PL217858B1 - Fragment apolipoproteiny B lub jego miejsce aktywne, zawierająca go kompozycja farmaceutyczna i szczepionka, zastosowanie tego fragmentu, szczepionka zawierająca przeciwciało przeciwko temu fragmentowi, sposób diagnozowania in vitro oraz zastosowanie tego przeciwciała - Google Patents
Fragment apolipoproteiny B lub jego miejsce aktywne, zawierająca go kompozycja farmaceutyczna i szczepionka, zastosowanie tego fragmentu, szczepionka zawierająca przeciwciało przeciwko temu fragmentowi, sposób diagnozowania in vitro oraz zastosowanie tego przeciwciałaInfo
- Publication number
- PL217858B1 PL217858B1 PL391615A PL39161502A PL217858B1 PL 217858 B1 PL217858 B1 PL 217858B1 PL 391615 A PL391615 A PL 391615A PL 39161502 A PL39161502 A PL 39161502A PL 217858 B1 PL217858 B1 PL 217858B1
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- Prior art keywords
- fragment
- peptide
- mda
- antibodies
- antibody
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Marine Sciences & Fisheries (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101232A SE0101232D0 (sv) | 2001-04-05 | 2001-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based elisa for determination of immune responses against oxidized low density liprotein |
| SE0103754A SE0103754L (sv) | 2001-04-05 | 2001-11-09 | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL217858B1 true PL217858B1 (pl) | 2014-08-29 |
Family
ID=26655437
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL391615A PL217858B1 (pl) | 2001-04-05 | 2002-04-05 | Fragment apolipoproteiny B lub jego miejsce aktywne, zawierająca go kompozycja farmaceutyczna i szczepionka, zastosowanie tego fragmentu, szczepionka zawierająca przeciwciało przeciwko temu fragmentowi, sposób diagnozowania in vitro oraz zastosowanie tego przeciwciała |
| PL02367301A PL367301A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
| PL385189A PL215401B1 (pl) | 2001-04-05 | 2002-04-05 | Fragment apolipoproteiny B lub jego miejsce aktywne, zawierajaca go kompozycja farmaceutyczna i szczepionka, zastosowanie tego fragmentu , szczepionka zawierajaca przeciwcialo przeciwko temu fragmentowi, sposób diagnozowania in vitro oraz zastosowanie tego przeciwciala |
| PL400308A PL400308A1 (pl) | 2001-04-05 | 2002-04-05 | Terapia immunizacyjna w oparciu o peptydy do leczenia miazdzycy oraz w oparciu o peptydy do okreslania odpowiedzi odpornosci przeciwko utlenionym lipoproteinom o niskiej gestosci |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL02367301A PL367301A1 (en) | 2001-04-05 | 2002-04-05 | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
| PL385189A PL215401B1 (pl) | 2001-04-05 | 2002-04-05 | Fragment apolipoproteiny B lub jego miejsce aktywne, zawierajaca go kompozycja farmaceutyczna i szczepionka, zastosowanie tego fragmentu , szczepionka zawierajaca przeciwcialo przeciwko temu fragmentowi, sposób diagnozowania in vitro oraz zastosowanie tego przeciwciala |
| PL400308A PL400308A1 (pl) | 2001-04-05 | 2002-04-05 | Terapia immunizacyjna w oparciu o peptydy do leczenia miazdzycy oraz w oparciu o peptydy do okreslania odpowiedzi odpornosci przeciwko utlenionym lipoproteinom o niskiej gestosci |
Country Status (18)
| Country | Link |
|---|---|
| EP (42) | EP2289934B1 (enExample) |
| JP (6) | JP2004529143A (enExample) |
| CN (4) | CN1505525B (enExample) |
| AT (2) | ATE415423T1 (enExample) |
| AU (1) | AU2002246484B8 (enExample) |
| BR (1) | BR0208685A (enExample) |
| CA (3) | CA2443223C (enExample) |
| CY (1) | CY1108817T1 (enExample) |
| DE (1) | DE60230029D1 (enExample) |
| DK (3) | DK2006301T3 (enExample) |
| EE (2) | EE200300487A (enExample) |
| ES (2) | ES2317999T3 (enExample) |
| IL (4) | IL158285A0 (enExample) |
| PL (4) | PL217858B1 (enExample) |
| PT (1) | PT1383526E (enExample) |
| RU (1) | RU2296582C2 (enExample) |
| SE (1) | SE0103754L (enExample) |
| WO (1) | WO2002080954A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030105003A1 (en) | 2001-04-05 | 2003-06-05 | Jan Nilsson | Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein |
| SE0103754L (sv) * | 2001-04-05 | 2002-10-06 | Forskarpatent I Syd Ab | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
| CA2460787A1 (en) | 2001-09-28 | 2003-04-03 | Esperion Therapeutics, Inc. | Prevention and treatment of restenosis by local administration of drug |
| AU2003267905B2 (en) * | 2002-10-04 | 2009-02-05 | Biolnvent International Ab | Peptide-based passive immunization therapy for treatment of atherosclerosis |
| SE0302312D0 (sv) | 2002-10-04 | 2003-08-27 | Forskarpatent I Syd Ab | Peptide-based passive immunization therapy for treatment of atherosclerosis |
| SE0302422D0 (sv) | 2003-09-11 | 2003-09-11 | Forskarpatent I Syd Ab | Peptide-based immunization therapy for treatment of atherosclerosis |
| SE0400683D0 (sv) | 2004-03-19 | 2004-03-19 | Forskarpatent I Syd Ab | Use of modified extracellular matrix proteins in diagnosis and treatment of a atherosclerosis |
| JP2007531537A (ja) | 2004-04-06 | 2007-11-08 | セダーズ−シナイ メディカル センター | アポリポタンパク質ａ−ｉおよびアポリポタンパク質ａ−ｉｍｉｌａｎｏをコードする組換えアデノ随伴ウイルスベクターによる血管疾患の予防および処置 |
| CN1968965B (zh) * | 2004-04-15 | 2015-12-16 | 阿瑟拉生物技术公司 | 磷酸胆碱偶联物和相应抗体 |
| EP1676602A1 (en) * | 2005-01-04 | 2006-07-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Continuous administration of epitopes derived from protein present in atherosclerotic plaque for the treatment of atherosclerosis |
| GB0517878D0 (en) | 2005-09-02 | 2005-10-12 | Bioinvent Int Ab | Immunotherapeutic treatment |
| JP2010515023A (ja) * | 2006-12-22 | 2010-05-06 | アボット・ラボラトリーズ | 心血管系自己免疫疾患パネルおよびその使用方法 |
| WO2008104194A1 (en) * | 2007-02-28 | 2008-09-04 | Bioinvent International Ab | Oxidized ldl and antibodies thereto for the treatment of atheroscleroti c plaques |
| BRPI0809193A2 (pt) | 2007-03-15 | 2014-09-23 | Novartis Ag | Compostos orgânicos e seus usos |
| JP6039879B2 (ja) * | 2007-11-05 | 2016-12-07 | ノルディック・ビオサイエンス・エー／エスＮｏｒｄｉｃ Ｂｉｏｓｃｉｅｎｃｅ Ａ／Ｓ | Ｃｖｄリスク評価のための生化学マーカー |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| JP5742002B2 (ja) * | 2008-08-15 | 2015-07-01 | 藤倉化成株式会社 | 動脈硬化診断用ポリペプチドマーカー、及び該マーカー等を用いる動脈硬化の検出を補助する方法、並びに動脈硬化診断用キット |
| EP2499488A1 (en) | 2009-11-14 | 2012-09-19 | Kuang-Yuh Chyu | Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis |
| US8506964B2 (en) | 2010-02-05 | 2013-08-13 | Cardiovax, Llc | Fusion proteins and related compositions, methods and systems for treatment and/or prevention of atherosclerosis |
| WO2012024309A2 (en) | 2010-08-18 | 2012-02-23 | Cedars-Sinai Medical Center | Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using apo a-i milano gene transfer |
| JP2013544243A (ja) | 2010-11-12 | 2013-12-12 | シーダース シナイ メディカル センター | 動脈瘤の治療及び／又は予防のための免疫調節方法及びシステム |
| RU2013126888A (ru) | 2010-11-12 | 2014-12-20 | Седарс-Синаи Медикал Сентер | ИММУНОМОДУЛИРУЮЩИЕ КОМПОЗИЦИИ, СПОСОБЫ И СИСТЕМЫ, СОДЕРЖАЩИЕ ИММУНОГЕННЫЕ ФРАГМЕНТЫ АроВ100 |
| US9205141B2 (en) | 2010-11-12 | 2015-12-08 | Cardio Vax, Llc | Immunomodulatory methods and systems for treatment and/or prevention of hypertension |
| AU2012294431B2 (en) | 2011-08-09 | 2017-03-30 | Athera Biotechnologies Ab | Antibodies binding to phosphorylcholine (PC) and/or PC conjugates |
| SI2742068T1 (sl) | 2011-08-09 | 2019-08-30 | Athera Biotechnologies Ab | Nova protitelesa proti fosforilholinu |
| RU2495048C1 (ru) * | 2012-04-18 | 2013-10-10 | Андрей Валентинович Исаев | Пептид, обладающий антиатеросклеротическим действием и композиция для профилактики и лечения атеросклероза сосудов |
| CA2888657C (en) | 2012-11-06 | 2022-05-03 | Les Hopitaux Universitaires De Geneve | Mimetic peptides |
| CN103520713B (zh) * | 2013-10-16 | 2015-10-28 | 西北农林科技大学 | 一种ApoB100酵母重组疫苗及其制备方法和应用 |
| CN103860470A (zh) * | 2014-03-05 | 2014-06-18 | 贵州中泰生物科技有限公司 | 一种口服高密度脂蛋白脂质体的制备方法 |
| CN105315364B (zh) * | 2014-06-17 | 2018-09-18 | 广州文瑞生物科技有限公司 | 胶原蛋白vi疫苗预防动脉粥样硬化 |
| EP3297652A4 (en) | 2015-05-19 | 2019-06-05 | La Jolla Institute for Allergy and Immunology | HUMAN APOB100 EPITOPES, METHOD AND USES FOR MODULATING INFLAMMATORY REACTIONS AND TREATING UNWANTED CARDIOVASCULAR EVENTS, DISEASES AND ATHEROSCLEROSIS |
| US10858422B2 (en) | 2016-05-31 | 2020-12-08 | Abcentra, Llc | Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody |
| CN108478817B (zh) * | 2018-03-16 | 2020-10-27 | 北京大学 | 一种动脉粥样硬化检测试剂及其制备方法 |
| US11690912B2 (en) | 2018-05-29 | 2023-07-04 | Abcentra, Llc | Methods for treatment of rheumatoid arthritis and accelerated atherosclerosis with an anti-Apo B100 antibody |
| WO2019232070A1 (en) | 2018-05-29 | 2019-12-05 | Abcentra, Llc | Compositions and methods for treatment of psoriasis |
| CN115025210B (zh) * | 2021-03-05 | 2025-09-05 | 香港中文大学 | 减少动脉粥样硬化进展的肽疫苗组合物和药物制剂 |
| CN115025211A (zh) * | 2021-11-02 | 2022-09-09 | 南京理工大学 | 用于动脉粥样硬化治疗的纳米疫苗及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970144A (en) | 1984-12-31 | 1990-11-13 | International Genetic Engineering | Peptide fragments of human apolipoprotein, type-specific antibodies and methods of use |
| US5972890A (en) | 1988-05-02 | 1999-10-26 | New England Deaconess Hospital Corporation | Synthetic peptides for arterial imaging |
| WO1993018067A1 (en) * | 1992-03-06 | 1993-09-16 | Abbott Laboratories | Immunocapture assay for direct quantitation of specific lipoprotein cholesterol levels |
| WO1994000592A1 (en) * | 1992-06-26 | 1994-01-06 | Exocell, Inc. | Monoclonal antibodies against glycated low density lipoprotein |
| DE69332485T2 (de) * | 1992-08-11 | 2003-11-13 | The President And Fellows Of Harvard College, Cambridge | Immunmodulierende peptide |
| KR0185334B1 (ko) | 1995-11-02 | 1999-04-01 | 김은영 | 인간 혈장 아포지단백질 비-100에 결합하는 생쥐 항체를 암호하는 씨디엔에이 |
| GB9609702D0 (en) * | 1996-05-09 | 1996-07-10 | Royal Free Hosp School Med | Anticoagulant peptides |
| GB9620153D0 (en) * | 1996-09-27 | 1996-11-13 | Univ Strathclyde | Non-naturally occurring lipoprotein particle |
| GB9705831D0 (en) * | 1997-03-20 | 1997-05-07 | Univ Leicester | Oxidised ldl |
| US6635623B1 (en) * | 1997-06-13 | 2003-10-21 | Baylor College Of Medicine | Lipoproteins as nucleic acid vectors |
| US6225070B1 (en) | 1997-08-07 | 2001-05-01 | The Regents Of The University Of California | Antibodies to oxidation-specific epitopes on lipoprotein and methods for their use in detecting, monitoring and inhibiting the growth of atheroma |
| US6156315A (en) * | 1997-10-10 | 2000-12-05 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting the binding of low density lipoprotein to blood vessel matrix |
| EP0911344B1 (en) * | 1997-10-15 | 2004-03-03 | Fujirebio Inc. | Anti-Apo-B-48 monoclonal antibody, hybridoma, and methods of use |
| US6579682B1 (en) * | 1998-03-10 | 2003-06-17 | The Regents Of University Of California | Methods and tools for identifying compounds which modulate atherosclerosis by impacting LDL-proteoglycan binding |
| WO2000002920A1 (en) * | 1998-07-13 | 2000-01-20 | University Of Otago | Inhibition of lipoprotein formation |
| IL126447A (en) * | 1998-10-04 | 2004-09-27 | Vascular Biogenics Ltd | An immune preparation that confers tolerance in oral administration and its use in the prevention and / or treatment of atherosclerosis |
| JP2003513027A (ja) * | 1999-10-26 | 2003-04-08 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | アテローム性動脈硬化症の診断、結像、治療用の薬剤及びその方法 |
| AU3087801A (en) * | 2000-02-04 | 2001-08-14 | Molecular Dynamics Inc | Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells |
| ATE265860T1 (de) * | 2000-03-03 | 2004-05-15 | Glaxosmithkline Biolog Sa | Impstoff zur behandlung von atherosclerosis |
| SE0000855D0 (sv) * | 2000-03-15 | 2000-03-15 | Karolinska Innovations Ab | Antigenic composition useful as a vaccine against atherosclerosis |
| GB0017641D0 (en) * | 2000-07-18 | 2000-09-06 | Medigene Oy | Peptides and their use |
| EP1186299A1 (en) * | 2000-09-12 | 2002-03-13 | Universitair Medisch Centrum Utrecht | The diagnosis, prevention, and/or succesful treatment of atherosclerosis, infectious diseases, and disturbances in the immune system |
| US20050048062A1 (en) * | 2000-10-25 | 2005-03-03 | Vincent Agnello | Method of inhibiting infection by hcv, other flaviviridae viruses, and any other virus that complexes to low density lipoprotein or to very low density lipoprotein in blood preventing viral entry into a cell |
| AU2002241603A1 (en) * | 2000-11-10 | 2002-06-03 | University Of Utah Research Foundation | Carrier system for specific artery wall gene delivery |
| SE0103754L (sv) * | 2001-04-05 | 2002-10-06 | Forskarpatent I Syd Ab | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
| MXPA03010456A (es) * | 2001-05-15 | 2004-12-06 | Japan Inmunores Lab Co Ltd | Peptidos reactivos a lipoproteina de alta densidad. |
| US7060681B2 (en) * | 2001-07-20 | 2006-06-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Compositions and methods for use of bioactive agents derived from sulfated and sulfonated amino acids |
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2001
- 2001-11-09 SE SE0103754A patent/SE0103754L/xx not_active Application Discontinuation
-
2002
- 2002-04-05 EP EP10181253.5A patent/EP2289934B1/en not_active Expired - Lifetime
- 2002-04-05 EE EEP200300487A patent/EE200300487A/xx unknown
- 2002-04-05 EP EP10181196A patent/EP2289928A1/en not_active Withdrawn
- 2002-04-05 DK DK08151489.5T patent/DK2006301T3/da active
- 2002-04-05 JP JP2002578993A patent/JP2004529143A/ja not_active Withdrawn
- 2002-04-05 EP EP02714667A patent/EP1383526B1/en not_active Expired - Lifetime
- 2002-04-05 AT AT02714667T patent/ATE415423T1/de active
- 2002-04-05 EP EP10180168A patent/EP2295461A1/en not_active Withdrawn
- 2002-04-05 EP EP10181167A patent/EP2289925A1/en not_active Withdrawn
- 2002-04-05 EP EP10180188A patent/EP2289916A1/en not_active Withdrawn
- 2002-04-05 PL PL391615A patent/PL217858B1/pl unknown
- 2002-04-05 ES ES02714667T patent/ES2317999T3/es not_active Expired - Lifetime
- 2002-04-05 EP EP10180838A patent/EP2289923A1/en not_active Withdrawn
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2009
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2013
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