KR20130132892A - 용리제 용액 - Google Patents

용리제 용액 Download PDF

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Publication number
KR20130132892A
KR20130132892A KR1020137017012A KR20137017012A KR20130132892A KR 20130132892 A KR20130132892 A KR 20130132892A KR 1020137017012 A KR1020137017012 A KR 1020137017012A KR 20137017012 A KR20137017012 A KR 20137017012A KR 20130132892 A KR20130132892 A KR 20130132892A
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KR
South Korea
Prior art keywords
eluent
reaction
solution
labeled
exchange column
Prior art date
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Ceased
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KR1020137017012A
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English (en)
Korean (ko)
Inventor
토릴드 윅스트롬
앤더스 스베드버그
오엘 크리스티안 헬스투엔
대그 엠. 에브제
리엔 오첸펠드
Original Assignee
지이 헬쓰케어 리미티드
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Publication of KR20130132892A publication Critical patent/KR20130132892A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B9/00—General methods of preparing halides
    • C01B9/08—Fluorides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR1020137017012A 2010-12-29 2011-12-21 용리제 용액 Ceased KR20130132892A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061427839P 2010-12-29 2010-12-29
US61/427,839 2010-12-29
PCT/EP2011/073670 WO2012089594A1 (en) 2010-12-29 2011-12-21 Eluent solution

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197001271A Division KR102218263B1 (ko) 2010-12-29 2011-12-21 용리제 용액

Publications (1)

Publication Number Publication Date
KR20130132892A true KR20130132892A (ko) 2013-12-05

Family

ID=45495902

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020137017012A Ceased KR20130132892A (ko) 2010-12-29 2011-12-21 용리제 용액
KR1020197001271A Active KR102218263B1 (ko) 2010-12-29 2011-12-21 용리제 용액
KR1020197030135A Active KR102137348B1 (ko) 2010-12-29 2012-12-21 시트레이트 완충제 내 18ｆ―플루시클로빈 조성물

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020197001271A Active KR102218263B1 (ko) 2010-12-29 2011-12-21 용리제 용액
KR1020197030135A Active KR102137348B1 (ko) 2010-12-29 2012-12-21 시트레이트 완충제 내 18ｆ―플루시클로빈 조성물

Country Status (16)

Country Link
US (3) US11504430B2 (https=)
EP (2) EP2658831B1 (https=)
JP (1) JP6018581B2 (https=)
KR (3) KR20130132892A (https=)
CN (2) CN108218650A (https=)
AU (1) AU2011351550B2 (https=)
BR (2) BR112013015396B1 (https=)
CA (1) CA2823063C (https=)
DK (3) DK2658831T3 (https=)
ES (2) ES2621950T3 (https=)
MX (1) MX363538B (https=)
PL (2) PL2658831T3 (https=)
PT (2) PT3766522T (https=)
RU (1) RU2608932C2 (https=)
SG (1) SG10201805198TA (https=)
WO (1) WO2012089594A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
KR20180016418A (ko) * 2015-05-20 2018-02-14 아웃앤아웃 케미스트리 에스피알엘 방사성의약품의 제조를 위한 복수의 합성 공정들의 연속 수행 방법, 및 상기 방법을 수행하기 위한 장치 및 카세트

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AU2011351550B2 (en) * 2010-12-29 2017-02-02 Ge Healthcare Limited Eluent solution
EP2768790A1 (en) * 2011-10-19 2014-08-27 Piramal Imaging SA IMPROVED METHOD FOR PRODUCTION OF F-18 LABELED Aß LIGANDS
CN109966515A (zh) * 2011-12-21 2019-07-05 通用电气健康护理有限公司 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
GB201214220D0 (en) * 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis
GB201221266D0 (en) 2012-11-27 2013-01-09 Ge Healthcare Ltd Aldehyde compositions
GB201305687D0 (en) * 2013-03-28 2013-05-15 Ge Healthcare Ltd Radiolabelling process
IL235650B (en) 2013-11-13 2019-10-31 Ge Healthcare Ltd Dual play tape
WO2015143019A2 (en) * 2014-03-18 2015-09-24 Mayo Foundation For Medical Education And Research Gaseous f-18 technologies
JP6827709B2 (ja) * 2016-04-25 2021-02-10 日本メジフィジックス株式会社 ２−［１８ｆ］フルオロ−２−デオキシ−ｄ−グルコースの製造方法
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
JP7148121B2 (ja) * 2018-08-31 2022-10-05 国立大学法人北海道大学 放射性核種１８ｆの精製方法
GB202005282D0 (en) 2020-04-09 2020-05-27 Blue Earth Diagnostics Ltd Pharmaceutical Formulations
JP7773990B2 (ja) * 2020-10-22 2025-11-20 日本メジフィジックス株式会社 放射性ジルコニウム錯体の製造方法
JP7127164B2 (ja) * 2021-01-19 2022-08-29 日本メジフィジックス株式会社 ２－［１８ｆ］フルオロ－２－デオキシ－ｄ－グルコースの製造方法
CN113372399A (zh) * 2021-06-04 2021-09-10 江苏华益科技有限公司 一种氟[18f]脱氧葡糖注射液的合成方法
CN119591463B (zh) * 2024-11-27 2025-12-09 遵义医科大学 一种 [18f] 三氟甲基末端烯烃的放射性标记方法

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ZA978758B (en) * 1996-10-02 1999-03-30 Du Pont Merck Pharma Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents
RU2165266C1 (ru) * 2000-06-28 2001-04-20 Центральный научно-исследовательский рентгенорадиологический институт Способ получения [2-18f]-2-дезоксиглюкозы
EP1356827A1 (en) 2002-04-24 2003-10-29 Mallinckrodt Inc. Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution
JP2006505610A (ja) 2002-11-05 2006-02-16 イヨン ベアム アプリカスィヨン エッス．アー． １８−ｆ標識放射性製剤の安定化
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180016418A (ko) * 2015-05-20 2018-02-14 아웃앤아웃 케미스트리 에스피알엘 방사성의약품의 제조를 위한 복수의 합성 공정들의 연속 수행 방법, 및 상기 방법을 수행하기 위한 장치 및 카세트
US11820790B2 (en) 2015-05-20 2023-11-21 Out And Out Chemistry S.P.R.L. Device and cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series
US12583881B2 (en) 2015-05-20 2026-03-24 Out And Out Chemistry S.P.R.L. Device and cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series

Also Published As

Publication number Publication date
PL3766522T3 (pl) 2022-07-04
SG10201805198TA (en) 2018-07-30
BR112014015042A8 (pt) 2017-07-04
DK3766522T3 (da) 2022-06-13
AU2011351550A1 (en) 2013-07-25
CN108218650A (zh) 2018-06-29
KR102137348B1 (ko) 2020-07-23
AU2011351550B2 (en) 2017-02-02
CN103270004A (zh) 2013-08-28
MX2013007699A (es) 2013-08-15
PT2793954T (pt) 2021-01-06
BR112013015396A2 (pt) 2016-09-20
EP2658831A1 (en) 2013-11-06
US20190192660A1 (en) 2019-06-27
EP3766522B1 (en) 2022-03-23
JP2014508731A (ja) 2014-04-10
PT3766522T (pt) 2022-06-14
CA2823063A1 (en) 2012-07-05
CA2823063C (en) 2020-08-11
DK2793954T3 (da) 2021-01-04
US20230068052A1 (en) 2023-03-02
JP6018581B2 (ja) 2016-11-02
BR112014015042B1 (pt) 2021-10-26
KR20190119673A (ko) 2019-10-22
WO2012089594A1 (en) 2012-07-05
US20130324715A1 (en) 2013-12-05
EP2658831B1 (en) 2017-02-15
BR112014015042A2 (pt) 2017-06-13
RU2013126979A (ru) 2015-03-20
ES2917875T3 (es) 2022-07-12
KR102218263B1 (ko) 2021-02-22
US11504430B2 (en) 2022-11-22
DK2658831T3 (en) 2017-04-24
KR20190008994A (ko) 2019-01-25
EP3766522A1 (en) 2021-01-20
BR112013015396B1 (pt) 2021-11-03
MX363538B (es) 2019-03-27
RU2608932C2 (ru) 2017-01-26
ES2621950T3 (es) 2017-07-05
PL2658831T3 (pl) 2017-07-31

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