PL3192874T3 - Oczyszczanie wirusa - Google Patents
Oczyszczanie wirusaInfo
- Publication number
- PL3192874T3 PL3192874T3 PL16002644T PL16002644T PL3192874T3 PL 3192874 T3 PL3192874 T3 PL 3192874T3 PL 16002644 T PL16002644 T PL 16002644T PL 16002644 T PL16002644 T PL 16002644T PL 3192874 T3 PL3192874 T3 PL 3192874T3
- Authority
- PL
- Poland
- Prior art keywords
- virus purification
- virus
- purification
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Manufacturing & Machinery (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7368508P | 2008-06-18 | 2008-06-18 | |
| PCT/GB2009/001527 WO2009153563A1 (en) | 2008-06-18 | 2009-06-18 | Virus purification |
| EP16002644.9A EP3192874B1 (en) | 2008-06-18 | 2009-06-18 | Virus purification |
| EP09766124.3A EP2307551B1 (en) | 2008-06-18 | 2009-06-18 | Purification of retroviral vectors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3192874T3 true PL3192874T3 (pl) | 2020-06-29 |
Family
ID=40940324
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16002644T PL3192874T3 (pl) | 2008-06-18 | 2009-06-18 | Oczyszczanie wirusa |
| PL09766124T PL2307551T3 (pl) | 2008-06-18 | 2009-06-18 | Oczyszczanie wektorów retrowirusowych |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09766124T PL2307551T3 (pl) | 2008-06-18 | 2009-06-18 | Oczyszczanie wektorów retrowirusowych |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9169491B2 (enExample) |
| EP (2) | EP3192874B1 (enExample) |
| JP (2) | JP5615271B2 (enExample) |
| CN (2) | CN102124115B (enExample) |
| DK (2) | DK2307551T3 (enExample) |
| ES (2) | ES2762864T3 (enExample) |
| PL (2) | PL3192874T3 (enExample) |
| WO (1) | WO2009153563A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2529020B1 (en) | 2010-01-28 | 2018-04-25 | The Children's Hospital of Philadelphia | A scalable manufacturing platform for viral vector purification and viral vectors so purified for use in gene therapy |
| CN102946907A (zh) | 2010-05-28 | 2013-02-27 | 牛津生物医学（英国）有限公司 | 慢病毒载体向脑的递送 |
| GB201118636D0 (en) | 2011-10-28 | 2011-12-07 | Oxford Biomedica Ltd | Nucleotide sequence |
| WO2013076309A1 (en) | 2011-11-24 | 2013-05-30 | Genethon | Scalable lentiviral vector production system compatible with industrial pharmaceutical applications |
| PT2790737T (pt) | 2011-12-12 | 2019-02-28 | Childrens Hospital Philadelphia | Sistema de produção de vetores lentivirais a grande escala comercial e vetores produzidos pelo mesmo |
| US9365832B2 (en) | 2012-01-09 | 2016-06-14 | Sanofi Pasteur Biologics, Llc | Purification of herpes virus |
| WO2013177172A2 (en) | 2012-05-21 | 2013-11-28 | Sanofi Pasteur Limited | Herpesvirus compositions and related methods |
| RS61387B2 (sr) | 2013-02-15 | 2024-06-28 | Bioverativ Therapeutics Inc | Gen optimizovanog faktora viii |
| PT2970920T (pt) * | 2013-03-15 | 2018-07-30 | Childrens Hospital Philadelphia | Processo de fabrico escalável para produzir vetores lentivirais recombinantes em sistema de cultura de células de suspensão livres de soro |
| FR3010720B1 (fr) | 2013-09-16 | 2017-08-11 | Genethon | Procede de production de virus enveloppes |
| FR3014901B1 (fr) * | 2013-12-17 | 2017-06-09 | Genethon | Procede de purification de virus ou vecteurs viraux enveloppes |
| GB201322798D0 (en) | 2013-12-20 | 2014-02-05 | Oxford Biomedica Ltd | Production system |
| US11008561B2 (en) | 2014-06-30 | 2021-05-18 | Bioverativ Therapeutics Inc. | Optimized factor IX gene |
| CN104371982A (zh) * | 2014-10-21 | 2015-02-25 | 武汉维诺赛生物技术有限公司 | 一种慢病毒的纯化方法 |
| WO2016071758A1 (en) | 2014-11-03 | 2016-05-12 | Leiden University Medical Center | T cell receptors directed against bob1 and uses thereof |
| EP3054007A1 (en) | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
| AU2016230828B2 (en) | 2015-03-10 | 2020-10-22 | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) | T-cell receptors directed against the preferentially expressed antigen of melanoma and uses thereof |
| ES2987957T3 (es) | 2015-11-23 | 2024-11-18 | Novartis Ag | Vectores de transferencia lentivirales optimizados y usos de los mismos |
| KR20180118659A (ko) | 2016-02-01 | 2018-10-31 | 바이오버라티브 테라퓨틱스 인크. | 최적화된 viii 인자 유전자 |
| CN107043784A (zh) * | 2016-02-05 | 2017-08-15 | 上海吉凯基因化学技术有限公司 | 一种慢病毒载体的制备方法 |
| JP2019519250A (ja) | 2016-05-10 | 2019-07-11 | ユナイテッド ステイツ ガバメント アズ リプレゼンテッド バイ ザ デパートメント オブ ベテランズ アフェアーズＵｎｉｔｅｄ Ｓｔａｔｅｓ Ｇｏｖｅｒｎｍｅｎｔ Ａｓ Ｒｅｐｒｅｓｅｎｔｅｄ Ｂｙ Ｔｈｅ Ｄｅｐａｒｔｍｅｎｔ Ｏｆ Ｖｅｔｅｒａｎｓ Ａｆｆａｉｒｓ | Ｈｉｖ−１感染と複製に必須な遺伝子を切断するｃｒｉｓｐｒ／ｃａｓの構築物のレンチウィルスによる送達 |
| GB201614050D0 (en) * | 2016-08-17 | 2016-09-28 | Glaxosmithkline Ip Dev Ltd | Method for purifying viral vectors |
| EP3714055A1 (en) | 2017-11-21 | 2020-09-30 | CRISPR Therapeutics AG | Materials and methods for treatment of autosomal dominant retinitis pigmentosa |
| CA3084633A1 (en) | 2017-12-21 | 2019-06-27 | Crispr Therapeutics Ag | Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp) |
| AU2018393050A1 (en) | 2017-12-21 | 2020-06-18 | Bayer Healthcare Llc | Materials and methods for treatment of Usher Syndrome Type 2A |
| FI3633040T3 (fi) | 2017-12-22 | 2023-08-03 | Oxford Biomedica Ltd | Retrovirusvektori |
| BR112020020204A2 (pt) * | 2018-04-05 | 2021-01-19 | Oxford University Innovation Limited | Composições e métodos para tratamento da distrofia macular |
| SG11202012366WA (en) | 2018-06-12 | 2021-01-28 | Kentucky Bioprocessing Inc | Virus and antigen purification and conjugation |
| US11529413B2 (en) | 2018-06-12 | 2022-12-20 | Kbio Holdings Limited | Virus and antigen purification and conjugation |
| US11696948B2 (en) | 2018-06-12 | 2023-07-11 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| US11690907B2 (en) | 2018-06-12 | 2023-07-04 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| JP2021533831A (ja) * | 2018-08-16 | 2021-12-09 | スペースクラフト セブン リミテッド ライアビリティ カンパニー | ウイルスベクターのための生成方法 |
| CN115835887A (zh) | 2019-03-10 | 2023-03-21 | 牛津生物医学（英国）有限公司 | 用于治疗帕金森病的基因治疗组合物和方法 |
| US20220243224A1 (en) * | 2019-04-15 | 2022-08-04 | Children's Hospital Medical Center | Viral vector manufacturing methods |
| KR20220047635A (ko) | 2019-08-23 | 2022-04-18 | 론자 워커스빌 아이엔씨. | 렌티바이러스 벡터의 생산을 위한 방법 및 작제물 |
| JP7803014B2 (ja) | 2019-09-30 | 2026-01-21 | バイオベラティブ セラピューティクス インコーポレイテッド | レンチウイルスベクター製剤 |
| WO2021094752A1 (en) | 2019-11-12 | 2021-05-20 | Oxford Biomedica (Uk) Limited | Production system |
| US20240052366A1 (en) | 2020-02-13 | 2024-02-15 | Oxford Biomedica (Uk) Limited | Production of Lentiviral Vectors |
| WO2021181108A1 (en) | 2020-03-13 | 2021-09-16 | Oxford Biomedica (Uk) Limited | Lentiviral vectors |
| EP4143326A1 (en) | 2020-04-27 | 2023-03-08 | University of Iowa Research Foundation | Compositions and methods for the treatment of cystic fibrosis |
| GB202007199D0 (en) | 2020-05-15 | 2020-07-01 | Oxford Biomedica Ltd | Viral vector production |
| JP2023537565A (ja) | 2020-06-24 | 2023-09-04 | バイオベラティブ セラピューティクス インコーポレイテッド | タンパク質を発現するように改変されたレンチウイルスベクターの調製物から遊離第ｖｉｉｉ因子を除去する方法 |
| CA3188923A1 (en) * | 2020-08-13 | 2022-02-17 | Michael Sean BURNHAM | Methods for producing clinical-grade lentiviral vector |
| CN112226418B (zh) * | 2020-09-25 | 2022-07-08 | 阜外华中心血管病医院 | 重组腺相关病毒纯化方法 |
| CN116529382A (zh) * | 2020-10-02 | 2023-08-01 | 吉恩勒克斯公司 | 由贴壁细胞在生物反应器中产生病毒 |
| GB202017725D0 (en) | 2020-11-10 | 2020-12-23 | Oxford Biomedica Ltd | Method |
| CN112899242A (zh) * | 2021-02-03 | 2021-06-04 | 苏州博腾生物制药有限公司 | 慢病毒纯化工艺 |
| GB202114532D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral Vectors |
| GB202114534D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Novel viral regulatory elements |
| GB202114528D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral vectors |
| GB202114530D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Retroviral vectors |
| GB202114529D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral vectors |
| KR20240093931A (ko) | 2021-10-29 | 2024-06-24 | 에이지씨 가부시키가이샤 | 세포 첨가용 조성물 |
| WO2023085382A1 (ja) | 2021-11-12 | 2023-05-19 | Ａｇｃ株式会社 | ウイルスの精製方法 |
| GB202117844D0 (en) | 2021-12-09 | 2022-01-26 | Oxford Biomedica Ltd | Purification method |
| GB202211935D0 (en) | 2022-08-16 | 2022-09-28 | Oxford Biomedica Ltd | envelope proteins |
| CN116240241A (zh) * | 2022-12-30 | 2023-06-09 | 上海本导基因技术有限公司 | 重组慢病毒载体的纯化制备方法 |
| KR20250141180A (ko) * | 2023-02-01 | 2025-09-26 | 인테리우스 바이오테라퓨틱스, 인코포레이티드 | 바이러스 입자의 여과 또는 정제를 위한 방법 |
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| WO2025235738A1 (en) * | 2024-05-08 | 2025-11-13 | Interius Biotherapeutics, Inc. | Methods of detecting residual dna in viral preparations |
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| PL2007883T3 (pl) * | 2006-04-20 | 2012-07-31 | Wyeth Llc | Sposób oczyszczania do izolacji oczyszczonego wirusa pęcherzykowatego zapalenia jamy ustnej z hodowli komórkowej |
| WO2008065430A2 (en) * | 2006-12-01 | 2008-06-05 | Oxford Biomedica (Uk) Limited | Promoter construct |
| MX2009009200A (es) * | 2007-03-01 | 2009-10-28 | Advanced Vision Therapies Inc | Tratamiento de enfermedades caracterizadas por la inflamacion. |
| RU2501811C2 (ru) * | 2007-11-13 | 2013-12-20 | Био-Текнолоджи Дженерал (Изрейел) Лтд. | Способ стерилизации посредством фильтрации разбавленных вязкоэластичных биополимеров (варианты) |
-
2009
- 2009-06-18 WO PCT/GB2009/001527 patent/WO2009153563A1/en not_active Ceased
- 2009-06-18 EP EP16002644.9A patent/EP3192874B1/en active Active
- 2009-06-18 PL PL16002644T patent/PL3192874T3/pl unknown
- 2009-06-18 CN CN200980132555.9A patent/CN102124115B/zh not_active Expired - Fee Related
- 2009-06-18 CN CN201410244813.5A patent/CN103993040B/zh not_active Expired - Fee Related
- 2009-06-18 PL PL09766124T patent/PL2307551T3/pl unknown
- 2009-06-18 US US12/487,215 patent/US9169491B2/en active Active
- 2009-06-18 ES ES16002644T patent/ES2762864T3/es active Active
- 2009-06-18 DK DK09766124.3T patent/DK2307551T3/en active
- 2009-06-18 DK DK16002644.9T patent/DK3192874T3/da active
- 2009-06-18 EP EP09766124.3A patent/EP2307551B1/en active Active
- 2009-06-18 JP JP2011514119A patent/JP5615271B2/ja active Active
- 2009-06-18 ES ES09766124.3T patent/ES2618851T3/es active Active
-
2014
- 2014-07-10 JP JP2014142447A patent/JP6002720B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN103993040A (zh) | 2014-08-20 |
| EP3192874A1 (en) | 2017-07-19 |
| DK3192874T3 (da) | 2019-12-16 |
| JP2014237661A (ja) | 2014-12-18 |
| EP2307551A1 (en) | 2011-04-13 |
| EP3192874B1 (en) | 2019-10-16 |
| ES2762864T3 (es) | 2020-05-26 |
| CN102124115B (zh) | 2020-03-03 |
| JP6002720B2 (ja) | 2016-10-05 |
| JP5615271B2 (ja) | 2014-10-29 |
| US20090325284A1 (en) | 2009-12-31 |
| PL2307551T3 (pl) | 2017-07-31 |
| US9169491B2 (en) | 2015-10-27 |
| ES2618851T3 (es) | 2017-06-22 |
| WO2009153563A1 (en) | 2009-12-23 |
| CN102124115A (zh) | 2011-07-13 |
| EP2307551B1 (en) | 2016-12-14 |
| CN103993040B (zh) | 2018-02-13 |
| DK2307551T3 (en) | 2017-03-20 |
| JP2011524887A (ja) | 2011-09-08 |
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