PL1797102T3 - Kompozycja zawierająca rodnik triarylometylowy przydatna w diagnostyce metodą MRI - Google Patents

Kompozycja zawierająca rodnik triarylometylowy przydatna w diagnostyce metodą MRI

Info

Publication number
PL1797102T3
PL1797102T3 PL05771194T PL05771194T PL1797102T3 PL 1797102 T3 PL1797102 T3 PL 1797102T3 PL 05771194 T PL05771194 T PL 05771194T PL 05771194 T PL05771194 T PL 05771194T PL 1797102 T3 PL1797102 T3 PL 1797102T3
Authority
PL
Poland
Prior art keywords
useful
composition
mri diagnostics
triarylmethyl radical
triarylmethyl
Prior art date
Application number
PL05771194T
Other languages
English (en)
Inventor
Mikkel Thaning
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of PL1797102T3 publication Critical patent/PL1797102T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806Suspensions, emulsions, colloids, dispersions
    • A61K49/1815Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Cosmetics (AREA)
  • Rectifiers (AREA)
PL05771194T 2004-07-30 2005-07-28 Kompozycja zawierająca rodnik triarylometylowy przydatna w diagnostyce metodą MRI PL1797102T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20043229 2004-07-30
EP05771194.7A EP1797102B1 (en) 2004-07-30 2005-07-28 Composition comprising triarylmethyl radical, useful in mri diagnostics
PCT/NO2005/000281 WO2006011809A1 (en) 2004-07-30 2005-07-28 Method of producing a composition, composition and its use

Publications (1)

Publication Number Publication Date
PL1797102T3 true PL1797102T3 (pl) 2015-10-30

Family

ID=35058362

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05771194T PL1797102T3 (pl) 2004-07-30 2005-07-28 Kompozycja zawierająca rodnik triarylometylowy przydatna w diagnostyce metodą MRI

Country Status (18)

Country Link
US (2) US20080095713A1 (pl)
EP (1) EP1797102B1 (pl)
JP (2) JP5367265B2 (pl)
KR (2) KR20070063504A (pl)
CN (1) CN101035796B (pl)
AU (1) AU2005267668B2 (pl)
BR (1) BRPI0513812B8 (pl)
CA (1) CA2575601C (pl)
DK (1) DK1797102T3 (pl)
ES (1) ES2545260T3 (pl)
HK (1) HK1107691A1 (pl)
IL (1) IL180897A (pl)
MX (1) MX2007001035A (pl)
NZ (1) NZ552898A (pl)
PL (1) PL1797102T3 (pl)
RU (1) RU2374252C2 (pl)
WO (1) WO2006011809A1 (pl)
ZA (1) ZA200701271B (pl)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0014463D0 (en) * 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
KR20070063504A (ko) * 2004-07-30 2007-06-19 지이 헬스케어 에이에스 조성물의 제조 방법, 조성물 및 그의 용도
WO2007064226A2 (en) * 2005-12-01 2007-06-07 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
ES2393750T3 (es) 2005-12-16 2012-12-27 Ge Healthcare As Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas
WO2007111515A2 (en) * 2006-03-29 2007-10-04 Ge Healthcare As Method to produce hyperpolarised carboxylates and sulphonates
CN101506179B (zh) 2006-08-30 2012-08-22 通用电气医疗集团股份有限公司 动态核极化(dnp)的方法及用于所述方法的化合物和组合物
WO2008086534A1 (en) 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof
US8731640B2 (en) 2007-03-28 2014-05-20 General Electric Company Fluid path system for dissolution and transport of a hyperpolarized material
US20080240998A1 (en) * 2007-03-28 2008-10-02 Urbahn John A Fluid path system for dissolution and transport of a hyperpolarized material
US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
KR20100023802A (ko) * 2007-05-17 2010-03-04 제너럴 일렉트릭 캄파니 과분극화 13c-피루베이트를 포함하는 영상화 매질을 사용하여 종양을 등급화하는 mr 방법
US9227173B2 (en) 2007-06-22 2016-01-05 General Electric Company Methods for dynamic filtration of pharmaceutical products
CN101970014A (zh) * 2007-07-26 2011-02-09 通用电气医疗集团英国有限公司 包含超极化的13c-乳酸盐的成像介质及其用途
EP2902041A1 (en) 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
US20110038804A1 (en) * 2007-12-21 2011-02-17 Anna Gisselsson Mr imaging agent, imaging medium and methods of imaging wherein such an imaging medium is used
WO2009129265A1 (en) 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
US8763410B2 (en) 2008-04-21 2014-07-01 General Electric Company Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media
DK2268321T3 (da) 2008-05-02 2013-12-02 Gen Electric Fremgangsmåde til bestemmelse af alanintransaminase (alt)-aktivitet ved 13c-mr-detektion under anvendelse af hyperpolariseret 13c-pyruvat
RU2543704C2 (ru) 2009-04-02 2015-03-10 ДжиИ ХЕЛТКЕР ЛИМИТЕД Применение магнитно-резонансной визуализирующей среды, содержащей гиперполяризованный 13с-пируват, для обнаружения воспаления или инфекции
EP2476009A1 (en) 2009-09-10 2012-07-18 GE Healthcare UK Limited 13c-mr detection using hyperpolarised 13c-fructose
DE102009054956A1 (de) * 2009-12-18 2011-06-22 Siemens Aktiengesellschaft, 80333 Magnetresonanztomographie-Bildgebung
JP5758982B2 (ja) 2010-04-08 2015-08-05 ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. 過分極基質の製造方法およびmriのための方法
KR101858269B1 (ko) 2010-05-03 2018-05-15 지이 헬쓰케어 리미티드 락테이트 탈수소효소 활성의 측정을 위한 과분극화된 락테이트 조영제
US20130149250A1 (en) * 2011-06-23 2013-06-13 The Regents Of The University Of California Hyperpolarized agents for mri characterization of redox systems in vivo
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
EP2950826B1 (en) 2013-01-31 2019-09-18 Bracco Imaging S.p.A Hyperpolarized esters as metabolic markers in mri
EP3016687B1 (en) 2013-07-01 2017-08-09 Bracco Imaging S.p.A Hyperpolarized 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for mr
US9874622B2 (en) 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2690987B2 (ja) 1987-06-23 1997-12-17 ハフスルンド・ニユコメド・イノベイション・アクチェボラーグ 磁気共鳴像形成における改良
GB8817137D0 (en) 1988-07-19 1988-08-24 Nycomed As Compositions
AU651570B2 (en) 1990-02-12 1994-07-28 Hafslund Nycomed Innovation Ab Triarylmethyl radicals and the use of inert carbon free radicals in MRI
US5435991A (en) 1991-08-09 1995-07-25 Nycomed Innovation Ab Use of persistent heterocyclic free-radicals in magnetic resonance imaging
US5728370A (en) 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
CN1200179A (zh) 1995-09-08 1998-11-25 耐克麦德英梅金公司 一种测定样品中氧气浓度的方法
ES2201462T3 (es) * 1997-03-06 2004-03-16 Amersham Health As Radicales libres de triarilmetilo como agentes mejoradores de la imagen.
AU8119298A (en) 1997-06-19 1999-01-04 Nycomed Imaging As Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6232497B1 (en) 1998-12-23 2001-05-15 Skw Trostberg Aktiengesellschaft Method for producing alkali metal and alkaline earth metal pyruvates
GB0014463D0 (en) 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
KR100794898B1 (ko) 2000-11-03 2008-01-14 지이 헬스케어 에이에스 분극된 nmr 샘플을 위한 방법 및 장치
US6617169B2 (en) * 2001-03-30 2003-09-09 Mclean Hospital Corporation Two-dimensional MR spectroscopy techniques
US6486671B1 (en) * 2001-05-14 2002-11-26 Ge Medical Systems Global Technologies Company Llc MRI image quality improvement using matrix regularization
US6958244B2 (en) * 2002-04-12 2005-10-25 Bruker Biospin Corp. Low-conductivity buffers for magnetic resonance measurements
JP5535435B2 (ja) * 2004-07-30 2014-07-02 ジーイー・ヘルスケア・アクスイェ・セルスカプ ラジカル及び、dnp処理における常磁性試薬としてのその使用
KR20070063504A (ko) * 2004-07-30 2007-06-19 지이 헬스케어 에이에스 조성물의 제조 방법, 조성물 및 그의 용도

Also Published As

Publication number Publication date
WO2006011809A1 (en) 2006-02-02
JP5745470B2 (ja) 2015-07-08
US9023320B2 (en) 2015-05-05
CA2575601C (en) 2013-05-28
CA2575601A1 (en) 2006-02-02
US20080095713A1 (en) 2008-04-24
BRPI0513812A (pt) 2008-05-13
US20080213186A1 (en) 2008-09-04
CN101035796B (zh) 2011-06-22
RU2007102843A (ru) 2008-09-10
NZ552898A (en) 2011-02-25
DK1797102T3 (en) 2015-08-24
AU2005267668B2 (en) 2011-10-20
RU2374252C2 (ru) 2009-11-27
IL180897A (en) 2010-11-30
JP5367265B2 (ja) 2013-12-11
ES2545260T3 (es) 2015-09-09
KR20070063504A (ko) 2007-06-19
JP2012236832A (ja) 2012-12-06
EP1797102B1 (en) 2015-05-27
MX2007001035A (es) 2007-07-11
KR101475635B1 (ko) 2014-12-22
KR20130028989A (ko) 2013-03-20
IL180897A0 (en) 2007-07-04
BRPI0513812B8 (pt) 2021-07-27
ZA200701271B (en) 2008-05-28
JP2008508266A (ja) 2008-03-21
EP1797102A1 (en) 2007-06-20
AU2005267668A1 (en) 2006-02-02
CN101035796A (zh) 2007-09-12
BRPI0513812B1 (pt) 2017-05-09
HK1107691A1 (en) 2008-04-11

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