DE60006587D1 - Makrozyclische liganden für metallpharmazeutika - Google Patents
Makrozyclische liganden für metallpharmazeutikaInfo
- Publication number
- DE60006587D1 DE60006587D1 DE60006587T DE60006587T DE60006587D1 DE 60006587 D1 DE60006587 D1 DE 60006587D1 DE 60006587 T DE60006587 T DE 60006587T DE 60006587 T DE60006587 T DE 60006587T DE 60006587 D1 DE60006587 D1 DE 60006587D1
- Authority
- DE
- Germany
- Prior art keywords
- metal
- relates
- pharmaceuticals
- macrocyclic chelants
- macrocyclic ligands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 230000001588 bifunctional effect Effects 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 238000002059 diagnostic imaging Methods 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000014187 peptide receptors Human genes 0.000 abstract 1
- 108010011903 peptide receptors Proteins 0.000 abstract 1
- 239000000816 peptidomimetic Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000012217 radiopharmaceutical Substances 0.000 abstract 1
- 229940121896 radiopharmaceutical Drugs 0.000 abstract 1
- 230000002799 radiopharmaceutical effect Effects 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6587—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having two phosphorus atoms as ring hetero atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15351299P | 1999-09-13 | 1999-09-13 | |
| US153512P | 1999-09-13 | ||
| PCT/US2000/024482 WO2001019838A1 (en) | 1999-09-13 | 2000-09-07 | Macrocyclic chelants for metallopharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60006587D1 true DE60006587D1 (de) | 2003-12-18 |
| DE60006587T2 DE60006587T2 (de) | 2004-09-16 |
Family
ID=22547523
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60024891T Expired - Fee Related DE60024891T2 (de) | 1999-09-13 | 2000-09-07 | Makrocyclische Chelatbildner für Metallopharmazeutika |
| DE60006587T Expired - Fee Related DE60006587T2 (de) | 1999-09-13 | 2000-09-07 | Makrozyclische liganden für metallpharmazeutika |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60024891T Expired - Fee Related DE60024891T2 (de) | 1999-09-13 | 2000-09-07 | Makrocyclische Chelatbildner für Metallopharmazeutika |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1246830B1 (de) |
| JP (1) | JP2003509434A (de) |
| AT (2) | ATE254130T1 (de) |
| AU (1) | AU7353400A (de) |
| CA (1) | CA2382057A1 (de) |
| DE (2) | DE60024891T2 (de) |
| ES (1) | ES2211602T3 (de) |
| WO (1) | WO2001019838A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITPD20030174A1 (it) * | 2003-07-31 | 2003-10-29 | Univ Padova | Coniugati polimerici per diagnostica e terapia |
| JP4559922B2 (ja) * | 2005-06-21 | 2010-10-13 | 株式会社東芝 | 蛍光性錯体及びそれを用いた照明装置 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362476A (en) * | 1984-10-18 | 1994-11-08 | Board Of Regents, The University Of Texas System | Alkyl phosphonate polyazamacrocyclic cheates for MRI |
| FR2612191B1 (fr) * | 1987-03-13 | 1989-06-16 | Centre Nat Rech Scient | Macrocycles organiques phosphores, procede de fabrication et applications |
| US5462725A (en) * | 1993-05-06 | 1995-10-31 | The Dow Chemical Company | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| JPH10500401A (ja) * | 1994-04-22 | 1998-01-13 | モンサント カンパニー | 金属錯体を用いる診断画像解析法 |
| JP3573310B2 (ja) * | 1996-02-20 | 2004-10-06 | 富士写真フイルム株式会社 | 平版印刷用不感脂化処理液 |
-
2000
- 2000-09-07 AU AU73534/00A patent/AU7353400A/en not_active Abandoned
- 2000-09-07 WO PCT/US2000/024482 patent/WO2001019838A1/en active IP Right Grant
- 2000-09-07 DE DE60024891T patent/DE60024891T2/de not_active Expired - Fee Related
- 2000-09-07 EP EP00961605A patent/EP1246830B1/de not_active Expired - Lifetime
- 2000-09-07 DE DE60006587T patent/DE60006587T2/de not_active Expired - Fee Related
- 2000-09-07 CA CA002382057A patent/CA2382057A1/en not_active Abandoned
- 2000-09-07 ES ES00961605T patent/ES2211602T3/es not_active Expired - Lifetime
- 2000-09-07 AT AT00961605T patent/ATE254130T1/de not_active IP Right Cessation
- 2000-09-07 JP JP2001523615A patent/JP2003509434A/ja active Pending
- 2000-09-07 AT AT03077312T patent/ATE312837T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2382057A1 (en) | 2001-03-22 |
| EP1246830B1 (de) | 2003-11-12 |
| AU7353400A (en) | 2001-04-17 |
| DE60024891T2 (de) | 2006-08-24 |
| ATE312837T1 (de) | 2005-12-15 |
| DE60006587T2 (de) | 2004-09-16 |
| DE60024891D1 (de) | 2006-01-19 |
| JP2003509434A (ja) | 2003-03-11 |
| ATE254130T1 (de) | 2003-11-15 |
| ES2211602T3 (es) | 2004-07-16 |
| EP1246830A1 (de) | 2002-10-09 |
| WO2001019838A1 (en) | 2001-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |