ATE200867T1 - Uebergangsmetall-nitridokomplex enthaltendes radiopharmazeutisches produkt mit einer neigung zum gehirn, verfahren zu deren herstellung - Google Patents

Uebergangsmetall-nitridokomplex enthaltendes radiopharmazeutisches produkt mit einer neigung zum gehirn, verfahren zu deren herstellung

Info

Publication number
ATE200867T1
ATE200867T1 AT92917875T AT92917875T ATE200867T1 AT E200867 T1 ATE200867 T1 AT E200867T1 AT 92917875 T AT92917875 T AT 92917875T AT 92917875 T AT92917875 T AT 92917875T AT E200867 T1 ATE200867 T1 AT E200867T1
Authority
AT
Austria
Prior art keywords
transition metal
production
pct
complex containing
radiopharmaceutical product
Prior art date
Application number
AT92917875T
Other languages
English (en)
Inventor
Roberto Pasqualini
Emmanuel Bellande
Veronique Comazzi
Jacques Laine
Original Assignee
Cis Bio Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cis Bio Int filed Critical Cis Bio Int
Application granted granted Critical
Publication of ATE200867T1 publication Critical patent/ATE200867T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT92917875T 1991-07-22 1992-07-22 Uebergangsmetall-nitridokomplex enthaltendes radiopharmazeutisches produkt mit einer neigung zum gehirn, verfahren zu deren herstellung ATE200867T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9109231A FR2679452B1 (fr) 1991-07-22 1991-07-22 Produit radiopharmaceutique ayant notamment un tropisme cerebral, comportant un complexe nitruro d'un metal de transition, et son procede de preparation.
PCT/FR1992/000718 WO1993001839A1 (fr) 1991-07-22 1992-07-22 Produit radiopharmaceutique ayant notamment un tropisme cerebral comportant un complexe nitruro d'un metal de transition, et son procede de preparation

Publications (1)

Publication Number Publication Date
ATE200867T1 true ATE200867T1 (de) 2001-05-15

Family

ID=9415380

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92917875T ATE200867T1 (de) 1991-07-22 1992-07-22 Uebergangsmetall-nitridokomplex enthaltendes radiopharmazeutisches produkt mit einer neigung zum gehirn, verfahren zu deren herstellung

Country Status (12)

Country Link
US (1) US5496929A (de)
EP (1) EP0596037B1 (de)
JP (1) JPH07500816A (de)
AT (1) ATE200867T1 (de)
AU (1) AU662351B2 (de)
CA (1) CA2113830A1 (de)
DE (1) DE69231811T2 (de)
DK (1) DK0596037T3 (de)
ES (1) ES2157905T3 (de)
FR (1) FR2679452B1 (de)
GR (1) GR3036304T3 (de)
WO (1) WO1993001839A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807884A (en) * 1992-10-30 1998-09-15 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5380747A (en) * 1992-10-30 1995-01-10 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5821260A (en) * 1992-10-30 1998-10-13 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
US5750088A (en) * 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US5792787A (en) * 1995-06-07 1998-08-11 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
FR2736834B1 (fr) * 1995-07-17 1997-08-29 Cis Bio Int Produits radiopharmaceutiques a tropisme cardiaque comportant un complexe nitruro d'un metal de transition et ayant une clairance myocardique rapide
PT949265E (pt) 1996-12-18 2003-08-29 Nihon Mediphysics Co Ltd Heterocomplexo de nitreto de um metal de transicao radioactivo
KR100845449B1 (ko) 2000-07-28 2008-07-10 니혼 메디피직스 가부시키가이샤 테크네튬-99ｍ 니트리드 이종복합체를 함유하는영상진단용 방사선 의약품
US8182789B2 (en) 2006-01-20 2012-05-22 Nihon Medi-Physics Co., Ltd. Intermediate compound of technetium nitride complex for radiodiagnostic imaging
EP2426107A1 (de) * 2010-08-05 2012-03-07 Universitat Autònoma De Barcelona Übergangsmetallkonjugierte Radiopharmazeutika als Therapie- und/oder Diagnosemittel

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3484511D1 (de) * 1983-12-29 1991-05-29 Commw Of Australia Herstellung von mit 99m tc markierten radioarzneimitteln.
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof
US5301278A (en) * 1988-04-29 1994-04-05 International Business Machines Corporation Flexible dynamic memory controller
ES2059831T3 (es) * 1988-11-25 1994-11-16 Cis Bio Int Producto radiofarmaceutico que tiene principalmente un tropismo cardiaco que comprende un complejo nitruro de un metal de transicion, y su procedimiento de preparacion.
AU8542591A (en) * 1990-06-18 1992-01-07 Mallinckrodt Medical, Inc. Metal-radionuclide complex comprising isonitrile ligands
FR2664166A1 (fr) * 1990-07-04 1992-01-10 Cis Bio Int Procede de preparation de complexes nitruro de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques.

Also Published As

Publication number Publication date
EP0596037B1 (de) 2001-05-02
ES2157905T3 (es) 2001-09-01
FR2679452B1 (fr) 1993-11-12
GR3036304T3 (en) 2001-10-31
CA2113830A1 (en) 1993-01-23
WO1993001839A1 (fr) 1993-02-04
DK0596037T3 (da) 2001-08-06
AU2432292A (en) 1993-02-23
EP0596037A1 (de) 1994-05-11
FR2679452A1 (fr) 1993-01-29
US5496929A (en) 1996-03-05
AU662351B2 (en) 1995-08-31
DE69231811D1 (de) 2001-06-07
DE69231811T2 (de) 2001-11-22
JPH07500816A (ja) 1995-01-26

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee