PL2733142T3 - Sposób wytwarzania {4,6-diamino-2-[1-(2-fluorobenzylo)-1H-pirazolo[3,4-b]pirydyn-3- ylo]pirymidyn-5-ylo}metylokarbaminianu metylu do zastosowania jako aktywny farmaceutycznie składnik - Google Patents
Sposób wytwarzania {4,6-diamino-2-[1-(2-fluorobenzylo)-1H-pirazolo[3,4-b]pirydyn-3- ylo]pirymidyn-5-ylo}metylokarbaminianu metylu do zastosowania jako aktywny farmaceutycznie składnikInfo
- Publication number
- PL2733142T3 PL2733142T3 PL14154762T PL14154762T PL2733142T3 PL 2733142 T3 PL2733142 T3 PL 2733142T3 PL 14154762 T PL14154762 T PL 14154762T PL 14154762 T PL14154762 T PL 14154762T PL 2733142 T3 PL2733142 T3 PL 2733142T3
- Authority
- PL
- Poland
- Prior art keywords
- methylcarbamate
- fluorobenzyl
- pyrazolo
- pyrimidin
- diamino
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title 1
- WXXSNCNJFUAIDG-UHFFFAOYSA-N riociguat Chemical compound N1=C(N)C(N(C)C(=O)OC)=C(N)N=C1C(C1=CC=CN=C11)=NN1CC1=CC=CC=C1F WXXSNCNJFUAIDG-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C325/00—Thioaldehydes; Thioketones; Thioquinones; Oxides thereof
- C07C325/02—Thioketones; Oxides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09177371 | 2009-11-27 | ||
| EP10781686.0A EP2504334B1 (de) | 2009-11-27 | 2010-11-22 | Verfahren zur reinigung von methyl-{4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamat |
| EP13151569.4A EP2604608B1 (de) | 2009-11-27 | 2010-11-22 | Verfahren zur Herstellung von Methyl-{4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}-methylcarbamat und dessen Aufreinigung für die Verwendung als pharmazeutischer Wirkstoff |
| EP14154762.0A EP2733142B1 (de) | 2009-11-27 | 2010-11-22 | Verfahren zur Herstellung von Methyl-{4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamat für die Verwendung als pharmazeutischer Wirkstoff |
| PCT/EP2010/067949 WO2011064171A2 (de) | 2009-11-27 | 2010-11-22 | Verfahren zur herstellung von methyl-{4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamat und dessen aufreinigung für die verwendung als pharmazeutischer wirkstoff |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2733142T3 true PL2733142T3 (pl) | 2019-03-29 |
Family
ID=43536603
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13151569T PL2604608T3 (pl) | 2009-11-27 | 2010-11-22 | Sposób wytwarzania {4,6-diamino-2-[1-(2-fluorobenzylo)-1H-pirazolo[3,4-b]pirydyn-3-ylo]pirymidyn-5-ylo}metylokarbaminianu metylu |
| PL14154762T PL2733142T3 (pl) | 2009-11-27 | 2010-11-22 | Sposób wytwarzania {4,6-diamino-2-[1-(2-fluorobenzylo)-1H-pirazolo[3,4-b]pirydyn-3- ylo]pirymidyn-5-ylo}metylokarbaminianu metylu do zastosowania jako aktywny farmaceutycznie składnik |
| PL18178602T PL3415515T3 (pl) | 2009-11-27 | 2010-11-22 | Sposób wytwarzania {4,6-diamino-2-[1-(2-fluorobenzylo)-1H-pirazolo[3,4-b]pirydyn-3-ylo]pirymidyn-5-ylo}metylokarbaminianu metylu |
| PL10781686T PL2504334T3 (pl) | 2009-11-27 | 2010-11-22 | Sposób oczyszczania {4,6-diamino-2-[1-(2-fluorobenzylo)-1H-pirazolo[3,4-b]pirydyn-3-ylo]pirymidyn-5-ylo}metylokarbaminianu metylu |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13151569T PL2604608T3 (pl) | 2009-11-27 | 2010-11-22 | Sposób wytwarzania {4,6-diamino-2-[1-(2-fluorobenzylo)-1H-pirazolo[3,4-b]pirydyn-3-ylo]pirymidyn-5-ylo}metylokarbaminianu metylu |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18178602T PL3415515T3 (pl) | 2009-11-27 | 2010-11-22 | Sposób wytwarzania {4,6-diamino-2-[1-(2-fluorobenzylo)-1H-pirazolo[3,4-b]pirydyn-3-ylo]pirymidyn-5-ylo}metylokarbaminianu metylu |
| PL10781686T PL2504334T3 (pl) | 2009-11-27 | 2010-11-22 | Sposób oczyszczania {4,6-diamino-2-[1-(2-fluorobenzylo)-1H-pirazolo[3,4-b]pirydyn-3-ylo]pirymidyn-5-ylo}metylokarbaminianu metylu |
Country Status (43)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201407881WA (en) | 2009-11-27 | 2015-01-29 | Genzyme Corp | An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
| PL2604608T3 (pl) * | 2009-11-27 | 2016-02-29 | Adverio Pharma Gmbh | Sposób wytwarzania {4,6-diamino-2-[1-(2-fluorobenzylo)-1H-pirazolo[3,4-b]pirydyn-3-ylo]pirymidyn-5-ylo}metylokarbaminianu metylu |
| DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
| DE102010043380A1 (de) | 2010-11-04 | 2012-05-10 | Bayer Schering Pharma Aktiengesellschaft | Benzyl-substituierte Carbamate und ihre Verwendung |
| DE102010043379A1 (de) | 2010-11-04 | 2012-05-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung |
| UA111754C2 (uk) | 2011-10-06 | 2016-06-10 | Байєр Фарма Акцієнгезелльшафт | Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань |
| UA120278C2 (uk) | 2011-11-25 | 2019-11-11 | Адверіо Фарма Гмбх | Заміщені 5-фтор-1н-піразолопіридини в кристалічній формі |
| AP2015008670A0 (en) * | 2013-02-21 | 2015-08-31 | Adverio Pharma Gmbh | Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-B]pyridino-3-yl]pyrimidino-5-yl} methyl carbamate |
| CN104327107A (zh) * | 2013-10-17 | 2015-02-04 | 广东东阳光药业有限公司 | 一种氟喹诺酮类抗菌药物的制备方法 |
| MX2017003664A (es) | 2014-09-19 | 2017-07-13 | Bayer Pharma AG | Indazoles sustituidos con benzilo como inhibidores de bub1. |
| WO2016113415A1 (en) | 2015-01-16 | 2016-07-21 | Sandoz Ag | Process for the preparation of riociguat essentially free from genotoxic impurities |
| CN105367568B (zh) * | 2015-11-18 | 2019-08-20 | 浙江京新药业股份有限公司 | 一种制备利奥西呱的方法 |
| CN105294686B (zh) * | 2015-11-30 | 2017-03-22 | 郑州大明药物科技有限公司 | 一种利奥西呱的制备方法 |
| JP2019502686A (ja) | 2015-12-14 | 2019-01-31 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | 消化管括約筋機能障害の治療へのｓＧＣ刺激薬の使用 |
| US10414766B2 (en) * | 2015-12-15 | 2019-09-17 | Alembic Pharmaceuticals Limited | Polymorph of Riociguat and its process for the preparation |
| CN108069960A (zh) * | 2016-11-15 | 2018-05-25 | 江苏豪森药业集团有限公司 | 利奥西呱中间体的制备方法 |
| WO2018096550A1 (en) * | 2016-11-28 | 2018-05-31 | Msn Laboratories Private Limited, R&D Center | Process for the preparation of methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl(methyl)carbamate and its polymorphs thereof |
| US20190381039A1 (en) | 2016-12-13 | 2019-12-19 | Cyclerion Therapeutics, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF ESOPHAGEAL MOTILITY DISORDERS |
| WO2018130226A1 (zh) * | 2017-01-16 | 2018-07-19 | 苏州科睿思制药有限公司 | 利奥西呱的新晶型及其制备方法和用途 |
| JP7542518B2 (ja) | 2018-07-11 | 2024-08-30 | ティセント セラピューティクス インコーポレーテッド | ミトコンドリア（ｍｉｔｏｃｈｏｎｒｉａｌ）障害の処置のためのｓＧＣ刺激剤の使用 |
| TWI830835B (zh) | 2018-12-17 | 2024-02-01 | 德商亞德維瑞醫藥有限公司 | 具改善性質之{4,6-二胺基-2-[5-氟-1-(2-氟芐基)-1H-吡唑並[3,4-b]吡啶-3-基]嘧啶-5-基}胺基甲酸甲酯活性化合物產物、其製造及調配物 |
| CA3169671A1 (en) * | 2020-02-03 | 2021-08-12 | Adverio Pharma Gmbh | Nanoformulations of methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate |
| CN111689961A (zh) * | 2020-06-01 | 2020-09-22 | 江苏华阳制药有限公司 | 一种利奧西呱的新晶型及其制备方法 |
| EP3925953A1 (en) * | 2020-06-16 | 2021-12-22 | Adverio Pharma GmbH | Process for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate |
| CN112316968B (zh) * | 2020-11-13 | 2022-03-01 | 中国石油大学(北京) | 一种粗对苯二甲酸加氢精制催化剂及其制备方法和应用 |
| CN112316932B (zh) * | 2020-11-13 | 2022-03-01 | 中国石油大学(北京) | 一种粗对苯二甲酸加氢精制催化剂及其制备方法和应用 |
| CN117229282A (zh) * | 2023-09-11 | 2023-12-15 | 安徽美诺华药物化学有限公司 | 一种利奥西呱的合成工艺 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950350A (en) * | 1974-12-27 | 1976-04-13 | Pfizer Inc. | Penam-dimethylsulfoxide complex |
| US4970210A (en) * | 1987-07-17 | 1990-11-13 | Abbott Laboratories | Triazinone lipoxygenase compounds |
| EP0409689B1 (en) * | 1989-07-18 | 1995-03-22 | Elf Atochem S.A. | A process for the purification of 1,1-bis(4-chlorophenyl)-2,2,2-trichloroethanol |
| GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| GB9301192D0 (en) | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
| DE19642255A1 (de) * | 1996-10-14 | 1998-04-16 | Bayer Ag | Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten |
| DE59713007D1 (de) * | 1996-10-14 | 2009-06-25 | Bayer Healthcare Ag | Neue heterocyclylmethyl-substituierte pyrazolderivate und ihre verwendung in der behandlung von herz-kreislauf-erkrankungen |
| TR200001338T2 (tr) * | 1997-11-12 | 2000-08-21 | Bayer Aktiengesellschaft | 2-Fenil-ikameli imidazotriazinonlar |
| DE19834045A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | (4-Amino-5-ethylpyrimidin-2-yl)-1-(2-fluorbenzyl)-1H-pyrazolo[3,4-b]pyridin |
| DE19846514A1 (de) | 1998-10-09 | 2000-04-20 | Bayer Ag | Neue Heterocyclyl-methyl-substituierte Pyrazole |
| DE10057751A1 (de) * | 2000-11-22 | 2002-05-23 | Bayer Ag | Neue Carbamat-substituierte Pyrazolopyridinderivate |
| DE10057754A1 (de) * | 2000-11-22 | 2002-05-23 | Bayer Ag | Neue Sulfonamid-substituierte Pyrazolopyridinderivate |
| CA2429308C (en) * | 2000-11-22 | 2010-09-21 | Bayer Aktiengesellschaft | Novel lactam-substituted pyrazolopyridine derivatives |
| AR031176A1 (es) * | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| DE10122894A1 (de) * | 2001-05-11 | 2002-11-14 | Bayer Ag | Neue Sulfonat-substituierte Pyrazolopyridinderivate |
| DE10132416A1 (de) * | 2001-07-04 | 2003-01-16 | Bayer Ag | Neue Morpholin-überbrückte Pyrazolopyridinderivate |
| US6738631B1 (en) | 2002-05-06 | 2004-05-18 | Nokia, Inc. | Vision-guided model-based point-and-click interface for a wireless handheld device |
| DE10220570A1 (de) * | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| JP4299573B2 (ja) * | 2003-04-25 | 2009-07-22 | 東洋シヤッター株式会社 | エレベータの扉装置 |
| DE10222550A1 (de) * | 2002-05-17 | 2003-11-27 | Bayer Ag | Substituierte Benzyl-pyrazolopyridine |
| DE10351903A1 (de) * | 2003-11-06 | 2005-06-09 | Bayer Healthcare Ag | Neue Kombination |
| KR200342343Y1 (ko) | 2003-11-17 | 2004-02-18 | 김강철 | 탄성체 유희용구 |
| KR20070008674A (ko) * | 2004-04-01 | 2007-01-17 | 아스테라스 세이야쿠 가부시키가이샤 | 피라진 유도체, 및 아데노신 길항제로서의 이의 약학적용도 |
| MY139887A (en) * | 2004-04-02 | 2009-11-30 | Mitsubishi Tanabe Pharma Corp | Tetrahydronaphthyridine derivatives and a process for preparing the same. |
| DE102006043443A1 (de) | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
| DE102009004245A1 (de) * | 2009-01-09 | 2010-07-15 | Bayer Schering Pharma Aktiengesellschaft | Neue anellierte, Heteroatom-verbrückte Pyrazol- und Imidazol-Derivate und ihre Verwendung |
| UY33041A (es) * | 2009-11-27 | 2011-06-30 | Bayer Schering Pharma Aktienegesellschaft | Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico |
| PL2604608T3 (pl) * | 2009-11-27 | 2016-02-29 | Adverio Pharma Gmbh | Sposób wytwarzania {4,6-diamino-2-[1-(2-fluorobenzylo)-1H-pirazolo[3,4-b]pirydyn-3-ylo]pirymidyn-5-ylo}metylokarbaminianu metylu |
| UY33040A (es) | 2009-11-27 | 2011-06-30 | Bayer Schering Pahrma Akitengesellschaft | Nuevas formas polimorfas de {4,6diamino-2-[1-(2-fluorobencil-1h-pirazol[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo |
| DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
| CA2804470A1 (en) | 2010-07-09 | 2012-01-12 | Bayer Intellectual Property Gmbh | Ring-fused pyrimidines and triazines and use thereof for the treatment and/or prophylaxis of cardiovascular diseases |
| DE102010040233A1 (de) | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Bicyclische Aza-Heterocyclen und ihre Verwendung |
| DE102010043380A1 (de) | 2010-11-04 | 2012-05-10 | Bayer Schering Pharma Aktiengesellschaft | Benzyl-substituierte Carbamate und ihre Verwendung |
| CA2834901A1 (en) | 2011-05-06 | 2012-11-15 | Bayer Intellectual Property Gmbh | Substituted imidazopyridines and imidazopyridazines and the use thereof |
| AU2012280246A1 (en) | 2011-07-06 | 2014-01-23 | Bayer Intellectual Property Gmbh | Heteroaryl-substituted pyrazolopyridines and use thereof as soluble guanylate cyclase stimulators |
| DE102012200360A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte Triazine und ihre Verwendung |
| ES2644781T3 (es) | 2012-03-06 | 2017-11-30 | Bayer Intellectual Property Gmbh | Azabiciclos sustituidos y su uso |
| BR112015020298A2 (pt) | 2013-03-01 | 2017-07-18 | Bayer Pharma AG | pirimidinas de anel fundido substituídas com trifluormetil e uso das mesmas |
-
2010
- 2010-11-22 PL PL13151569T patent/PL2604608T3/pl unknown
- 2010-11-22 EP EP19214991.2A patent/EP3699180A1/de not_active Withdrawn
- 2010-11-22 KR KR1020177021646A patent/KR101861981B1/ko active Active
- 2010-11-22 EA EA201891964A patent/EA036422B1/ru not_active IP Right Cessation
- 2010-11-22 CA CA2781799A patent/CA2781799C/en active Active
- 2010-11-22 DK DK10781686.0T patent/DK2504334T3/en active
- 2010-11-22 EP EP18178602.1A patent/EP3415515B1/de active Active
- 2010-11-22 MY MYPI2012002343A patent/MY173711A/en unknown
- 2010-11-22 SI SI201031762T patent/SI2733142T1/sl unknown
- 2010-11-22 SI SI201031982T patent/SI3415515T1/sl unknown
- 2010-11-22 PT PT131515694T patent/PT2604608E/pt unknown
- 2010-11-22 PT PT14154762T patent/PT2733142T/pt unknown
- 2010-11-22 SI SI201030773T patent/SI2504334T1/sl unknown
- 2010-11-22 EA EA201590948A patent/EA031632B1/ru not_active IP Right Cessation
- 2010-11-22 RS RS20150773A patent/RS54433B1/sr unknown
- 2010-11-22 EP EP14154762.0A patent/EP2733142B1/de active Active
- 2010-11-22 PL PL14154762T patent/PL2733142T3/pl unknown
- 2010-11-22 LT LTEP18178602.1T patent/LT3415515T/lt unknown
- 2010-11-22 PT PT107816860T patent/PT2504334E/pt unknown
- 2010-11-22 LT LTEP14154762.0T patent/LT2733142T/lt unknown
- 2010-11-22 MX MX2012005938A patent/MX2012005938A/es active IP Right Grant
- 2010-11-22 ES ES10781686.0T patent/ES2524826T3/es active Active
- 2010-11-22 MY MYPI2017001426A patent/MY180184A/en unknown
- 2010-11-22 NZ NZ600199A patent/NZ600199A/en unknown
- 2010-11-22 JP JP2012540386A patent/JP5859451B2/ja active Active
- 2010-11-22 AU AU2010323227A patent/AU2010323227B2/en active Active
- 2010-11-22 HU HUE13151569A patent/HUE026778T2/en unknown
- 2010-11-22 DK DK18178602.1T patent/DK3415515T3/da active
- 2010-11-22 NZ NZ625983A patent/NZ625983A/en unknown
- 2010-11-22 PE PE2012000706A patent/PE20121742A1/es active IP Right Grant
- 2010-11-22 PH PH1/2012/501023A patent/PH12012501023A1/en unknown
- 2010-11-22 EA EA201270636A patent/EA022813B1/ru not_active IP Right Cessation
- 2010-11-22 ES ES14154762.0T patent/ES2693746T3/es active Active
- 2010-11-22 CU CU2012000082A patent/CU24084B1/es active IP Right Grant
- 2010-11-22 UA UAA201207918A patent/UA110779C2/uk unknown
- 2010-11-22 PL PL18178602T patent/PL3415515T3/pl unknown
- 2010-11-22 PE PE2017002307A patent/PE20180203A1/es unknown
- 2010-11-22 CA CA2936852A patent/CA2936852C/en active Active
- 2010-11-22 TR TR2018/16146T patent/TR201816146T4/tr unknown
- 2010-11-22 WO PCT/EP2010/067949 patent/WO2011064171A2/de not_active Ceased
- 2010-11-22 KR KR1020127013611A patent/KR101766931B1/ko active Active
- 2010-11-22 SI SI201031061T patent/SI2604608T1/sl unknown
- 2010-11-22 CN CN201080053951.5A patent/CN102791707B/zh active Active
- 2010-11-22 BR BR122019002289-5A patent/BR122019002289B1/pt active IP Right Grant
- 2010-11-22 BR BR122019002291A patent/BR122019002291B8/pt active IP Right Grant
- 2010-11-22 NZ NZ715101A patent/NZ715101A/en unknown
- 2010-11-22 DK DK14154762.0T patent/DK2733142T3/en active
- 2010-11-22 CN CN201410201245.0A patent/CN104059064B/zh active Active
- 2010-11-22 ES ES13151569.4T patent/ES2553035T3/es active Active
- 2010-11-22 HU HUE14154762A patent/HUE040328T2/hu unknown
- 2010-11-22 PT PT181786021T patent/PT3415515T/pt unknown
- 2010-11-22 HR HRP20141073AT patent/HRP20141073T1/hr unknown
- 2010-11-22 PL PL10781686T patent/PL2504334T3/pl unknown
- 2010-11-22 EP EP13151569.4A patent/EP2604608B1/de active Active
- 2010-11-22 BR BR112012012617A patent/BR112012012617B8/pt active IP Right Grant
- 2010-11-22 ES ES18178602T patent/ES2775902T3/es active Active
- 2010-11-22 RS RS20200159A patent/RS59908B1/sr unknown
- 2010-11-22 EP EP10781686.0A patent/EP2504334B1/de active Active
- 2010-11-22 RS RS20181208A patent/RS57790B1/sr unknown
- 2010-11-22 RS RSP20140579 patent/RS53585B1/sr unknown
- 2010-11-22 DK DK13151569.4T patent/DK2604608T3/en active
- 2010-11-23 UY UY0001033048A patent/UY33048A/es not_active Application Discontinuation
- 2010-11-24 AR ARP100104326A patent/AR079134A1/es active IP Right Grant
- 2010-11-25 JO JOP/2010/0415A patent/JO3107B1/ar active
- 2010-11-26 TW TW099140893A patent/TWI496781B/zh active
- 2010-11-29 US US12/955,510 patent/US8492544B2/en active Active
-
2012
- 2012-05-09 IL IL219683A patent/IL219683A/en active IP Right Grant
- 2012-05-23 EC ECSP12011921 patent/ECSP12011921A/es unknown
- 2012-05-23 CL CL2012001329A patent/CL2012001329A1/es unknown
- 2012-05-24 DO DO2012000144A patent/DOP2012000144A/es unknown
- 2012-05-24 CR CR20120280A patent/CR20120280A/es unknown
- 2012-05-24 CO CO12085990A patent/CO6551708A2/es unknown
- 2012-05-24 TN TNP2012000257A patent/TN2012000257A1/en unknown
- 2012-05-24 GT GT201200158A patent/GT201200158A/es unknown
- 2012-05-25 MA MA34924A patent/MA33783B1/fr unknown
- 2012-06-21 ZA ZA2012/04610A patent/ZA201204610B/en unknown
-
2013
- 2013-07-18 US US13/945,639 patent/US8853398B2/en active Active
-
2014
- 2014-06-04 US US14/295,922 patent/US10030014B2/en active Active
- 2014-11-03 SM SM201400164T patent/SMT201400164B/xx unknown
- 2014-11-21 CY CY20141100969T patent/CY1115861T1/el unknown
-
2015
- 2015-05-25 JP JP2015105630A patent/JP6133931B2/ja active Active
- 2015-08-27 IL IL240878A patent/IL240878B/en active IP Right Grant
- 2015-10-14 AU AU2015243005A patent/AU2015243005B2/en active Active
- 2015-11-18 HR HRP20151243TT patent/HRP20151243T1/hr unknown
-
2017
- 2017-01-04 JP JP2017000073A patent/JP6371871B2/ja active Active
- 2017-02-02 JO JOP/2017/0033A patent/JO3650B1/ar active
- 2017-02-02 JO JOP/2017/0032A patent/JO3651B1/ar active
- 2017-04-05 IL IL251601A patent/IL251601B/en active IP Right Grant
- 2017-04-05 IL IL251603A patent/IL251603B/en active IP Right Grant
- 2017-05-05 AU AU2017203023A patent/AU2017203023B2/en active Active
-
2018
- 2018-03-08 EC ECIEPI201818453A patent/ECSP18018453A/es unknown
- 2018-06-05 US US16/000,382 patent/US10351562B2/en active Active
- 2018-07-06 JP JP2018128949A patent/JP6514398B2/ja active Active
- 2018-10-30 HR HRP20181785TT patent/HRP20181785T1/hr unknown
-
2019
- 2019-06-06 US US16/433,743 patent/US10570130B2/en active Active
-
2020
- 2020-03-10 HR HRP20200397TT patent/HRP20200397T1/hr unknown
- 2020-03-17 DO DO2020000062A patent/DOP2020000062A/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20181785T1 (hr) | Proces za pripremanje metil-{4,6-diamino-2-[1-(2-fluorobenzil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}metilkarbamata za uporabu kao farmaceutski aktivnog sastojka | |
| IL219861A0 (en) | Process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate and its purification for use as pharmaceutically active compound | |
| IL220544A (en) | History of n - (h1 - indazole - 4 - ram) imidazo [2,1 - a] pyridine - 3 - carboxamide, processes for their preparation and pharmaceutical preparations containing them | |
| IL219424A (en) | Imidazo derivative [b – 1,2] pyridazine, combinations, distant preparations containing them and process for their preparation and use as pde10 inhibitors | |
| IL224555A (en) | 2 - (Primary Amino) - 8 - (Alkyl / Cycloalkyl) - 7 - Oxo - 8,7 - Dihydropyrido [3,2 - d] - 6 - Carbonitriles, their preparation and pharmaceutical preparations containing them | |
| IL215644A (en) | N-phenylsulfonyl-2- (h1-pyrrolo [3,2- b] pyridine-5-yloxy) benzamide and anticancer drugs containing them | |
| ZA201100429B (en) | Novel imidazo [1,2-a]pyrimidine derivatives,method for the preparation thereof,use thereof as medicaments,pharmaceutical compositions and novel use in particular as met inhibitors | |
| IL215074A0 (en) | Substituted imidazo[1,2-a]pyridine derivatives, pharmaceutical compositions, and methods of use as beta-secretase inhibitors | |
| IL226095A (en) | History of {4– [5– (1-methyl– h1– pyrazole – 4 – ram) - h1– pyrrolo [3,2– b] pyridin-3-ram] pyrimidin-2-yl} reliable and medications containing them | |
| IL210708A0 (en) | Imidazo [1,2-a]pyrimidine derivatives method for the production thereof application thereof as medicaments pharmaceutical compositions and use thereof as met inhibitors | |
| IL210074A (en) | Process for the preparation of pyrido derivatives [2, 3 – d] pyrimidine-7-il-phenyl | |
| IL217293A (en) | Annotations of 9,8,7,6-tetrahydropyrimido {{a-2,1 pyramidine-4-one) | |
| IL219826A0 (en) | Novel polymorphic forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate | |
| IL217294A (en) | History 3,2 - Dihydro - 1h - Imidazo [1, 2 - a] - Pyrimidin - 5 - On, process for their preparation, pharmaceutical preparations containing them and their use in the preparation of medicines | |
| IL206673A0 (en) | Imidazo[1,2-a]pyridine-2-carboxamide derivatives, their preparation and their therapeutic application | |
| IL219712A0 (en) | Novel solvates of methyl {4, 6 -diamino-2-[1-(2-fluorobenzyl)- 1h-pyrazolo[3,4-b] pyridin - 3 - yl] pyrimidin - 5 -yl} carbamate | |
| IL206669A0 (en) | 6-HETEROCYCLIC IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | |
| IL213208A0 (en) | 6-cycloamino-3-(1h-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof | |
| HK1169389A (en) | Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof |