Inc. | Compositions for lipid matrix-assisted chemical ligation |
WO2001091805A2 (en) | 2000-06-02 | 2001-12-06 | Bracco Research Usa | Compounds for targeting endothelial cells |
US8263739B2 (en) * | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
US7311893B2 (en) * | 2000-07-25 | 2007-12-25 | Neurochem (International) Limited | Amyloid targeting imaging agents and uses thereof |
AU2002251678A1 (en) * | 2000-11-29 | 2002-08-19 | Bracco International B.V. | Linkable sialyl lewis x analogs |
US7893223B2 (en) | 2001-07-17 | 2011-02-22 | Bracco Imaging S.P.A. | Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
EP1587944A4 (de) | 2002-03-01 | 2007-03-21 | Dyax Corp | Kdr und vegf/kdr-bindende peptide und ihre diagnostische und therapeutische veranwendung bei der diagnose und therapie |
US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
AU2003213730A1 (en) | 2002-03-01 | 2003-09-16 | Bracco International B.V. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US7922998B2 (en) | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
US7850947B2 (en) | 2003-01-13 | 2010-12-14 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
US7611692B2 (en) | 2003-01-13 | 2009-11-03 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
US8420050B2 (en) | 2003-01-13 | 2013-04-16 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
EP1583564B1 (de) | 2003-01-13 | 2009-07-01 | Bracco Imaging S.p.A | Verbesserte linker für radiopharmazeutische verbindungen |
US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
DK2949658T3 (en) | 2003-03-03 | 2018-10-01 | Dyax Corp | Peptides that specifically bind HGF receptor (cMet) and uses thereof |
KR101106533B1 (ko) * | 2003-07-24 | 2012-01-20 | 브라코 이미징 에스.피.에이. | 안정한 방사성의약 조성물 및 제조 방법 |
DK1737889T3 (da) | 2004-10-19 | 2011-01-03 | Lonza Ag | Fremgangsmåde til fastfase-peptidsyntese |
EP1700608A1 (de) | 2005-03-10 | 2006-09-13 | Schering AG | Chelate für radioaktiv markierte Konjugate mit einer stabilisierenden Seitenkette |
US8278274B2 (en) | 2006-12-11 | 2012-10-02 | Bracco Imaging Spa | Fibrin-binding peptides and conjugates thereof |
AU2009215426B2 (en) * | 2008-02-21 | 2015-06-11 | Burnham Institute For Medical Research | Methods and compositions related to peptides and proteins with C-terminal elements |
EP2147684A1 (de) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Selektiv gegen Metallproteasen wirkende Diagnosemittel |
US20120045393A1 (en) | 2009-03-17 | 2012-02-23 | Linder Karen E | Lhrh-ii peptide analogs |
KR20120048563A (ko) | 2009-06-22 | 2012-05-15 | 번햄 인스티튜트 포 메디칼 리서치 | C?말단 요소를 가진 펩타이드 및 단백질의 사용방법 및 그 조성물 |
WO2015171543A1 (en) | 2014-05-05 | 2015-11-12 | California Institute Of Technology | Mutant akt-specific capture agents, compositions, and methods of using and making |
CN108290927B (zh) | 2015-07-15 | 2022-06-24 | 加州理工学院 | Il-17f-特异性捕获剂、组合物以及使用和制造的方法 |
KR20180104166A (ko) | 2016-02-09 | 2018-09-19 | 브라코 스위스 에스.에이. | 셀렉틴 표적화를 위한 재조합 키메라 단백질 |
CN109476721B (zh) | 2016-04-04 | 2022-06-28 | 英蒂分子公司 | Cd8-特异性捕获剂、组合物及使用和制备方法 |
US11884707B2 (en) | 2016-09-29 | 2024-01-30 | Regeneron Pharmaceuticals, Inc. | Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same |
WO2018085375A1 (en) | 2016-11-01 | 2018-05-11 | Ohio State Innovation Foundation | Methods for the iodination of biomolecules |
WO2018232345A1 (en) | 2017-06-15 | 2018-12-20 | Indi Molecular, Inc. | Il-17f and il-17a-specific capture agents, compositions, and methods of using and making |
US11638764B2 (en) | 2018-11-08 | 2023-05-02 | Indi Molecular, Inc. | Theranostic capture agents, compositions, and methods of using and making |
US20200291391A1 (en) | 2019-03-12 | 2020-09-17 | Indi Molecular, Inc. | Cross-linked epitopes and methods of use thereof |
WO2020236969A1 (en) | 2019-05-20 | 2020-11-26 | Indi Molecular, Inc. | Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1) |
US11414460B2 (en) | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
CA3227425A1 (en) | 2021-07-26 | 2023-02-02 | Arvinas Operations, Inc. | Methods of manufacturing a bifunctional compound |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4390528A (en) * | 1981-11-16 | 1983-06-28 | Research Corporation | Tuftsinyl-tuftsin |
US4980147A (en) * | 1984-06-25 | 1990-12-25 | University Of Utah Research Foundation | Radiolabeled technetium chelates for use in renal function determinations |
FR2575753B1 (fr) * | 1985-01-07 | 1987-02-20 | Adir | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5187264A (en) * | 1986-05-28 | 1993-02-16 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
ATE52516T1 (de) * | 1986-05-28 | 1990-05-15 | Mallinckrodt Inc | Technetiumchelate fuer die bestimmung der nierenfunktion. |
US5082930A (en) * | 1986-05-29 | 1992-01-21 | Mallinckrodt Medical, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
FR2610934B1 (fr) * | 1987-02-13 | 1989-05-05 | Adir | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5091514A (en) * | 1987-03-26 | 1992-02-25 | Neorx Corporation | Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy |
US4965392A (en) * | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
FR2616663B1 (fr) * | 1987-06-16 | 1989-08-18 | Adir | Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5021567A (en) * | 1987-09-24 | 1991-06-04 | Abbott Laboratories | 8-hydroxyquinoline chelating agents |
US5202451A (en) * | 1988-02-17 | 1993-04-13 | Neorx Corporation | Anchimeric radiometal chelating compounds |
US5202109A (en) * | 1988-06-10 | 1993-04-13 | Neorx Corporation | Conjugates for bone imaging and bone cancer therapy |
IT1230712B (it) * | 1989-02-10 | 1991-10-29 | Sclavo Spa | Composizione per vaccini |
WO1990009172A1 (en) * | 1989-02-16 | 1990-08-23 | Pfizer Inc. | Phosphorus containing renin inhibitors |
US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
US5248764A (en) * | 1989-06-16 | 1993-09-28 | Merck Frosst Canada, Inc. | Chelate derivatives of atrial natriuretic factor (ANF) |
US5028593A (en) * | 1989-08-15 | 1991-07-02 | Board Of Regents, The University Of Texas System | Tuftsin analogs |
IT1232311B (it) * | 1989-09-04 | 1992-01-28 | Sclavo Spa | Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare. |
US5175257A (en) * | 1989-12-29 | 1992-12-29 | Neorx Corporation | Radiolabeled proteins for diagnostic or therapeutic use |
EP0454302A3 (en) * | 1990-03-30 | 1992-10-14 | Banyu Pharmaceutical Co., Ltd. | Tuftsin derivatives |
US5112594A (en) * | 1991-04-04 | 1992-05-12 | Mallinckrodt Medical, Inc. | Kit for preparing a technetium-99m myocardial imaging agent |
ATE188387T1 (de) * | 1991-02-08 | 2000-01-15 | Diatide Inc | Technetium-99m markierte polypeptide zur bildformung |
AU1995392A (en) * | 1991-05-08 | 1992-12-21 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
WO1993012819A1 (en) * | 1992-01-03 | 1993-07-08 | Rhomed Incorporated | Protein- and peptide-metal ion pharmaceutical applications |
GB9209641D0 (en) * | 1992-05-02 | 1992-06-17 | Johnson Matthey Plc | Improvements in radiolabelling |
AU7261994A (en) * | 1993-07-19 | 1995-02-20 | Resolution Pharmaceuticals Inc. | Hydrazino-type radionuclide chelators having an n3s configuration |
ATE334704T1 (de) * | 1993-11-16 | 2006-08-15 | Bracco Int Bv | Immobilisiertes markierungsverfahren |
US5480970A (en) * | 1993-12-22 | 1996-01-02 | Resolution Pharmaceuticals | Metal chelators |
US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
US5804158A (en) * | 1995-05-31 | 1998-09-08 | Resolution Pharmaceuticals Inc. | Sequestered imaging agents |
-
1994
- 1994-07-22 US US08/279,155 patent/US5662885A/en not_active Expired - Lifetime
-
1995
- 1995-04-28 JP JP50532396A patent/JP3753734B2/ja not_active Expired - Fee Related
- 1995-04-28 CN CN95195127A patent/CN1158133A/zh active Pending
- 1995-04-28 AT AT95916539T patent/ATE194845T1/de not_active IP Right Cessation
- 1995-04-28 CA CA002194551A patent/CA2194551A1/en not_active Abandoned
- 1995-04-28 US US08/612,842 patent/US5976495A/en not_active Expired - Lifetime
- 1995-04-28 WO PCT/CA1995/000249 patent/WO1996003427A1/en not_active Application Discontinuation
- 1995-04-28 EP EP95916539A patent/EP0772628B1/de not_active Expired - Lifetime
- 1995-04-28 HU HU9700196A patent/HUT77137A/hu unknown
- 1995-04-28 DE DE69518083T patent/DE69518083T2/de not_active Expired - Lifetime
- 1995-04-28 AU AU23011/95A patent/AU700772B2/en not_active Ceased
-
1996
- 1996-08-28 US US08/703,988 patent/US5780006A/en not_active Expired - Lifetime
-
1997
- 1997-01-21 NO NO970273A patent/NO970273L/no unknown
Also Published As
Publication number | Publication date |
---|---|
JPH10502931A (ja) | 1998-03-17 |
NO970273D0 (no) | 1997-01-21 |
DE69518083D1 (de) | 2000-08-24 |
NO970273L (no) | 1997-03-12 |
JP3753734B2 (ja) | 2006-03-08 |
CA2194551A1 (en) | 1996-02-08 |
EP0772628A1 (de) | 1997-05-14 |
US5780006A (en) | 1998-07-14 |
HUT77137A (hu) | 1998-03-02 |
WO1996003427A1 (en) | 1996-02-08 |
CN1158133A (zh) | 1997-08-27 |
US5976495A (en) | 1999-11-02 |
US5662885A (en) | 1997-09-02 |
AU2301195A (en) | 1996-02-22 |
AU700772B2 (en) | 1999-01-14 |
EP0772628B1 (de) | 2000-07-19 |
ATE194845T1 (de) | 2000-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |