PL3185012T3 - Sposób identyfikacji, selekcji i analizy komórek nowotworowych - Google Patents
Sposób identyfikacji, selekcji i analizy komórek nowotworowychInfo
- Publication number
- PL3185012T3 PL3185012T3 PL17156147T PL17156147T PL3185012T3 PL 3185012 T3 PL3185012 T3 PL 3185012T3 PL 17156147 T PL17156147 T PL 17156147T PL 17156147 T PL17156147 T PL 17156147T PL 3185012 T3 PL3185012 T3 PL 3185012T3
- Authority
- PL
- Poland
- Prior art keywords
- identification
- selection
- analysis
- tumour cells
- tumour
- Prior art date
Links
- 210000004881 tumor cell Anatomy 0.000 title 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C5/00—Separating dispersed particles from liquids by electrostatic effect
- B03C5/005—Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Optics & Photonics (AREA)
- Multimedia (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITTO2008A000814A IT1391619B1 (it) | 2008-11-04 | 2008-11-04 | Metodo per l'individuazione, selezione e analisi di cellule tumorali |
PCT/IB2009/007316 WO2010052543A1 (en) | 2008-11-04 | 2009-11-04 | Method for identification, selection and analysis of tumour cells |
EP09775275.2A EP2350647B1 (en) | 2008-11-04 | 2009-11-04 | Method for identification, selection and analysis of tumour cells |
EP17156147.5A EP3185012B1 (en) | 2008-11-04 | 2009-11-04 | Method for identification, selection and analysis of tumour cells |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3185012T3 true PL3185012T3 (pl) | 2022-06-13 |
Family
ID=41137040
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL17156147T PL3185012T3 (pl) | 2008-11-04 | 2009-11-04 | Sposób identyfikacji, selekcji i analizy komórek nowotworowych |
PL09775275T PL2350647T3 (pl) | 2008-11-04 | 2009-11-04 | Sposób identyfikacji selekcji i analizy komórek nowotworowych |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL09775275T PL2350647T3 (pl) | 2008-11-04 | 2009-11-04 | Sposób identyfikacji selekcji i analizy komórek nowotworowych |
Country Status (13)
Country | Link |
---|---|
US (2) | US10234447B2 (pl) |
EP (2) | EP2350647B1 (pl) |
JP (1) | JP5814124B2 (pl) |
KR (1) | KR101680619B1 (pl) |
CN (1) | CN102272595B (pl) |
CA (1) | CA2742769C (pl) |
CY (1) | CY1118888T1 (pl) |
DK (2) | DK2350647T3 (pl) |
ES (2) | ES2624827T3 (pl) |
IT (1) | IT1391619B1 (pl) |
PL (2) | PL3185012T3 (pl) |
PT (1) | PT3185012T (pl) |
WO (1) | WO2010052543A1 (pl) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITBO20040420A1 (it) | 2004-07-07 | 2004-10-07 | Type S R L | Macchina per taglio e formatura di piattine metalliche |
ITBO20050481A1 (it) | 2005-07-19 | 2007-01-20 | Silicon Biosystems S R L | Metodo ed apparato per la manipolazione e/o l'individuazione di particelle |
ITBO20050646A1 (it) | 2005-10-26 | 2007-04-27 | Silicon Biosystem S R L | Metodo ed apparato per la caratterizzazione ed il conteggio di particelle |
ITTO20060226A1 (it) | 2006-03-27 | 2007-09-28 | Silicon Biosystem S P A | Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche |
ITTO20060273A1 (it) * | 2006-04-12 | 2007-10-13 | Silicon Biosystem S P A | Metodi ed apparati per la selezione e/o il processamento di particellle, in particolare per la lisi selettiva e/o ottimizzata di cellule |
ITTO20070771A1 (it) * | 2007-10-29 | 2009-04-30 | Silicon Biosystems Spa | Metodo e apparato per la identificazione e manipolazione di particelle |
US10895575B2 (en) | 2008-11-04 | 2021-01-19 | Menarini Silicon Biosystems S.P.A. | Method for identification, selection and analysis of tumour cells |
US9192943B2 (en) | 2009-03-17 | 2015-11-24 | Silicon Biosystems S.P.A. | Microfluidic device for isolation of cells |
JP5916991B2 (ja) * | 2010-11-09 | 2016-05-11 | オリンパス株式会社 | 遺伝子異常細胞の解析方法 |
US9197859B2 (en) | 2010-11-30 | 2015-11-24 | Cellnumerate Corporation | Rapid, no-flow, whole-blood, and volumetric circulating cell counting system and method |
IT1403518B1 (it) | 2010-12-22 | 2013-10-31 | Silicon Biosystems Spa | Dispositivo microfluidico per la manipolazione di particelle |
DE102011076221B3 (de) * | 2011-05-20 | 2012-07-12 | Siemens Aktiengesellschaft | Automatisierter CTC Nachweis |
KR20140104946A (ko) * | 2011-10-05 | 2014-08-29 | 시레카 테라노스틱스, 엘엘씨 | 스펙트럼 이미징에 의해 생물학적 표본을 분석하는 방법 및 시스템 |
ITTO20110990A1 (it) | 2011-10-28 | 2013-04-29 | Silicon Biosystems Spa | Metodo ed apparato per l'analisi ottica di particelle a basse temperature |
ITBO20110766A1 (it) | 2011-12-28 | 2013-06-29 | Silicon Biosystems Spa | Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico |
JP6140192B2 (ja) * | 2012-02-01 | 2017-05-31 | ベンタナ メディカル システムズ, インコーポレイテッド | 組織試料中で遺伝子を検出するための系 |
CN102661941B (zh) * | 2012-04-19 | 2015-04-22 | 湖南大学 | 基于拉曼活性纳米颗粒混合组装的循环肿瘤细胞的耦合增强sers高通量生物传感方法 |
AU2013263337A1 (en) * | 2012-05-15 | 2014-12-04 | Diatech Oncology | Tumor cell isolation/purification process and methods for use thereof |
NZ703411A (en) | 2012-06-27 | 2017-09-29 | Berg Llc | Use of markers in the diagnosis and treatment of prostate cancer |
KR20140073215A (ko) | 2012-12-06 | 2014-06-16 | 삼성전자주식회사 | 세포 분리용 조성물, 키트 및 이를 이용한 세포 분리 방법 |
CN103122387B (zh) * | 2013-02-05 | 2015-02-04 | 苏州华益美生物科技有限公司 | 循环肿瘤细胞(CTCs)荧光PCR快速超敏检测试剂盒及其应用 |
FR3002634B1 (fr) * | 2013-02-28 | 2015-04-10 | Commissariat Energie Atomique | Procede d'observation d'au moins un objet, tel qu'une entite biologique, et systeme d'imagerie associe |
CN103411981B (zh) * | 2013-07-25 | 2016-06-22 | 宁波大学 | 一种利用介电频谱特性鉴别胃癌腺上皮细胞的方法 |
AU2014352822B2 (en) * | 2013-11-22 | 2019-06-20 | The General Hospital Corporation | Microfluidic methods and systems for isolating particle clusters |
CN103602748A (zh) * | 2013-11-28 | 2014-02-26 | 瑞希基因科技(北京)股份有限公司 | 一种结合荧光定量pcr技术的焦磷酸测序方法 |
CN103869060B (zh) * | 2014-03-07 | 2017-02-01 | 复旦大学附属中山医院 | 基于磁珠和微流控芯片的循环肿瘤干细胞检测试剂盒 |
WO2016023008A1 (en) * | 2014-08-07 | 2016-02-11 | The General Hospital Corporation | Platelet-targeted microfluidic isolation of cells |
AU2015360694B2 (en) | 2014-12-08 | 2021-10-14 | Berg Llc | Use of markers including filamin a in the diagnosis and treatment of prostate cancer |
WO2016104308A1 (ja) * | 2014-12-25 | 2016-06-30 | コニカミノルタ株式会社 | 細胞画像解析方法及び細胞画像解析装置 |
JP6582486B2 (ja) * | 2015-03-27 | 2019-10-02 | コニカミノルタ株式会社 | 血液中の稀少細胞検出方法 |
EP3286565A1 (en) * | 2015-04-21 | 2018-02-28 | Genentech, Inc. | Compositions and methods for prostate cancer analysis |
CN106244553A (zh) * | 2015-10-22 | 2016-12-21 | 厦门人瑞生物医药科技有限公司 | 循环肿瘤细胞的分离和检测方法 |
KR102406596B1 (ko) * | 2016-02-23 | 2022-06-10 | 노을 주식회사 | 패치를 이용하는 ctc 진단 방법 및 장치 |
KR20170099737A (ko) | 2016-02-23 | 2017-09-01 | 노을 주식회사 | 접촉식 염색 패치 및 이를 이용하는 염색 방법 |
KR102045068B1 (ko) * | 2016-02-23 | 2019-11-15 | 노을 주식회사 | 중합 효소 연쇄 반응 패치, 이를 이용하는 진단 방법 및 장치 |
US10371610B2 (en) | 2016-02-23 | 2019-08-06 | Noul Co., Ltd. | Contact-type patch, staining method using the same, and manufacturing method thereof |
CN105950558A (zh) * | 2016-05-27 | 2016-09-21 | 武汉大学 | 一种基于双抗及细胞密度的高特异性高纯度的肿瘤细胞分选方法 |
US20190211377A1 (en) * | 2016-12-22 | 2019-07-11 | Roche Molecular Systems, Inc. | Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile |
JP7215675B2 (ja) * | 2017-01-16 | 2023-01-31 | 凸版印刷株式会社 | 腫瘍状態の評価方法 |
CN106918713B (zh) * | 2017-03-14 | 2019-04-12 | 复旦大学附属中山医院 | 一种全自动生物样品组分分选装置 |
CN106840816A (zh) * | 2017-03-14 | 2017-06-13 | 骏实生物科技(上海)有限公司 | 一种全自动循环肿瘤细胞阴性富集装置 |
WO2018184966A1 (en) | 2017-04-03 | 2018-10-11 | F. Hoffmann-La Roche Ag | Antibodies binding to steap-1 |
KR102034244B1 (ko) * | 2017-09-01 | 2019-10-18 | 주식회사 코어파마 | 순환암세포를 선택적으로 사멸시키는 시스템 |
CN107918013A (zh) * | 2017-09-25 | 2018-04-17 | 浙江天科高新技术发展有限公司 | 化学发光酶免测定循环肿瘤细胞中K‑Ras蛋白的方法及试剂盒 |
CN109554450A (zh) * | 2017-09-25 | 2019-04-02 | 上海艾壳基因技术有限公司 | 循环肿瘤细胞捕获并进行全基因转录组检测的方法 |
JP7306618B2 (ja) * | 2017-09-26 | 2023-07-11 | 東ソー株式会社 | がんの転移形成能に関与する因子および前記因子を用いたがん患者の予後予測方法 |
CN110093417B (zh) * | 2018-01-31 | 2021-03-02 | 北京大学 | 一种检测肿瘤单细胞体细胞突变的方法 |
CN111939992A (zh) * | 2020-07-23 | 2020-11-17 | 侯双 | 捕获和富集循环肿瘤细胞的微流体系统的制备方法及微流体装置 |
DE102021203897A1 (de) | 2021-04-20 | 2022-10-20 | Robert Bosch Gesellschaft mit beschränkter Haftung | Verfahren zum Erkennen von kernhaltigen Zellen in einer Probenflüssigkeit eines Patienten unter Verwendung einer mikrofluidischen Vorrichtung und mikrofluidische Vorrichtung |
WO2023027083A1 (ja) * | 2021-08-23 | 2023-03-02 | 静岡県 | 遺伝子変異の検出方法及び体細胞変異と生殖細胞系列変異とを区別する方法 |
WO2023150760A2 (en) * | 2022-02-04 | 2023-08-10 | Cornell University | Enrichment and characterization of rare circulating cells, including progenitor cells, from peripheral blood, and uses thereof |
CN115896028B (zh) * | 2022-12-21 | 2024-01-02 | 珠海圣美生物诊断技术有限公司 | 分离循环肿瘤细胞用的试剂组合及其用途 |
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DK2350647T3 (en) | 2017-05-15 |
EP3185012B1 (en) | 2022-02-09 |
CN102272595A (zh) | 2011-12-07 |
CN102272595B (zh) | 2016-01-20 |
EP2350647B1 (en) | 2017-02-15 |
EP3185012A1 (en) | 2017-06-28 |
KR20110136782A (ko) | 2011-12-21 |
ITTO20080814A1 (it) | 2010-05-05 |
ES2624827T3 (es) | 2017-07-17 |
DK3185012T3 (da) | 2022-04-11 |
CA2742769A1 (en) | 2010-05-14 |
WO2010052543A1 (en) | 2010-05-14 |
ES2910715T3 (es) | 2022-05-13 |
IT1391619B1 (it) | 2012-01-11 |
JP2012507733A (ja) | 2012-03-29 |
EP2350647A1 (en) | 2011-08-03 |
PL2350647T3 (pl) | 2017-07-31 |
US10234447B2 (en) | 2019-03-19 |
WO2010052543A8 (en) | 2011-03-03 |
PT3185012T (pt) | 2022-04-19 |
US20190293632A1 (en) | 2019-09-26 |
CY1118888T1 (el) | 2018-01-10 |
JP5814124B2 (ja) | 2015-11-17 |
US20120071335A1 (en) | 2012-03-22 |
KR101680619B1 (ko) | 2016-11-29 |
CA2742769C (en) | 2017-07-04 |
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