ES2157905T3 - Producto radiofarmaceutico que tiene particularmente un tropismo cerebral que comprende un complejo nitruro de un metal de transicion, y su procedimiento de preparacion. - Google Patents

Producto radiofarmaceutico que tiene particularmente un tropismo cerebral que comprende un complejo nitruro de un metal de transicion, y su procedimiento de preparacion.

Info

Publication number
ES2157905T3
ES2157905T3 ES92917875T ES92917875T ES2157905T3 ES 2157905 T3 ES2157905 T3 ES 2157905T3 ES 92917875 T ES92917875 T ES 92917875T ES 92917875 T ES92917875 T ES 92917875T ES 2157905 T3 ES2157905 T3 ES 2157905T3
Authority
ES
Spain
Prior art keywords
pct
preparation procedure
transitional metal
radiopharmaceutical product
nitride complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92917875T
Other languages
English (en)
Inventor
Roberto Pasqualini
Emmanuel Bellande
Veronique Comazzi
Jacques Laine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIS Bio International SA
Original Assignee
CIS Bio International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CIS Bio International SA filed Critical CIS Bio International SA
Application granted granted Critical
Publication of ES2157905T3 publication Critical patent/ES2157905T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION CONCIERNE A UN PRODUCTO RADIOFARMACEUTICO QUE TIENE EN PARTICULAR UN TROPISMO CEREBRAL QUE INCLUYE UN COMPLEJO NITRURO DE UN METAL DE TRANSICION, Y SU PROCESO DE PREPARACION. ESTE COMPLEJO RESPONDE A LA FORMULA (I): (M N) L1L2 EN LA CUAL M ES UN METAL DE TRANSICION, POR EJEMPLO TC99M, RE 186 O RE 188, Y L1 Y L2 QUE PUEDEN SER IDENTICOS O DIFERENTES, RESPONDEN A LA FORMULA (II) EN LA CUAL R1 Y R2 PUEDEN SER RADICALES ALQUILO, V Y W PUEDEN SER O, S O SE; N=0 O 1; L=0 O 1, M=0 O 1, Y X REPRESENTA N-C, C, P O AS.
ES92917875T 1991-07-22 1992-07-22 Producto radiofarmaceutico que tiene particularmente un tropismo cerebral que comprende un complejo nitruro de un metal de transicion, y su procedimiento de preparacion. Expired - Lifetime ES2157905T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9109231A FR2679452B1 (fr) 1991-07-22 1991-07-22 Produit radiopharmaceutique ayant notamment un tropisme cerebral, comportant un complexe nitruro d'un metal de transition, et son procede de preparation.

Publications (1)

Publication Number Publication Date
ES2157905T3 true ES2157905T3 (es) 2001-09-01

Family

ID=9415380

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92917875T Expired - Lifetime ES2157905T3 (es) 1991-07-22 1992-07-22 Producto radiofarmaceutico que tiene particularmente un tropismo cerebral que comprende un complejo nitruro de un metal de transicion, y su procedimiento de preparacion.

Country Status (12)

Country Link
US (1) US5496929A (es)
EP (1) EP0596037B1 (es)
JP (1) JPH07500816A (es)
AT (1) ATE200867T1 (es)
AU (1) AU662351B2 (es)
CA (1) CA2113830A1 (es)
DE (1) DE69231811T2 (es)
DK (1) DK0596037T3 (es)
ES (1) ES2157905T3 (es)
FR (1) FR2679452B1 (es)
GR (1) GR3036304T3 (es)
WO (1) WO1993001839A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807884A (en) * 1992-10-30 1998-09-15 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5783596A (en) * 1992-10-30 1998-07-21 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5380747A (en) * 1992-10-30 1995-01-10 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
US5750088A (en) * 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US5792787A (en) * 1995-06-07 1998-08-11 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
FR2736834B1 (fr) * 1995-07-17 1997-08-29 Cis Bio Int Produits radiopharmaceutiques a tropisme cardiaque comportant un complexe nitruro d'un metal de transition et ayant une clairance myocardique rapide
ATE239745T1 (de) * 1996-12-18 2003-05-15 Nihon Mediphysics Co Ltd Nitrid-heterokomplexe von radioaktiven übergangsmetallen
WO2002009771A1 (en) * 2000-07-28 2002-02-07 Nihon Medi-Physics Co., Ltd. Radiopharmaceutical for diagnostic imaging containing a technetium-99m nitride heterocomplex
JP5027144B2 (ja) 2006-01-20 2012-09-19 日本メジフィジックス株式会社 放射性画像診断のための窒化テクネチウム錯体の中間体化合物
EP2426107A1 (en) * 2010-08-05 2012-03-07 Universitat Autònoma De Barcelona Transition metal conjugated radiopharmaceuticals useful as therapeutic and/or diagnostic agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851515A (en) * 1983-12-29 1989-07-25 The Commonwealth Of Australia Preparation of 99m Tc radiopharmaceuticals
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof
US5301278A (en) * 1988-04-29 1994-04-05 International Business Machines Corporation Flexible dynamic memory controller
CA2003880C (fr) * 1988-11-25 2002-01-08 Roberto Pasqualini Produit radiopharmaceutique ayant notamment un tropisme cardiaque comportant un complexe nitruro d'un metal de transition, et son procede de preparation
CA2085364A1 (en) * 1990-06-18 1991-12-19 Alfons M. Verbruggen Metal-radionuclide complex comprising isonitrile ligands
FR2664166A1 (fr) * 1990-07-04 1992-01-10 Cis Bio Int Procede de preparation de complexes nitruro de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques.

Also Published As

Publication number Publication date
ATE200867T1 (de) 2001-05-15
FR2679452A1 (fr) 1993-01-29
DE69231811D1 (de) 2001-06-07
AU2432292A (en) 1993-02-23
US5496929A (en) 1996-03-05
JPH07500816A (ja) 1995-01-26
GR3036304T3 (en) 2001-10-31
EP0596037B1 (fr) 2001-05-02
AU662351B2 (en) 1995-08-31
DE69231811T2 (de) 2001-11-22
CA2113830A1 (en) 1993-01-23
DK0596037T3 (da) 2001-08-06
WO1993001839A1 (fr) 1993-02-04
EP0596037A1 (fr) 1994-05-11
FR2679452B1 (fr) 1993-11-12

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