ATE415423T1 - Immunisierungstherapie zur behandlung von atherosklerose - Google Patents

Immunisierungstherapie zur behandlung von atherosklerose

Info

Publication number
ATE415423T1
ATE415423T1 AT02714667T AT02714667T ATE415423T1 AT E415423 T1 ATE415423 T1 AT E415423T1 AT 02714667 T AT02714667 T AT 02714667T AT 02714667 T AT02714667 T AT 02714667T AT E415423 T1 ATE415423 T1 AT E415423T1
Authority
AT
Austria
Prior art keywords
treatment
atherosclerosis
immunization therapy
cardiovascular diseases
peptides
Prior art date
Application number
AT02714667T
Other languages
German (de)
English (en)
Inventor
Jan Nilsson
Prediman Shah
Original Assignee
Forskarpatent I Syd Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0101232A external-priority patent/SE0101232D0/xx
Application filed by Forskarpatent I Syd Ab filed Critical Forskarpatent I Syd Ab
Application granted granted Critical
Publication of ATE415423T1 publication Critical patent/ATE415423T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
AT02714667T 2001-04-05 2002-04-05 Immunisierungstherapie zur behandlung von atherosklerose ATE415423T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0101232A SE0101232D0 (sv) 2001-04-05 2001-04-05 Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based elisa for determination of immune responses against oxidized low density liprotein
SE0103754A SE0103754L (sv) 2001-04-05 2001-11-09 Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid

Publications (1)

Publication Number Publication Date
ATE415423T1 true ATE415423T1 (de) 2008-12-15

Family

ID=26655437

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02714667T ATE415423T1 (de) 2001-04-05 2002-04-05 Immunisierungstherapie zur behandlung von atherosklerose
AT08151489T ATE510851T1 (de) 2001-04-05 2002-04-05 Auf peptiden basierende immunisierungstherapie zur behandlung von atherosklerose

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT08151489T ATE510851T1 (de) 2001-04-05 2002-04-05 Auf peptiden basierende immunisierungstherapie zur behandlung von atherosklerose

Country Status (18)

Country Link
EP (42) EP2289934B1 (enExample)
JP (6) JP2004529143A (enExample)
CN (4) CN1505525B (enExample)
AT (2) ATE415423T1 (enExample)
AU (1) AU2002246484B8 (enExample)
BR (1) BR0208685A (enExample)
CA (3) CA2443223C (enExample)
CY (1) CY1108817T1 (enExample)
DE (1) DE60230029D1 (enExample)
DK (3) DK2006301T3 (enExample)
EE (2) EE200300487A (enExample)
ES (2) ES2317999T3 (enExample)
IL (4) IL158285A0 (enExample)
PL (4) PL217858B1 (enExample)
PT (1) PT1383526E (enExample)
RU (1) RU2296582C2 (enExample)
SE (1) SE0103754L (enExample)
WO (1) WO2002080954A1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030105003A1 (en) 2001-04-05 2003-06-05 Jan Nilsson Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein
SE0103754L (sv) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
CA2460787A1 (en) 2001-09-28 2003-04-03 Esperion Therapeutics, Inc. Prevention and treatment of restenosis by local administration of drug
AU2003267905B2 (en) * 2002-10-04 2009-02-05 Biolnvent International Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
SE0302312D0 (sv) 2002-10-04 2003-08-27 Forskarpatent I Syd Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
SE0302422D0 (sv) 2003-09-11 2003-09-11 Forskarpatent I Syd Ab Peptide-based immunization therapy for treatment of atherosclerosis
SE0400683D0 (sv) 2004-03-19 2004-03-19 Forskarpatent I Syd Ab Use of modified extracellular matrix proteins in diagnosis and treatment of a atherosclerosis
JP2007531537A (ja) 2004-04-06 2007-11-08 セダーズ−シナイ　メディカル　センター アポリポタンパク質ａ−ｉおよびアポリポタンパク質ａ−ｉｍｉｌａｎｏをコードする組換えアデノ随伴ウイルスベクターによる血管疾患の予防および処置
CN1968965B (zh) * 2004-04-15 2015-12-16 阿瑟拉生物技术公司 磷酸胆碱偶联物和相应抗体
EP1676602A1 (en) * 2005-01-04 2006-07-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Continuous administration of epitopes derived from protein present in atherosclerotic plaque for the treatment of atherosclerosis
GB0517878D0 (en) 2005-09-02 2005-10-12 Bioinvent Int Ab Immunotherapeutic treatment
JP2010515023A (ja) * 2006-12-22 2010-05-06 アボット・ラボラトリーズ 心血管系自己免疫疾患パネルおよびその使用方法
WO2008104194A1 (en) * 2007-02-28 2008-09-04 Bioinvent International Ab Oxidized ldl and antibodies thereto for the treatment of atheroscleroti c plaques
BRPI0809193A2 (pt) 2007-03-15 2014-09-23 Novartis Ag Compostos orgânicos e seus usos
JP6039879B2 (ja) * 2007-11-05 2016-12-07 ノルディック・ビオサイエンス・エー／エスＮｏｒｄｉｃ Ｂｉｏｓｃｉｅｎｃｅ Ａ／Ｓ Ｃｖｄリスク評価のための生化学マーカー
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
JP5742002B2 (ja) * 2008-08-15 2015-07-01 藤倉化成株式会社 動脈硬化診断用ポリペプチドマーカー、及び該マーカー等を用いる動脈硬化の検出を補助する方法、並びに動脈硬化診断用キット
EP2499488A1 (en) 2009-11-14 2012-09-19 Kuang-Yuh Chyu Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis
US8506964B2 (en) 2010-02-05 2013-08-13 Cardiovax, Llc Fusion proteins and related compositions, methods and systems for treatment and/or prevention of atherosclerosis
WO2012024309A2 (en) 2010-08-18 2012-02-23 Cedars-Sinai Medical Center Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using apo a-i milano gene transfer
JP2013544243A (ja) 2010-11-12 2013-12-12 シーダース シナイ メディカル センター 動脈瘤の治療及び／又は予防のための免疫調節方法及びシステム
RU2013126888A (ru) 2010-11-12 2014-12-20 Седарс-Синаи Медикал Сентер ИММУНОМОДУЛИРУЮЩИЕ КОМПОЗИЦИИ, СПОСОБЫ И СИСТЕМЫ, СОДЕРЖАЩИЕ ИММУНОГЕННЫЕ ФРАГМЕНТЫ АроВ100
US9205141B2 (en) 2010-11-12 2015-12-08 Cardio Vax, Llc Immunomodulatory methods and systems for treatment and/or prevention of hypertension
AU2012294431B2 (en) 2011-08-09 2017-03-30 Athera Biotechnologies Ab Antibodies binding to phosphorylcholine (PC) and/or PC conjugates
SI2742068T1 (sl) 2011-08-09 2019-08-30 Athera Biotechnologies Ab Nova protitelesa proti fosforilholinu
RU2495048C1 (ru) * 2012-04-18 2013-10-10 Андрей Валентинович Исаев Пептид, обладающий антиатеросклеротическим действием и композиция для профилактики и лечения атеросклероза сосудов
CA2888657C (en) 2012-11-06 2022-05-03 Les Hopitaux Universitaires De Geneve Mimetic peptides
CN103520713B (zh) * 2013-10-16 2015-10-28 西北农林科技大学 一种ApoB100酵母重组疫苗及其制备方法和应用
CN103860470A (zh) * 2014-03-05 2014-06-18 贵州中泰生物科技有限公司 一种口服高密度脂蛋白脂质体的制备方法
CN105315364B (zh) * 2014-06-17 2018-09-18 广州文瑞生物科技有限公司 胶原蛋白vi疫苗预防动脉粥样硬化
EP3297652A4 (en) 2015-05-19 2019-06-05 La Jolla Institute for Allergy and Immunology HUMAN APOB100 EPITOPES, METHOD AND USES FOR MODULATING INFLAMMATORY REACTIONS AND TREATING UNWANTED CARDIOVASCULAR EVENTS, DISEASES AND ATHEROSCLEROSIS
US10858422B2 (en) 2016-05-31 2020-12-08 Abcentra, Llc Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody
CN108478817B (zh) * 2018-03-16 2020-10-27 北京大学 一种动脉粥样硬化检测试剂及其制备方法
US11690912B2 (en) 2018-05-29 2023-07-04 Abcentra, Llc Methods for treatment of rheumatoid arthritis and accelerated atherosclerosis with an anti-Apo B100 antibody
WO2019232070A1 (en) 2018-05-29 2019-12-05 Abcentra, Llc Compositions and methods for treatment of psoriasis
CN115025210B (zh) * 2021-03-05 2025-09-05 香港中文大学 减少动脉粥样硬化进展的肽疫苗组合物和药物制剂
CN115025211A (zh) * 2021-11-02 2022-09-09 南京理工大学 用于动脉粥样硬化治疗的纳米疫苗及其制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970144A (en) 1984-12-31 1990-11-13 International Genetic Engineering Peptide fragments of human apolipoprotein, type-specific antibodies and methods of use
US5972890A (en) 1988-05-02 1999-10-26 New England Deaconess Hospital Corporation Synthetic peptides for arterial imaging
WO1993018067A1 (en) * 1992-03-06 1993-09-16 Abbott Laboratories Immunocapture assay for direct quantitation of specific lipoprotein cholesterol levels
WO1994000592A1 (en) * 1992-06-26 1994-01-06 Exocell, Inc. Monoclonal antibodies against glycated low density lipoprotein
DE69332485T2 (de) * 1992-08-11 2003-11-13 The President And Fellows Of Harvard College, Cambridge Immunmodulierende peptide
KR0185334B1 (ko) 1995-11-02 1999-04-01 김은영 인간 혈장 아포지단백질 비-100에 결합하는 생쥐 항체를 암호하는 씨디엔에이
GB9609702D0 (en) * 1996-05-09 1996-07-10 Royal Free Hosp School Med Anticoagulant peptides
GB9620153D0 (en) * 1996-09-27 1996-11-13 Univ Strathclyde Non-naturally occurring lipoprotein particle
GB9705831D0 (en) * 1997-03-20 1997-05-07 Univ Leicester Oxidised ldl
US6635623B1 (en) * 1997-06-13 2003-10-21 Baylor College Of Medicine Lipoproteins as nucleic acid vectors
US6225070B1 (en) 1997-08-07 2001-05-01 The Regents Of The University Of California Antibodies to oxidation-specific epitopes on lipoprotein and methods for their use in detecting, monitoring and inhibiting the growth of atheroma
US6156315A (en) * 1997-10-10 2000-12-05 The Trustees Of Columbia University In The City Of New York Method for inhibiting the binding of low density lipoprotein to blood vessel matrix
EP0911344B1 (en) * 1997-10-15 2004-03-03 Fujirebio Inc. Anti-Apo-B-48 monoclonal antibody, hybridoma, and methods of use
US6579682B1 (en) * 1998-03-10 2003-06-17 The Regents Of University Of California Methods and tools for identifying compounds which modulate atherosclerosis by impacting LDL-proteoglycan binding
WO2000002920A1 (en) * 1998-07-13 2000-01-20 University Of Otago Inhibition of lipoprotein formation
IL126447A (en) * 1998-10-04 2004-09-27 Vascular Biogenics Ltd An immune preparation that confers tolerance in oral administration and its use in the prevention and / or treatment of atherosclerosis
JP2003513027A (ja) * 1999-10-26 2003-04-08 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア アテローム性動脈硬化症の診断、結像、治療用の薬剤及びその方法
AU3087801A (en) * 2000-02-04 2001-08-14 Molecular Dynamics Inc Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells
ATE265860T1 (de) * 2000-03-03 2004-05-15 Glaxosmithkline Biolog Sa Impstoff zur behandlung von atherosclerosis
SE0000855D0 (sv) * 2000-03-15 2000-03-15 Karolinska Innovations Ab Antigenic composition useful as a vaccine against atherosclerosis
GB0017641D0 (en) * 2000-07-18 2000-09-06 Medigene Oy Peptides and their use
EP1186299A1 (en) * 2000-09-12 2002-03-13 Universitair Medisch Centrum Utrecht The diagnosis, prevention, and/or succesful treatment of atherosclerosis, infectious diseases, and disturbances in the immune system
US20050048062A1 (en) * 2000-10-25 2005-03-03 Vincent Agnello Method of inhibiting infection by hcv, other flaviviridae viruses, and any other virus that complexes to low density lipoprotein or to very low density lipoprotein in blood preventing viral entry into a cell
AU2002241603A1 (en) * 2000-11-10 2002-06-03 University Of Utah Research Foundation Carrier system for specific artery wall gene delivery
SE0103754L (sv) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
MXPA03010456A (es) * 2001-05-15 2004-12-06 Japan Inmunores Lab Co Ltd Peptidos reactivos a lipoproteina de alta densidad.
US7060681B2 (en) * 2001-07-20 2006-06-13 Ecole Polytechnique Federale De Lausanne (Epfl) Compositions and methods for use of bioactive agents derived from sulfated and sulfonated amino acids

Also Published As

Publication number Publication date
EP2295459A1 (en) 2011-03-16
CA2606839A1 (en) 2002-10-17
CA2443223C (en) 2013-11-26
EP2147928A3 (en) 2010-04-14
PL367301A1 (en) 2005-02-21
CA2827167A1 (en) 2002-10-17
CN1505525B (zh) 2012-11-07
BR0208685A (pt) 2004-03-30
EP2305706A1 (en) 2011-04-06
EP2295461A1 (en) 2011-03-16
EP2289926A1 (en) 2011-03-02
ES2317999T3 (es) 2009-05-01
PL215401B1 (pl) 2013-12-31
CN103122031B (zh) 2015-07-22
CN103122031A (zh) 2013-05-29
CN101486766A (zh) 2009-07-22
SE0103754D0 (sv) 2001-11-09
EP2295458A1 (en) 2011-03-16
JP5300820B2 (ja) 2013-09-25
SE0103754L (sv) 2002-10-06
EP1918300A3 (en) 2009-06-17
DE60230029D1 (de) 2009-01-08
EP2289924A1 (en) 2011-03-02
EP2295460B1 (en) 2015-06-03
EP2289916A1 (en) 2011-03-02
EP2289935A1 (en) 2011-03-02
DK2006301T3 (da) 2011-09-12
EP2295457A1 (en) 2011-03-16
CN101284874B (zh) 2012-10-03
WO2002080954A1 (en) 2002-10-17
PL217858B1 (pl) 2014-08-29
EP2295463A1 (en) 2011-03-16
JP2013144687A (ja) 2013-07-25
EP2295464A1 (en) 2011-03-16
JP5300819B2 (ja) 2013-09-25
JP5270456B2 (ja) 2013-08-21
EP2289921A1 (en) 2011-03-02
IL158285A0 (en) 2004-05-12
AU2002246484B8 (en) 2007-06-14
RU2296582C2 (ru) 2007-04-10
CN101284874A (zh) 2008-10-15
EP2289932A1 (en) 2011-03-02
IL158285A (en) 2009-12-24
EP2289931A1 (en) 2011-03-02
EP2289925A1 (en) 2011-03-02
EP2289920A1 (en) 2011-03-02
EP2147930A2 (en) 2010-01-27
CN1505525A (zh) 2004-06-16
EP2289929A1 (en) 2011-03-02
JP5613890B2 (ja) 2014-10-29
EP2147929A3 (en) 2010-04-14
AU2002246484A1 (en) 2002-10-21
EP2289930A1 (en) 2011-03-02
EP2289923A1 (en) 2011-03-02
JP2011063598A (ja) 2011-03-31
ES2546293T3 (es) 2015-09-22
EE200700052A (et) 2008-08-15
EP2289927A1 (en) 2011-03-02
EP2305708A1 (en) 2011-04-06
EP2289919A1 (en) 2011-03-02
EP2295464B1 (en) 2015-06-03
EP2289934A1 (en) 2011-03-02
ATE510851T1 (de) 2011-06-15
PL400308A1 (pl) 2012-12-17
AU2002246484B2 (en) 2007-04-19
IL188286A0 (en) 2008-03-20
EP2295460A1 (en) 2011-03-16
EE200300487A (et) 2004-02-16
RU2003132443A (ru) 2005-02-27
EP2289918A1 (en) 2011-03-02
CA2606839C (en) 2015-06-09
PT1383526E (pt) 2009-02-27
EP2295462A1 (en) 2011-03-16
EP2289922A1 (en) 2011-03-02
EP1383526B1 (en) 2008-11-26
EP2147929A2 (en) 2010-01-27
EP2289917A1 (en) 2011-03-02
DK1383526T3 (da) 2009-03-30
EP1383526A1 (en) 2004-01-28
EP2289934B1 (en) 2013-11-13
IL195356A0 (en) 2009-08-03
JP2004529143A (ja) 2004-09-24
EP2147680A3 (en) 2010-04-14
EP2147680A2 (en) 2010-01-27
EP2289915A1 (en) 2011-03-02
EP2147930A3 (en) 2010-04-14
CY1108817T1 (el) 2014-04-09
EP2289912A1 (en) 2011-03-02
EP1918300A2 (en) 2008-05-07
JP2011068654A (ja) 2011-04-07
EP2289928A1 (en) 2011-03-02
EP2006301A1 (en) 2008-12-24
EP2147928A2 (en) 2010-01-27
CA2443223A1 (en) 2002-10-17
EP2006301B1 (en) 2011-05-25
EP2305707A1 (en) 2011-04-06
EP2289913A1 (en) 2011-03-02
EP2289914A1 (en) 2011-03-02
JP2008169215A (ja) 2008-07-24
JP2009191078A (ja) 2009-08-27
EP2289933A1 (en) 2011-03-02
DK2295464T3 (en) 2015-08-17

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