CA2823063C - A method for preparation of f for use in a radiofluorination reaction - Google Patents
A method for preparation of f for use in a radiofluorination reaction Download PDFInfo
- Publication number
- CA2823063C CA2823063C CA2823063A CA2823063A CA2823063C CA 2823063 C CA2823063 C CA 2823063C CA 2823063 A CA2823063 A CA 2823063A CA 2823063 A CA2823063 A CA 2823063A CA 2823063 C CA2823063 C CA 2823063C
- Authority
- CA
- Canada
- Prior art keywords
- eluent
- reaction
- solution
- radiofluorination reaction
- radiofluorination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B9/00—General methods of preparing halides
- C01B9/08—Fluorides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061427839P | 2010-12-29 | 2010-12-29 | |
| US61/427,839 | 2010-12-29 | ||
| PCT/EP2011/073670 WO2012089594A1 (en) | 2010-12-29 | 2011-12-21 | Eluent solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2823063A1 CA2823063A1 (en) | 2012-07-05 |
| CA2823063C true CA2823063C (en) | 2020-08-11 |
Family
ID=45495902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2823063A Active CA2823063C (en) | 2010-12-29 | 2011-12-21 | A method for preparation of f for use in a radiofluorination reaction |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11504430B2 (https=) |
| EP (2) | EP2658831B1 (https=) |
| JP (1) | JP6018581B2 (https=) |
| KR (3) | KR20130132892A (https=) |
| CN (2) | CN108218650A (https=) |
| AU (1) | AU2011351550B2 (https=) |
| BR (2) | BR112013015396B1 (https=) |
| CA (1) | CA2823063C (https=) |
| DK (3) | DK2658831T3 (https=) |
| ES (2) | ES2621950T3 (https=) |
| MX (1) | MX363538B (https=) |
| PL (2) | PL2658831T3 (https=) |
| PT (2) | PT3766522T (https=) |
| RU (1) | RU2608932C2 (https=) |
| SG (1) | SG10201805198TA (https=) |
| WO (1) | WO2012089594A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011351550B2 (en) * | 2010-12-29 | 2017-02-02 | Ge Healthcare Limited | Eluent solution |
| EP2768790A1 (en) * | 2011-10-19 | 2014-08-27 | Piramal Imaging SA | IMPROVED METHOD FOR PRODUCTION OF F-18 LABELED Aß LIGANDS |
| CN109966515A (zh) * | 2011-12-21 | 2019-07-05 | 通用电气健康护理有限公司 | 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物 |
| GB201411569D0 (en) | 2014-06-30 | 2014-08-13 | Ge Healthcare Ltd | Novel formulation and method of synthesis |
| US11534494B2 (en) | 2011-12-21 | 2022-12-27 | Ge Healthcare Limited | Formulation and method of synthesis |
| GB201214220D0 (en) * | 2012-08-09 | 2012-09-19 | Ge Healthcare Ltd | Radiosynthesis |
| GB201221266D0 (en) | 2012-11-27 | 2013-01-09 | Ge Healthcare Ltd | Aldehyde compositions |
| GB201305687D0 (en) * | 2013-03-28 | 2013-05-15 | Ge Healthcare Ltd | Radiolabelling process |
| IL235650B (en) | 2013-11-13 | 2019-10-31 | Ge Healthcare Ltd | Dual play tape |
| WO2015143019A2 (en) * | 2014-03-18 | 2015-09-24 | Mayo Foundation For Medical Education And Research | Gaseous f-18 technologies |
| NL2014828B1 (en) | 2015-05-20 | 2017-01-31 | Out And Out Chemistry S P R L | Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method. |
| JP6827709B2 (ja) * | 2016-04-25 | 2021-02-10 | 日本メジフィジックス株式会社 | ２−［１８ｆ］フルオロ−２−デオキシ−ｄ−グルコースの製造方法 |
| US10695450B2 (en) | 2016-07-26 | 2020-06-30 | Laboratoires Cyclopharma | Synthesis of a radioactive agent composition |
| JP7148121B2 (ja) * | 2018-08-31 | 2022-10-05 | 国立大学法人北海道大学 | 放射性核種１８ｆの精製方法 |
| GB202005282D0 (en) | 2020-04-09 | 2020-05-27 | Blue Earth Diagnostics Ltd | Pharmaceutical Formulations |
| JP7773990B2 (ja) * | 2020-10-22 | 2025-11-20 | 日本メジフィジックス株式会社 | 放射性ジルコニウム錯体の製造方法 |
| JP7127164B2 (ja) * | 2021-01-19 | 2022-08-29 | 日本メジフィジックス株式会社 | ２－［１８ｆ］フルオロ－２－デオキシ－ｄ－グルコースの製造方法 |
| CN113372399A (zh) * | 2021-06-04 | 2021-09-10 | 江苏华益科技有限公司 | 一种氟[18f]脱氧葡糖注射液的合成方法 |
| CN119591463B (zh) * | 2024-11-27 | 2025-12-09 | 遵义医科大学 | 一种 [18f] 三氟甲基末端烯烃的放射性标记方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5425063A (en) * | 1993-04-05 | 1995-06-13 | Associated Universities, Inc. | Method for selective recovery of PET-usable quantities of [18 F] fluoride and [13 N] nitrate/nitrite from a single irradiation of low-enriched [18 O] water |
| ZA978758B (en) * | 1996-10-02 | 1999-03-30 | Du Pont Merck Pharma | Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents |
| RU2165266C1 (ru) * | 2000-06-28 | 2001-04-20 | Центральный научно-исследовательский рентгенорадиологический институт | Способ получения [2-18f]-2-дезоксиглюкозы |
| EP1356827A1 (en) | 2002-04-24 | 2003-10-29 | Mallinckrodt Inc. | Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution |
| JP2006505610A (ja) | 2002-11-05 | 2006-02-16 | イヨン ベアム アプリカスィヨン エッス．アー． | １８−ｆ標識放射性製剤の安定化 |
| GB0422004D0 (en) * | 2004-10-05 | 2004-11-03 | Amersham Plc | Method of deprotection |
| GB0425501D0 (en) | 2004-11-19 | 2004-12-22 | Amersham Plc | Fluoridation process |
| US7235216B2 (en) * | 2005-05-01 | 2007-06-26 | Iba Molecular North America, Inc. | Apparatus and method for producing radiopharmaceuticals |
| GB0524851D0 (en) * | 2005-12-06 | 2006-01-11 | Ge Healthcare Ltd | Radiolabelling method using polymers |
| CA2654369C (en) * | 2006-06-21 | 2014-10-14 | Ge Healthcare Limited | Radiopharmaceutical products |
| US20100056826A1 (en) | 2006-11-09 | 2010-03-04 | Nihon Medi-Physicis Co., Ltd. | Radioactive diagnostic imaging agent |
| PT2106808T (pt) | 2006-12-21 | 2018-03-26 | Nihon Mediphysics Co Ltd | Agente de imagiologia de diagnóstico radioativo compreendendo ácido 1-amino-3-[18f]fluoro-ciclobutanocarboxílico |
| JP5258583B2 (ja) | 2007-02-13 | 2013-08-07 | 日本メジフィジックス株式会社 | 放射性画像診断剤の製造方法 |
| EP2017359A3 (en) * | 2007-06-11 | 2009-08-05 | Trasis S.A. | Method for the elution of 18F fluoride trapped on an anion-exchange resin in a form suitable for efficient radiolabeling without any evaporation step |
| KR101009712B1 (ko) * | 2007-02-22 | 2011-01-19 | 재단법인 아산사회복지재단 | 양성자성 용매와 이에 녹는 염들을 이용한 음이온 교환고분자 지지체로부터의 플루오린-18 플루오라이드 용리와이를 이용한 플루오린-18의 표지방법 |
| WO2008106442A1 (en) | 2007-02-27 | 2008-09-04 | Ge Healthcare Limited | Synthesis of [18f] fluoromethyl benzene using benzyl pentafluorobenzenesulfonate |
| EP1990310A1 (en) | 2007-04-23 | 2008-11-12 | Trasis S.A. | Method for the preparation of reactive 18F fluoride, and for the labeling of radiotracers, using a modified non-ionic solid support and without any evaporation step |
| WO2009045535A2 (en) * | 2007-10-04 | 2009-04-09 | Sloan-Kettering Institute For Cancer Research | Fluorine-18 derivative of dasatinib and uses thereof |
| KR101583544B1 (ko) | 2007-12-19 | 2016-01-08 | 니혼 메디피직스 가부시키가이샤 | 방사성 불소 표식 유기 화합물의 제조방법 |
| US20090171272A1 (en) | 2007-12-29 | 2009-07-02 | Tegg Troy T | Deflectable sheath and catheter assembly |
| US8980221B2 (en) * | 2008-01-03 | 2015-03-17 | Ge Healthcare Limited | Fluoride processing method |
| EP2110367A1 (en) * | 2008-04-14 | 2009-10-21 | Bayer Schering Pharma Aktiengesellschaft | Purification strategy for direct nucleophilic procedures |
| GB0819293D0 (en) | 2008-10-21 | 2008-11-26 | Hammersmith Imanet Ltd | Radiofluorination |
| EP2373597A2 (en) * | 2008-12-04 | 2011-10-12 | Bayer Pharma Aktiengesellschaft | Radioisotope-labeled lysine and ornithine derivatives, their use and processes for their preparation |
| TW201033713A (en) | 2009-03-03 | 2010-09-16 | Wintek Corp | Reflective color-changing liquid crystal display |
| SG185782A1 (en) * | 2010-06-04 | 2013-01-30 | Piramal Imaging Sa | Method for production of f-18 labeled amyloid beta ligands |
| AU2011351550B2 (en) * | 2010-12-29 | 2017-02-02 | Ge Healthcare Limited | Eluent solution |
| GB201214220D0 (en) * | 2012-08-09 | 2012-09-19 | Ge Healthcare Ltd | Radiosynthesis |
-
2011
- 2011-12-21 AU AU2011351550A patent/AU2011351550B2/en active Active
- 2011-12-21 KR KR1020137017012A patent/KR20130132892A/ko not_active Ceased
- 2011-12-21 BR BR112013015396-2A patent/BR112013015396B1/pt active IP Right Grant
- 2011-12-21 PL PL11808853T patent/PL2658831T3/pl unknown
- 2011-12-21 CA CA2823063A patent/CA2823063C/en active Active
- 2011-12-21 KR KR1020197001271A patent/KR102218263B1/ko active Active
- 2011-12-21 RU RU2013126979A patent/RU2608932C2/ru active
- 2011-12-21 EP EP11808853.3A patent/EP2658831B1/en active Active
- 2011-12-21 JP JP2013546670A patent/JP6018581B2/ja active Active
- 2011-12-21 DK DK11808853.3T patent/DK2658831T3/en active
- 2011-12-21 ES ES11808853.3T patent/ES2621950T3/es active Active
- 2011-12-21 WO PCT/EP2011/073670 patent/WO2012089594A1/en not_active Ceased
- 2011-12-21 US US13/997,808 patent/US11504430B2/en active Active
- 2011-12-21 CN CN201810077584.0A patent/CN108218650A/zh active Pending
- 2011-12-21 MX MX2013007699A patent/MX363538B/es unknown
- 2011-12-21 CN CN2011800634887A patent/CN103270004A/zh active Pending
-
2012
- 2012-12-21 KR KR1020197030135A patent/KR102137348B1/ko active Active
- 2012-12-21 DK DK20196030.9T patent/DK3766522T3/da active
- 2012-12-21 DK DK12806500.0T patent/DK2793954T3/da active
- 2012-12-21 PT PT201960309T patent/PT3766522T/pt unknown
- 2012-12-21 SG SG10201805198TA patent/SG10201805198TA/en unknown
- 2012-12-21 ES ES20196030T patent/ES2917875T3/es active Active
- 2012-12-21 BR BR112014015042-7A patent/BR112014015042B1/pt active IP Right Grant
- 2012-12-21 EP EP20196030.9A patent/EP3766522B1/en active Active
- 2012-12-21 PL PL20196030T patent/PL3766522T3/pl unknown
- 2012-12-21 PT PT128065000T patent/PT2793954T/pt unknown
-
2019
- 2019-02-28 US US16/288,650 patent/US20190192660A1/en not_active Abandoned
-
2022
- 2022-10-10 US US17/962,686 patent/US20230068052A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20161121 |
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| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 13TH ANNIV.) - STANDARD Year of fee payment: 13 |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20241209 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20241209 |
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| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 14TH ANNIV.) - STANDARD Year of fee payment: 14 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20251121 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20251121 |