PL174539B1 - Sposób wytwarzania krystalicznego monohydratu beta-laktamu - Google Patents
Sposób wytwarzania krystalicznego monohydratu beta-laktamuInfo
- Publication number
- PL174539B1 PL174539B1 PL94303676A PL30367694A PL174539B1 PL 174539 B1 PL174539 B1 PL 174539B1 PL 94303676 A PL94303676 A PL 94303676A PL 30367694 A PL30367694 A PL 30367694A PL 174539 B1 PL174539 B1 PL 174539B1
- Authority
- PL
- Poland
- Prior art keywords
- monohydrate
- dihydrate
- crystalline
- lactam
- relative humidity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/071,550 US5374719A (en) | 1993-06-04 | 1993-06-04 | Process for converting loracarbef dihydrate to loracarbef monohydrate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL303676A1 PL303676A1 (en) | 1994-12-12 |
| PL174539B1 true PL174539B1 (pl) | 1998-08-31 |
Family
ID=22102051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL94303676A PL174539B1 (pl) | 1993-06-04 | 1994-06-01 | Sposób wytwarzania krystalicznego monohydratu beta-laktamu |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5374719A (OSRAM) |
| EP (1) | EP0627430B1 (OSRAM) |
| JP (1) | JP3442479B2 (OSRAM) |
| KR (1) | KR100311699B1 (OSRAM) |
| CN (1) | CN1042424C (OSRAM) |
| AT (1) | ATE146472T1 (OSRAM) |
| AU (1) | AU678000B2 (OSRAM) |
| BR (1) | BR9402149A (OSRAM) |
| CA (1) | CA2125001C (OSRAM) |
| CO (1) | CO4230100A1 (OSRAM) |
| CZ (1) | CZ283468B6 (OSRAM) |
| DE (1) | DE69401163T2 (OSRAM) |
| DK (1) | DK0627430T3 (OSRAM) |
| ES (1) | ES2097002T3 (OSRAM) |
| FI (1) | FI108132B (OSRAM) |
| GR (1) | GR3022111T3 (OSRAM) |
| HU (1) | HU217066B (OSRAM) |
| IL (1) | IL109871A (OSRAM) |
| MY (1) | MY110724A (OSRAM) |
| NO (1) | NO306302B1 (OSRAM) |
| NZ (1) | NZ260653A (OSRAM) |
| PE (1) | PE13195A1 (OSRAM) |
| PH (1) | PH30304A (OSRAM) |
| PL (1) | PL174539B1 (OSRAM) |
| RU (1) | RU2124013C1 (OSRAM) |
| TW (1) | TW252980B (OSRAM) |
| UA (1) | UA27812C2 (OSRAM) |
| YU (1) | YU33394A (OSRAM) |
| ZA (1) | ZA943827B (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5550231A (en) * | 1993-06-15 | 1996-08-27 | Eli Lilly And Company | Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof |
| US5580977A (en) * | 1995-03-01 | 1996-12-03 | Eli Lilly And Company | Process for preparing loracarbef monohydrate |
| MXPA04010608A (es) * | 2002-04-29 | 2004-12-13 | Actelion Pharmaceuticals Ltd | Derivados de 7-aril-3,9-diazabiciclo(3.3.1)non-6-eno y sus usos como inhibidores de renina en el tratamiento de enfermedades de hipertension, cardiovasculares o renales. |
| US20070225285A1 (en) * | 2005-11-04 | 2007-09-27 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3531481A (en) * | 1969-04-21 | 1970-09-29 | Lilly Co Eli | Method for manufacture of crystalline cephalosporin |
| US3502663A (en) * | 1969-04-21 | 1970-03-24 | Lilly Co Eli | Crystalline cephalosporin,method for its manufacture |
| JPS5672698A (en) * | 1979-11-14 | 1981-06-16 | Kyowa Hakko Kogyo Co Ltd | Preparation of optically active cephalosporin analogue |
| YU46699B (sh) * | 1987-10-06 | 1994-04-05 | Eli Lilly And Co. | Kristalni monohidratni oblik 1-karbacefalosporina |
| US4977257A (en) * | 1988-11-14 | 1990-12-11 | Eli Lilly And Company | DMF solvates of a β-lactam antibiotic |
| CA2002596A1 (en) * | 1988-11-14 | 1990-05-14 | Thomas M. Eckrich | Hydrates of b-lactam antibiotic |
-
1993
- 1993-06-04 US US08/071,550 patent/US5374719A/en not_active Expired - Lifetime
-
1994
- 1994-06-01 TW TW083105006A patent/TW252980B/zh active
- 1994-06-01 DK DK94303945.3T patent/DK0627430T3/da active
- 1994-06-01 BR BR9402149A patent/BR9402149A/pt not_active Application Discontinuation
- 1994-06-01 AT AT94303945T patent/ATE146472T1/de not_active IP Right Cessation
- 1994-06-01 CZ CZ941342A patent/CZ283468B6/cs not_active IP Right Cessation
- 1994-06-01 DE DE69401163T patent/DE69401163T2/de not_active Expired - Fee Related
- 1994-06-01 EP EP94303945A patent/EP0627430B1/en not_active Expired - Lifetime
- 1994-06-01 ZA ZA943827A patent/ZA943827B/xx unknown
- 1994-06-01 NZ NZ260653A patent/NZ260653A/en unknown
- 1994-06-01 PL PL94303676A patent/PL174539B1/pl not_active IP Right Cessation
- 1994-06-01 ES ES94303945T patent/ES2097002T3/es not_active Expired - Lifetime
- 1994-06-01 PE PE1994243644A patent/PE13195A1/es not_active Application Discontinuation
- 1994-06-02 KR KR1019940012340A patent/KR100311699B1/ko not_active Expired - Fee Related
- 1994-06-02 CO CO94023737A patent/CO4230100A1/es unknown
- 1994-06-02 PH PH48386A patent/PH30304A/en unknown
- 1994-06-02 AU AU64516/94A patent/AU678000B2/en not_active Ceased
- 1994-06-02 NO NO942048A patent/NO306302B1/no not_active IP Right Cessation
- 1994-06-02 UA UA94005241A patent/UA27812C2/uk unknown
- 1994-06-02 CA CA002125001A patent/CA2125001C/en not_active Expired - Fee Related
- 1994-06-02 MY MYPI94001408A patent/MY110724A/en unknown
- 1994-06-02 IL IL10987194A patent/IL109871A/en not_active IP Right Cessation
- 1994-06-03 YU YU33394A patent/YU33394A/sh unknown
- 1994-06-03 RU RU94019424A patent/RU2124013C1/ru not_active IP Right Cessation
- 1994-06-03 CN CN94106984A patent/CN1042424C/zh not_active Expired - Fee Related
- 1994-06-03 HU HU9401675A patent/HU217066B/hu not_active IP Right Cessation
- 1994-06-03 FI FI942633A patent/FI108132B/fi not_active IP Right Cessation
- 1994-06-03 JP JP12228394A patent/JP3442479B2/ja not_active Expired - Fee Related
-
1996
- 1996-12-19 GR GR960403422T patent/GR3022111T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Decisions on the lapse of the protection rights |
Effective date: 20050601 |