PL2643349T3 - Zaprojektowane białka z powtórzeniami wiążące się z albuminą surowicy - Google Patents
Zaprojektowane białka z powtórzeniami wiążące się z albuminą surowicyInfo
- Publication number
- PL2643349T3 PL2643349T3 PL11788815T PL11788815T PL2643349T3 PL 2643349 T3 PL2643349 T3 PL 2643349T3 PL 11788815 T PL11788815 T PL 11788815T PL 11788815 T PL11788815 T PL 11788815T PL 2643349 T3 PL2643349 T3 PL 2643349T3
- Authority
- PL
- Poland
- Prior art keywords
- serum albumin
- repeat proteins
- proteins binding
- designed repeat
- designed
- Prior art date
Links
- 102000007562 Serum Albumin Human genes 0.000 title 1
- 108010071390 Serum Albumin Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10192711 | 2010-11-26 | ||
| PCT/EP2011/071083 WO2012069654A1 (fr) | 2010-11-26 | 2011-11-25 | Protéines de répétition conçues se liant à l'albumine sérique |
| EP11788815.6A EP2643349B1 (fr) | 2010-11-26 | 2011-11-25 | Liaison de protéines de répétition conçues à l'albumine sérique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2643349T3 true PL2643349T3 (pl) | 2020-03-31 |
Family
ID=43858162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11788815T PL2643349T3 (pl) | 2010-11-26 | 2011-11-25 | Zaprojektowane białka z powtórzeniami wiążące się z albuminą surowicy |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9284361B2 (fr) |
| EP (3) | EP2643348A2 (fr) |
| JP (3) | JP6173216B2 (fr) |
| KR (3) | KR20140032356A (fr) |
| CN (3) | CN103459415B (fr) |
| AU (2) | AU2011333665B2 (fr) |
| BR (3) | BR112013012786B1 (fr) |
| CA (2) | CA2818990C (fr) |
| DK (1) | DK2643349T3 (fr) |
| ES (1) | ES2758352T3 (fr) |
| PL (1) | PL2643349T3 (fr) |
| RU (2) | RU2636552C2 (fr) |
| WO (2) | WO2012069655A2 (fr) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| JP6173216B2 (ja) | 2010-11-26 | 2017-08-02 | モレキュラー・パートナーズ・アーゲーＭｏｌｅｃｕｌａｒ Ｐａｒｔｎｅｒｓ Ａｇ | 設計アンキリンリピートタンパク質のための改善されたキャッピングモジュール |
| DK2846836T3 (da) | 2012-05-07 | 2019-11-11 | Allergan Inc | Fremgangsmåde til behandling af amd hos patienter, der er refraktære overfor anti-vegf-terapi |
| CN104508129A (zh) | 2012-06-28 | 2015-04-08 | 分子伴侣公司 | 设计的与血小板衍生生长因子结合的锚蛋白重复序列蛋白 |
| CA2883264A1 (fr) * | 2012-10-15 | 2014-04-24 | Universitat Zurich Prorektorat Mnw | Ligands her2 bispecifiques pour la therapie du cancer |
| EP2738180A1 (fr) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Protéines de liaison comportant au moins deux domaines de liaison ciblant HER2 |
| EP2961773B1 (fr) * | 2013-02-26 | 2019-03-20 | Roche Glycart AG | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t |
| WO2014191574A1 (fr) | 2013-05-31 | 2014-12-04 | Molecular Partners Ag | Protéines à répétition d'ankyrine élaborées se liant au facteur de croissance d'hépatocyte |
| KR20150097304A (ko) | 2014-02-18 | 2015-08-26 | 삼성전자주식회사 | 항 EGFR DARPin을 포함하는 EGFR/HER2 이중 특이 항체 |
| EP3167395B1 (fr) | 2014-07-07 | 2020-09-02 | Yeda Research and Development Co., Ltd. | Procedé de conception informatique des proteines |
| NZ735803A (en) | 2015-04-02 | 2021-12-24 | Molecular Partners Ag | Designed ankyrin repeat domains with binding specificity for serum albumin |
| CA3036301C (fr) * | 2016-09-22 | 2021-04-20 | Molecular Partners Ag | Proteines recombinantes de liaison comprenant des domaines de repetitiond'ankyrine |
| JP7291624B2 (ja) * | 2016-11-01 | 2023-06-15 | アローヘッド ファーマシューティカルズ インコーポレイテッド | アルファ－ｖベータ－６インテグリンリガンド及びその使用 |
| WO2018165046A1 (fr) | 2017-03-07 | 2018-09-13 | Igc Bio, Inc. | Pipeline informatique pour modélisation et conception d'anticorps |
| US11655293B2 (en) | 2018-02-22 | 2023-05-23 | Universitat Zurich | Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT |
| EP3623382A1 (fr) | 2018-09-14 | 2020-03-18 | Universität Zürich | Ligands vers gm-csf ou un récepteur gm-csf destinés à être utilisés dans une leucémie chez un patient ayant subi une allo-hct |
| WO2019180243A1 (fr) | 2018-03-22 | 2019-09-26 | Charité-Universitätsmedizin Berlin | Immunité médiée par les lymphocytes t réactifs vis-à-vis d'une protéine associée à crispr |
| WO2019238966A1 (fr) | 2018-06-15 | 2019-12-19 | Universität Bern | Ligands de light ou de son récepteur ltssr destinés à être utilisés dans des malignités hématologiques |
| AU2019358419A1 (en) | 2018-10-08 | 2021-04-15 | Universität Zürich | HER2-binding tetrameric polypeptides |
| WO2020104627A1 (fr) | 2018-11-21 | 2020-05-28 | Universität Zürich | Conjugaison photochimiquement induite de radiométaux à de petites molécules, peptides et nanoparticules dans une réaction monotope simultanée |
| EP3677911A3 (fr) | 2019-01-03 | 2020-07-29 | Universität Basel | Utilisation de ligand non agoniste pour la suppression de métastases |
| EP3908274A1 (fr) | 2019-01-11 | 2021-11-17 | Universitätsspital Basel | Inhibiteurs de sglt-2 ou antagonistes d'il-1r pour la réduction de l'hypoglycémie après chirurgie bariatrique |
| US20220178926A1 (en) | 2019-04-10 | 2022-06-09 | Universität Zürich | A method for determining the likelihood of a patient being responsive to cancer immunotherapy |
| CA3139051A1 (fr) | 2019-06-04 | 2020-12-10 | Christian REICHEN | Proteines multispecifiques |
| BR112021024231A2 (pt) * | 2019-06-04 | 2022-04-26 | Molecular Partners Ag | Proteínas de ligação fap recombinantes e uso da mesma |
| CN114206908A (zh) | 2019-06-04 | 2022-03-18 | 分子伴侣公司 | 具有改善的稳定性的经设计的锚蛋白重复结构域 |
| US20220332845A1 (en) | 2019-09-05 | 2022-10-20 | Genome Biologics Ug | Inhibition of mthfd1l for use in hypertrophic heart disease and heart failure |
| JP2023506763A (ja) | 2019-12-11 | 2023-02-20 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換えペプチド－ｍｈｃ複合体結合タンパク質並びにそれらの生成及び使用 |
| MX2022007120A (es) | 2019-12-11 | 2022-09-09 | Molecular Partners Ag | Proteínas de unión al complejo péptido-mhc recombinantes y su generación y uso. |
| WO2021122813A1 (fr) | 2019-12-16 | 2021-06-24 | Universität Basel | Agents favorisant l'angiogenèse pour la prévention d'un cancer métastatique |
| WO2021176008A1 (fr) | 2020-03-04 | 2021-09-10 | Cornell University | Agents ciblant baf155 ou brg1 destinés à être utilisés dans le traitement du cancer avancé de la prostate |
| EP4132578A1 (fr) | 2020-04-06 | 2023-02-15 | Universität Zürich | Ligands artc1 pour le traitement du cancer |
| KR20230006558A (ko) | 2020-05-06 | 2023-01-10 | 몰리큘라 파트너스 아게 | 신규한 안키린 반복 결합 단백질 및 그의 용도 |
| JP2023528207A (ja) * | 2020-05-14 | 2023-07-04 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換えｃｄ４０結合タンパク質及びそれらの使用 |
| EP4149959A1 (fr) | 2020-05-14 | 2023-03-22 | Molecular Partners AG | Protéines multispécifiques |
| JP2023504675A (ja) | 2020-05-19 | 2023-02-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ガンの処置のための結合分子 |
| WO2021239844A1 (fr) | 2020-05-27 | 2021-12-02 | Universitätsspital Basel | Inhibiteurs de sglt-2 ou antagonistes d'il-1r pour la réduction de l'hypoglycémie chez un patient atteint de prédiabète |
| WO2021239999A1 (fr) | 2020-05-28 | 2021-12-02 | Universität Zürich | Protéine de fusion de ligand pd-l1 il-12 |
| EP3957649A1 (fr) | 2020-08-18 | 2022-02-23 | Athebio AG | Modules de coiffage de domaines de répétition d'ankyrine à n-terminaux améliorés |
| EP4199964A1 (fr) | 2020-08-18 | 2023-06-28 | Universität Zürich | Anticorps anti-il-2 priorisant cd25 |
| US11981710B2 (en) * | 2020-08-18 | 2024-05-14 | Athebio Ag | N-terminal capping modules of ankyrin repeat domains |
| CN114106194B (zh) * | 2020-08-31 | 2024-01-16 | 中国科学院天津工业生物技术研究所 | 一种用于治疗糖尿病和/或肥胖症的融合蛋白 |
| WO2022098743A1 (fr) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imagerie et procédés thérapeutiques ciblant le récepteur 1 de folate (folr1) |
| WO2022098745A1 (fr) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, systèmes d'administration et méthodes utiles dans la thérapie antitumorale |
| JP2023554379A (ja) | 2020-12-16 | 2023-12-27 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換えｃｄ３結合タンパク質及びそれらの使用 |
| AU2021403833A1 (en) | 2020-12-16 | 2023-07-27 | Molecular Partners Ag | Novel slow-release prodrugs |
| EP4291901A1 (fr) | 2021-02-11 | 2023-12-20 | Universität Zürich | Utilisation de marqueurs dans des échantillons métastatiques de ganglions lymphatiques pour le pronostic du cancer du sein |
| EP4043481A1 (fr) * | 2021-02-15 | 2022-08-17 | Affilogic | Composés et procédés pour prolonger la demi-vie de biomolécules |
| WO2022190018A1 (fr) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Nouveaux agents de mise en contact de cd123 à base de darpin |
| JP2024508969A (ja) | 2021-03-09 | 2024-02-28 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規のＤＡＲＰｉｎに基づくＣＤ３３エンゲージャ |
| JP2024509890A (ja) | 2021-03-09 | 2024-03-05 | モレキュラー パートナーズ アクチェンゲゼルシャフト | プロテアーゼ切断可能なプロドラッグ |
| JP2024509904A (ja) | 2021-03-09 | 2024-03-05 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規なＤＡＲＰｉｎに基づく多重特異性Ｔ細胞エンゲージャ |
| WO2022219185A1 (fr) | 2021-04-16 | 2022-10-20 | Athebio Ag | Modules de coiffage n-terminaux de domaines de répétition d'ankyrine |
| KR20240045259A (ko) | 2021-08-05 | 2024-04-05 | 이뮤노스 테라퓨틱스 아게 | Hla 융합 단백질을 포함하는 약학 조성물 |
| CN118103060A (zh) | 2021-08-05 | 2024-05-28 | 免疫标记治疗股份公司 | 包括hla融合蛋白的组合药物 |
| WO2023021006A1 (fr) | 2021-08-16 | 2023-02-23 | Universität Zürich | Agents de ciblage de l'il-1 pour le traitement du pityriasis rubra pilaire |
| WO2023021050A1 (fr) | 2021-08-17 | 2023-02-23 | Athebio Ag | Variants de domaines de répétition d'ankyrine |
| EP4137508A1 (fr) | 2021-08-17 | 2023-02-22 | Athebio AG | Variantes de domaines de répétition d'ankyrine |
| WO2023036849A1 (fr) | 2021-09-07 | 2023-03-16 | ETH Zürich | Identification et prédiction de futurs variants de coronavirus |
| EP4163380A1 (fr) | 2021-10-08 | 2023-04-12 | ETH Zurich | Dispositif et procédé de manipulation de vésicules extracellulaires |
| WO2023110983A1 (fr) | 2021-12-14 | 2023-06-22 | Molecular Partners Ag | Domaines de répétition modélisés à double spécificité de liaison et leur utilisation |
| WO2023110942A1 (fr) | 2021-12-14 | 2023-06-22 | Charité-Universitätsmedizin Berlin | Prévention de guérison d'une fracture altérée |
| EP4260907A1 (fr) | 2022-04-11 | 2023-10-18 | Universität Zürich | Agents pour le traitement de l'endométriose et d'autres néoplasmes gynécologiques bénins |
| WO2024002914A1 (fr) | 2022-06-27 | 2024-01-04 | Charité-Universitätsmedizin Berlin | Prédiction de la cicatrisation des tendons et composition pour l'améliorer |
| US20240132546A1 (en) | 2022-07-31 | 2024-04-25 | Molecular Partners Ag | Charge modified designed repeat domains and their use |
| WO2024037743A1 (fr) | 2022-08-16 | 2024-02-22 | Athebio Ag | Variants de domaines de répétition d'ankyrine |
| WO2023194628A2 (fr) | 2022-08-16 | 2023-10-12 | Athebio Ag | Variants de domaines de répétition d'ankyrine |
| WO2024038307A1 (fr) | 2022-08-19 | 2024-02-22 | Novartis Ag | Schémas posologiques pour molécules de liaison au sars-cov-2 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE151110T1 (de) | 1988-09-02 | 1997-04-15 | Protein Eng Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5348867A (en) | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
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