PL209822B1 - Pochodna chinoliny lub chinazoliny, zawierająca ją kompozycja farmaceutyczna i zastosowanie - Google Patents
Pochodna chinoliny lub chinazoliny, zawierająca ją kompozycja farmaceutyczna i zastosowanieInfo
- Publication number
- PL209822B1 PL209822B1 PL367105A PL36710502A PL209822B1 PL 209822 B1 PL209822 B1 PL 209822B1 PL 367105 A PL367105 A PL 367105A PL 36710502 A PL36710502 A PL 36710502A PL 209822 B1 PL209822 B1 PL 209822B1
- Authority
- PL
- Poland
- Prior art keywords
- chloroform
- solution
- added
- mixture
- thiazol
- Prior art date
Links
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title claims 2
- 125000003943 azolyl group Chemical group 0.000 title abstract description 3
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 126
- 150000003839 salts Chemical class 0.000 claims abstract description 25
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 7
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 7
- 150000002367 halogens Chemical class 0.000 claims abstract description 7
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 4
- -1 3-isoxazolyl Chemical group 0.000 claims description 136
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 64
- 206010028980 Neoplasm Diseases 0.000 claims description 34
- 229910052739 hydrogen Inorganic materials 0.000 claims description 21
- 239000001257 hydrogen Substances 0.000 claims description 21
- 150000003246 quinazolines Chemical class 0.000 claims description 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 18
- 201000010099 disease Diseases 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 201000011510 cancer Diseases 0.000 claims description 15
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 14
- 201000001320 Atherosclerosis Diseases 0.000 claims description 10
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 10
- 208000007766 Kaposi sarcoma Diseases 0.000 claims description 10
- 201000004681 Psoriasis Diseases 0.000 claims description 10
- 230000001684 chronic effect Effects 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 5
- 150000003248 quinolines Chemical class 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 4
- SPMVMDHWKHCIDT-UHFFFAOYSA-N 1-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-3-(5-methyl-3-isoxazolyl)urea Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1Cl)=CC=C1NC(=O)NC=1C=C(C)ON=1 SPMVMDHWKHCIDT-UHFFFAOYSA-N 0.000 claims description 3
- 150000002431 hydrogen Chemical class 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- GNOMMUQGOOPKSZ-UHFFFAOYSA-N 1-[2-chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-(1,3-thiazol-2-yl)urea Chemical compound C=12C=C(OC)C(OC)=CC2=NC=NC=1OC(C=C1Cl)=CC=C1NC(=O)NC1=NC=CS1 GNOMMUQGOOPKSZ-UHFFFAOYSA-N 0.000 claims description 2
- KDDTWIVRCCWDFL-UHFFFAOYSA-N 1-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]-3-(4-methyl-1,3-thiazol-2-yl)urea Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1F)=CC=C1NC(=O)NC1=NC(C)=CS1 KDDTWIVRCCWDFL-UHFFFAOYSA-N 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- ZIYRESLEDFVZIW-UHFFFAOYSA-N 1-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]-3-(1,3-thiazol-2-yl)urea Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1F)=CC=C1NC(=O)NC1=NC=CS1 ZIYRESLEDFVZIW-UHFFFAOYSA-N 0.000 claims 1
- NXXBCDHYUFWPFQ-UHFFFAOYSA-N 2-tert-butyl-1,3,4-thiadiazole Chemical compound CC(C)(C)C1=NN=CS1 NXXBCDHYUFWPFQ-UHFFFAOYSA-N 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 abstract description 8
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- 239000012453 solvate Substances 0.000 abstract 1
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- 238000011161 development Methods 0.000 description 49
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- QXTRPGAMVIONMK-UHFFFAOYSA-N 2-amino-5-ethyl-1,3,4-thiadiazole Chemical compound CCC1=NN=C(N)S1 QXTRPGAMVIONMK-UHFFFAOYSA-N 0.000 description 8
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 8
- XMXLBDNVSIHRRA-UHFFFAOYSA-N 2-amino-4,5-dimethyl-thiazole Natural products CC=1N=C(N)SC=1C XMXLBDNVSIHRRA-UHFFFAOYSA-N 0.000 description 7
- JWNJXRODWCORFX-UHFFFAOYSA-N 2-chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyaniline Chemical compound C=12C=C(OC)C(OC)=CC2=NC=NC=1OC1=CC=C(N)C(Cl)=C1 JWNJXRODWCORFX-UHFFFAOYSA-N 0.000 description 7
- FECRYRZVCNTJHP-UHFFFAOYSA-N 3-chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyaniline Chemical compound C=12C=C(OC)C(OC)=CC2=NC=NC=1OC1=CC=C(N)C=C1Cl FECRYRZVCNTJHP-UHFFFAOYSA-N 0.000 description 7
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001132775 | 2001-04-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL367105A1 PL367105A1 (en) | 2005-02-21 |
| PL209822B1 true PL209822B1 (pl) | 2011-10-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL367105A PL209822B1 (pl) | 2001-04-27 | 2002-04-26 | Pochodna chinoliny lub chinazoliny, zawierająca ją kompozycja farmaceutyczna i zastosowanie |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6821987B2 (OSRAM) |
| EP (2) | EP1382604B1 (OSRAM) |
| JP (1) | JP2010077131A (OSRAM) |
| KR (1) | KR100879669B1 (OSRAM) |
| CN (1) | CN1273466C (OSRAM) |
| AT (1) | ATE396988T1 (OSRAM) |
| AU (1) | AU2002255284B2 (OSRAM) |
| BE (1) | BE2018C008I2 (OSRAM) |
| BR (1) | BRPI0209216B8 (OSRAM) |
| CA (1) | CA2445333C (OSRAM) |
| DE (2) | DE60226912D1 (OSRAM) |
| DK (1) | DK1382604T3 (OSRAM) |
| ES (1) | ES2256466T3 (OSRAM) |
| FR (1) | FR18C1006I2 (OSRAM) |
| IL (1) | IL158459A0 (OSRAM) |
| MX (1) | MXPA03009662A (OSRAM) |
| NL (1) | NL300927I9 (OSRAM) |
| NO (2) | NO326325B1 (OSRAM) |
| NZ (1) | NZ529046A (OSRAM) |
| PL (1) | PL209822B1 (OSRAM) |
| RU (1) | RU2283841C2 (OSRAM) |
| TW (1) | TWI324154B (OSRAM) |
| WO (1) | WO2002088110A1 (OSRAM) |
| ZA (1) | ZA200307861B (OSRAM) |
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| US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US20040048780A1 (en) * | 2000-05-10 | 2004-03-11 | The Trustees Of Columbia University In The City Of New York | Method for treating and preventing cardiac arrhythmia |
| US20040229781A1 (en) * | 2000-05-10 | 2004-11-18 | Marks Andrew Robert | Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias |
| US7393652B2 (en) | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
| US6489125B1 (en) * | 2000-05-10 | 2002-12-03 | The Trustees Of Columbia University In The City Of New York | Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor |
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| US7544678B2 (en) | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
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| JP2728878B2 (ja) | 1987-12-15 | 1998-03-18 | 大倉工業株式会社 | 中空押出成形板 |
| GB9000644D0 (en) * | 1990-01-11 | 1990-03-14 | Erba Carlo Spa | New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds |
| EP0860433B1 (en) * | 1995-11-07 | 2002-07-03 | Kirin Beer Kabushiki Kaisha | Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of growth factor receptor originating in platelet and pharmaceutical compositions containing the same |
| JP4194678B2 (ja) | 1997-11-28 | 2008-12-10 | キリンファーマ株式会社 | キノリン誘導体およびそれを含む医薬組成物 |
| ATE529109T1 (de) * | 1997-12-22 | 2011-11-15 | Bayer Healthcare Llc | Hemmung der p38 kinase aktivität durch substituierte heterocyclische harnstoffe |
| ES2153340T3 (es) * | 1997-12-22 | 2006-02-01 | Bayer Pharmaceuticals Corp. | Inhibicion de la quinasa raf utilizando ureas heterociclicas sustituidas. |
| HU230789B1 (en) * | 1999-01-22 | 2018-05-02 | Kyowa Hakko Kirin Co | Quinoline derivatives and quinazoline derivatives, pharmaceutical compositions containing them and their use |
| EP1243582A4 (en) * | 1999-12-24 | 2003-06-04 | Kirin Brewery | CHINOLINE AND CHINAZOLINE DERIVATIVES AND MEDICATIONS CONTAINING THEM |
| JP2002030083A (ja) | 2000-07-18 | 2002-01-29 | Kirin Brewery Co Ltd | Ｎ−（２−クロロ−４−｛［６−メトキシ−７−（３−ピリジルメトキシ）−４−キノリル］オキシ｝フェニル）−ｎ’−プロピルウレアの二塩酸塩 |
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- 2002-04-26 CN CNB028126246A patent/CN1273466C/zh not_active Expired - Lifetime
- 2002-04-26 MX MXPA03009662A patent/MXPA03009662A/es active IP Right Grant
- 2002-04-26 ES ES02724651T patent/ES2256466T3/es not_active Expired - Lifetime
- 2002-04-26 CA CA2445333A patent/CA2445333C/en not_active Expired - Lifetime
- 2002-04-26 WO PCT/JP2002/004279 patent/WO2002088110A1/ja not_active Ceased
-
2003
- 2003-10-08 ZA ZA200307861A patent/ZA200307861B/en unknown
- 2003-10-14 NO NO20034595A patent/NO326325B1/no not_active IP Right Cessation
-
2004
- 2004-06-07 US US10/861,446 patent/US7211587B2/en not_active Expired - Fee Related
-
2009
- 2009-10-21 JP JP2009242477A patent/JP2010077131A/ja not_active Withdrawn
-
2018
- 2018-01-31 NL NL300927C patent/NL300927I9/nl unknown
- 2018-02-05 NO NO2018005C patent/NO2018005I1/no unknown
- 2018-02-06 FR FR18C1006C patent/FR18C1006I2/fr active Active
- 2018-02-08 BE BE2018C008C patent/BE2018C008I2/nl unknown
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