PL2658831T3 - Roztwór eluentu - Google Patents

Roztwór eluentu

Info

Publication number
PL2658831T3
PL2658831T3 PL11808853T PL11808853T PL2658831T3 PL 2658831 T3 PL2658831 T3 PL 2658831T3 PL 11808853 T PL11808853 T PL 11808853T PL 11808853 T PL11808853 T PL 11808853T PL 2658831 T3 PL2658831 T3 PL 2658831T3
Authority
PL
Poland
Prior art keywords
eluent solution
eluent
solution
Prior art date
Application number
PL11808853T
Other languages
English (en)
Polish (pl)
Inventor
Torild Wickstrom
Anders Svadberg
Ole Kristian Hjelstuen
Dag M. Evje
Liane Ochsenfeld
Original Assignee
Ge Healthcare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Limited filed Critical Ge Healthcare Limited
Publication of PL2658831T3 publication Critical patent/PL2658831T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0404Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B9/00General methods of preparing halides
    • C01B9/08Fluorides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001Acyclic or carbocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PL11808853T 2010-12-29 2011-12-21 Roztwór eluentu PL2658831T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061427839P 2010-12-29 2010-12-29
EP11808853.3A EP2658831B1 (en) 2010-12-29 2011-12-21 Eluent solution

Publications (1)

Publication Number Publication Date
PL2658831T3 true PL2658831T3 (pl) 2017-07-31

Family

ID=45495902

Family Applications (2)

Application Number Title Priority Date Filing Date
PL11808853T PL2658831T3 (pl) 2010-12-29 2011-12-21 Roztwór eluentu
PL20196030T PL3766522T3 (pl) 2010-12-29 2012-12-21 Zautomatyzowany sposób wytwarzania kompozycji 18f-flucyklowiny

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL20196030T PL3766522T3 (pl) 2010-12-29 2012-12-21 Zautomatyzowany sposób wytwarzania kompozycji 18f-flucyklowiny

Country Status (16)

Country Link
US (3) US11504430B2 (https=)
EP (2) EP2658831B1 (https=)
JP (1) JP6018581B2 (https=)
KR (3) KR102218263B1 (https=)
CN (2) CN108218650A (https=)
AU (1) AU2011351550B2 (https=)
BR (2) BR112013015396B1 (https=)
CA (1) CA2823063C (https=)
DK (3) DK2658831T3 (https=)
ES (2) ES2621950T3 (https=)
MX (1) MX363538B (https=)
PL (2) PL2658831T3 (https=)
PT (2) PT2793954T (https=)
RU (1) RU2608932C2 (https=)
SG (1) SG10201805198TA (https=)
WO (1) WO2012089594A1 (https=)

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CA2823063C (en) * 2010-12-29 2020-08-11 Ge Healthcare Limited A method for preparation of f for use in a radiofluorination reaction
US20140243533A1 (en) * 2011-10-19 2014-08-28 Piramal Imaging Sa Method for production of f-18 labeled a-beta ligands
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
KR20140102700A (ko) * 2011-12-21 2014-08-22 지이 헬쓰케어 리미티드 시트레이트 완충제 내 18f―플루시클로빈 조성물
GB201214220D0 (en) * 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis
GB201221266D0 (en) 2012-11-27 2013-01-09 Ge Healthcare Ltd Aldehyde compositions
GB201305687D0 (en) * 2013-03-28 2013-05-15 Ge Healthcare Ltd Radiolabelling process
ES3005832T3 (en) * 2013-11-13 2025-03-17 Ge Healthcare Ltd Dual run cassette for the synthesis of 18f-labelled compounds
US9988336B2 (en) * 2014-03-18 2018-06-05 Mayo Foundation For Medical Education And Research Gaseous F-18 technologies
NL2014828B1 (en) * 2015-05-20 2017-01-31 Out And Out Chemistry S P R L Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method.
JP6827709B2 (ja) * 2016-04-25 2021-02-10 日本メジフィジックス株式会社 2−[18f]フルオロ−2−デオキシ−d−グルコースの製造方法
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
JP7148121B2 (ja) * 2018-08-31 2022-10-05 国立大学法人北海道大学 放射性核種18fの精製方法
GB202005282D0 (en) * 2020-04-09 2020-05-27 Blue Earth Diagnostics Ltd Pharmaceutical Formulations
KR20230092982A (ko) * 2020-10-22 2023-06-26 니혼 메디피직스 가부시키가이샤 방사성 지르코늄 착체의 제조 방법
JP7127164B2 (ja) * 2021-01-19 2022-08-29 日本メジフィジックス株式会社 2-[18f]フルオロ-2-デオキシ-d-グルコースの製造方法
CN113372399A (zh) * 2021-06-04 2021-09-10 江苏华益科技有限公司 一种氟[18f]脱氧葡糖注射液的合成方法
CN119591463B (zh) * 2024-11-27 2025-12-09 遵义医科大学 一种 [18f] 三氟甲基末端烯烃的放射性标记方法

Family Cites Families (28)

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US5425063A (en) 1993-04-05 1995-06-13 Associated Universities, Inc. Method for selective recovery of PET-usable quantities of [18 F] fluoride and [13 N] nitrate/nitrite from a single irradiation of low-enriched [18 O] water
ZA978758B (en) * 1996-10-02 1999-03-30 Du Pont Merck Pharma Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents
RU2165266C1 (ru) * 2000-06-28 2001-04-20 Центральный научно-исследовательский рентгенорадиологический институт Способ получения [2-18f]-2-дезоксиглюкозы
EP1356827A1 (en) 2002-04-24 2003-10-29 Mallinckrodt Inc. Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution
ES2347535T3 (es) 2002-11-05 2010-11-02 Ion Beam Applications S.A. Estabilizacion de composiciones acuosas de 2-fluoro-2-desoxi-d-glucosa marcada con el isotopo 18f con etanol.
GB0422004D0 (en) * 2004-10-05 2004-11-03 Amersham Plc Method of deprotection
GB0425501D0 (en) * 2004-11-19 2004-12-22 Amersham Plc Fluoridation process
US7235216B2 (en) * 2005-05-01 2007-06-26 Iba Molecular North America, Inc. Apparatus and method for producing radiopharmaceuticals
GB0524851D0 (en) * 2005-12-06 2006-01-11 Ge Healthcare Ltd Radiolabelling method using polymers
PL2029178T3 (pl) 2006-06-21 2012-08-31 Ge Healthcare Ltd Produkty radiofarmaceutyczne
WO2008056481A1 (en) 2006-11-09 2008-05-15 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
PL2106808T3 (pl) 2006-12-21 2018-07-31 Nihon Medi-Physics Co., Ltd. Promieniotwórczy znacznik do obrazowania diagnostycznego zawierający kwas 1-amino-3-[18F]fluorocyklobutanokarboksylowy
TWI406674B (zh) 2007-02-13 2013-09-01 日本藥學物理公司 Method for manufacturing diagnostic radiographic diagnostic agents
EP2017359A3 (en) * 2007-06-11 2009-08-05 Trasis S.A. Method for the elution of 18F fluoride trapped on an anion-exchange resin in a form suitable for efficient radiolabeling without any evaporation step
KR101009712B1 (ko) 2007-02-22 2011-01-19 재단법인 아산사회복지재단 양성자성 용매와 이에 녹는 염들을 이용한 음이온 교환고분자 지지체로부터의 플루오린-18 플루오라이드 용리와이를 이용한 플루오린-18의 표지방법
US20100150835A1 (en) * 2007-02-27 2010-06-17 Bengt Langstrom Synthesis of [18F] Fluoromethyl Benzene Using Benzyl Pentafluorobenzenesulfonate
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KR101583544B1 (ko) * 2007-12-19 2016-01-08 니혼 메디피직스 가부시키가이샤 방사성 불소 표식 유기 화합물의 제조방법
US20090171272A1 (en) 2007-12-29 2009-07-02 Tegg Troy T Deflectable sheath and catheter assembly
EP2238074A2 (en) * 2008-01-03 2010-10-13 GE Healthcare UK Limited Fluoride processing method
EP2110367A1 (en) * 2008-04-14 2009-10-21 Bayer Schering Pharma Aktiengesellschaft Purification strategy for direct nucleophilic procedures
GB0819293D0 (en) * 2008-10-21 2008-11-26 Hammersmith Imanet Ltd Radiofluorination
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TW201033713A (en) 2009-03-03 2010-09-16 Wintek Corp Reflective color-changing liquid crystal display
SG185782A1 (en) * 2010-06-04 2013-01-30 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
CA2823063C (en) * 2010-12-29 2020-08-11 Ge Healthcare Limited A method for preparation of f for use in a radiofluorination reaction
GB201214220D0 (en) * 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis

Also Published As

Publication number Publication date
AU2011351550A1 (en) 2013-07-25
US20190192660A1 (en) 2019-06-27
US20130324715A1 (en) 2013-12-05
DK2793954T3 (da) 2021-01-04
AU2011351550B2 (en) 2017-02-02
BR112014015042B1 (pt) 2021-10-26
ES2621950T3 (es) 2017-07-05
RU2608932C2 (ru) 2017-01-26
CN108218650A (zh) 2018-06-29
PT3766522T (pt) 2022-06-14
MX363538B (es) 2019-03-27
BR112013015396B1 (pt) 2021-11-03
MX2013007699A (es) 2013-08-15
US20230068052A1 (en) 2023-03-02
KR102218263B1 (ko) 2021-02-22
PL3766522T3 (pl) 2022-07-04
KR20190008994A (ko) 2019-01-25
EP3766522A1 (en) 2021-01-20
PT2793954T (pt) 2021-01-06
WO2012089594A1 (en) 2012-07-05
CA2823063A1 (en) 2012-07-05
CA2823063C (en) 2020-08-11
KR20130132892A (ko) 2013-12-05
ES2917875T3 (es) 2022-07-12
CN103270004A (zh) 2013-08-28
DK2658831T3 (en) 2017-04-24
SG10201805198TA (en) 2018-07-30
KR102137348B1 (ko) 2020-07-23
DK3766522T3 (da) 2022-06-13
KR20190119673A (ko) 2019-10-22
JP2014508731A (ja) 2014-04-10
US11504430B2 (en) 2022-11-22
BR112014015042A8 (pt) 2017-07-04
BR112014015042A2 (pt) 2017-06-13
EP2658831B1 (en) 2017-02-15
JP6018581B2 (ja) 2016-11-02
EP3766522B1 (en) 2022-03-23
BR112013015396A2 (pt) 2016-09-20
RU2013126979A (ru) 2015-03-20
EP2658831A1 (en) 2013-11-06

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